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71. 发明申请

US20120087923A1 Antibodies to OPGL 有权
标题翻译： OPGL的抗体
公开(公告)号：US20120087923A1
公开(公告)日：2012-04-12
申请号：US13296201
申请日：2011-11-14
申请人： William J. Boyle , Francis H. Martin , Jose R. Corvalan , C. Geoffrey Davis
发明人： William J. Boyle , Francis H. Martin , Jose R. Corvalan , C. Geoffrey Davis
IPC分类号： A61K39/395 , A61P19/08
CPC分类号： C07K16/2875 , A61K39/39541 , A61K39/3955 , A61K45/06 , A61K2039/505 , A61K2039/507 , C07K16/241 , C07K2317/21 , C07K2317/51 , C07K2317/515 , C07K2317/54 , C07K2317/55 , C07K2317/56 , C07K2317/622 , C07K2317/76 , C07K2317/92 , A61K2300/00
摘要： Antibodies that interact with osteoprotegerin ligand (OPGL) are described. Methods of treating osteopenic disorders by administering a pharmaceutically effective amount of antibodies to OPGL are described. Methods of detecting the amount of OPGL in a sample using antibodies to OPGL are described.
摘要翻译：描述了与骨保护素配体（OPGL）相互作用的抗体。描述了通过向OPGL施用药学有效量的抗体来治疗骨质疏松症的方法。描述使用OPGL抗体检测样品中OPGL的量的方法。

72. 发明授权

US07807795B2 Antibodies to osteoprotegerin binding proteins 有权
标题翻译：骨保护蛋白结合蛋白的抗体
公开(公告)号：US07807795B2
公开(公告)日：2010-10-05
申请号：US09211297
申请日：1998-12-14
申请人： William J. Boyle
发明人： William J. Boyle
IPC分类号： C07K16/00
CPC分类号： C07K14/70578 , A61K38/00 , A61K39/00 , C07K14/70575 , C07K2319/30
摘要： A novel polypeptide, osteoprotegerin binding protein, involved in osteoclast maturation has been identified based upon its affinity for osteoprotegerin. Nucleic acid sequences encoding the polypeptide, or a fragment, analog, or derivative thereof, vectors and host cells for production, and binding assays are described. Antibodies specifically binding osteoprotegerin binding protein are also described. Compositions and methods for the treatment of bone diseases such as osteoporosis, bone loss due to arthritis or metastasis, hypercalcemia, and Paget's disease are also provided.
摘要翻译：已经基于其对骨保护素的亲和力鉴定了参与破骨细胞成熟的新型多肽，骨保护蛋白结合蛋白。描述编码多肽或其片段，类似物或衍生物，用于产生的载体和宿主细胞和结合测定的核酸序列。还描述了特异性结合骨保护蛋白结合蛋白的抗体。还提供了用于治疗骨质疏松症，由于关节炎或转移引起的骨丢失，高钙血症和佩吉特氏病等骨疾病的组合物和方法。

