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71. 发明申请

US20100321692A1 Refractive Index Matching in Capillary Illumination 有权
$Refractive Index Matching in Capillary Illumination$
标题翻译：毛细管照射中的折射率匹配
公开(公告)号：US20100321692A1
公开(公告)日：2010-12-23
申请号：US12637717
申请日：2009-12-14
申请人： Richard T. REEL , Eric S. Nordman , Tomoyuki Sakai , Satoshi Takahashi , Ryoji Inaba
发明人： Richard T. REEL , Eric S. Nordman , Tomoyuki Sakai , Satoshi Takahashi , Ryoji Inaba
IPC分类号： G01N21/00 , G01N21/41
CPC分类号： G01N21/64 , F21V5/00 , G01N21/645 , G01N27/44721 , G01N2021/6463 , G01N2201/068 , Y10T436/143333
摘要： System and method for fluorescent light excitation and detection from samples to enhance the numerical aperture and/or reduce the cross-talk of the fluorescent light.
摘要翻译：用于荧光灯激发和检测样品的系统和方法，以提高数值孔径和/或减少荧光灯的串扰。

72. 发明授权

US07736481B2 Electrophoresis device and electrophoresis method 有权
标题翻译：电泳装置及电泳方法
公开(公告)号：US07736481B2
公开(公告)日：2010-06-15
申请号：US12071835
申请日：2008-02-27
申请人： Miho Ozawa , Ryoji Inaba
发明人： Miho Ozawa , Ryoji Inaba
IPC分类号： G01N27/453 , G01N27/447
CPC分类号： G01N27/44704
摘要： To reduce the elongation of the migration time for the first electrophoresis cycle in successive electrophoresis cycles and improve the reliability of electrophoresis analysis. The present invention relates to making the condition of a migration medium at the start of the first electrophoresis analysis in successive electrophoresis analyses after the temperature in a thermostatic oven reaches a desired preset temperature substantially the same as the conditions after the successive electrophoresis analyses. Preferably, a voltage is applied to a separation medium filling a capillary during preheating of the thermostatic oven. Preferably, the temperature in the thermostatic oven during preheating is set higher than the temperature in the thermostatic oven during electrophoresis analysis. Preferably, a buffer solution is heated during preheating of the thermostatic oven. Preferably, the capillary is filled with a preheated separation medium during preheating of the thermostatic oven. According to the present invention, the reliability of the first electrophoresis analysis in successive electrophoresis analyses is improved.
摘要翻译：减少连续电泳循环中第一次电泳循环的迁移时间延长，提高电泳分析的可靠性。本发明涉及在恒温炉中的温度达到与连续电泳分析后的条件基本相同的所需预设温度后，在连续电泳分析中开始第一次电泳分析时的迁移介质条件。优选地，在预热恒温炉期间，将电压施加到填充毛细管的分离介质上。优选地，预热期间恒温炉中的温度设定为高于电泳分析期间恒温炉中的温度。优选地，在预热恒温炉期间加热缓冲溶液。优选地，在预热恒温炉期间，用预热的分离介质填充毛细管。根据本发明，提高了连续电泳分析中的第一次电泳分析的可靠性。

