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1. 发明授权

US07657292B2 Method for evaluating extracellular water concentration in tissue 失效
标题翻译：评估组织中细胞外水浓度的方法
公开(公告)号：US07657292B2
公开(公告)日：2010-02-02
申请号：US11283506
申请日：2005-11-18
申请人： Clark R. Baker, Jr. , Joseph Schmitt , Shannon Campbell , Nick Durr , Carine Hoarau , Rafeal Ostrowski , Martin Debreczeny
发明人： Clark R. Baker, Jr. , Joseph Schmitt , Shannon Campbell , Nick Durr , Carine Hoarau , Rafeal Ostrowski , Martin Debreczeny
IPC分类号： A61B5/145
CPC分类号： G01N21/359 , A61B5/0059 , A61B5/0537 , A61B5/4869 , G01N21/274
摘要： The present disclosure provides systems, devices, and/or methods for assessing body fluid-related metrics and/or changes therein. The disclosure further provides systems, devices, and/or methods for correlating body fluid-related metrics in a particular tissue with the corresponding whole-body metric. The disclosure also provides, systems, devices, and/or methods for assessment of such metrics to facilitate diagnosis and/or therapeutic interventions related to maintaining and/or restoring body fluid balance.
摘要翻译：本公开提供了用于评估体液相关度量和/或其中变化的系统，装置和/或方法。本公开还提供用于将特定组织中的体液相关度量与相应的全身度量相关联的系统，装置和/或方法。本公开还提供了用于评估这些度量的系统，装置和/或方法，以促进与维持和/或恢复体液平衡相关的诊断和/或治疗干预。

2. 发明申请

US20190046891A1 FLEXIBLE INTERCONNECTABLE BRICK ASSEMBLY 审中-公开
公开(公告)号：US20190046891A1
公开(公告)日：2019-02-14
申请号：US15672752
申请日：2017-08-09
申请人： Joseph Schmitt , Brian Semling
发明人： Joseph Schmitt , Brian Semling
IPC分类号： A63H33/10 , A63H33/08
摘要： A flexible interconnectable brick assembly includes a connector panel having a top side, a bottom side and a perimeter edge. The connector panel is resiliently flexible and is comprised of an elastomeric material. The perimeter edge includes a first end edge, a second end edge, a first lateral edge and a second lateral edge. A top adhesive is positioned on and covers the top side of the connector panel. A plurality of female interconnection members is positioned on the bottom side of the connector panel and each releasably and frictionally receives a male interconnection member of a brick.

3. 发明申请

US20070129614A1 Device and method for monitoring body fluid and electrolyte disorders 失效
标题翻译：用于监测体液和电解质紊乱的装置和方法
公开(公告)号：US20070129614A1
公开(公告)日：2007-06-07
申请号：US11698968
申请日：2007-01-26
申请人： Joseph Schmitt , Martin Debreczeny
发明人： Joseph Schmitt , Martin Debreczeny
IPC分类号： A61B5/00
CPC分类号： G01N21/3554 , A61B5/0053 , A61B5/0059 , A61B5/02438 , A61B5/14546 , G01N21/359 , G01N2021/3181
摘要： Devices and methods for measuring body fluid-related metric using spectrophotometry that may be used to facilitate diagnosis and therapeutic interventions aimed at restoring body fluid balance. In one embodiment, the present invention provides a device for measuring a body-tissue water content metric as a fraction of the fat-free tissue content of a patient using optical spectrophotometry. The device includes a probe housing configured to be placed near a tissue location which is being monitored; light emission optics connected to the housing and configured to direct radiation at the tissue location; light detection optics connected to the housing and configured to receive radiation from the tissue location; and a processing device configured to process radiation from the light emission optics and the light detection optics to compute the metric where the metric includes a ratio of the water content of a portion of patient's tissue in relation to the lean or fat-free content of a portion of patient's tissue.
摘要翻译：用于使用分光光度法测量体液相关度量的装置和方法，其可用于促进用于恢复体液平衡的诊断和治疗干预。在一个实施方案中，本发明提供了一种用于使用光学分光光度法测量身体组织含水量度量作为患者的无脂肪组织含量的一部分的装置。该装置包括被配置成放置在被监视的组织位置附近的探针壳体; 光发射光学器件连接到壳体并且被配置成在组织位置处引导辐射; 光检测光学器件连接到壳体并被配置为从组织位置接收辐射; 以及处理装置，其被配置为处理来自所述发光光学器件和所述光检测光学器件的辐射，以计算所述度量，其中所述度量包括患者组织的一部分的水含量相对于所述贫血或无脂肪含量的比例部分患者组织。

