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71. 发明申请

US20090264515A1 POLYNUCLEOTIDE THERAPY 审中-公开
标题翻译：多核苷酸治疗
公开(公告)号：US20090264515A1
公开(公告)日：2009-10-22
申请号：US12467866
申请日：2009-05-18
申请人： Paulo Fontoura , Hideki Garren , William H. Robinson , Lawrence Steinman , Pedro Jose Ruiz , Paul J. Utz
发明人： Paulo Fontoura , Hideki Garren , William H. Robinson , Lawrence Steinman , Pedro Jose Ruiz , Paul J. Utz
IPC分类号： A61K31/7088 , A61P21/00
CPC分类号： A61K39/001 , A61K38/2026 , A61K39/0007 , A61K39/0008 , A61K48/00 , A61K2039/53 , A61K2039/55522 , A61K2039/55561 , C07K2319/30
摘要： This invention provides a method of treating or preventing a disease in an animal associated with one or more self-protein(s), -polypeptide(s), or -peptide(s) that is present or involved in a non-physiologic process in the animal comprising administering to the animal a self-vector comprising a polynucleotide encoding the self-protein(s), -polypeptide(s) or -peptide(s) associated with the disease. Administration of the self-vector comprising a polynucleotide encoding the self-protein(s), -polypeptide(s) or -peptide(s) modulates an immune response to the self-protein(s), -polypeptide(s) or -peptide(s) expressed from administration of the self-vector. The invention also provides a composition comprising a polynucleotide encoding one or more self-protein(s), -polypeptide(s), or -peptide(s) that is present non-physiologically in a treated animal useful in treating or preventing a disease associated with the self-protein(s), -polypeptide(s), or -peptide(s) present in and/or the target of a non-physiologic process in the animal.
摘要翻译：本发明提供了一种治疗或预防与一种或多种自身蛋白，多肽或肽存在或参与非生理过程的一种或多种自身相关的动物疾病的方法，所述动物包括向所述动物施用包含编码与所述疾病相关的自身蛋白质多肽或多肽的多核苷酸的自身载体。施用包含编码自身蛋白，多肽或多肽的多核苷酸的自身载体调节对自身蛋白质的多肽或肽的免疫应答（s）表示自我向量的管理。本发明还提供了一种组合物，其包含编码一种或多种自身蛋白质，多肽或多肽或多肽的多核苷酸，所述多肽或多肽在治疗动物中非生理性地存在，可用于治疗或预防相关疾病其中存在于动物的非生理过程的和/或靶中的自身蛋白质，多肽或多肽。

72. 发明申请

US20090215722A1 Inhibition of Antigen Presentation with Poorly Catabolized Polymers 有权
标题翻译：用低分解聚合物抑制抗原呈递
公开(公告)号：US20090215722A1
公开(公告)日：2009-08-27
申请号：US12463315
申请日：2009-05-08
申请人： Gregory I. Frost , Per Borgstrom
发明人： Gregory I. Frost , Per Borgstrom
IPC分类号： A61K31/721 , A61P37/06
CPC分类号： A61K39/00 , A61K31/715 , A61K31/721 , A61K39/001
摘要： Methods to prevent the rejection of immunogenic tissues in an animal by administering a non-immunogenic, poorly catabolized molecule in an amount sufficient to inhibit an immune response are described herein. Also described are compositions that are useful for inhibiting immune responses in animals that are recipients of cellular transplants. For example, these methods and compositions can be used to prevent the rejection of xenografted and allografted tissues in an animal.
摘要翻译：本文描述了通过施用足以抑制免疫应答的量的非免疫原性差的分解代谢分子来防止动物中免疫原性组织排斥的方法。还描述了可用于抑制作为细胞移植受体的动物中的免疫应答的组合物。例如，这些方法和组合物可用于防止动物中异种移植和同种异体移植组织的排斥。

