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71. 发明授权

US07927305B2 Systems, methods, and devices for injecting media contrast 有权
标题翻译：用于注入媒体对比度的系统，方法和设备
公开(公告)号：US07927305B2
公开(公告)日：2011-04-19
申请号：US11738372
申请日：2007-04-20
申请人： Travis Yribarren , Richard Newhauser , Randolf von Oepen , James M. Jacobs
发明人： Travis Yribarren , Richard Newhauser , Randolf von Oepen , James M. Jacobs
IPC分类号： A61M37/00 , A61M5/00
CPC分类号： A61M25/10 , A61B2017/22038 , A61M5/007 , A61M5/14526 , A61M5/172 , A61M2025/0004 , A61M2025/0681 , A61M2025/1052
摘要： A system for delivering a contrast medium to a treatment site including a delivery device, and a portable power injector. The delivery device includes a guidewire lumen and a contrast injection lumen, the guidewire lumen and contrast injection lumen being at least partially coaxial. The portable power injector includes an injector body and is configured to contain a contrast medium. The injector body has a plunger disposed therein. The portable power injector also includes a pressure generator, the pressure generator being configured to apply a pressure to the plunger to drive the contrast medium from the injector body and through a distal end of the contrast injection lumen.
摘要翻译：一种用于将造影剂输送到包括输送装置和便携式动力注射器的治疗部位的系统。输送装置包括导丝管腔和造影剂注射内腔，导丝管腔和造影剂注射腔至少部分同轴。便携式动力注射器包括注射器主体并且构造成容纳造影剂。喷射器主体具有设置在其中的柱塞。便携式动力注射器还包括压力发生器，压力发生器被配置为向柱塞施加压力以从注射器主体和造影剂注射腔的远端驱动造影剂。

72. 发明授权

US07824434B2 Self foreshortening fastener 失效
标题翻译：自动缩短紧固件
公开(公告)号：US07824434B2
公开(公告)日：2010-11-02
申请号：US11146433
申请日：2005-06-06
申请人： Randolf von Oepen
发明人： Randolf von Oepen
IPC分类号： A61B17/04
CPC分类号： A61B17/866 , A61B2017/00004
摘要： Disclosed is a fastener that can be mounted to a bone of a patient and can foreshorten and swell of a desired period of time. The fastener can include a head portion and a body portion extending from the head portion. At least one of the head portion and the body portion has a first width that changes to a second width greater than the first width and collectively the head portion and the body portion have a first length that changes to a second length shorter than the first length upon the head portion and the body portion being exposed to a temperature below a glass transition temperature of a polymeric material forming the head portion and the body portion.
摘要翻译：公开了一种紧固件，其可以安装到患者的骨骼并且可以缩短和膨胀期望的时间段。紧固件可以包括头部和从头部延伸的主体部分。所述头部和所述主体部分中的至少一个具有变成大于所述第一宽度的第二宽度的第一宽度，并且所述头部部分和所述主体部分具有变成比所述第一长度短的第二长度的第一长度在头部和主体部分暴露于形成头部和主体部分的聚合物材料的玻璃化转变温度以下的温度。

73. 发明授权

US07811314B2 Methods and apparatus for stenting comprising enhanced embolic protection coupled with improved protections against restenosis and thrombus formation 有权
标题翻译：用于支架置入的方法和装置包括增强的栓塞保护以及改进的针对再狭窄和血栓形成的保护
公开(公告)号：US07811314B2
公开(公告)日：2010-10-12
申请号：US11732244
申请日：2007-04-02
申请人： Joost J. Fierens , Silvio R. Schaffner , Marc Gianotti , Gerd Seibold , Randolf von Oepen
发明人： Joost J. Fierens , Silvio R. Schaffner , Marc Gianotti , Gerd Seibold , Randolf von Oepen
IPC分类号： A61F2/06
CPC分类号： A61F2/07 , A61F2/82 , A61F2/856 , A61F2/90 , A61F2/91 , A61F2/915 , A61F2/958 , A61F2002/0086 , A61F2002/91508 , A61F2002/91533 , A61F2002/91558 , A61F2220/0008 , A61F2220/0016 , A61F2220/005
摘要： Apparatus and methods for stenting are provided comprising a stent attached to a porous biocompatible material that is permeable to endothelial cell ingrowth, but impermeable to release of emboli of predetermined size. Preferred stent designs are provided, as well as preferred manufacturing techniques. Apparatus and methods are also provided for use at a vessel branching. Moreover, embodiments of the present invention may comprise a coating configured for localized delivery of therapeutic agents. Embodiments of the present invention are expected to provide enhanced embolic protection, improved force distribution, and improved recrossability, while reducing a risk of restenosis and thrombus formation.
摘要翻译：提供了用于支架置入的装置和方法，其包括附着于多孔生物相容性材料的支架，所述多孔生物相容性材料可渗透内皮细胞向内生长，但不能透过预定尺寸的栓塞。提供优选的支架设计，以及优选的制造技术。还提供了用于血管分支的装置和方法。此外，本发明的实施方案可以包括被配置用于局部递送治疗剂的涂层。预期本发明的实施方案可提供增强的栓塞保护，改善的力分布和改善的再交联性，同时降低再狭窄和血栓形成的风险。

