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1. 发明授权

US07056722B1 Apparatus and method of preparation of stable, long term thrombin from plasma and thrombin formed thereby 有权
标题翻译：从其形成的血浆和凝血酶制备稳定的长期凝血酶的装置和方法
公开(公告)号：US07056722B1
公开(公告)日：2006-06-06
申请号：US09709237
申请日：2000-11-10
申请人： Philip Henry Coelho , Phil Kingsley , Jim Brausch , James H. Godsey , Gail Rock
发明人： Philip Henry Coelho , Phil Kingsley , Jim Brausch , James H. Godsey , Gail Rock
IPC分类号： C12N9/74 , C12Q1/56
CPC分类号： G01N33/86 , A61J3/002 , A61K35/16 , A61L24/108 , C12N9/6429 , C12Y304/21005 , G01N33/4905 , G01N2333/974
摘要： A sterile method for preparing stable thrombin component from a single donor's plasma in which the thrombin component is harvested simultaneously from the clotting and adhesive proteins component from the same donor plasma in less than one hour. The combined components provide an improved biological hemostatic agent and tissue sealant by virtue of its freedom from the risk of contaminating viruses or bacteria from allogenic human or bovine blood sources. The thrombin provides polymerization of the clotting and adhesive proteins in less than five seconds, and is sufficiently stable to provide that fast clotting over a six hour period. Further, the clotting times can be predictably lengthened by diluting the thrombin with saline.
摘要翻译：一种用于从单个供体血浆中制备稳定的凝血酶组分的无菌方法，其中凝血酶组分在不到一小时的时间内从同一供体血浆的凝血和粘附蛋白组分同时收获。组合的组分由于其免于污染来自同种异体人或牛血源的病毒或细菌的风险而提供改进的生物止血剂和组织密封剂。凝血酶在不到5秒内提供凝血和粘附蛋白的聚合，并且足够稳定，以便在6小时内提供快速凝血。此外，通过用盐水稀释凝血酶可以可预测地延长凝血时间。

2. 发明授权

US06472162B1 Method for preparing thrombin for use in a biological glue 有权
标题翻译：制备用于生物胶的凝血酶的方法
公开(公告)号：US06472162B1
公开(公告)日：2002-10-29
申请号：US09328350
申请日：1999-06-04
申请人： Philip Henry Coelho , Phil Kingsley , Jim Brausch , James H. Godsey , Gail Rock , Trista K. Madsen , Sona B. Frausto
发明人： Philip Henry Coelho , Phil Kingsley , Jim Brausch , James H. Godsey , Gail Rock , Trista K. Madsen , Sona B. Frausto
IPC分类号： C12Q156
CPC分类号： C12N9/6429 , A61K38/4833 , C12Y304/21005
摘要： A sterile method for preparing stable thrombin component from a single donor's plasma in which the thrombin component and the clotting and adhesive proteins component are harvested simultaneously from the same donor plasma in less than one hour. The combined components provide an improved biological hemostatic agent and tissue sealant by virtue of its freedom from the risk of contaminating viruses or bacteria from allogenic human or bovine blood sources. The thrombin provides polymerization of the clotting and adhesive proteins in less than five seconds, and is sufficiently stable to provide that fast clotting over a six hour period. Further, the clotting times can be predictably lengthened by diluting the thrombin with saline.
摘要翻译：一种用于从单一供体血浆中制备稳定的凝血酶组分的无菌方法，其中凝血酶组分和凝血和粘附蛋白组分在少于1小时内从相同供体血浆同时收获。组合的组分由于其免于污染来自同种异体人或牛血源的病毒或细菌的风险而提供改进的生物止血剂和组织密封剂。凝血酶在不到5秒内提供凝血和粘附蛋白的聚合，并且足够稳定，以便在6小时内提供快速凝血。此外，通过用盐水稀释凝血酶可以可预测地延长凝血时间。

3. 发明授权

US06274090B1 Apparatus and method of preparation of stable, long term thrombin from plasma and thrombin formed thereby 有权
标题翻译：从其形成的血浆和凝血酶制备稳定的长期凝血酶的装置和方法
公开(公告)号：US06274090B1
公开(公告)日：2001-08-14
申请号：US09129988
申请日：1998-08-05
申请人： Philip Henry Coelho , Phil Kingsley , Jim Brausch , James H. Godsey , Gail Rock
发明人： Philip Henry Coelho , Phil Kingsley , Jim Brausch , James H. Godsey , Gail Rock
IPC分类号： B01L1100
CPC分类号： G01N33/86 , A61J3/002 , A61K35/16 , A61L24/108 , C12N9/6429 , C12Y304/21005 , G01N33/4905 , G01N2333/974
摘要： A sterile method for preparing stable thrombin component from a single donor's plasma in which the thrombin component is harvested simultaneously from the clotting and adhesive proteins component from the same donor plasma in less than one hour. The combined components provide an improved biological hemostatic agent and tissue sealant by virtue of its freedom from the risk of contaminating viruses or bacteria from allogenic human or bovine blood sources. The thrombin provides polymerization of the clotting and adhesive proteins in less than five seconds, and is sufficiently stable to provide that fast clotting over a six hour period. Further, the clotting times can be predictably lengthened by diluting the thrombin with saline.
摘要翻译：一种用于从单个供体血浆中制备稳定的凝血酶组分的无菌方法，其中凝血酶组分在不到一小时的时间内从同一供体血浆的凝血和粘附蛋白组分同时收获。组合的组分由于其免于污染来自同种异体人或牛血源的病毒或细菌的风险而提供改进的生物止血剂和组织密封剂。凝血酶在不到5秒内提供凝血和粘附蛋白的聚合，并且足够稳定，以便在6小时内提供快速凝血。此外，通过用盐水稀释凝血酶可以可预测地延长凝血时间。

