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71. 发明申请

US20090115457A1 Apparatus and Methods for Self-Biasing Differential Signaling Circuitry Having Multimode Output Configurations for Low Voltage Applications 有权
标题翻译：具有用于低电压应用的多模输出配置的自偏压差分信号电路的装置和方法
公开(公告)号：US20090115457A1
公开(公告)日：2009-05-07
申请号：US12352916
申请日：2009-01-13
申请人： Junho Cho , Nancy Chan , Ramesh Senthinathan , Stephen Yue , Richard W. Fung
发明人： Junho Cho , Nancy Chan , Ramesh Senthinathan , Stephen Yue , Richard W. Fung
IPC分类号： H03K19/20
CPC分类号： H03K17/302 , H03K17/04106
摘要： The present disclosure relates to a differential signaling circuit including differential signaling circuitry having at least one output and one input, that can operate in multiple mode of operations while using a single, low voltage supply source. Two or more switches are included and configured to selectively couple a supply voltage to the output dependent on a mode of operation of the differential signaling circuitry. The circuit also includes a switch control biasing circuit operatively coupled to at least one of the switches and to the output of the differential signaling circuitry. The switch control biasing circuit provides a switch control biasing voltage to control a state of the switch based on a voltage level of the output. Further, a bulk biasing circuit is included and operatively coupled to the switch. The bulk biasing circuit selectively provides a bulk biasing voltage to the switch based on the voltage level of the output.
摘要翻译：本公开涉及一种差分信号电路，其包括具有至少一个输出和一个输入的差分信号电路，其可以在使用单个低电压电源时在多种操作模式下操作。两个或更多个开关被包括并且被配置为根据差分信号电路的操作模式来选择性地将电源电压耦合到输出。电路还包括可操作地耦合到至少一个开关和差分信号电路的输出的开关控制偏置电路。开关控制偏置电路提供开关控制偏置电压，以基于输出的电压电平来控制开关的状态。此外，体积偏置电路被包括并且可操作地耦合到开关。体积偏置电路基于输出的电压电平选择性地向开关提供体积偏置电压。

72. 发明申请

US20090035809A1 Modified Carbocyanine Dyes and Their Conjugates 有权
标题翻译：改性碳花青染料及其共轭物
公开(公告)号：US20090035809A1
公开(公告)日：2009-02-05
申请号：US12129641
申请日：2008-05-29
申请人： Wai-Yee Leung , Ching-Ying Cheung , Stephen Yue
发明人： Wai-Yee Leung , Ching-Ying Cheung , Stephen Yue
IPC分类号： G01N1/30 , C07D209/04 , C07D417/02 , C07D209/56 , G01N33/53 , C07H1/00 , C07K1/107 , G01N33/68 , C07D471/02 , C07D498/02
CPC分类号： G01N1/30 , A61K41/0057 , C07C66/02 , C07D209/08 , C07D209/12 , C07D209/14 , C07D209/16 , C07D209/18 , C07D209/24 , C07D209/54 , C07D209/60 , C07D209/96 , C07D401/04 , C07D403/06 , C07D403/12 , C07D403/14 , C07D417/06 , C07D417/14 , C07D471/04 , C07D498/04 , C07K1/13 , C09B23/02 , C09B23/06 , C09B23/083 , C09B23/107 , C12Q1/6825 , C40B70/00 , G01N31/22 , G01N33/533 , G01N33/535 , G01N33/58 , G01N33/581 , G01N33/582 , G01N2001/302 , Y10T436/143333
摘要： Chemically reactive carbocyanine dyes incorporating an indolium ring moiety that is substituted at the 3-position by a reactive group or by a conjugated substance, and their uses, are described. Conjugation through this position results in spectral properties that are uniformly superior to those of conjugates of spectrally similar dyes wherein attachment is at a different position. The invention includes derivative compounds having one or more benzo nitrogens.
摘要翻译：描述了结合通过反应性基团或共轭物质在3位被取代的吲哚环部分的化学活性碳菁染料及其用途。通过该位置的共轭导致光谱性质均匀地优于光谱相似的染料的缀合物，其中附着在不同的位置。本发明包括具有一个或多个苯并氮的衍生化合物。