74. 发明申请

US20180056043A1 ADJUSTABLE GUIDEWIRE RECEIVING MEMBER 审中-公开
公开(公告)号：US20180056043A1
公开(公告)日：2018-03-01
申请号：US15662066
申请日：2017-07-27
申请人： Randolf von Oepen , Sean A. McNiven , Francisco Valencia
发明人： Randolf von Oepen , Sean A. McNiven , Francisco Valencia
IPC分类号： A61M25/09
CPC分类号： A61M25/0905 , A61B17/00234 , A61B17/3468 , A61B2017/00243 , A61B2017/00292 , A61B2017/00309 , A61B2017/00323 , A61B2017/00336 , A61B2017/00477 , A61B2017/00783 , A61B2017/1205 , A61B2017/22042 , A61B2090/3966 , A61F2/2427 , A61F2/2436 , A61M25/0045 , A61M25/0069 , A61M25/0074 , A61M25/0097 , A61M25/0108 , A61M25/0138 , A61M2025/0004 , A61M2025/0079 , A61M2025/09116 , A61M2025/09125 , A61M2025/09175
摘要： An intravascular device delivery system has an elongated member with an outer sleeve and a distal cap longitudinally fixed to a guidewire receiving member. The guidewire receiving member is moveable longitudinally relative to the outer sleeve to move the distal cap relative to the outer sleeve.

75. 发明申请

US20180028779A1 MECHANICAL INTERLOCK FOR CATHETERS 审中-公开
公开(公告)号：US20180028779A1
公开(公告)日：2018-02-01
申请号：US15662076
申请日：2017-07-27
申请人： Randolf von Oepen , Sean A. McNiven , Francisco Valencia
发明人： Randolf von Oepen , Sean A. McNiven , Francisco Valencia
IPC分类号： A61M25/00 , A61M25/06 , A61F2/24 , A61M25/01
CPC分类号： A61M25/0051 , A61B17/00234 , A61B2017/00243 , A61B2017/00309 , A61B2017/00323 , A61B2017/00477 , A61B2017/00526 , A61B2017/00783 , A61B2017/00991 , A61F2/2427 , A61M25/0045 , A61M25/005 , A61M25/0102 , A61M25/0136 , A61M25/0138 , A61M25/0141 , A61M25/0147 , A61M25/0662 , A61M2025/0004 , A61M2025/0006 , A61M2025/0063 , A61M2025/0161 , A61M2025/0175 , A61M2025/0681
摘要： An intravascular device delivery system has an elongated member with a flexible hypotube. The hypotube can be rotationally keyed to a steerable catheter. The flexible hypotube includes one or more cuts to allow bending of the flexible hypotube within a first plane. The steerable catheter is steerable to bend the flexible hypotube within the first plane, and longitudinally movable relative to the flexible hypotube to allow distal movement of the steerable catheter relative to a distal end of the flexible hypotube.