73. 发明申请

US20100004673A1 EMBOLIC FILTERING DEVICES FOR BIFURCATED VESSELS 审中-公开
标题翻译：用于混合血管的EMBOLIC FILTERING装置
公开(公告)号：US20100004673A1
公开(公告)日：2010-01-07
申请号：US12491051
申请日：2009-06-24
申请人： ANDY E. DENISON , William J. Boyle
发明人： ANDY E. DENISON , William J. Boyle
IPC分类号： A61F2/01
CPC分类号： A61F2/013 , A61F2002/018 , A61F2002/065 , A61F2230/0008 , A61F2230/001 , A61F2230/008
摘要： An embolic filtering device for use in a bifurcated vessel includes delivery device having a first guide wire and a second guide wire. The second guide wire diverges from the distal-end region of the first guide wire. The filter device also includes a filter support having a first deployment member and a second deployment member. These deployment members can be formed as a first loop and a second loop. A bifurcated filter element is coupled to the filter support. The distal-end region of the first guide wire extends through a first leg of the filter element and the second guide wire extends through a second leg of the filter element. During use, the first leg of the filter element is deployed within a first branch of the bifurcated vessel and the second leg of the filter element is deployed within a second branch of the bifurcated vessel.
摘要翻译：用于分叉容器的栓塞过滤装置包括具有第一导丝和第二导丝的输送装置。第二引导线从第一导丝的远端区域分叉。过滤装置还包括具有第一展开构件和第二展开构件的过滤器支撑件。这些展开部件可以形成为第一环和第二环。分离的过滤元件连接到过滤器支撑件。第一导丝的远端区域延伸穿过过滤元件的第一腿部，并且第二导丝线延伸穿过过滤元件的第二腿部。在使用期间，过滤元件的第一腿部分在分叉容器的第一分支内，并且过滤元件的第二腿部分在分叉容器的第二分支内。

74. 发明授权

US07572272B2 Embolic filtering devices for bifurcated vessels 有权
标题翻译：用于分叉血管的栓塞过滤装置
公开(公告)号：US07572272B2
公开(公告)日：2009-08-11
申请号：US11108309
申请日：2005-04-18
申请人： Andy E. Denison , William J. Boyle
发明人： Andy E. Denison , William J. Boyle
IPC分类号： A61M29/00 , A61B17/22 , A61D1/02 , A61F2/06
CPC分类号： A61F2/013 , A61F2002/018 , A61F2002/065 , A61F2230/0008 , A61F2230/001 , A61F2230/008
摘要： An embolic filtering device for use in a bifurcated vessel includes delivery device having a first guide wire and a second guide wire. The second guide wire diverges from the distal-end region of the first guide wire. The filter device also includes a filter support having a first deployment member and a second deployment member. These deployment members can be formed as a first loop and a second loop. A bifurcated filter element is coupled to the filter support. The distal-end region of the first guide wire extends through a first leg of the filter element and the second guide wire extends through a second leg of the filter element. During use, the first leg of the filter element is deployed within a first branch of the bifurcated vessel and the second leg of the filter element is deployed within a second branch of the bifurcated vessel.
摘要翻译：用于分叉容器的栓塞过滤装置包括具有第一导丝和第二导丝的输送装置。第二引导线从第一导丝的远端区域分叉。过滤装置还包括具有第一展开构件和第二展开构件的过滤器支撑件。这些展开部件可以形成为第一环和第二环。分离的过滤元件连接到过滤器支撑件。第一导丝的远端区域延伸穿过过滤元件的第一腿部，并且第二导丝线延伸穿过过滤元件的第二腿部。在使用期间，过滤元件的第一腿部分在分叉容器的第一分支内，并且过滤元件的第二腿部分在分叉容器的第二分支内。

75. 发明授权

US07101353B2 Splittable medical valve 有权
公开(公告)号：US07101353B2
公开(公告)日：2006-09-05
申请号：US10287407
申请日：2002-11-04
申请人： Chun Kee Lui , William J. Boyle
发明人： Chun Kee Lui , William J. Boyle
IPC分类号： A61M5/178
CPC分类号： A61M39/0606 , A61B2017/3466 , A61M25/0668 , A61M39/02 , A61M39/045 , A61M2039/062 , A61M2039/0633 , A61M2039/064 , A61M2039/066
摘要： A hemostatic valve couples to a sheath proximal hub having an inside and an outside surface. The hemostatic valve has a valve body having a proximal porting and end, and a distal portion and end. A passageway extends longitudinally through the valve body between the proximal and distal ends. A sealing element is positioned within the passageway. The distal portion of the valve body includes a pair of contact surfaces forming an annular gap receiving the sheath proximal hub of the sheath so that the contact surfaces sandwich the sheath proximal hub forming a seal on both the inside and outside surfaces of the hub. The valve body and the sheath proximal hub includes two oppositely placed longitudinal lines of fissure that allow the hub to be separated into two halves with the valve body.

