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71. 发明申请

US20100310656A1 Immunotherapy and prevention of autoimmune hepatitis 审中-公开
标题翻译：免疫治疗和预防自身免疫性肝炎
公开(公告)号：US20100310656A1
公开(公告)日：2010-12-09
申请号：US12662663
申请日：2010-04-27
申请人： Aldar S. Bourinbaiar , Vichai Jirathitikal
发明人： Aldar S. Bourinbaiar , Vichai Jirathitikal
IPC分类号： A61K39/29 , C07K14/00 , A61K9/00 , A61K39/12 , A61K35/12 , A61K39/00 , A61P31/12 , A61P31/00
CPC分类号： C07K14/005 , A61K9/2054 , A61K39/0008 , A61K39/001 , A61K39/12 , A61K39/29 , A61K39/292 , A61K2039/542 , A61K2039/55588 , C12N2730/10134 , C12N2770/32422 , C12N2770/32434
摘要： The invention is within the field of immunology and microbiology, more specifically the field of virology and is related to immunotherapy and prophylaxis of hepatitis and autoimmune diseases. The composition useful for these purposes is disclosed, including the methods of making and using said composition.
摘要翻译：本发明属于免疫学和微生物学领域，更具体地涉及病毒学领域，涉及免疫治疗和预防肝炎和自身免疫性疾病。公开了用于这些目的的组合物，包括制备和使用所述组合物的方法。

72. 发明申请

US20100260816A1 INDUCTION OF IMMUNOLOGICAL TOLERANCE 审中-公开
标题翻译：诱导免疫耐受性
公开(公告)号：US20100260816A1
公开(公告)日：2010-10-14
申请号：US12823545
申请日：2010-06-25
申请人： PAUL P. LATTA
发明人： PAUL P. LATTA
IPC分类号： A61K39/00 , A61F2/00 , A61P3/10 , A61P25/16 , A61P25/28 , A61P19/02 , A61P7/06 , A61P1/16
CPC分类号： A61K35/39 , A61K9/0024 , A61K9/5031 , A61K39/0008 , A61K39/001 , A61K2035/122 , A61K2035/128 , A61K2039/515 , C12N5/0677
摘要： A method of creating tolerance to transplanted cells, tissue, or organs without the need for continuous immunosuppression. A tolerizing dose of a cell or tissue within a membrane structure is implanted into a patient. Once the patient becomes tolerant to the cell or tissue, a tissue or organ is implanted which will no longer be recognized as foreign matter. The method makes animal organs practical for human use, prevents autoimmune destruction as well as immune rejection. It has applications in treatment and prevention of many mammalian diseases.
摘要翻译：一种产生对移植细胞，组织或器官的耐受性而不需要连续免疫抑制的方法。将膜结构内的细胞或组织的耐受剂量植入患者体内。一旦患者变得对细胞或组织变得容忍，植入将不再被识别为异物的组织或器官。该方法使动物器官适用于人类，防止自身免疫破坏以及免疫排斥。它具有治疗和预防许多哺乳动物疾病的应用。

73. 发明申请

US20100249221A1 IN VIVO AND EX VIVO GENE TRANSFER INTO RENAL TISSUE USING GUTLESS ADENOVIRUS VECTORS 有权
公开(公告)号：US20100249221A1
公开(公告)日：2010-09-30
申请号：US12778360
申请日：2010-05-12
申请人： Lakshman R. SEHGAL , Jonathan Wong
发明人： Lakshman R. SEHGAL , Jonathan Wong
IPC分类号： A61K31/7088 , C12N15/63 , A61P13/12
CPC分类号： C12N15/86 , A61K38/00 , A61K38/44 , A61K39/001 , A61K48/00 , A61K48/005 , A61K48/0058 , A61K48/0075 , C07K14/7455 , C12N7/00 , C12N2710/10343 , C12N2830/008 , C12Y113/11052
摘要： A method for treating a renal disease in a subject is disclosed. The method includes administering into a kidney of the subject with an effective amount of a gutless adenoviral vector containing a polynucleotide encoding a therapeutic agent. The gutless adenoviral vector contains the nucleotide sequence of SEQ ID NO:13 or SEQ ID NO:15 and expresses the therapeutic agent in a kidney tissue of the subject.