73. 发明申请

US20080199875A1 UNSYMMETRICAL CYANINE DIMER COMPOUNDS AND THEIR APPLICATION 有权
标题翻译：不对称氰基二异氰酸酯化合物及其应用
公开(公告)号：US20080199875A1
公开(公告)日：2008-08-21
申请号：US12099020
申请日：2008-04-07
申请人： Stephen Yue , Ching-Ying Cheung
发明人： Stephen Yue , Ching-Ying Cheung
IPC分类号： C12Q1/68 , C07D401/14 , C07H21/00 , G01N21/76
CPC分类号： C12Q1/6816 , Y10S436/80 , C12Q2563/173
摘要： Embodiments of the present invention provide methods and nucleic acid reporter molecules for the detection of nucleic acid in a sample. The nucleic acid reporter molecule comprises two unsymmetrical cyanine monomer moieties, which may be the same or different, that are covalently attached by a linker comprising at least one aromatic, heteroaromatic, cyclic or heterocyclic moiety comprising 3-20 non-hydrogen atoms selected from the group consisting of O, N, S, P and C. The linker may be rigid, relatively flexible or some degree thereof. The unsymmetrical cyanine monomer moieties comprise a substituted or unsubstituted benzazolium moiety and a substituted or unsubstituted pyridinium or quinolinium moiety that is connected by a methine bridge that is monomethine, trimethine or pentamethine. The linkers form the cyanine dimer compounds by attaching to the pyridinium or quinolinium moiety of the monomer moieties. The present nucleic acid reporter molecules find utility in forming a nucleic acid-reporter molecule complex and detecting the nucleic acid. In particular, present nucleic acid reporter molecules with a rigid linker and monomer moieties with a monomethine bridge find utility in detecting RNA in the presence of DNA.
摘要翻译：本发明的实施方案提供了用于检测样品中核酸的方法和核酸报告分子。核酸报告分子包含两个不对称的花青单体部分，其可以相同或不同，其通过包含至少一个芳族，杂芳族，环状或杂环部分的连接体共价连接，该部分包含3-20个非氢原子，所述非氢原子选自由O，N，S，P和C组成的组。接头可以是刚性的，相对柔性的或其某种程度的。不对称花青单体部分包含取代或未取代的苯并唑鎓部分和通过单甲基，三甲基或五甲氧基的次甲基桥连接的取代或未取代的吡啶鎓或喹啉鎓部分。连接体通过连接到单体部分的吡啶鎓或喹啉鎓部分而形成花青二聚体化合物。本发明的核酸报告分子可用于形成核酸 - 报道分子复合物并检测核酸。特别地，具有刚性连接体和具有单甲基桥的单体部分的本发明的核酸报告分子在DNA存在下可用于检测RNA。

74. 发明申请

US20060263844A1 Flourescent chemical compounds having high selectivity for double standard DNA, and methods for their use 有权
标题翻译：对双标准DNA具有高选择性的荧光化合物及其使用方法
公开(公告)号：US20060263844A1
公开(公告)日：2006-11-23
申请号：US11432814
申请日：2006-05-11
申请人： Jolene Bradford , Ching-Ying Cheung , Shih-Jung Huang , Patrick Pinson , Stephen Yue
发明人： Jolene Bradford , Ching-Ying Cheung , Shih-Jung Huang , Patrick Pinson , Stephen Yue
IPC分类号： C12Q1/02
CPC分类号： G01N33/582 , C07D215/10 , C07D215/227 , C07D277/72 , C07D277/74 , C07D417/04 , C07D417/06 , C07D417/14 , C12Q1/6876 , G01N21/6428 , G01N21/6486 , G01N2021/6439 , G01N2201/06113 , Y10T436/143333
摘要： Chemical compounds having a high selectivity for double stranded DNA over RNA and single stranded DNA are disclosed. The chemical compounds are stains that become fluorescent upon illumination and interaction with double stranded DNA, but exhibit reduced or no fluorescence in the absence of double stranded DNA. The compounds can be used in a variety of biological applications to qualitatively or quantitatively assay DNA, even in the presence of RNA.
摘要翻译：公开了对RNA和单链DNA具有对双链DNA的高选择性的化合物。化学化合物是在照射时变成荧光并与双链DNA相互作用的污渍，但在不存在双链DNA的情况下表现出减少的或没有荧光。该化合物可用于各种生物学应用中，以定性或定量测定DNA，即使在RNA的存在下。