73. 发明授权

US07601252B2 Multi-capillary electrophoresis apparatus 有权
标题翻译：多毛细管电泳仪
公开(公告)号：US07601252B2
公开(公告)日：2009-10-13
申请号：US11312550
申请日：2005-12-21
申请人： Motohiro Yamazaki , Masaya Kojima , Ryoji Inaba
发明人： Motohiro Yamazaki , Masaya Kojima , Ryoji Inaba
IPC分类号： G01N27/453
CPC分类号： G01N27/44782 , G01N27/44708
摘要： Scattering on analysis in a multi-capillary electrophoresis apparatus is suppressed. The multi-capillary electrophoresis apparatus has a multi-capillary array that has a sample and a separation medium for separating a sample charged therein, and has a sampling section formed at ends of the capillaries and a detector part for acquiring information depending on the sample thus separated, a means for applying a voltage between the sampling section and the detector part, a chamber part having an air blowing mechanism and a temperature controlling mechanism, a capillary housing base provided on a leeward side of the air blowing mechanism and housing the multi-capillary array, and a first straightening plate provided between the chamber part and the capillary housing base.
摘要翻译：抑制了在多毛细管电泳装置中的分析散射。多毛细管电泳装置具有多毛细管阵列，其具有样品和用于分离装入其中的样品的分离介质，并且在毛细管的端部形成有采样部，以及用于根据样品获取信息的检测器部用于在采样部分和检测器部分之间施加电压的装置，具有送风机构和温度控制机构的室部分，设置在吹风机构的背风侧的毛细管壳体基座，毛细管阵列，以及设置在腔室部分和毛细管壳体基座之间的第一矫直板。

74. 发明授权

US07473342B2 Capillary array and capillary electrophoresis apparatus 有权
标题翻译：毛细管阵列和毛细管电泳仪
公开(公告)号：US07473342B2
公开(公告)日：2009-01-06
申请号：US11395158
申请日：2006-04-03
申请人： Seiichi Ugai , Tomonari Morioka , Ryoji Inaba , Akihiro Suzuki , Yoshinori Ookoshi , Yoshiyuki Okishima , Tsukasa Ohira , Motohiro Yamazaki , Takashi Gomi
发明人： Seiichi Ugai , Tomonari Morioka , Ryoji Inaba , Akihiro Suzuki , Yoshinori Ookoshi , Yoshiyuki Okishima , Tsukasa Ohira , Motohiro Yamazaki , Takashi Gomi
IPC分类号： G01N27/00
CPC分类号： G01N27/44708
摘要： In a case where the temperature of capillaries cannot be controlled rapidly in accordance with the change of the amount of heat generated from the capillaries, the phoretic speed of the sample is not controlled constant to lower the analyzing performance for the sample. This invention intends to stabilize the electrophoretic speed. The surface of a substrate on which a plurality of capillaries are arranged is in contact with a member capable of temperature control thereby controlling the temperature of the capillaries. Since a member capable of controlling the temperature and the capillaries are in direct contact with each other according to the invention, the temperature of the capillary can be controlled rapidly at a high accuracy, so that electrophoretic speed is stabilized.
摘要翻译：在毛细管的温度不能根据毛细管产生的热量的变化而不能快速控制的情况下，不将样品的凝胶速度控制在一定程度以降低样品的分析性能。本发明旨在稳定电泳速度。其上布置有多个毛细管的基板的表面与能够进行温度控制的构件接触，从而控制毛细管的温度。由于根据本发明能够控制温度和毛细管的构件彼此直接接触，所以可以高精度地快速地控制毛细管的温度，使得电泳速度稳定。

75. 发明授权

US07438793B2 Capillary array having load header 有权
标题翻译：具有负载头的毛细管阵列
公开(公告)号：US07438793B2
公开(公告)日：2008-10-21
申请号：US10812004
申请日：2004-03-30
申请人： Toshio Hanada , Ryoji Inaba
发明人： Toshio Hanada , Ryoji Inaba
IPC分类号： G01N27/453
CPC分类号： G01N27/44708 , G01N27/44782
摘要： A multi-capillary array which can be used for a multi-capillary electrophoresis apparatus to effectively disperse the heat generated within a load header. In a load header of the capillary array used for the multi-capillary electrophoresis, an insulated holder, a connection plate and tubular electrodes are closely arranged without substantial formation of gaps. The heat generated within the load header can be dispersed effectively to the external side by eliminating an air-layer within the load header.
摘要翻译：一种多毛细管阵列，其可用于多毛细管电泳装置以有效地分散在负载集管内产生的热量。在用于多毛细管电泳的毛细管阵列的负载集管中，绝缘保持器，连接板和管状电极紧密排列而没有实质上的间隙形成。通过消除负载集管内的空气层，可以将负载集管内产生的热量有效地分散到外部。

