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71. 发明申请

US20170020392A1 Methods for Stent Strut Detection and Related Measurement and Display Using Optical Coherence Tomography 审中-公开
标题翻译：使用光学相干断层扫描的支架支架检测和相关测量和显示的方法
公开(公告)号：US20170020392A1
公开(公告)日：2017-01-26
申请号：US15288199
申请日：2016-10-07
申请人： LightLab Imaging, Inc.
发明人： Chenyang Xu
IPC分类号： A61B5/00 , G06T7/40 , G06K9/46 , G06T5/00 , G06K9/62 , G06T7/00 , G06T7/20
CPC分类号： A61B5/0066 , A61B5/0084 , A61B5/6852 , A61B5/7425 , A61B2576/00 , G06K9/46 , G06K9/6267 , G06K2009/4666 , G06T5/00 , G06T7/0012 , G06T7/11 , G06T7/246 , G06T7/73 , G06T7/90 , G06T2207/10101 , G06T2207/20061 , G06T2207/20182 , G06T2207/30101
摘要： In one embodiment, the invention relates to a processor based method for generating positional and other information relating to a stent in the lumen of a vessel using a computer. The method includes the steps of generating an optical coherence image data set in response to an OCT scan of a sample containing at least one stent; and identifying at least one one-dimensional local cue in the image data set relating to the position of the stent.
摘要翻译：在一个实施例中，本发明涉及一种基于处理器的方法，用于使用计算机产生与容器内腔中的支架相关的位置信息和其它信息。该方法包括以下步骤：响应于包含至少一个支架的样本的OCT扫描产生光学相干图像数据集; 以及识别与所述支架的位置有关的图像数据集中的至少一个一维局部提示。

72. 发明授权

US09488464B1 Swept mode-hopping laser system, methods, and devices for frequency-domain optical coherence tomography 有权
公开(公告)号：US09488464B1
公开(公告)日：2016-11-08
申请号：US14045537
申请日：2013-10-03
申请人： Joseph M. Schmitt
发明人： Joseph M. Schmitt
IPC分类号： G01B9/02
CPC分类号： G01B9/02091 , G01B9/02004 , G01B9/02069 , H01S3/1062 , H01S5/141
摘要： In part, the invention relates to frequency-domain optical coherence tomography system. The system includes a tunable laser comprising a laser output for transmitting laser light and a laser cavity having a length L, a gain element disposed within the laser cavity; a tunable wavelength selective element disposed within the laser cavity; a reference reflector disposed outside of the laser cavity; an interferometer in optical communication with the laser output and the reference reflector, wherein the interferometer is configured to transmit a portion of the laser light to a sample and combine light scattered from the sample with light scattered from the reference reflector; and a detector in optical communication with the interferometer that receives the combination of light scattered from the sample and the light scattered from the reference reflector and transforms the combination of light into an electronic signal comprising measurement data with respect to the sample.

73. 发明授权

US09138147B2 Lumen morphology image reconstruction based on the scan line data of OCT 有权
标题翻译：基于OCT扫描线数据的流明形态学图像重建
公开(公告)号：US09138147B2
公开(公告)日：2015-09-22
申请号：US12888347
申请日：2010-09-22
申请人： Joseph M. Schmitt , Joel M. Friedman , Christopher Petroff , Amr Elbasiony
发明人： Joseph M. Schmitt , Joel M. Friedman , Christopher Petroff , Amr Elbasiony
IPC分类号： A61B6/00 , A61B5/00 , A61B5/02 , G06T7/00 , G06K9/00 , A61B19/00 , A61F2/82
CPC分类号： A61B5/0066 , A61B5/02007 , A61B5/6852 , A61B2034/102 , A61F2/82 , G06T7/0012 , G06T2200/24 , G06T2207/10016 , G06T2207/10101 , G06T2207/30101
摘要： A method and apparatus of automatically locating in an image of a blood vessel the lumen boundary at a position in the vessel and from that measuring the diameter of the vessel. From the diameter of the vessel and estimated blood flow rate, a number of clinically significant physiological parameters are then determined and various user displays of interest generated. One use of these images and parameters is to aid the clinician in the placement of a stent. The system, in one embodiment, uses these measurements to allow the clinician to simulate the placement of a stent and to determine the effect of the placement. In addition, from these patient parameters various patient treatments are then performed.
摘要翻译：一种自动定位在血管图像中的管腔边界在容器中的位置以及从测量血管直径的方法和装置。从容器的直径和估计的血流速度，然后确定许多临床显着的生理参数，并且生成各种用户显示关注。这些图像和参数的一个用途是帮助临床医生放置支架。在一个实施例中，该系统使用这些测量来允许临床医生模拟支架的放置并确定放置的影响。此外，从这些患者参数，然后执行各种患者治疗。

