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71. 发明授权

US09521840B2 Film-shaped tissue storage transport container and storage transport method 有权
标题翻译：薄膜状组织储存运输容器和储存运输方法
公开(公告)号：US09521840B2
公开(公告)日：2016-12-20
申请号：US14310357
申请日：2014-06-20
申请人： Terumo Kabushiki Kaisha
发明人： Manami Kawasaki
IPC分类号： A01N1/02 , A61J1/20
CPC分类号： A01N1/0273 , A61J1/2096
摘要： A film-shaped tissue storage transport container and storage transport method. The storage transport container includes: an external container; a coupling mechanism which couples a container main body and a lid member of the external container; an internal container which is positioned within the external container; an interposed unit having elasticity and which is sandwiched between the internal container and the lid member; and a storage fluid with which the internal container is filled. A film-shaped tissue is present in a floating state in the storage fluid with which the internal container is filled.
摘要翻译：薄膜状组织储存运输容器和储存运输方法。储存运输容器包括：外部容器; 联接机构，其将容器主体和外部容器的盖部件联接; 位于外部容器内的内部容器; 具有弹性的夹持单元，其夹在内部容器和盖构件之间; 以及填充内部容器的储存流体。膜状组织以浮动状态存在于内部容器被填充的储存流体中。

72. 发明申请

US20160342942A1 Biologic Stability, Delivery Logistics and Administration of Time and/or Temperature Sensitive Biologic Based Materials 审中-公开
公开(公告)号：US20160342942A1
公开(公告)日：2016-11-24
申请号：US15158739
申请日：2016-05-19
申请人： Biologistex CCM, LLC
发明人： Michael Rice , Bruce McCormick , Aby J. Mathew , Kevin O'Donnell
IPC分类号： G06Q10/08 , A01N1/02 , H04Q9/00 , B65D43/02 , B65D81/38
CPC分类号： G01N33/483 , A01N1/0273 , A61J1/00 , A61J1/03 , A61J2200/44 , A61J2200/50 , A61J2200/72 , A61J2205/60 , B65D43/02 , B65D81/3813 , B65D2201/00 , B65D2203/10 , G06Q10/0832 , H04Q9/00 , H04Q2209/40 , H04Q2209/43 , H04Q2209/823
摘要： In some embodiments, alerts are sent to appropriate parties if an insulated container is not properly packed out to insure the approximate safe temperature of the materials. In other embodiments, a countdown timer is used to keep track of the time that the biologic has been in transit, and ensure that the amount of time does not exceed the known shelf life of the biologic. In still other embodiments, the payload container is equipped with its own sensors, such as temperature sensors, and communications devices, such as a close range communication device, capable of transmitting information regarding a range of parameters, including, but not limited to, temperature, humidity, location and time, from the payload container to an end user. In other embodiments, shielding and/or radiation sensors are included in insulated shipping or storage containers, or payload containers, to shield and monitor the radiation exposure of the payload.

73. 发明申请

US20160338908A1 Biologic Stability, Delivery Logistics and Administration of Time and/or Temperature Sensitive Biologic Based Materials 有权
公开(公告)号：US20160338908A1
公开(公告)日：2016-11-24
申请号：US15158768
申请日：2016-05-19
申请人： Biologistex CCM, LLC
发明人： Michael Rice , Bruce McCormick
IPC分类号： A61J1/00 , H04Q9/00
CPC分类号： G01N33/483 , A01N1/0273 , A61J1/00 , A61J1/03 , A61J2200/44 , A61J2200/50 , A61J2200/72 , A61J2205/60 , B65D43/02 , B65D81/3813 , B65D2201/00 , B65D2203/10 , G06Q10/0832 , H04Q9/00 , H04Q2209/40 , H04Q2209/43 , H04Q2209/823
摘要： In some embodiments, alerts are sent to appropriate parties if an insulated container is not properly packed out to insure the approximate safe temperature of the materials. In other embodiments, a countdown timer is used to keep track of the time that the biologic has been in transit, and ensure that the amount of time does not exceed the known shelf life of the biologic. In still other embodiments, the payload container is equipped with its own sensors, such as temperature sensors, and communications devices, such as a close range communication device, capable of transmitting information regarding a range of parameters, including, but not limited to, temperature, humidity, location and time, from the payload container to an end user. In other embodiments, shielding and/or radiation sensors are included in insulated shipping or storage containers, or payload containers, to shield and monitor the radiation exposure of the payload.