76. 发明授权

US07097834B1 Osteoprotegerin binding proteins 有权
公开(公告)号：US07097834B1
公开(公告)日：2006-08-29
申请号：US09211315
申请日：1998-12-14
申请人： William J. Boyle
发明人： William J. Boyle
IPC分类号： A61K39/395 , A61K39/44
CPC分类号： C07K14/70578 , A61K38/00 , A61K39/00 , C07K14/70575 , C07K2319/30
摘要： A novel polypeptide, osteoprotegerin binding protein, involved in osteolcast maturation has been identified based upon its affinity for osteoprotegerin. Nucleic acid sequences encoding the polypeptide, or a fragment, analog or derivative thereof, vectors and host cells for production, methods of preparing osteoprotegerin binding protein, and binding assays are also described. Compositions and methods for the treatment of bone diseases such as osteoporosis, bone loss due to arthritis or metastasis, hypercalcemia, and Paget's disease are also provided.

77. 发明授权

US06712791B2 Splittable medical valve 有权
标题翻译：可分离医用阀
公开(公告)号：US06712791B2
公开(公告)日：2004-03-30
申请号：US09751017
申请日：2000-12-28
申请人： Chun Kee Lui , William J. Boyle
发明人： Chun Kee Lui , William J. Boyle
IPC分类号： A61M5178
CPC分类号： A61M39/06 , A61B2017/3466 , A61M25/0668 , A61M39/0613 , A61M2039/0686
摘要： A splittable medical valve is disclosed that is configured with a interfacing region that permits the valve to be placed over or inside of a tubular medical device, such as a splittable introducer sheath, to prevent loss of bodily fluids and/or reduce ingress of air-borne pathogens. The valve further includes a sealing element configured to accept passage of a medical device, such as a catheter, sheath, pacemaker lead, or other ancillary device therethrough, whereby the valve body is split along one or more lines or fissure to allow removal of the valve from around the ancillary device.
摘要翻译：公开了一种可分开的医疗阀，其配置有接口区域，该接口区域允许将阀放置在管状医疗装置（例如可分开的引导器护套）之上或之上，以防止体液的流失和/或减少空气 - 携带病原体阀还包括密封元件，该密封元件被配置为接纳诸如导管，护套，起搏器引线或其他辅助装置之类的医疗装置的通过，从而阀体沿着一条或多条线或裂缝分开，以允许阀门附近的辅助设备。

78. 发明授权

US06506203B1 Low profile sheathless embolic protection system 有权
公开(公告)号：US06506203B1
公开(公告)日：2003-01-14
申请号：US09740560
申请日：2000-12-19
申请人： William J. Boyle , Richard S. Stack
发明人： William J. Boyle , Richard S. Stack
IPC分类号： A61M2900
CPC分类号： A61F2/013 , A61F2002/015 , A61F2002/018 , A61F2230/0006 , A61F2230/008
摘要： A system used in a blood vessel when an interventional procedure is being performed in a stenosed or occluded region, which is capable of enabling a support device and filter supported thereon, to be inserted into the blood vessel and to cross the stenosis therein in a low profile without a sheath extending thereabout. The filter is adapted to filter the blood in the blood vessel. The system is further capable of enabling the support device and filter to be positioned distal to the interventional procedure site, and to be activated to expand at the distal location so as to enable the filter to capture any embolic material that may be created and released into the bloodstream during the interventional procedure. The system is also capable of enabling the support device and filter to be activated to contract to a return profile for enabling the filter to retain the embolic material captured therein and the removal of the support device and filter from the blood vessel. The system includes a filter, adapted to be deployed distal to the interventional procedure site, and to pass blood therethrough and capture embolic material which may be released into the blood in the blood vessel during the interventional procedure. A support device is adapted to support the filter, and to retain a low profile so as to enable the filter to be inserted into and cross the stenosis in the blood vessel, to a position distal to the interventional procedure site, without a sheath extending about the filter and the support device. The support device is further adapted to deform for expansion thereof into open position to enable the filter to capture embolic material, and to enable the collapsing thereof to retain the embolic material captured in the filter, and to enable removal of the support device and the filter. The system also includes a mechanism, connected to the support device, adapted to be activated so as to enable the support device to deform for expansion thereof.