74. 发明申请

US20150192405A1 Methods and Apparatus for Swept-Source Optical Coherence Tomography 有权
标题翻译：扫描源光学相干断层扫描的方法和装置
公开(公告)号：US20150192405A1
公开(公告)日：2015-07-09
申请号：US14535489
申请日：2014-11-07
申请人： Joseph M. Schmitt
发明人： Joseph M. Schmitt
IPC分类号： G01B9/02
CPC分类号： G01B9/02091 , A61B5/0066 , A61B5/0073 , G01B9/02004 , G01B9/02043 , G01B9/02069 , G01B2290/25 , G01B2290/60 , H01S3/1062 , H01S5/141 , H01S5/146 , H01S5/5036
摘要： In one embodiment of the invention, a semiconductor optical amplifier (SOA) in a laser ring is chosen to provide low polarization-dependent gain (PDG) and a booster semiconductor optical amplifier, outside of the ring, is chosen to provide high polarization-dependent gain. The use of a semiconductor optical amplifier with low polarization-dependent gain nearly eliminates variations in the polarization state of the light at the output of the laser, but does not eliminate the intra-sweep variations in the polarization state at the output of the laser, which can degrade the performance of the SS-OCT system.
摘要翻译：在本发明的一个实施例中，选择激光环中的半导体光放大器（SOA）以提供低偏振相关增益（PDG），并且选择在环外部的升压半导体光放大器以提供高偏振相关获得。使用具有低偏振相关增益的半导体光放大器几乎消除了在激光器的输出处的光的偏振状态的变化，但是不消除激光器的输出处的偏振状态的扫描内变化，这可能会降低SS-OCT系统的性能。

75. 发明授权

US09069396B2 Controller and user interface device, systems, and methods 有权
标题翻译：控制器和用户界面设备，系统和方法
公开(公告)号：US09069396B2
公开(公告)日：2015-06-30
申请号：US13798017
申请日：2013-03-12
申请人： Desmond Adler , Joshua M. Gomes , David Winston , Susan Moynihan
发明人： Desmond Adler , Joshua M. Gomes , David Winston , Susan Moynihan
IPC分类号： G06F3/033 , G06F3/038 , G06F3/048 , G06F3/0489 , G06F3/0354 , G06F3/0338 , G05G9/047
CPC分类号： G05B15/02 , G05G1/10 , G05G9/047 , G06F3/0338 , G06F3/0346 , G06F3/03543 , G06F3/038 , G06F3/048 , G06F3/04842 , G06F3/04845 , G06F3/04847 , G06F3/04892
摘要： A data collection system controller that includes a housing such as a cover. The housing includes a user facing section and a support facing section defining a hole. The controller also includes a first input device adjacent the user facing section and a second input device. The second input device includes a knob comprising a third input device and a rotatable shaft extending through the hole and partially disposed within the knob. In one embodiment, the second input device is an XYZ joystick with a button. In one embodiment, the joystick and the first input device are angled relative to each other on either side of an elbow joint. In part, the invention relates to a method of controlling the display of image data obtained with respect to a blood vessel.
摘要翻译：一种数据采集系统控制器，其包括诸如盖的壳体。壳体包括面向用户的部分和限定孔的支撑面对部分。控制器还包括与用户面对部分相邻的第一输入装置和第二输入装置。第二输入装置包括旋钮，其包括第三输入装置和延伸穿过孔并部分地设置在旋钮内的旋转轴。在一个实施例中，第二输入装置是具有按钮的XYZ操纵杆。在一个实施例中，操纵杆和第一输入装置在肘关节的任一侧上相对于彼此成角度。部分地，本发明涉及一种控制相对于血管获得的图像数据的显示的方法。