74. 发明授权

US09357767B2 Organ transporter 有权
标题翻译：器官运输
公开(公告)号：US09357767B2
公开(公告)日：2016-06-07
申请号：US13545321
申请日：2012-07-10
申请人： Christopher P. Steinman , Rick W. Walker , Kirk C. Palmerton , Jeffrey S. Louis , David Pettinato , Matthew Copithorne , Brian L Otts , Peter Demuylder , James Guarrera , Ben O. Arrington
发明人： Christopher P. Steinman , Rick W. Walker , Kirk C. Palmerton , Jeffrey S. Louis , David Pettinato , Matthew Copithorne , Brian L Otts , Peter Demuylder , James Guarrera , Ben O. Arrington
IPC分类号： A01N1/02
CPC分类号： A01N1/0247 , A01N1/0273
摘要： A perfusion apparatus includes a coolant container having a basin-receiving recess that is at least partly surrounded by an inner chamber; a basin that is shaped to fit within the basin-receiving recess of the coolant container; and a cradle that is shaped to accept an organ and fit within the basin. The basin-receiving recess of the coolant container, the basin and the cradle each have positioning elements that are oriented such that the cradle is keyed to fit within the basin and the basin is keyed to fit within the coolant container, each in a single predetermined orientation. The plurality of positioning elements on the basin may include a plurality of protrusions on an outer surface of the basin.
摘要翻译：灌注装置包括：冷却剂容器，其具有至少部分地被内腔包围的盆容纳凹部; 成形为容纳在冷却剂容器的盆接收凹部内的盆; 和一个成形为接受器官并装配在盆内的摇篮。冷却剂容器，盆和托架的盆容纳凹槽各自具有定位元件，其定位成使得支架被键合以配合在盆内，并且盆被键合以装配在冷却剂容器内，每个以单个预定的方向。盆上的多个定位元件可以包括在盆的外表面上的多个突起。

75. 发明申请

US20160053219A1 SYSTEMS, METHODS, AND DEVICES FOR TEMPERATURE CONTROL 审中-公开
标题翻译：用于温度控制的系统，方法和装置
公开(公告)号：US20160053219A1
公开(公告)日：2016-02-25
申请号：US14835227
申请日：2015-08-25
申请人： OpGen, Inc.
发明人： George Terrance Walker , Tony Rockweiler
IPC分类号： C12M1/34 , C12M1/24 , C12N1/04
CPC分类号： C12M41/12 , A01N1/0273 , B01L2200/185 , B65D81/18 , C09K5/063 , C12M41/36 , C12M41/46 , C12N1/04
摘要： Systems, methods, and devices are disclosed for improved temperature control, particularly within a predetermined range of temperatures near or above varying ambient temperatures. Previously-unrealized advantages are recognized for maintaining samples, particularly medical and/or biological specimens, at a temperature within a predetermined range of temperatures near or above ambient temperature that selectively promote and/or selectively inhibit organism growth, organism viability, biochemical reactions, and/or chemical reactions. Systems, methods, and devices may include at least phase change material selected and configured to maintain a sample at a predetermined temperature range between about 22° Celsius and about 100° Celsius during a predetermined time period.
摘要翻译：公开了用于改善温度控制的系统，方法和装置，特别是在接近或高于变化的环境温度的预定温度范围内。认识到在温度接近或高于环境温度的预定温度范围内维持样品，特别是医学和/或生物样品的先前未实现的优点，其选择性地促进和/或选择性抑制生物体生长，生物活力，生物化学反应和 /或化学反应。系统，方法和装置可以包括至少相变材料，所述相变材料被选择和配置成在预定时间段内将样品维持在约22摄氏度和约100摄氏度之间的预定温度范围。