4. 发明申请

US20180250429A1 DEVICE AND METHOD FOR STERILIZATION OF INSTRUMENTS AND SURFACES 审中-公开
公开(公告)号：US20180250429A1
公开(公告)日：2018-09-06
申请号：US15974115
申请日：2018-05-08
申请人： Gail Rock
发明人： Gail Rock
IPC分类号： A61L2/18 , A61L2/10 , A61L2/00 , A61L2/08 , A61L2/26
CPC分类号： A61L2/18 , A61L2/0088 , A61L2/08 , A61L2/10 , A61L2/26 , A61L2202/11 , A61L2202/24
摘要： A device for decontaminating a medical device, the device including a compartment adapted to contain a medical device and a solution, the solution comprising a photoactivatable substance; and a light system providing 360 degrees of exposure to the compartment. Also, a method for decontaminating a medical device, the method including placing a medical device in a compartment with a solution, the solution comprising a photoactivatable substance; incubating the medical device in the solution to allow the photoactivatable substance to attach to pathogens; and exposing the compartment to 360 degrees of light exposure to activate the photoactivatable substance.

5. 发明授权

US4628026A Method and apparatus for automated double fluorochromization analysis in lymphocytotoxicity testing 失效
标题翻译：淋巴细胞毒性试验中自动双色荧光色素分析的方法和装置
公开(公告)号：US4628026A
公开(公告)日：1986-12-09
申请号：US552090
申请日：1983-11-15
申请人： Dietlind Gardell , Gail Rock
发明人： Dietlind Gardell , Gail Rock
IPC分类号： G01N21/25 , G01N21/64 , G01N33/53 , G01N33/554
CPC分类号： G01N21/6428 , G01N21/6452 , G01N21/6458 , G01N2021/6419 , G01N2021/6421 , G01N2201/0446 , G01N2201/0484 , Y10S435/963 , Y10S435/966 , Y10S435/973 , Y10S436/80 , Y10S436/805 , Y10S436/807 , Y10S436/808 , Y10S436/809 , Y10S436/821
摘要： An automated system for rapid sequential photometric analysis of a collection of double fluorochrome stained lymphocyte specimens, useful for antibody screening or lymphocytotoxicity analysis. The specimens are sequentially alternately irradiated with light of two distinguishable wavelengths, producing fluorescence at two distinguishable wavelengths. The fluorescent emission light intensity for each irradiation of each specimen is measured using a photometer and computer. The computer controls the synchronization of the irradiation through alternately selected condenser sets with the sequential movement of specimens into the optical path of the irradiating and detected light, and calculates the quotient of the light intensities emitted from each specimen at the two selected fluorescent light wavelengths. These quotients are compared against a control ratio (for lymphocytotoxicity analysis) to classify the specimen. Also described is a method of preparing specimens for such analysis, which requires that a complement be added to the first staining solution after the latter is applied to the specimens, then this combination agitated, and then the second staining solution added and the specimen incubated.
摘要翻译：一种用于快速顺序光度分析双重荧光染色淋巴细胞标本的自动化系统，可用于抗体筛选或淋巴细胞毒性分析。用两个可辨别的波长的光顺序地交替地照射样品，在两个可区别的波长处产生荧光。使用光度计和计算机测量每个样品的每次照射的荧光发射光强度。计算机通过交替选择的聚光器组来控制照射的同步，同时将样品顺序移动到照射和检测光的光路中，并计算在两个选定的荧光波长处从每个样品发射的光强度的商。将这些商与对照比（用于淋巴细胞毒性分析）进行比较以对样品进行分类。还描述了制备用于这种分析的样品的方法，其要求在将样品应用于样品后将补体添加到第一染色溶液中，然后将该组合搅拌，然后加入第二染色溶液并将样品孵育。

6. 发明授权

US11426479B2 Device and method for sterilization of instruments and surfaces 有权
公开(公告)号：US11426479B2
公开(公告)日：2022-08-30
申请号：US15974115
申请日：2018-05-08
申请人： Gail Rock
发明人： Gail Rock
IPC分类号： A61L2/10 , A61L2/18 , A61L2/00 , A61L2/08 , A61L2/26
摘要： A device for decontaminating a medical device, the device including a compartment adapted to contain a medical device and a solution, the solution comprising a photoactivatable substance; and a light system providing 360 degrees of exposure to the compartment. Also, a method for decontaminating a medical device, the method including placing a medical device in a compartment with a solution, the solution comprising a photoactivatable substance; incubating the medical device in the solution to allow the photoactivatable substance to attach to pathogens; and exposing the compartment to 360 degrees of light exposure to activate the photoactivatable substance.

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