76. 发明授权

US08948613B2 Intensity noise reduction methods and apparatus for interferometric sensing and imaging systems 有权
标题翻译：用于干涉测量和成像系统的强度降噪方法和装置
公开(公告)号：US08948613B2
公开(公告)日：2015-02-03
申请号：US13050410
申请日：2011-03-17
申请人： Joseph M. Schmitt , Victor Grinberg
发明人： Joseph M. Schmitt , Victor Grinberg
IPC分类号： H04B10/06 , G01B9/02 , H03G3/30 , H04B10/67
CPC分类号： G01B9/02055 , G01B9/02004 , G01B9/02044 , G01B9/02074 , G01B9/02083 , H03G3/3084 , H04B10/616 , H04B10/671
摘要： In part, aspects of the invention relate to methods, apparatus, and systems for intensity and/or pattern line noise reduction in a data collection system such as an optical coherence tomography system that uses an electromagnetic radiation source and interferometric principles. In one embodiment, the noise is intensity noise or line pattern noise and the source is a laser such as a swept laser. One or more attenuators responsive to one or more control signals can be used in conjunction with an analog or digital feedback network in one embodiment.
摘要翻译：部分地，本发明的方面涉及数据采集系统中的强度和/或图案线噪声降低的方法，装置和系统，例如使用电磁辐射源和干涉原理的光学相干断层摄影系统。在一个实施例中，噪声是强度噪声或线图案噪声，并且源是诸如扫描激光器的激光器。在一个实施例中，响应于一个或多个控制信号的一个或多个衰减器可以与模拟或数字反馈网络结合使用。

77. 发明申请

US20140379269A1 SYSTEMS, METHODS AND APPARATUS FOR DETERMINING A FRACTIONAL FLOW RESERVE 审中-公开
标题翻译：系统，方法和装置，用于确定一个流量流动储备
公开(公告)号：US20140379269A1
公开(公告)日：2014-12-25
申请号：US14126152
申请日：2012-08-01
申请人： Joseph Schmitt
发明人： Joseph Schmitt
IPC分类号： G01N21/85 , A61B5/02 , A61B5/00 , G01B9/02 , G01N21/47
CPC分类号： G01N21/85 , A61B5/0066 , A61B5/0084 , A61B5/02007 , A61B5/02028 , A61B5/0215 , A61B5/4836 , A61B5/489 , A61B5/6852 , A61B34/10 , A61B2576/02 , G01B9/02091 , G01N21/4795
摘要： In one aspect, the invention relates to system comprising: a processor configured to receive a first optical coherence tomography (OCT) data set obtained during a pullback of a data collection probe along a first length of a first blood vessel; determine a minimum lumen area disposed along the first length using the first OCT data set; and determine a first FFR value along the first length based on the minimum lumen area. In one embodiment, the first FFR value is an estimated FFR. In another aspect, the invention relates to a method that includes measuring, using OCT, the area of a lumen of a vessel for which the vessel's FFR is to be determined; and calculating, using a computer, A2m/(A2m+k) or YA2min/(YA2min+k) as a FFR value. In one embodiment, k is about 0.7 mm2 and γ is patient-specific variable that depends on the coronary branch in which the images were obtained.
摘要翻译：一方面，本发明涉及一种系统，包括：处理器，被配置为接收沿着第一血管的第一长度在数据采集探头的回退期间获得的第一光学相干断层摄影（OCT）数据集; 使用所述第一OCT数据集来确定沿所述第一长度设置的最小流明面积; 并且基于最小管腔面积确定沿着第一长度的第一FFR值。在一个实施例中，第一FFR值是估计的FFR。在另一方面，本发明涉及一种方法，其包括使用OCT测量要确定所述血管的FFR的血管腔的面积; 并使用计算机计算A2m /（A2m + k）或YA2min /（YA2min + k）作为FFR值。在一个实施方案中，k为约0.7mm 2，γ为取决于获得图像的冠状动脉分支的患者特异性变量。

78. 发明申请

US20140276011A1 Lumen Morphology and Vascular Resistance Measurements Data Collection Systems, Apparatus and Methods 审中-公开
标题翻译：流明形态和血管阻力测量数据采集系统，装置和方法
公开(公告)号：US20140276011A1
公开(公告)日：2014-09-18
申请号：US13796710
申请日：2013-03-12
申请人： Joseph M. Schmitt , Joel M. Friedman , Christopher Petroff , Amr Elbasiony
发明人： Joseph M. Schmitt , Joel M. Friedman , Christopher Petroff , Amr Elbasiony
IPC分类号： A61B5/02 , A61B5/00
CPC分类号： A61B5/02007 , A61B5/0066 , A61B5/0084
摘要： A method and apparatus of automatically locating in an image of a blood vessel the lumen boundary at a position in the vessel and from that measuring the diameter of the vessel. From the diameter of the vessel and estimate blood flow rate, a number of clinically significant physiological parameters are then determine and various user displays of interest generated. One use of these images and parameters is to aid the clinician in the placement of a stent. The system, in one embodiment, uses these measurements to allow the clinician to simulate the placement of a stent and to determine the effect of the placement. In addition, from these patient parameters various patient treatments are then performed.
摘要翻译：一种自动定位在血管图像中的管腔边界在容器中的位置以及从测量血管直径的方法和装置。从容器的直径和估计血流速度，然后确定许多临床显着的生理参数，并且生成各种用户显示兴趣。这些图像和参数的一个用途是帮助临床医生放置支架。在一个实施例中，该系统使用这些测量来允许临床医生模拟支架的放置并确定放置的影响。此外，从这些患者参数，然后执行各种患者治疗。