73. 发明授权

US07556809B2 Active antiangiogenic therapy 有权
标题翻译：主动抗血管生成治疗
公开(公告)号：US07556809B2
公开(公告)日：2009-07-07
申请号：US10511384
申请日：2003-04-11
申请人： Mónica Bequet Romero , Boris Ernesto Acevedo Castro , Jorge Victor Gavilondo Cowley , Luis Enrique Fernández Molina , Omar Lopez Ocejo , Ricardo de la Caridad Silva Rodriguez , Alexis Musachio Lasa , Ernesto Galban Rodriguez , Dania Marcia Vázquez Blomquist
发明人： Mónica Bequet Romero , Boris Ernesto Acevedo Castro , Jorge Victor Gavilondo Cowley , Luis Enrique Fernández Molina , Omar Lopez Ocejo , Ricardo de la Caridad Silva Rodriguez , Alexis Musachio Lasa , Ernesto Galban Rodriguez , Dania Marcia Vázquez Blomquist
IPC分类号： A61K39/095 , A61K39/39 , A61K38/18 , A61K38/04 , A61K39/395 , C07K4/12
CPC分类号： C07K14/715 , A61K38/1858 , A61K38/1866 , A61K39/0005 , A61K39/0008 , A61K39/001 , A61K39/0011 , A61K48/005 , A61K2039/5256 , A61K2039/5258 , A61K2039/53 , A61K2039/55516 , A61K2039/55594 , C07K14/515 , C07K14/52 , C07K14/71
摘要： Application of oligonucleotide and polypeptide sequences of molecules of the family of the vascular permeability factor (VPF), their receptors, and co-receptors, as well as their modifications, in the active immunotherapy of pathologic entities in which course is associated to the increase of angiogenesis.These procedures can be employed in the single or combined therapy for the treatment of cancer and its metastasis, acute and chronic inflammatory processes, infectious diseases, autoimmune diseases, diabetic and newborn retinopathies, organ transplant rejection, macular degeneration, neovascular glaucoma, hemangioma, and angiofibroma, among others.
摘要翻译：血管通透性因子（VPF）家族的分子的寡核苷酸和多肽序列在病理实体的主动免疫治疗中的应用及其修饰，其中该过程与增加相关血管生成。这些方法可以用于治疗癌症及其转移，急性和慢性炎症过程，感染性疾病，自身免疫性疾病，糖尿病和新生儿视网膜病变，器官移植排斥，黄斑变性，新生血管性青光眼，血管瘤和血管纤维瘤等。

74. 发明授权

US07501124B2 Methods of inducing T-cell non-responsiveness with anti-gp39 24-31 antibodies 失效
标题翻译：用抗gp39 24-31抗体诱导T细胞非反应性的方法
公开(公告)号：US07501124B2
公开(公告)日：2009-03-10
申请号：US10962033
申请日：2004-10-07
申请人： Randolph J. Noelle , Fiona H. Durie , David C. Parker , Michael C. Appel , Nancy E. Phillips , John P. Mordes , Dale L. Grenier , Aldo A. Rossini
发明人： Randolph J. Noelle , Fiona H. Durie , David C. Parker , Michael C. Appel , Nancy E. Phillips , John P. Mordes , Dale L. Grenier , Aldo A. Rossini
IPC分类号： A61K39/395 , A61K35/26 , A61K35/28 , C07K16/28
CPC分类号： A61K39/001 , A61K35/17 , A61K35/39 , A61K38/00 , A61K2039/505 , C07K14/705 , C07K16/2875 , C07K2317/73 , Y10S514/885 , A61K2300/00
摘要： Methods for inducing T cell tolerance to a tissue or organ graft in a transplant recipeint are disclosed. The methods involve administering to a subject: 1) an allogeneic or xenogeneic cell which expresses donor antigens and which has a ligand on the cell surface which interacts with a receptor on the surface of a recipient T cell which mediates contact-dependent helper effector function; and 2) an antagonist of the receptor which inhibits interaction of the ligand with the receptor. In a preferred embodiment, the allogeneic or xenogeneic cell is a B cell, preferably a resting B cell, and the molecule on the surface of the T cell which mediates contact-dependent helper effector function is gp39. A preferred gp39 antagonist is an anti-gp39 antibody. The allogeneic or xenogeneic cell and the gp39 antagonist are typically administered to a transplant recipient prior to transplantation of the tissue or organ. The methods of the invention can be used to induce T cell tolerance to transplants such as liver, kidney, heart, lung, skin, muscle, neuronal tissue, stomach and intestine. A method for treating diabetes comprising administering to a subject allogeneic or xenogeneic cells expressing donor antigens, a gp39 antagonist and pancreatic islets is also disclosed.
摘要翻译：公开了在移植食谱中诱导T细胞对组织或器官移植物的耐受性的方法。所述方法包括对受试者施用：1）同种异体或异种细胞，其表达供体抗原，并且其在细胞表面上具有与介导接触依赖性辅助效应子功能的受体T细胞表面上的受体相互作用的配体; 和2）抑制配体与受体相互作用的受体拮抗剂。在一个优选的实施方案中，同种异体或异种细胞是B细胞，优选静止的B细胞，并且介导接触依赖性辅助效应子功能的T细胞表面上的分子是gp39。优选的gp39拮抗剂是抗gp39抗体。同种异体或异种细胞和gp39拮抗剂通常在移植组织或器官之前给予移植受体。本发明的方法可用于诱导移植物如肝，肾，心脏，肺，皮肤，肌肉，神经元组织，胃和肠的T细胞耐受性。还公开了一种用于治疗糖尿病的方法，其包括向受试者施用表达供体抗原的同种异体或异种细胞，gp39拮抗剂和胰岛。