4. 发明申请

US20140094697A1 OPTICAL COHERENCE TOMOGRAPHY AND PRESSURE BASED SYSTEMS AND METHODS 审中-公开
标题翻译：光学相干和基于压力的系统和方法
公开(公告)号：US20140094697A1
公开(公告)日：2014-04-03
申请号：US14122574
申请日：2012-05-14
申请人： Christopher Petroff , Joseph Schmitt
发明人： Christopher Petroff , Joseph Schmitt
IPC分类号： A61B5/00 , A61B1/015 , A61B5/026 , A61B5/02 , A61B5/0215 , A61B1/07
CPC分类号： A61B5/0084 , A61B1/015 , A61B1/07 , A61B5/0066 , A61B5/02028 , A61B5/0215 , A61B5/02158 , A61B5/026 , A61B5/1076 , A61B5/1077 , A61B5/6852 , A61B5/6876 , A61B5/7278 , A61B5/7282 , A61B2562/0233 , A61B2562/0247 , A61B2576/023
摘要： In part, the invention relates to methods, apparatus, and systems suitable for determining a fractional flow reserve (FFR) and variations of modifications thereof One embodiment relates to a method and apparatus for obtaining a corrected FFR in a vessel having a stenosis. In one aspect, the invention relates to an apparatus for measuring corrected FFR of a vessel having a stenosis. In one embodiment, the apparatus includes a probe comprising an optical coherence tomography assembly and a pressure assembly; and a processor in communication with the optical coherence tomography assembly and the pressure assembly. In one embodiment, the pressure assembly measures values of pressure in predetermined locations the vessel and communicates them to the processor. In one embodiment, a dual guidewire is used to reduce the interference in the pressure measurement.
摘要翻译：部分地，本发明涉及适合于确定分数流量储备（FFR）及其变型的方法，装置和系统。一个实施方案涉及用于在具有狭窄的血管中获得校正的FFR的方法和装置。一方面，本发明涉及一种用于测量具有狭窄的血管的校正FFR的装置。在一个实施例中，该装置包括包括光学相干断层摄影组件和压力组件的探针; 以及与光学相干断层摄影组件和压力组件通信的处理器。在一个实施例中，压力组件测量容器的预定位置的压力值并将其传送到处理器。在一个实施例中，使用双引导线来减小压力测量中的干扰。

5. 发明申请

US20100253949A1 Miniature Optical Elements for Fiber-Optic Beam Shaping 有权
标题翻译：用于光纤光束成形的微型光学元件
公开(公告)号：US20100253949A1
公开(公告)日：2010-10-07
申请号：US12765501
申请日：2010-04-22
申请人： Desmond Adler , Stephen McCartin , Christopher Petersen , Joseph Schmitt
发明人： Desmond Adler , Stephen McCartin , Christopher Petersen , Joseph Schmitt
IPC分类号： G01B9/02 , G02B6/26 , G01B11/14
CPC分类号： G02B6/262 , A61B1/00137 , A61B1/005 , A61B1/07 , A61B5/0066 , A61B5/0068 , A61B5/0071 , A61B5/0084 , A61B5/02007 , A61B5/6852 , A61B5/6876 , A61B6/504 , G01B9/02091 , G02B5/08 , G02B6/32 , G02B6/4204 , G02B6/4206 , G02B6/4214 , G02B23/2423 , G02B23/26 , G02B27/005 , G02B27/0911 , G02B27/095 , G02B27/0955 , G02B27/0977 , G02B27/0994
摘要： In part, the invention relates to optical caps having at least one lensed surface configured to redirect and focus light outside of the cap. The cap is placed over an optical fiber. Optical radiation travels through the fiber and interacts with the optical surface or optical surfaces of the cap, resulting in a beam that is either focused at a distance outside of the cap or substantially collimated. The optical elements such as the elongate caps described herein can be used with various data collection modalities such optical coherence tomography. In part, the invention relates to a lens assembly that includes a micro-lens; a beam director in optical communication with the micro-lens; and a substantially transparent film or cover. The substantially transparent film is capable of bi-directionally transmitting light, and generating a controlled amount of backscatter. The film can surround a portion of the beam director.
摘要翻译：部分地，本发明涉及具有至少一个透镜表面的光学盖，该透镜表面被配置为将光重新定向并聚焦在盖的外侧。盖子放置在光纤上。光辐射穿过光纤并且与盖的光学表面或光学表面相互作用，导致在聚焦在帽子之外的距离或基本准直的光束。诸如本文所述的细长帽的光学元件可以与诸如光学相干断层摄影的各种数据收集模式一起使用。部分地，本发明涉及一种包括微透镜的透镜组件; 与微透镜进行光通信的光束导向器; 和基本上透明的薄膜或盖。基本透明的薄膜能够双向透射光，并产生受控量的反向散射。胶片可以围绕光束导向器的一部分。