76. 发明授权

US09045843B2 Electropolishing fixture with lever arm 有权
标题翻译：电动抛光夹具带杠杆臂
公开(公告)号：US09045843B2
公开(公告)日：2015-06-02
申请号：US13618455
申请日：2012-09-14
申请人： Anthony S. Andreacchi , Randolf von Oepen , William E. Webler , Rodney Charles Ow
发明人： Anthony S. Andreacchi , Randolf von Oepen , William E. Webler , Rodney Charles Ow
IPC分类号： C25F7/00 , C25F3/16
CPC分类号： C25F3/16 , C25F7/00
摘要： An electropolishing system that includes electropolishing fixtures. The electropolishing fixtures include pendulum assemblies configured to establish electrical contact between a device being electropolished and an anode and to reposition the device during the electropolishing process.
摘要翻译：电抛光系统，包括电抛光灯具。电抛光固定装置包括构造成在电抛光装置和阳极之间建立电接触并且在电抛光过程期间重新定位装置的摆动组件。

77. 发明授权

US08814926B2 Methods and apparatus for stenting comprising enhanced embolic protection coupled with improved protections against restenosis and thrombus formation 有权
标题翻译：用于支架置入的方法和装置包括增强的栓塞保护以及改进的针对再狭窄和血栓形成的保护
公开(公告)号：US08814926B2
公开(公告)日：2014-08-26
申请号：US13089039
申请日：2011-04-18
申请人： Joost J. Fierens , Silvio R. Schaffner , Marc Gianotti , Gerd Seibold , Randolf von Oepen
发明人： Joost J. Fierens , Silvio R. Schaffner , Marc Gianotti , Gerd Seibold , Randolf von Oepen
IPC分类号： A61F2/82
CPC分类号： A61F2/07 , A61F2/82 , A61F2/856 , A61F2/90 , A61F2/91 , A61F2/915 , A61F2/958 , A61F2002/0086 , A61F2002/91508 , A61F2002/91533 , A61F2002/91558 , A61F2220/0008 , A61F2220/0016 , A61F2220/005
摘要： Apparatus and methods for stenting are provided comprising a stent attached to a porous biocompatible material that is permeable to endothelial cell ingrowth, but impermeable to release of emboli of predetermined size. Preferred stent designs are provided, as well as preferred manufacturing techniques. Apparatus and methods are also provided for use at a vessel branching. Moreover, embodiments of the present invention may comprise a coating configured for localized delivery of therapeutic agents. Embodiments of the present invention are expected to provide enhanced embolic protection, improved force distribution, and improved recrossability, while reducing a risk of restenosis and thrombus formation.
摘要翻译：提供了用于支架置入的装置和方法，其包括附着于多孔生物相容性材料的支架，所述多孔生物相容性材料可渗透内皮细胞向内生长，但不能透过预定尺寸的栓塞。提供优选的支架设计，以及优选的制造技术。还提供了用于血管分支的装置和方法。此外，本发明的实施方案可以包括被配置用于局部递送治疗剂的涂层。预期本发明的实施方案可提供增强的栓塞保护，改善的力分布和改善的再交联性，同时降低再狭窄和血栓形成的风险。

78. 发明授权

US08790393B2 Heat-treated tantalum-alloy products, implantable medical devices incorporating same, and methods of processing tantalum-alloy products 有权
标题翻译：热处理的钽合金产品，结合其的可植入医疗装置以及加工钽合金产品的方法
公开(公告)号：US08790393B2
公开(公告)日：2014-07-29
申请号：US13271869
申请日：2011-10-12
申请人： Rainer Bregulla , Randolf von Oepen , Pamela A Kramer-Brown , Austin M Leach
发明人： Rainer Bregulla , Randolf von Oepen , Pamela A Kramer-Brown , Austin M Leach
IPC分类号： A61F2/91
CPC分类号： A61L31/022 , A61L31/14
摘要： The present disclosure is directed to tantalum-alloy products, implantable medical devices that incorporate tantalum-alloy products such as stents or other implantable medical devices, methods of making and/or processing the tantalum-alloy products and implantable medical devices, and methods of using the implantable medical devices. In an embodiment, a stent includes a stent body having a plurality of struts. At least a portion of the stent body is made from a tantalum alloy. The tantalum alloy includes a tantalum content of about 77 weight % (“wt %”) to about 92 wt %, a niobium content of about 7 wt % to about 13 wt %, and a tungsten content of about 1 wt % to about 10 wt %. The tantalum alloy exhibits at least one mechanical property modified by heat treatment thereof, such as yield strength, ultimate tensile strength, or ductility.
摘要翻译：本公开涉及钽合金产品，结合钽合金产品例如支架或其他可植入医疗装置的可植入医疗装置，制造和/或加工钽合金产品和可植入医疗装置的方法以及使用方法可植入医疗器械。在一个实施例中，支架包括具有多个支柱的支架主体。支架主体的至少一部分由钽合金制成。钽合金包括约77重量％（“重量％”）至约92重量％的钽含量，约7重量％至约13重量％的铌含量和约1重量％至约10重量％的钨含量重量％。钽合金表现出至少一种通过其热处理改性的机械性能，例如屈服强度，极限拉伸强度或延展性。