75. 发明申请

US20080274131A1 Molecular antigen arrary 审中-公开
标题翻译：分子抗原可以是arrary
公开(公告)号：US20080274131A1
公开(公告)日：2008-11-06
申请号：US12010107
申请日：2008-01-18
申请人： Wolfgang A. Renner , Martin Bachmann , Alain Tissot , Patrick Maurer , Franziska Lechner , Peter Sebbel , Christine Piossek , Rainer Ortmann , Rainer Luond , Matthias Staufenbiel , Peter Frey
发明人： Wolfgang A. Renner , Martin Bachmann , Alain Tissot , Patrick Maurer , Franziska Lechner , Peter Sebbel , Christine Piossek , Rainer Ortmann , Rainer Luond , Matthias Staufenbiel , Peter Frey
IPC分类号： A61K39/12 , A61P31/12
CPC分类号： A61K39/12 , A61K38/00 , A61K39/0005 , A61K39/0007 , A61K39/0008 , A61K39/001 , A61K39/35 , A61K39/385 , A61K39/39 , A61K47/6901 , A61K2039/5256 , A61K2039/5258 , A61K2039/6075 , A61K2039/627 , C07K14/005 , C07K14/523 , C07K14/5409 , C07K14/5437 , C07K16/00 , C07K16/082 , C07K16/22 , C07K16/2863 , C07K16/2875 , C07K16/40 , C07K16/4291 , C07K2317/34 , C07K2317/52 , C07K2317/55 , C07K2319/00 , C07K2319/30 , C12N7/00 , C12N2730/10122 , C12N2730/10123 , C12N2795/18122 , C12N2795/18134 , Y02A50/412 , Y02A50/467
摘要： The present invention is related to the fields of molecular biology, virology, immunology and medicine. The invention provides a composition comprising an ordered and repetitive antigen or antigenic determinant array. The invention also provides a process for producing an antigen or antigenic determinant in an ordered and repetitive array. The ordered and repetitive antigen or antigenic determinant is useful in the production of vaccines for the treatment of infectious diseases, the treatment of allergies and as a pharmaccine to prevent or cure cancer and to efficiently induce self-specific immune responses, in particular antibody responses.
摘要翻译：本发明涉及分子生物学，病毒学，免疫学和医学领域。本发明提供包含有序重复抗原或抗原决定簇的组合物。本发明还提供了以有序和重复阵列产生抗原或抗原决定簇的方法。有序和重复的抗原或抗原决定簇可用于生产用于治疗感染性疾病，治疗过敏症和用作预防或治愈癌症并有效诱导自身特异性免疫应答，特别是抗体反应的药物的疫苗。