6. 发明申请

US20060253016A1 Systems and methods to assess one or more body fluid metrics 有权
标题翻译：评估一种或多种体液指标的系统和方法
公开(公告)号：US20060253016A1
公开(公告)日：2006-11-09
申请号：US11282947
申请日：2005-11-18
申请人： Clark R. Baker , Joseph Schmitt
发明人： Clark R. Baker , Joseph Schmitt
IPC分类号： A61B5/00 , A61B5/05 , A61B8/00
CPC分类号： A61B5/0059 , A61B5/02438 , A61B5/14546 , A61B5/4869 , A61B5/4878 , G01N21/3554 , G01N21/359 , G01N21/474 , G01N2021/3181
摘要： The present disclosure provides systems, devices, and/or methods for assessing body fluid-related metrics and/or changes therein. The disclosure further provides systems, devices, and/or methods for correlating body fluid-related metrics in a particular tissue with the corresponding whole-body metric. The disclosure also provides, systems, devices, and/or methods for assessment of such metrics to facilitate diagnosis and/or therapeutic interventions related to maintaining and/or restoring body fluid balance.
摘要翻译：本公开提供了用于评估体液相关度量和/或其中变化的系统，装置和/或方法。本公开还提供用于将特定组织中的体液相关度量与相应的全身度量相关联的系统，装置和/或方法。本公开还提供了用于评估这些度量的系统，装置和/或方法，以促进与维持和/或恢复体液平衡相关的诊断和/或治疗干预。

7. 发明申请

US20060241503A1 Optical coherence tomography apparatus and methods 有权
标题翻译：光学相干断层扫描仪和方法
公开(公告)号：US20060241503A1
公开(公告)日：2006-10-26
申请号：US11351896
申请日：2006-02-10
申请人： Joseph Schmitt , Amanda Koski , Michael Atlas , Christopher Petersen
发明人： Joseph Schmitt , Amanda Koski , Michael Atlas , Christopher Petersen
IPC分类号： A61B6/00
CPC分类号： G01B9/02091 , A61B5/0066 , A61B5/6852 , G01B9/0205 , G01B2290/65 , G01B2290/70 , G01N21/474 , G01N21/4795 , G01N21/8507 , G01N2021/1787 , G01N2021/8514 , G01N2021/8528 , G02B6/262
摘要： In one aspect, the invention relates to an imaging probe. The imaging probe includes an elongate body having a proximal end and distal end, the elongate body adapted to enclose a portion of a slidable optical fiber, the optical fiber having a longitudinal axis; and a first optical assembly attached to a distal end of the fiber. The first optical assembly includes a beam director adapted to direct light emitted from the fiber to a plane at a predetermined angle to the longitudinal axis, a linear actuator disposed at the proximal portion of the elongated body, the actuator adapted to affect relative linear motion between the elongate body and the optical fiber; and a second optical assembly located at the distal portion of the elongate body and attached thereto, the second optical assembly comprising a reflector in optical communication with the first optical assembly, the reflector adapted to direct the light to a position distal to the elongate body.
摘要翻译：一方面，本发明涉及一种成像探针。成像探头包括具有近端和远端的细长主体，细长主体适于包围可滑动光纤的一部分，光纤具有纵向轴线; 以及附接到纤维的远端的第一光学组件。第一光学组件包括光束引导器，其适于将从光纤发射的光引导到与纵向轴线成预定角度的平面;线性致动器，设置在细长主体的近端部分处，该致动器适于影响细长体和光纤; 以及第二光学组件，其位于所述细长主体的远端部分并附接到其上，所述第二光学组件包括与所述第一光学组件光学连通的反射器，所述反射器适于将光引导到远离所述细长主体的位置。