74. 发明授权

US07799350B2 Use of cytokines and mitogens to inhibit graft versus host disease 有权
标题翻译：使用细胞因子和促分裂原抑制移植物抗宿主病
公开(公告)号：US07799350B2
公开(公告)日：2010-09-21
申请号：US11873352
申请日：2007-10-16
申请人： David A. Horwitz
发明人： David A. Horwitz
IPC分类号： A61K35/26 , A61K35/28 , C12N5/08
CPC分类号： C12N5/0636 , A61K39/001 , A61K2035/122 , A61K2035/124 , C12N2501/15 , C12N2501/23 , C12N2501/59 , C12N2501/599 , Y10S435/81 , Y10S514/885
摘要： A method for inducing T cell tolerance in peripheral blood mononuclear cells (PBMCs) comprising adding a suppressive composition to said cells.
摘要翻译：一种在外周血单核细胞（PBMC）中诱导T细胞耐受的方法，包括向所述细胞添加抑制组合物。

75. 发明授权

US07785873B2 Antigen arrays for treatment of bone disease 失效
标题翻译：用于治疗骨病的抗原阵列
公开(公告)号：US07785873B2
公开(公告)日：2010-08-31
申请号：US11589321
申请日：2006-10-30
申请人： Martin Bachmann , Patrik Maurer , Gunther Spohn
发明人： Martin Bachmann , Patrik Maurer , Gunther Spohn
IPC分类号： C12N15/63 , A61K48/00
CPC分类号： A61K39/0007 , A61K38/00 , A61K39/0005 , A61K39/0008 , A61K39/001 , A61K39/35 , A61K39/385 , A61K39/39 , A61K47/6901 , A61K2039/5256 , A61K2039/5258 , A61K2039/6075 , A61K2039/627 , C07K14/005 , C07K14/523 , C07K14/5409 , C07K14/5437 , C07K14/70575 , C07K16/00 , C07K16/082 , C07K16/22 , C07K16/2863 , C07K16/2875 , C07K16/40 , C07K16/4291 , C07K2317/52 , C07K2317/55 , C07K2319/00 , C07K2319/30 , C12N2730/10122 , C12N2730/10123 , C12N2795/18122
摘要： The present invention is related to the fields of molecular biology, virology, immunology and medicine. The invention provides a composition comprising an ordered and repetitive antigen or antigenic determinant array, and in particular a RANKL protein, RANKL fragment or RANKL peptide-VLP-array. More specifically, the invention provides a composition comprising a virus-like particle and at least one RANKL protein, RANKL fragment or RANKL peptide bound thereto. The invention also provides a process for producing the conjugates and the ordered and repetitive arrays, respectively. The compositions of the invention are useful in the production of vaccines for the treatment of bone diseases and as a pharmaccine to prevent or cure bone diseases and to efficiently induce immune responses, in particular antibody responses. Furthermore, the compositions of the invention are particularly useful to efficiently induce self-specific immune responses within the indicated context.
摘要翻译：本发明涉及分子生物学，病毒学，免疫学和医学领域。本发明提供包含有序和重复抗原或抗原决定簇，特别是RANKL蛋白，RANKL片段或RANKL肽-VLP阵列的组合物。更具体地，本发明提供包含病毒样颗粒和与其结合的至少一种RANKL蛋白，RANKL片段或RANKL肽的组合物。本发明还提供了分别制备共轭物和有序和重复阵列的方法。本发明的组合物可用于生产用于治疗骨疾病的疫苗和用于预防或治愈骨疾病并有效诱导免疫应答，特别是抗体应答的药物。此外，本发明的组合物特别有用于在指定的上下文中有效诱导自身特异性免疫应答。

76. 发明申请

US20100104587A1 METHODS OF MODULATING THE NEGATIVE CHEMOTAXIS OF IMMUNE CELLS 有权
标题翻译：调节免疫细胞阴性化学的方法
公开(公告)号：US20100104587A1
公开(公告)日：2010-04-29
申请号：US12572445
申请日：2009-10-02
申请人： Surendra Chavan , Jonathan L. Moon , Lopa Bhatt
发明人： Surendra Chavan , Jonathan L. Moon , Lopa Bhatt
IPC分类号： A61K39/395 , C12N5/00 , A61K31/7052 , A61K38/16 , A61K38/46 , A61K38/44 , A61P37/04
CPC分类号： A61K39/39558 , A61K39/001 , A61K39/0011 , A61K2039/505 , A61K2039/54 , A61K2039/577 , C07K16/30 , C07K2317/24 , C07K2317/622 , C07K2317/76 , C12N15/113 , C12N2310/11 , C12N2320/30 , C12N2320/32
摘要： The current invention is directed to methods of inducing migration of an immune cell toward a cancer cell comprising inhibiting the activity of a chemorepellant released from the cancer cell.
摘要翻译：本发明涉及诱导免疫细胞向癌细胞迁移的方法，包括抑制从癌细胞释放的化学预防剂的活性。