76. 发明申请

US20080254050A1 Antiangiogenic active immunotherapy 审中-公开
标题翻译：抗血管生成活性免疫治疗
公开(公告)号：US20080254050A1
公开(公告)日：2008-10-16
申请号：US11787522
申请日：2007-04-17
申请人： Monica Bequet Romero , Boris Ernesto Acevedo Castro , Jorge Victor Gavilondo Cowley , Luis Enrique Fernandez Molina , Omar Lopez Ocejo , Ricardo de la Caridad Silva Rodriguez , Alexis Musachio Lasa , Ernesto Galban Rodriguez , Dania Marcia Vazquez Blomquist
发明人： Monica Bequet Romero , Boris Ernesto Acevedo Castro , Jorge Victor Gavilondo Cowley , Luis Enrique Fernandez Molina , Omar Lopez Ocejo , Ricardo de la Caridad Silva Rodriguez , Alexis Musachio Lasa , Ernesto Galban Rodriguez , Dania Marcia Vazquez Blomquist
IPC分类号： A61K39/00 , A61P37/00
CPC分类号： C07K14/715 , A61K38/1858 , A61K38/1866 , A61K39/0005 , A61K39/0008 , A61K39/001 , A61K39/0011 , A61K48/005 , A61K2039/5256 , A61K2039/5258 , A61K2039/53 , A61K2039/55516 , A61K2039/55594 , C07K14/515 , C07K14/52 , C07K14/71
摘要： Application of oligonucleotide and polypeptide sequences of molecules of the family of the vascular permeability factor (VPF), their receptors, and co-receptors, as well as their modifications, in the active immunotherapy of pathologic entities in which course is associated to the increase of angiogenesis.These procedures can be employed in the single or combined therapy for the treatment of cancer and its metastasis, acute and chronic inflammatory processes, infectious diseases, autoimmune diseases, diabetic and newborn retinopathies, organ transplant rejection, macular degeneration, neovascular glaucoma, hemangioma, and angiofibroma, among others.
摘要翻译：血管通透性因子（VPF）家族的分子的寡核苷酸和多肽序列在病理实体的主动免疫治疗中的应用及其修饰，其中该过程与增加相关血管生成。这些方法可以用于治疗癌症及其转移，急性和慢性炎症过程，感染性疾病，自身免疫性疾病，糖尿病和新生儿视网膜病变，器官移植排斥，黄斑变性，新生血管性青光眼，血管瘤和血管纤维瘤等。

77. 发明申请

US20080124348A1 Immune regulation 有权
标题翻译：免疫调节
公开(公告)号：US20080124348A1
公开(公告)日：2008-05-29
申请号：US11784281
申请日：2007-04-06
申请人： Christian A. Leguern
发明人： Christian A. Leguern
IPC分类号： A61K39/00 , A61P7/00
CPC分类号： A61K39/001 , A61K45/06 , A61K2039/5154 , A61K2039/5158 , C07K16/2833 , C07K2317/73 , C12N5/0639
摘要： A method of regulating the immune system of a subject that involves removing antigen presenting cells from subject and loading preselected class II peptide fragments onto the subjects APC's outside the body of the subject.
摘要翻译：调节受试者的免疫系统的方法，其涉及从受试者中除去抗原呈递细胞并将预选的II类肽片段加载到受试者体外的受试者APC上。

78. 发明授权

US07361742B2 Methods and materials for treating inflammatory conditions 失效
标题翻译：治疗炎症的方法和材料
公开(公告)号：US07361742B2
公开(公告)日：2008-04-22
申请号：US10724662
申请日：2003-12-01
申请人： Rikard Holmdahl , Lars T. Hellman
发明人： Rikard Holmdahl , Lars T. Hellman
IPC分类号： C07K19/00
CPC分类号： C07K14/472 , A61K39/0008 , A61K39/001 , C07K2319/24 , C07K2319/50 , Y10S530/806
摘要： The invention provides methods and materials for treating inflammatory conditions. Specifically, the invention provides polypeptides, isolated nucleic acids, host cells, and methods that can be used to induce an antibody response in a mammal against an antigen such as C5 or C5a. For example, the methods and materials described herein can be used to reduce the effects of C5a within a mammal by reducing the amount of total and receptor bound C5a in the mammal.
摘要翻译：本发明提供了治疗炎性病症的方法和材料。具体地说，本发明提供多肽，分离的核酸，宿主细胞和可用于在哺乳动物中针对抗原如C5或C5a诱导抗体应答的方法。例如，本文所述的方法和材料可用于通过减少哺乳动物中总的和受体结合的C5a的量来减少哺乳动物内C5a的作用。