75. 发明申请

US20060199242A1 Chemical probe compounds that become fluorescent upon reduction, and methods for their use 审中-公开
公开(公告)号：US20060199242A1
公开(公告)日：2006-09-07
申请号：US11366784
申请日：2006-03-01
申请人： Ching-Ying Cheung , Diane Gray , Stephen Yue
发明人： Ching-Ying Cheung , Diane Gray , Stephen Yue
IPC分类号： C12Q1/18 , G01N33/18 , C07D417/02
CPC分类号： G01N33/1806 , C07D211/62 , C07D295/112 , C07D401/14 , C07D417/06 , C07D417/14 , C09B23/04 , C12Q1/04 , C12Q1/18 , G01N21/643 , G01N33/52 , G01N33/582 , G01N2021/6432
摘要： Chemical stain compounds containing a fluorophore and a reducible quenching unit are disclosed. The reducible quenching unit quenches the fluorophore while in its oxidized state. Upon reduction, the quenching properties of the quenching unit are diminished or eliminated. The chemical compounds can be used in a variety of applications, including the detection of bacterial cells, monitoring the electron transport chain function of bacterial cells, monitoring the oxidation state of non-biological systems, and assaying the effectiveness of antibacterial or antimicrobial agents.

76. 发明申请

US20060103101A1 Angled bushing mount for stabilizer bar 审中-公开
标题翻译：用于稳定杆的倾斜衬套安装
公开(公告)号：US20060103101A1
公开(公告)日：2006-05-18
申请号：US10992590
申请日：2004-11-18
申请人： Timothy Sowinski , Mark Kleckner , Joseph Fader , Stephen Yue , Luiz Lopes , William Elders , Maurice Bechard , Leo Medeiros , Pete Kiousis
发明人： Timothy Sowinski , Mark Kleckner , Joseph Fader , Stephen Yue , Luiz Lopes , William Elders , Maurice Bechard , Leo Medeiros , Pete Kiousis
IPC分类号： B60G21/055
CPC分类号： B60G21/0551 , B60G2202/135 , B60G2204/1222 , B60G2204/41
摘要： A stabilizer bar includes having bends forming angled portions. The angled portions are supported by bushings that are secured by straps to a vehicle frame. The stabilizer bar rotates about a axis. The bushings supporting the stabilizer bar have an axes that are transverse to the pivotal axis of the stabilizer bar and to one another. The bushings have flared or thickened portions at their outer ends to provide additional bushing material since the misaligned pivotal axis permits the stabilizer bar to deflect the bushing as it rotates. The straps may be cupped so that they laterally locate the bushings as the stabilizer bar rotate about its pivotal axis.
摘要翻译：稳定杆包括具有形成成角度部分的弯曲部。倾斜部分由通过带子固定到车架的衬套支撑。稳定杆围绕轴旋转。支撑稳定杆的衬套具有横向于稳定杆的枢转轴线并彼此相对的轴线。衬套在其外端具有扩口或加厚部分以提供额外的衬套材料，因为不对准的枢轴允许稳定杆在其旋转时使套管偏转。带子可以被杯形，使得当稳定杆围绕其枢转轴线旋转时，它们横向地定位衬套。