8. 发明申请

US20050201662A1 Scanning miniature optical probes with optical distortion correction and rotational control 审中-公开
标题翻译：扫描具有光学失真校正和旋转控制的微型光学探头
公开(公告)号：US20050201662A1
公开(公告)日：2005-09-15
申请号：US11108465
申请日：2005-04-18
申请人： Christopher Petersen , Edward McNamara , Ronald Lamport , Michael Atlas , Joseph Schmitt , Eric Swanson , Paul Magnin
发明人： Christopher Petersen , Edward McNamara , Ronald Lamport , Michael Atlas , Joseph Schmitt , Eric Swanson , Paul Magnin
IPC分类号： G02B23/26 , A61B1/00 , A61B5/00 , G02B23/24 , A61B18/18
CPC分类号： G02B23/2407 , A61B5/0066 , A61B5/0084 , A61B5/6852 , G01B9/0205 , G01B9/02091
摘要： Optical probes having a diameter less than substantially 500 μm for use in scanning light from a long, highly flexible fiber to a sample. In one embodiment the probe includes a viscous damping fluid suitable to prevent non-uniform rotational distortion (NURD).
摘要翻译：直径小于大约500μm的光学探针用于从长的，高度柔性的光纤到样品的光线扫描。在一个实施例中，探针包括适于防止不均匀旋转失真（NURD）的粘性阻尼流体。

9. 发明申请

US20140379269A1 SYSTEMS, METHODS AND APPARATUS FOR DETERMINING A FRACTIONAL FLOW RESERVE 审中-公开
标题翻译：系统，方法和装置，用于确定一个流量流动储备
公开(公告)号：US20140379269A1
公开(公告)日：2014-12-25
申请号：US14126152
申请日：2012-08-01
申请人： Joseph Schmitt
发明人： Joseph Schmitt
IPC分类号： G01N21/85 , A61B5/02 , A61B5/00 , G01B9/02 , G01N21/47
CPC分类号： G01N21/85 , A61B5/0066 , A61B5/0084 , A61B5/02007 , A61B5/02028 , A61B5/0215 , A61B5/4836 , A61B5/489 , A61B5/6852 , A61B34/10 , A61B2576/02 , G01B9/02091 , G01N21/4795
摘要： In one aspect, the invention relates to system comprising: a processor configured to receive a first optical coherence tomography (OCT) data set obtained during a pullback of a data collection probe along a first length of a first blood vessel; determine a minimum lumen area disposed along the first length using the first OCT data set; and determine a first FFR value along the first length based on the minimum lumen area. In one embodiment, the first FFR value is an estimated FFR. In another aspect, the invention relates to a method that includes measuring, using OCT, the area of a lumen of a vessel for which the vessel's FFR is to be determined; and calculating, using a computer, A2m/(A2m+k) or YA2min/(YA2min+k) as a FFR value. In one embodiment, k is about 0.7 mm2 and γ is patient-specific variable that depends on the coronary branch in which the images were obtained.
摘要翻译：一方面，本发明涉及一种系统，包括：处理器，被配置为接收沿着第一血管的第一长度在数据采集探头的回退期间获得的第一光学相干断层摄影（OCT）数据集; 使用所述第一OCT数据集来确定沿所述第一长度设置的最小流明面积; 并且基于最小管腔面积确定沿着第一长度的第一FFR值。在一个实施例中，第一FFR值是估计的FFR。在另一方面，本发明涉及一种方法，其包括使用OCT测量要确定所述血管的FFR的血管腔的面积; 并使用计算机计算A2m /（A2m + k）或YA2min /（YA2min + k）作为FFR值。在一个实施方案中，k为约0.7mm 2，γ为取决于获得图像的冠状动脉分支的患者特异性变量。

10. 发明申请

US20070118027A1 Method for evaluating extracellular water concentration in tissue 失效
标题翻译：评估组织中细胞外水浓度的方法
公开(公告)号：US20070118027A1
公开(公告)日：2007-05-24
申请号：US11283506
申请日：2005-11-18
申请人： Clark Baker , Joseph Schmitt , Shannon Campbell , Nick Durr , Carine Hoarau , Rafael Ostrowski , Martin Debreczeny
发明人： Clark Baker , Joseph Schmitt , Shannon Campbell , Nick Durr , Carine Hoarau , Rafael Ostrowski , Martin Debreczeny
IPC分类号： A61B5/00
CPC分类号： G01N21/359 , A61B5/0059 , A61B5/0537 , A61B5/4869 , G01N21/274
摘要： The present disclosure provides systems, devices, and/or methods for assessing body fluid-related metrics and/or changes therein. The disclosure further provides systems, devices, and/or methods for correlating body fluid-related metrics in a particular tissue with the corresponding whole-body metric. The disclosure also provides, systems, devices, and/or methods for assessment of such metrics to facilitate diagnosis and/or therapeutic interventions related to maintaining and/or restoring body fluid balance.
摘要翻译：本公开提供了用于评估体液相关度量和/或其中变化的系统，装置和/或方法。本公开还提供用于将特定组织中的体液相关度量与相应的全身度量相关联的系统，装置和/或方法。本公开还提供了用于评估这些度量的系统，装置和/或方法，以促进与维持和/或恢复体液平衡相关的诊断和/或治疗干预。

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