76. 发明授权

US08962303B2 Apparatus and method for maintaining and/or restoring viability of organs 有权
标题翻译：用于维持和/或恢复器官活力的装置和方法
公开(公告)号：US08962303B2
公开(公告)日：2015-02-24
申请号：US13137385
申请日：2011-08-10
申请人： Donald R. Owen , David C. Kravitz , John Brassil , Kelvin G. M. Brockbank , Andrew Burroughs , Dickon Isaacs , Douglas Schein
发明人： Donald R. Owen , David C. Kravitz , John Brassil , Kelvin G. M. Brockbank , Andrew Burroughs , Dickon Isaacs , Douglas Schein
IPC分类号： A01N1/02
CPC分类号： G06F17/30876 , A01N1/02 , A01N1/0247 , A01N1/0273 , H04L67/02
摘要： An organ perfusion apparatus and method monitor, sustain and/or restore viability of organs and preserve organs for storage and/or transport. Other apparatus include an organ transporter, an organ cassette and an organ diagnostic device. In perfusion, organ perfusion pressure is preferably controlled in response to a sensor disposed in an end of tubing placed in the organ, by a pneumatically pressurized medical fluid reservoir, providing perfusion pressure fine tuning, overpressurization prevention and emergency flow cut-off. In the hypothermic mode, the organ is perfused with a medical fluid, preferably a simple crystalloid solution containing antioxidants, intermittently or in slow continuous flow. The medical fluid may be fed into the organ from an intermediary tank having a low pressure head to avoid organ overpressurization. Viability of the organ may be automatically monitored, preferably by monitoring characteristics of the medical fluid perfusate. The perfusion process can be automatically controlled using a control program.
摘要翻译：器官灌注装置和方法监测，维持和/或恢复器官的活力并保存器官用于储存和/或运输。其他装置包括器官输送器，器官盒和器官诊断装置。在灌注中，器官灌注压力优选地响应于设置在置于器官中的管的末端中的传感器，通过气动加压的医用液体储存器进行控制，提供灌注压力微调，超压预防和紧急流量截止。在低体温模式中，器官用液体灌注，优选地是含有抗氧化剂的简单晶体溶液，间歇地或以缓慢的连续流动。可以从具有低压头的中间容器将药液输送到器官中，以避免器官过压。可以自动监测器官的活力，优选通过监测医用流体灌注液的特性。可以使用控制程序自动控制灌注过程。

77. 发明申请

US20150048085A1 VESSELS AND METHODS FOR CRYOPRESERVATION 审中-公开
标题翻译：用于CRYOPRESERVATION的血管和方法
公开(公告)号：US20150048085A1
公开(公告)日：2015-02-19
申请号：US14081326
申请日：2013-11-15
申请人： CORNING INCORPORATED
发明人： Jessica Monique Brown , Nicholas Michael Illsley , Gregory Roger Martin , Ana Maria del Pilar Pardo , Allison Jean Tanner
IPC分类号： A01N1/02
CPC分类号： A01N1/0284 , A01N1/0242 , A01N1/0263 , A01N1/0268 , A01N1/0273 , A61J1/05 , A61J1/1412 , A61J1/16 , A61M5/145 , A61M5/2425 , C12M23/48 , C12M33/04 , C12M45/22
摘要： An article including, either: a frame having an interior cavity, and a flexible liner situated within the interior cavity; or a deformable frame having an interior cavity, as defined herein. Either frame can receive a sample, such as liquid having suspended live cells, and cooling freezes the sample to a solid sample. The solid sample can be readily ejected from the article having either a frame with the flexible liner, or the deformable frame, without extensive thawing. The solid sample can be rapidly displaced from the article by the methods and apparatus disclosed herein.
摘要翻译：一种制品，包括：具有内部空腔的框架和位于所述内部空腔内的柔性衬里; 或具有如本文所定义的内腔的可变形框架。任一框架可以接收样品，例如具有悬浮活细胞的液体，并且冷却将样品冻结成固体样品。固体样品可以容易地从具有柔性衬垫的框架或可变形框架的制品中排出，而无需大量解冻。通过本文公开的方法和装置，固体样品可以快速地从制品中移位。

78. 发明申请

US20150004077A1 INTEGRATED HUMAN ORGAN-ON-CHIP MICROPHYSIOLOGICAL SYSTEMS 有权
标题翻译：综合人机界面微生物系统
公开(公告)号：US20150004077A1
公开(公告)日：2015-01-01
申请号：US14362841
申请日：2012-12-10
申请人： PRESIDENT AND FELLOWS OF HARVARD COLLEGE , VANDERBILT UNIVERSITY
发明人： John P. Wikswo , Philip C. Samson , Frank Emmanuel Block, III , Ronald S. Reiserer , Kevin Kit Parker , John A. McLean , Lisa Joy McCawley , Dmitry Markov , Daniel Levner , Donald E. Ingber , Geraldine A. Hamilton , Josue A. Goss , Robert Cunningham , David E. Cliffel , Jennifer Robin McKenzie , Anthony Bahinski , Christopher David Hinojosa
IPC分类号： G01N33/50
CPC分类号： C12M23/16 , A01N1/02 , A01N1/021 , A01N1/0247 , A01N1/0273 , B01L3/5027 , B01L3/502715 , B01L9/52 , B01L2200/0684 , B01L2200/0689 , B01L2200/146 , B01L2200/147 , B01L2300/044 , B01L2300/0636 , B01L2300/0654 , B01L2300/0663 , B01L2300/0867 , B01L2300/0877 , B01L2300/123 , B01L2300/18 , B01L2400/0487 , B01L2400/0622 , B01L2400/0644 , C12M21/08 , C12M23/42 , C12M29/10 , C12M35/04 , C12M35/08 , C12M41/00 , C12M41/12 , C12M41/46 , G01N33/5005 , G01N33/5082 , G01N33/5088
摘要： The invention provides integrated Organ-on-Chip microphysiological systems representations of living Organs and support structures for such microphysiological systems.
摘要翻译：本发明提供了用于这种微生物系统的活体器官和支持结构的集成的片上微生物系统表示。