77. 发明申请

US20060103100A1 Integrated stabilizer bar bushing and strap 审中-公开
标题翻译：集成稳定杆套管和带子
公开(公告)号：US20060103100A1
公开(公告)日：2006-05-18
申请号：US10992162
申请日：2004-11-18
申请人： Joseph Fader , Mark Kleckner , Maurice Bechard , Stephen Yue , Luiz Lopes , William Elders , Timothy Sowinski , Leo Medeiros , Pete Kiousis
发明人： Joseph Fader , Mark Kleckner , Maurice Bechard , Stephen Yue , Luiz Lopes , William Elders , Timothy Sowinski , Leo Medeiros , Pete Kiousis
IPC分类号： B60G21/055
CPC分类号： B60G21/0551 , B60G2204/1222 , B60G2204/41 , B60G2204/4404 , B60G2206/7101 , B60G2206/80
摘要： A suspension assembly includes an inventive bushing having an integrated bushing and strap supporting a stabilizer bar. The bushing includes a body having a hole for receiving the stabilizer bar. A base of the body may include a cut so that the bushing can be spread apart to insert the stabilizer bar through the cut and into the hole. The bushing includes a shell around the exterior of the body that provides legs which are used to secure the inventive bushing to the vehicle frame. The shell includes one or more layers of cords similar to the steel belting of a tire to provide structural integrity to the shell. Layers of cords can be arranged at angles relative to one another to provide increased lateral stability.
摘要翻译：悬架组件包括具有支撑稳定杆的集成衬套和带的发明衬套。衬套包括具有用于接收稳定杆的孔的主体。身体的基部可以包括切口，使得衬套可以分开以将稳定杆插入穿过切口并进入孔中。衬套包括围绕主体外部的外壳，其提供用于将本发明衬套固定到车架上的腿部。壳体包括与轮胎的钢带相似的一层或多层帘线，以向壳提供结构完整性。帘线层可以以相对于彼此的角度布置以提供增加的横向稳定性。

78. 发明申请

US20050239096A1 Detection of immobilized nucleic acid 有权
标题翻译：检测固定化核酸
公开(公告)号：US20050239096A1
公开(公告)日：2005-10-27
申请号：US10956868
申请日：2004-09-30
申请人： Matthew Beaudet , W. Cox , Stephen Yue
发明人： Matthew Beaudet , W. Cox , Stephen Yue
IPC分类号： C07D413/02 , C07D417/02 , C07D417/06 , C09B23/02 , C12Q1/68 , C07D43/02
CPC分类号： G01N21/64 , C07D417/06 , C09B23/02 , C09B23/04 , C12Q1/6816 , C12Q1/6825 , G01N1/30 , G01N2001/302 , Y10T436/143333 , C12Q2563/173 , C12Q2565/125
摘要： The present invention provides methods for determining the presence of immobilized nucleic acid employing unsymmetrical cyanine dyes that are derivatives of thiazole orange, a staining solution and select fluorogenic compounds that are characterized as being essentially non-genotoxic. The methods comprise immobilizing nucleic acid, single or double stranded DNA, RNA or a combination thereof, on a solid or semi solid support, contacting the immobilized nucleic acid with an unsymmetrical cyanine dye compound and then illuminating the immobilized nucleic acid with an appropriate wavelength whereby the presence of the nucleic acid is determined. The cyanine dye compounds are typically present in an aqueous staining solution comprising the dye compound and a tris acetate or tris borate buffer wherein the solution facilitates the contact of the dye compound and the immobilized nucleic acid. Typically the solid or semi-solid support is selected from the group consisting of a polymeric gel, a membrane, an array, a glass bead, a glass slide, and a polymeric microparticle. Preferably, the polymeric gel is agarose or polyacrylamide. The methods employing the non-genotoxic compounds represent an improvement over commonly used methods employing ethidium bromide wherein the present methods retain the advantages of ethidium bromide, ease of use and low cost, but without the disadvantageous, known mutagen requiring special handling and waste procedures.
摘要翻译：本发明提供了使用作为噻唑橙衍生物的不对称花青染料确定固定化核酸的存在的方法，染色溶液和选择性荧光化合物，其特征在于基本上是非遗传毒性的。所述方法包括在固体或半固体支持物上固定核酸，单链或双链DNA，RNA或其组合，使固定的核酸与不对称的花青染料化合物接触，然后用合适的波长照射固定的核酸，由此确定核酸的存在。花青染料化合物通常存在于包含染料化合物和三乙酸盐或三硼酸盐缓冲液的水性染色溶液中，其中溶液促进染料化合物和固定化核酸的接触。通常，固体或半固体支持物选自聚合物凝胶，膜，阵列，玻璃珠，载玻片和聚合物微粒。优选地，聚合物凝胶是琼脂糖或聚丙烯酰胺。使用非遗传毒性化合物的方法代表了使用溴化乙锭的常用方法的改进，其中本发明的方法保留了溴化乙锭的优点，易于使用和低成本，但没有不利的已知的需要特殊处理和废物方法的诱变剂。