77. 发明申请

US20100061965A1 RESPIRATORY SYNCYTIAL VIRUS RENDERS DENDRITIC CELLS TOLEROGENIC 审中-公开
标题翻译：呼吸道同类病毒Renders DENDRITIC CELLS TOLEROGENIC
公开(公告)号：US20100061965A1
公开(公告)日：2010-03-11
申请号：US12479253
申请日：2009-06-05
申请人： JOHN E. CONNOLLY , JACQUES F. BANCHEREAU , MICHELLE A. GILL
发明人： JOHN E. CONNOLLY , JACQUES F. BANCHEREAU , MICHELLE A. GILL
IPC分类号： A61K45/00 , C12N5/0784 , C12N5/0783 , A61P37/06
CPC分类号： A61K39/001 , A61K2035/122 , A61K2039/5154 , C12N5/064 , C12N2760/16111 , C12N2760/18511
摘要： The present invention includes compositions, methods and systems for inducing immune tolerance using antigen presenting cells by infecting isolated antigen presenting cells with an effective amount of respiratory syncytial virus (RSV) or portions thereof sufficient to infect the antigen presenting cells and contacting CD4+, CD8+ or both CD4+ T cells and CD8+ T cells with the RSV-infected antigen presenting cells, wherein the CD4+, CD8+ or both CD4 and CD8+ T cells are rendered tolerogenic as measured in vitro by a mixed leukocyte reaction.
摘要翻译：本发明包括用抗原呈递细胞诱导免疫耐受的组合物，方法和系统，其通过用有效量的呼吸道合胞病毒（RSV）或其部分感染分离的抗原呈递细胞，其足以感染抗原呈递细胞并接触CD4 +，CD8 +或具有RSV感染的抗原呈递细胞的CD4 + T细胞和CD8 + T细胞都是CD4 +，CD8 +或CD4 + CD8 + T细胞都具有耐受性，通过混合白细胞反应体外测定。

78. 发明申请

US20090280109A1 ILT3 and ILT4-related compositions and methods 审中-公开
标题翻译： ILT3和ILT4相关的组合物和方法
公开(公告)号：US20090280109A1
公开(公告)日：2009-11-12
申请号：US12072119
申请日：2008-02-22
申请人： Nicole Suciu-Foca , Zhuoru Liu , Chih-Chao Chang , Raffaello Cortesini
发明人： Nicole Suciu-Foca , Zhuoru Liu , Chih-Chao Chang , Raffaello Cortesini
IPC分类号： A61K39/395
CPC分类号： A61K31/593 , A61K35/15 , A61K35/17 , A61K38/2066 , A61K39/0008 , A61K39/001 , A61K39/0011 , A61K2035/122 , A61K2039/505 , A61K2039/5154 , C12N5/064 , C12N2500/38 , C12N2501/23 , C12N2502/11 , G01N33/564 , A61K2300/00
摘要： This invention provides compositions which comprise at least two of a CD4+CD25+ cell, IL-10, a CD8+CD28− cell and a vitamin D3 analog. This invention also provides methods for generating a tolerogenic antigen-presenting cell, and increasing the expression of ILT3 and/or ILT4 by an antigen-presenting cell. This invention further provides methods for inhibiting the onset of or treating the rejection of an antigenic substance and inhibiting the onset of or treating an autoimmune disease in a subject. This invention further provides methods for treating and preventing AIDS, cancer, and Hepatitis C-related disorders, and for identifying agents useful for such purposes. Finally, this invention provides related compositions and kits.
摘要翻译：本发明提供了包含CD4 + CD25 +细胞，IL-10，CD8 + CD28-细胞和维生素D3类似物中的至少两种的组合物。本发明还提供了产生耐受性抗原呈递细胞的方法，并且通过抗原呈递细胞增加ILT3和/或ILT4的表达。本发明还提供了抑制受试者的抗原性物质的排斥或抑制自身免疫性疾病的发生或治疗的方法。本发明还提供了用于治疗和预防艾滋病，癌症和丙型肝炎相关疾病以及用于鉴定用于此目的的药剂的方法。最后，本发明提供了相关的组合物和试剂盒。