79. 发明授权

US08389271B2 Method and apparatus for controlling air pressure in an organ or tissue container 有权
标题翻译：用于控制器官或组织容器中的空气压力的方法和装置
公开(公告)号：US08389271B2
公开(公告)日：2013-03-05
申请号：US12654772
申请日：2009-12-31
申请人： David Walter Wright , Douglas Schein , John Brassil
发明人： David Walter Wright , Douglas Schein , John Brassil
IPC分类号： A01N1/00 , A01N1/02 , B01F3/04
CPC分类号： A01N1/0273 , A01N1/02 , A01N1/0247 , Y10S435/809
摘要： An organ perfusion apparatus and method monitor, sustain and/or restore viability of organs and preserve organs for storage and/or transport. Other apparatus include an organ transporter, an organ cassette and an organ diagnostic device. The apparatus and methods include the organ cassette with one or more openings configured to allow tubing to pass through the openings and be connected to the organ or tissue within the cassette, and including a pressure control device to allow pressure inside the portable housing to be varied.
摘要翻译：器官灌注装置和方法监测，维持和/或恢复器官的活力并保存器官用于储存和/或运输。其他装置包括器官输送器，器官盒和器官诊断装置。该装置和方法包括具有一个或多个开口的器官盒，其被配置为允许管道穿过开口并连接到盒内的器官或组织，并且包括压力控制装置，以允许便携式外壳内的压力变化。

80. 发明授权

US08268547B2 Method of transporting and storing a kidney 有权
标题翻译：运输和储存肾脏的方法
公开(公告)号：US08268547B2
公开(公告)日：2012-09-18
申请号：US11257066
申请日：2005-10-25
申请人： Donald R. Owen , David C. Kravitz
发明人： Donald R. Owen , David C. Kravitz
IPC分类号： A01N1/02
CPC分类号： G06F17/30876 , A01N1/02 , A01N1/0247 , A01N1/0273 , H04L67/02
摘要： An organ perfusion apparatus and method monitor, sustain and/or restore viability of organs and preserve organs for storage and/or transport. The method includes perfusing the organ at hypothermic and/or normothermic temperatures, preferably after hypothermic organ flushing for organ transport and/or storage. The method can be practiced with prior or subsequent static or perfusion hypothermic exposure of the organ. Organ viability is restored by restoring high energy nucleotide (e.g., ATP) levels by perfusing the organ with a medical fluid, such as an oxygenated cross-linked hemoglobin-based bicarbonate medical fluid, at normothermic temperatures. In perfusion, organ perfusion pressure is preferably controlled in response to a sensor disposed in an end of tubing placed in the organ, by a pneumatically pressurized medical fluid reservoir, providing perfusion pressure fine tuning, overpressurization prevention and emergency flow cut-off. In the hypothermic mode, the organ is perfused with a medical fluid, preferably a simple crystalloid solution containing antioxidants, intermittently or in slow continuous flow. The medical fluid may be fed into the organ from an intermediary tank having a low pressure head to avoid organ overpressurization. Preventing overpressurization prevents or reduces damage to vascular endothelial lining and to organ tissue in general. Viability of the organ may be automatically monitored, preferably by monitoring characteristics of the medical fluid perfusate. The perfusion process can be automatically controlled using a control program.
摘要翻译：器官灌注装置和方法监测，维持和/或恢复器官的活力并保存器官用于储存和/或运输。该方法包括在低温和/或正常体温温度下灌注器官，优选在用于器官运输和/或储存的低温器官冲洗之后。该方法可以在先前或随后的器官的静态或灌注低温暴露下进行。通过用正常体温温度下的医用流体例如氧合交联血红蛋白的碳酸氢盐医疗液灌注器官，恢复高能量核苷酸（例如ATP）水平来恢复器官存活力。在灌注中，器官灌注压力优选地响应于设置在置于器官中的管的末端中的传感器，通过气动加压的医用液体储存器进行控制，提供灌注压力微调，超压预防和紧急流量截止。在低体温模式中，器官用液体灌注，优选地是含有抗氧化剂的简单晶体溶液，间歇地或以缓慢的连续流动。可以从具有低压头的中间容器将药液输送到器官中，以避免器官过压。防止过度加压防止或减少对血管内皮衬里和器官组织的损害。可以自动监测器官的活力，优选通过监测医用流体灌注液的特性。可以使用控制程序自动控制灌注过程。

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