76. 发明授权

US07422672B2 Capillary array apparatus, method of manufacturing the same, and electrophoresis analysis method 有权
标题翻译：毛细管阵列装置及其制造方法以及电泳分析方法
公开(公告)号：US07422672B2
公开(公告)日：2008-09-09
申请号：US10732221
申请日：2003-12-11
申请人： Syozo Kasai , Takayasu Furukawa , Ryoji Inaba , Daiki Numai , Tomoyuki Tobita
发明人： Syozo Kasai , Takayasu Furukawa , Ryoji Inaba , Daiki Numai , Tomoyuki Tobita
IPC分类号： G01N27/453
CPC分类号： B01L7/00 , B01L3/5025 , B01L2300/0838 , B01L2300/1805 , B01L2300/1894 , B01L2400/0421 , G01N27/44726
摘要： An electrophoresis analysis method and apparatus capable of maintaining high reliability upon a repeated use of the same gel. A heat transfer medium selected from the group consisting of solids, liquids and gels is filled in substantially all of the gaps between the electrode and each capillary. A hollow electrode into which a capillary is inserted has a plurality of retaining shapes such that the capillary can be fixed at the center of the electrode. The heat from the capillary can be efficiently dissipated via the electrode, and also the temperature increase in the capillary can be prevented. Further, temperature increases due to the heating of the capillaries during operation can be controlled and thereby thermal deterioration of the gel can be prevented.
摘要翻译：一种能够在重复使用相同凝胶时保持高可靠性的电泳分析方法和装置。选自固体，液体和凝胶的传热介质填充在电极和每个毛细管之间的基本上所有的间隙中。插入有毛细管的中空电极具有多个保持形状，使得毛细管可以固定在电极的中心。可以通过电极有效地消耗来自毛细管的热量，并且可以防止毛细管中的温度升高。此外，可以控制由于操作期间毛细管的加热引起的温度升高，从而可以防止凝胶的热劣化。

77. 发明申请

US20080202932A1 Electrophoresis device and electrophoresis method 有权
标题翻译：电泳装置及电泳方法
公开(公告)号：US20080202932A1
公开(公告)日：2008-08-28
申请号：US12071835
申请日：2008-02-27
申请人： Miho Ozawa , Ryoji Inaba
发明人： Miho Ozawa , Ryoji Inaba
IPC分类号： G01N27/453
CPC分类号： G01N27/44704
摘要： To reduce the elongation of the migration time for the first electrophoresis cycle in successive electrophoresis cycles and improve the reliability of electrophoresis analysis. The present invention relates to making the condition of a migration medium at the start of the first electrophoresis analysis in successive electrophoresis analyses after the temperature in a thermostatic oven reaches a desired preset temperature substantially the same as the conditions after the successive electrophoresis analyses. Preferably, a voltage is applied to a separation medium filling a capillary during preheating of the thermostatic oven. Preferably, the temperature in the thermostatic oven during preheating is set higher than the temperature in the thermostatic oven during electrophoresis analysis. Preferably, a buffer solution is heated during preheating of the thermostatic oven. Preferably, the capillary is filled with a preheated separation medium during preheating of the thermostatic oven. According to the present invention, the reliability of the first electrophoresis analysis in successive electrophoresis analyses is improved.
摘要翻译：减少连续电泳循环中第一次电泳循环的迁移时间延长，提高电泳分析的可靠性。本发明涉及在恒温炉中的温度达到与连续电泳分析后的条件基本相同的所需预设温度后，在连续电泳分析中开始第一次电泳分析时的迁移介质条件。优选地，在预热恒温炉期间将电压施加到填充毛细管的分离介质上。优选地，预热期间恒温炉中的温度设定为高于电泳分析期间恒温炉中的温度。优选地，在预热恒温炉期间加热缓冲溶液。优选地，在预热恒温炉期间，用预热的分离介质填充毛细管。根据本发明，提高了连续电泳分析中的第一次电泳分析的可靠性。