79. 发明授权

US08753281B2 Opto-acoustic imaging devices and methods 有权
标题翻译：光声成像装置及方法
公开(公告)号：US08753281B2
公开(公告)日：2014-06-17
申请号：US13618520
申请日：2012-09-14
申请人： Joseph M. Schmitt , Christopher Petersen , Toro Ohasi , Tetsuya Nakamatsu
发明人： Joseph M. Schmitt , Christopher Petersen , Toro Ohasi , Tetsuya Nakamatsu
IPC分类号： A61B8/14 , A61B6/00
CPC分类号： A61B5/0066 , A61B5/0095 , A61B5/6852 , A61B8/12 , A61B8/445 , A61B8/4461
摘要： In one aspect, the invention relates to a probe. The probe includes a sheath, a flexible, bi-directionally rotatable, optical subsystem positioned within the sheath, the optical subsystem comprising a transmission fiber, the optical subsystem capable of transmitting and collecting light of a predetermined range of wavelengths along a first beam having a predetermined beam size. The probe also includes an ultrasound subsystem, the ultrasound subsystem positioned within the sheath and adapted to propagate energy of a predetermined range of frequencies along a second beam having a second predetermined beam size, wherein a portion of the first and second beams overlap a region during a scan.
摘要翻译：一方面，本发明涉及一种探针。探针包括位于护套内的护套，柔性双向可旋转的光学子系统，光学子系统包括传输光纤，该光学子系统能够沿着具有第一光束的第一光束发射和收集预定波长范围的光预定的光束尺寸。所述探针还包括超声子系统，所述超声子系统位于护套内并且适于沿具有第二预定光束尺寸的第二光束传播预定频率范围的能量，其中第一和第二光束的一部分在扫描。

80. 发明申请

US20140142427A1 Automated Fluid Delivery Catheter and System 审中-公开
标题翻译：自动流体输送导管和系统
公开(公告)号：US20140142427A1
公开(公告)日：2014-05-22
申请号：US13792910
申请日：2013-03-11
申请人： LIGHTLAB IMAGING, INC.
发明人： Christopher Petroff
IPC分类号： A61M25/00 , A61B5/00
CPC分类号： A61B5/0073 , A61B5/0066 , A61B5/0215 , A61B5/6852 , A61B8/12 , A61M39/10 , A61M39/24 , A61M2025/0024 , A61M2025/0035 , A61M2039/242
摘要： In part, the invention relates to catheters, methods, and blood clearing technologies suitable for use in an optical coherence tomography system. The optical coherence tomography system includes a control system, a probe including a catheter defining a lumen and a rotatable optical fiber located within the lumen, a fluid cartridge holder in communication with the lumen of the probe, a pump to move fluid from the fluid cartridge to the lumen of the probe; and a motor configured to rotate and pull the optical fiber through the lumen of a blood vessel. The pump and the motor are controlled by the control system. The catheter can include a wall that bounds the lumen of the probe, which defines a flush port and includes a valve in fluid communication with the flush port, the valve configured to permit fluid from the lumen to pass through the wall.
摘要翻译：部分地，本发明涉及适用于光学相干断层摄影系统的导管，方法和血液清除技术。光学相干断层摄影系统包括控制系统，包括限定内腔的导管和位于内腔内的可旋转光纤的探针，与探针的内腔连通的流体盒保持器，用于将流体从流体盒到探头的内腔; 以及电动机，其构造成使光纤旋转并拉动通过血管的内腔。泵和电机由控制系统控制。导管可以包括限定探针的内腔的壁，该壁限定了冲洗口，并且包括与冲洗口流体连通的阀，所述阀构造成允许来自内腔的流体通过壁。

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