79. 发明申请

US20050191643A1 Cyanine compounds and their application as quenching compounds 有权
标题翻译：花青化合物及其作为淬灭化合物的应用
公开(公告)号：US20050191643A1
公开(公告)日：2005-09-01
申请号：US10916822
申请日：2004-08-11
申请人： Rosaria Haugland , Ching-Ying Cheung , Stephen Yue
发明人： Rosaria Haugland , Ching-Ying Cheung , Stephen Yue
IPC分类号： C07D209/12 , C07D209/24 , C07D401/04 , C07D471/02 , C07D491/02 , C07D498/02 , C12Q1/68
CPC分类号： C12Q1/6876 , C07D209/12 , C07D209/14 , C07D209/24 , C07D401/04 , C09B23/12
摘要： The present invention provides methods and non-fluorescent carbocyanine quencher compounds having the general formula: Wherein the A moiety is a substituted pyridinium, unsubstituted pyridinium, substituted quinolinium, unsubstituted quinolinium, substituted benzazolium, unsubstituted benzazolium, substituted indolinium, or substituted indolinium. The invention further provides luminescent donor molecule-quencher pairs and luminescent donor molecule-quencher-luminescent acceptor molecule conjugates wherein the quencher is a cyanine compound of the present invention. The energy transfer pairs are used to detect an analyte of interest in a sample.
摘要翻译：本发明提供了具有以下通式的方法和非荧光碳花青猝灭剂：其中A部分是取代的吡啶鎓，未取代的吡啶鎓，取代的喹啉鎓，未取代的喹啉鎓，取代的苯并唑鎓，未取代的苯并咪唑鎓，取代的吲哚鎓或取代的吲哚啉鎓。本发明还提供了发光供体分子猝灭剂对和发光供体分子 - 猝灭剂 - 发光受体分子缀合物，其中猝灭剂是本发明的花青化合物。能量转移对用于检测样品中感兴趣的分析物。

80. 发明申请

US20050127633A1 Spray formed stabilizer bar lateral retainer 审中-公开
标题翻译：喷涂成型稳定杆横向保持架
公开(公告)号：US20050127633A1
公开(公告)日：2005-06-16
申请号：US10734467
申请日：2003-12-12
申请人： Joseph Fader , Mark Kleckner , Maurice Bechard , Stephen Yue , Luiz Lopes , William Elders , Timothy Sowinski , Leo Medeiros , Pete Kiousis
发明人： Joseph Fader , Mark Kleckner , Maurice Bechard , Stephen Yue , Luiz Lopes , William Elders , Timothy Sowinski , Leo Medeiros , Pete Kiousis
IPC分类号： B60G11/20 , B60G21/055 , C23C4/00 , F16F1/16 , B60G21/05
CPC分类号： B60G21/0551 , B60G11/20 , B60G2204/44 , B60G2204/45 , B60G2206/427 , B60G2206/8106 , B60G2206/8403 , C23C4/00 , F16F1/16
摘要： An anti-shift collar prevents lateral movement of a stabilizer bar assembly. The anti-shift collar is thermally formed to a central segment of the stabilizer bar and is locked to the central segment thereby.
摘要翻译：防滑轴环可防止稳定杆组件的横向移动。防偏移轴环热稳定地安装在稳定杆的中心部分上，并由此锁定在中心部分上。

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