79. 发明申请

US20090264515A1 POLYNUCLEOTIDE THERAPY 审中-公开
标题翻译：多核苷酸治疗
公开(公告)号：US20090264515A1
公开(公告)日：2009-10-22
申请号：US12467866
申请日：2009-05-18
申请人： Paulo Fontoura , Hideki Garren , William H. Robinson , Lawrence Steinman , Pedro Jose Ruiz , Paul J. Utz
发明人： Paulo Fontoura , Hideki Garren , William H. Robinson , Lawrence Steinman , Pedro Jose Ruiz , Paul J. Utz
IPC分类号： A61K31/7088 , A61P21/00
CPC分类号： A61K39/001 , A61K38/2026 , A61K39/0007 , A61K39/0008 , A61K48/00 , A61K2039/53 , A61K2039/55522 , A61K2039/55561 , C07K2319/30
摘要： This invention provides a method of treating or preventing a disease in an animal associated with one or more self-protein(s), -polypeptide(s), or -peptide(s) that is present or involved in a non-physiologic process in the animal comprising administering to the animal a self-vector comprising a polynucleotide encoding the self-protein(s), -polypeptide(s) or -peptide(s) associated with the disease. Administration of the self-vector comprising a polynucleotide encoding the self-protein(s), -polypeptide(s) or -peptide(s) modulates an immune response to the self-protein(s), -polypeptide(s) or -peptide(s) expressed from administration of the self-vector. The invention also provides a composition comprising a polynucleotide encoding one or more self-protein(s), -polypeptide(s), or -peptide(s) that is present non-physiologically in a treated animal useful in treating or preventing a disease associated with the self-protein(s), -polypeptide(s), or -peptide(s) present in and/or the target of a non-physiologic process in the animal.
摘要翻译：本发明提供了一种治疗或预防与一种或多种自身蛋白，多肽或肽存在或参与非生理过程的一种或多种自身相关的动物疾病的方法，所述动物包括向所述动物施用包含编码与所述疾病相关的自身蛋白质多肽或多肽的多核苷酸的自身载体。施用包含编码自身蛋白，多肽或多肽的多核苷酸的自身载体调节对自身蛋白质的多肽或肽的免疫应答（s）表示自我向量的管理。本发明还提供了一种组合物，其包含编码一种或多种自身蛋白质，多肽或多肽或多肽的多核苷酸，所述多肽或多肽在治疗动物中非生理性地存在，可用于治疗或预防相关疾病其中存在于动物的非生理过程的和/或靶中的自身蛋白质，多肽或多肽。

80. 发明申请

US20090215722A1 Inhibition of Antigen Presentation with Poorly Catabolized Polymers 有权
标题翻译：用低分解聚合物抑制抗原呈递
公开(公告)号：US20090215722A1
公开(公告)日：2009-08-27
申请号：US12463315
申请日：2009-05-08
申请人： Gregory I. Frost , Per Borgstrom
发明人： Gregory I. Frost , Per Borgstrom
IPC分类号： A61K31/721 , A61P37/06
CPC分类号： A61K39/00 , A61K31/715 , A61K31/721 , A61K39/001
摘要： Methods to prevent the rejection of immunogenic tissues in an animal by administering a non-immunogenic, poorly catabolized molecule in an amount sufficient to inhibit an immune response are described herein. Also described are compositions that are useful for inhibiting immune responses in animals that are recipients of cellular transplants. For example, these methods and compositions can be used to prevent the rejection of xenografted and allografted tissues in an animal.
摘要翻译：本文描述了通过施用足以抑制免疫应答的量的非免疫原性差的分解代谢分子来防止动物中免疫原性组织排斥的方法。还描述了可用于抑制作为细胞移植受体的动物中的免疫应答的组合物。例如，这些方法和组合物可用于防止动物中异种移植和同种异体移植组织的排斥。

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