79. 发明授权

US06316408B1 Methods of use for osetoprotegerin binding protein receptors 失效
标题翻译：卵磷脂结合蛋白受体的使用方法
公开(公告)号：US06316408B1
公开(公告)日：2001-11-13
申请号：US09052521
申请日：1998-03-30
申请人： William J. Boyle
发明人： William J. Boyle
IPC分类号： C07K1400
CPC分类号： C07K14/70578 , A61K38/00 , A61K39/00 , C07K14/70575 , C07K2319/30
摘要： A novel polypeptide, osteoprotegerin binding protein, involved in osteolcast maturation has been identified based upon its affinity for osteoprotegerin. Nucleic acid sequences encoding the polypeptide, or a fragment, analog or derivative thereof, vectors and host cells for production, methods of preparing osteoprotegerin binding protein, and binding assays are also described. Compositions and methods for the treatment of bone diseases such as osteoporosis, bone loss due to arthritis or metastasis, hypercalcemia, and Paget's disease are also provided. Receptors for osteoprotegerin binding proteins are also described. The receptors, and agonists and antagonists thereof, may be used to treat bone diseases.
摘要翻译：已经基于其对骨保护素的亲和力，鉴定了参与骨转播成熟的新型多肽，骨保护蛋白结合蛋白。还描述了编码多肽或其片段，类似物或衍生物的核酸序列，用于产生的载体和宿主细胞，制备骨保护蛋白结合蛋白的方法和结合测定。还提供了用于治疗骨疾病如骨质疏松症，由于关节炎或转移引起的骨丢失，高钙血症和佩吉特氏病的组合物和方法。还描述了用于骨保护蛋白结合蛋白的受体。受体及其激动剂及其拮抗剂可用于治疗骨疾病。

80. 发明授权

US5824303A Eck receptor ligands 失效
公开(公告)号：US5824303A
公开(公告)日：1998-10-20
申请号：US445065
申请日：1995-05-19
申请人： Timothy D. Bartley , William J. Boyle , Gary M. Fox , Andrew A. Welcher , Ella Magal , Richard A. Lindberg , Vann P. Parker
发明人： Timothy D. Bartley , William J. Boyle , Gary M. Fox , Andrew A. Welcher , Ella Magal , Richard A. Lindberg , Vann P. Parker
IPC分类号： A61K38/00 , A61K38/17 , A61K38/18 , A61K39/00 , A61P1/16 , A61P7/06 , A61P29/00 , A61P35/00 , A61P43/00 , C07K14/47 , C07K14/52 , C07K14/705 , C12N15/09 , C12N15/12 , C12P21/02 , C12Q1/02 , C12R1/91 , G01N33/566 , G01N33/573 , A61K38/45 , C12N9/12
CPC分类号： C07K14/705 , A61K38/1709 , A61K38/185 , C07K14/47 , C07K14/52 , G01N33/566 , G01N33/573 , A61K39/00 , G01N2500/00 , Y10S514/886 , Y10S514/893
摘要： Ligands which bind to the eck receptor are disclosed. More particularly, polypeptides which bind specifically to the eck receptor (eck receptor binding proteins or EBPs) and DNA sequences encoding said polypeptides are disclosed. Methods of treatment using eck receptor ligands and soluble eck receptor and disclosed, as are pharmaceutical compositions containing same. A rapid and sensitive method for the detection of receptor binding activity in crude samples is provided.

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