78. 发明申请

US20070163882A1 Capillary electrophoresis apparatus and electrophoresis method 有权
标题翻译：毛细管电泳仪和电泳法
公开(公告)号：US20070163882A1
公开(公告)日：2007-07-19
申请号：US11653332
申请日：2007-01-16
申请人： Motohiro Yamazaki , Ryoji Inaba , Satoshi Takahashi , Isao Haraura , Tomoyuki Sakai
发明人： Motohiro Yamazaki , Ryoji Inaba , Satoshi Takahashi , Isao Haraura , Tomoyuki Sakai
IPC分类号： C07K1/26 , G01N27/00
CPC分类号： G01N27/44704 , G01N27/44721
摘要： An object of the present invention is to provide a capillary electrophoresis apparatus in which simultaneity can be ensured between sensitivity and data acquisition to decrease a pull-up signal while spectral data acquisition is eliminated in each capillary exchange. The invention relates to a capillary electrophoresis apparatus in which capillary position shift is detected in each capillary exchange by detecting a capillary position. A capillary position measuring light source is provided in the capillary electrophoresis apparatus of the invention. The capillary is irradiated with light emitted from the capillary position measuring light source, a capillary image is detected with a two-dimensional detector, and thereby a position deviation of the capillary is determined. On the basis of the position deviation of the capillary, a data acquisition area is set in the two-dimensional detector, or a reference fluorescent light spectrum determined from the capillary at the standard position is corrected.
摘要翻译：本发明的目的是提供一种毛细管电泳装置，其中在每个毛细管交换中消除光谱数据采集时，可以在灵敏度和数据采集之间确保同时性，以减小上拉信号。本发明涉及一种毛细管电泳装置，其中通过检测毛细管位置在每个毛细管交换中检测毛细管位置偏移。在本发明的毛细管电泳装置中设置毛细管位置测定光源。用从毛细管位置测量光源发射的光照射毛细管，用二维检测器检测毛细管图像，从而确定毛细管的位置偏差。基于毛细管的位置偏差，在二维检测器中设置数据获取区域，或者校正从标准位置处的毛细管确定的参考荧光光谱。

79. 发明申请

US20060076239A1 Electrophoresis apparatus 审中-公开
标题翻译：电泳仪
公开(公告)号：US20060076239A1
公开(公告)日：2006-04-13
申请号：US11245491
申请日：2005-10-07
申请人： Ryoji Inaba , Motohiro Yamazaki , Akihiro Suzuki , Miho Ozawa , Daizo Tokinaga , Tomonari Morioka , Seiichi Ugai
发明人： Ryoji Inaba , Motohiro Yamazaki , Akihiro Suzuki , Miho Ozawa , Daizo Tokinaga , Tomonari Morioka , Seiichi Ugai
IPC分类号： G01N27/447
CPC分类号： G01N27/447
摘要： In an electrophoresis apparatus comprising capillaries for containing therein fluorescence-labeled substances, and a sensor for irradiating the capillaries with exciting light and detecting fluorescences, the sensor has a substrate including a datum surface for holding thereon the capillaries, and a groove sinking from the datum surface, and the groove has a plurality of reflecting surfaces for reflecting thereon the fluorescences emitted from the capillaries by a plurality of times.
摘要翻译：在包括用于在其中含有荧光标记物质的毛细管的电泳装置和用于用激发光照射毛细管并检测荧光的传感器中，传感器具有包括用于保持毛细管的基准表面的基底和从基准面凹下的凹槽表面，并且凹槽具有多个反射表面，用于在其上反射从毛细管发射的荧光多次。

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