79. 发明申请

US20140180433A1 STENT WITH ROUGH SURFACE AND ITS MANUFACTURE 审中-公开
标题翻译：具有粗糙表面的STENT及其制造
公开(公告)号：US20140180433A1
公开(公告)日：2014-06-26
申请号：US14135257
申请日：2013-12-19
申请人： Albert Schomig , Adnan Kastrati , Randolf von Oepen
发明人： Albert Schomig , Adnan Kastrati , Randolf von Oepen
IPC分类号： A61F2/82 , A61L31/16
CPC分类号： A61F2/82 , A61F2/91 , A61F2/915 , A61F2210/0076 , A61L31/14 , A61L31/16 , A61L2400/18 , B24C1/06 , B24C1/083 , B24C1/10
摘要： A stent is provided wherein at least an outer surface portion is roughened to a predetermined extent and wherein a drug or a therapeutic agent can be applied to said surface. This results in an improved stent, which can be manufactured at low costs and which can further avoid thrombus formation and a stenosis.
摘要翻译：提供了一种支架，其中至少外表面部分被粗糙化到预定的程度，并且其中可以将药物或治疗剂施加到所述表面。这导致改进的支架，其可以以低成本制造，并且可以进一步避免血栓形成和狭窄。

80. 发明申请

US20130102937A1 Methods and Devices for Treating Hypertension 审中-公开
标题翻译：治疗高血压的方法和装置
公开(公告)号：US20130102937A1
公开(公告)日：2013-04-25
申请号：US13656344
申请日：2012-10-19
申请人： Kevin Joe Ehrenreich , Randolf von Oepen , Kelly Justin McCrystle
发明人： Kevin Joe Ehrenreich , Randolf von Oepen , Kelly Justin McCrystle
IPC分类号： A61H1/00
CPC分类号： A61H23/02 , A61B5/0205 , A61B5/02208 , A61B5/053 , A61B5/1112 , A61B5/4818 , A61B5/6803 , A61B5/6833 , A61B5/6843 , A61B2562/0219 , A61H1/00 , A61H23/00 , A61H23/0236 , A61H23/0245 , A61H23/04 , A61H2023/002 , A61H2201/0196 , A61H2201/0207 , A61H2201/1207 , A61H2201/1609 , A61H2201/1614 , A61H2201/165 , A61H2201/5002 , A61H2201/5007 , A61H2201/5015 , A61H2201/5028 , A61H2201/5035 , A61H2201/5038 , A61H2201/5041 , A61H2201/5043 , A61H2201/5058 , A61H2201/5084 , A61H2201/5092 , A61H2201/5097 , A61H2230/045 , A61H2230/065 , A61H2230/208 , A61H2230/305 , A61H2230/505 , A61H2230/705 , B33Y80/00
摘要： Devices, systems and methods are described which control blood pressure and nervous system activity by stimulating baroreceptors. By selectively and controllably activating baroreceptors and/or nerves, the present invention reduces blood pressure and alters the sympathetic nervous system; thereby minimizing deleterious effects on the heart, vasculature and other organs and tissues. A baroreceptor activation device or other sensory activation device is positioned near a dermal bone to provide the treatment.
摘要翻译：描述了通过刺激压力感受器来控制血压和神经系统活动的装置，系统和方法。通过选择性地和可控制地激活压力感受器和/或神经，本发明降低血压并改变交感神经系统; 从而最小化对心脏，脉管系统和其他器官和组织的有害影响。压力感受器激活装置或其他感觉激活装置位于皮肤骨附近以提供治疗。

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