79. 发明申请

US20070117129A1 Antigen arrays for treatment of bone disease 失效
标题翻译：用于治疗骨病的抗原阵列
公开(公告)号：US20070117129A1
公开(公告)日：2007-05-24
申请号：US11589321
申请日：2006-10-30
申请人： Martin Bachmann , Patrik Maurer , Gunther Spohn
发明人： Martin Bachmann , Patrik Maurer , Gunther Spohn
IPC分类号： C12Q1/68 , C12N5/06 , C12N5/16
CPC分类号： A61K39/0007 , A61K38/00 , A61K39/0005 , A61K39/0008 , A61K39/001 , A61K39/35 , A61K39/385 , A61K39/39 , A61K47/6901 , A61K2039/5256 , A61K2039/5258 , A61K2039/6075 , A61K2039/627 , C07K14/005 , C07K14/523 , C07K14/5409 , C07K14/5437 , C07K14/70575 , C07K16/00 , C07K16/082 , C07K16/22 , C07K16/2863 , C07K16/2875 , C07K16/40 , C07K16/4291 , C07K2317/52 , C07K2317/55 , C07K2319/00 , C07K2319/30 , C12N2730/10122 , C12N2730/10123 , C12N2795/18122
摘要： The present invention is related to the fields of molecular biology, virology, immunology and medicine. The invention provides a composition comprising an ordered and repetitive antigen or antigenic determinant array, and in particular a RANKL protein, RANKL fragment or RANKL peptide-VLP-array. More specifically, the invention provides a composition comprising a virus-like particle and at least one RANKL protein, RANKL fragment or RANKL peptide bound thereto. The invention also provides a process for producing the conjugates and the ordered and repetitive arrays, respectively. The compositions of the invention are useful in the production of vaccines for the treatment of bone diseases and as a pharmaccine to prevent or cure bone diseases and to efficiently induce immune responses, in particular antibody responses. Furthermore, the compositions of the invention are particularly useful to efficiently induce self-specific immune responses within the indicated context.
摘要翻译：本发明涉及分子生物学，病毒学，免疫学和医学领域。本发明提供包含有序和重复抗原或抗原决定簇，特别是RANKL蛋白，RANKL片段或RANKL肽-VLP阵列的组合物。更具体地，本发明提供包含病毒样颗粒和与其结合的至少一种RANKL蛋白，RANKL片段或RANKL肽的组合物。本发明还提供了分别制备共轭物和有序和重复阵列的方法。本发明的组合物可用于生产用于治疗骨疾病的疫苗和用于预防或治愈骨疾病并有效诱导免疫应答，特别是抗体应答的药物。此外，本发明的组合物特别有用于在指定的上下文中有效诱导自身特异性免疫应答。

80. 发明申请

US20060286670A1 Transplant acceptance inducing cells of monocytic origin and their preparation and use 审中-公开
标题翻译：移植接受诱导单核细胞来源的细胞及其制备和使用
公开(公告)号：US20060286670A1
公开(公告)日：2006-12-21
申请号：US10520931
申请日：2003-07-11
申请人： Bernd Kremer , Fred Fandrich , Maren Schulze
发明人： Bernd Kremer , Fred Fandrich , Maren Schulze
IPC分类号： C12N5/00 , C12N5/02 , C12N5/08
CPC分类号： A61K39/001 , A61K2035/122 , A61K2035/124 , A61K2039/5154 , C07K16/28 , C07K16/2833 , C12N5/0636 , C12N5/0645 , C12N2501/22 , C12N2501/24 , C12N2502/11
摘要： The invention relates to transplant acceptance inducing cells of monocytic origin, their production as well as their use for generating transplant acceptance. The invention also relates to the monoclonal antibody GM-7, which specifically recognises human transplant acceptance inducing cells of the invention. The invention further relates to the use of the antibody GM-7 for detection and/or selection transplant-acceptance inducing cells.
摘要翻译：本发明涉及单核细胞来源的移植接受诱导细胞，其生产以及其用于产生移植接受的用途。本发明还涉及特异性识别本发明的人移植接受诱导细胞的单克隆抗体GM-7。本发明还涉及抗体GM-7用于检测和/或选择移植接受诱导细胞的用途。

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