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71. 发明授权

US6040058A Slippery, tenaciously adhering hydrophilic polyurethane hydrogel coatings, coated metal substrate materials, and coated medical devices 失效
标题翻译：滑溜，强力粘附亲水性聚氨酯水凝胶涂层，涂层金属基材和涂层医疗器械
公开(公告)号：US6040058A
公开(公告)日：2000-03-21
申请号：US126374
申请日：1998-08-27
申请人： Fritz Hostettler , David Rhum , Michael R. Forman , Michael N. Helmus , Ni Ding
发明人： Fritz Hostettler , David Rhum , Michael R. Forman , Michael N. Helmus , Ni Ding
IPC分类号： A61L29/08 , A61L31/10 , C08G18/10 , C08G18/28 , C08J7/04 , B32B15/08
CPC分类号： C08J7/047 , A61L29/085 , A61L31/10 , C08G18/10 , C08G18/283 , C08J7/04 , C08G2230/00 , C08J2475/00 , Y10T428/31554 , Y10T428/31562 , Y10T428/31565 , Y10T428/31569 , Y10T428/31587 , Y10T428/31678
摘要： A process for the preparation of slippery, hydrophilic polyurethane hydrogel coating compositions, and materials composed of a polymeric plastic or rubber substrate or a metal substrate with a coating of a slippery, hydrophilic polyurethane hydrogel thereon, such that the coating composition tenaciously adheres to the substrate, are disclosed. The coating compositions and coated materials are non-toxic and biocompatible, and are ideally suited for use on medical devices, particularly, catheters, catheter balloons and stents. The coating compositions, coated materials and coated devices demonstrate low coefficients of friction in contact with body fluids, especially blood, as well as a high degree of wear permanence over prolonged use of the device. The hydrogel coating compositions are capable of being dried to facilitate storage of the devices to which they have been applied, and can be instantly reactivated for later use by exposure to water.
摘要翻译：用于制备光滑的亲水性聚氨酯水凝胶涂料组合物的方法，以及由聚合物塑料或橡胶基材或金属基材组成的材料，其上具有光滑的亲水性聚氨酯水凝胶的涂层，使得涂料组合物坚韧地粘附于基材，被披露。涂料组合物和涂层材料是无毒的和生物相容的，并且理想地适用于医疗装置，特别是导管，导管气囊和支架。涂层组合物，涂覆材料和涂覆的装置表现出与体液，特别是血液接触的低摩擦系数，以及在长时间使用该装置时高度的磨损持久性。水凝胶涂料组合物能够被干燥以促进其已被施加到其上的装置的储存，并且可以立即重新活化以便随后通过暴露于水中使用。

72. 发明授权

US5662960A Process for producing slippery, tenaciously adhering hydrogel coatings containing a polyurethane-urea polymer hydrogel commingled with a poly (n-vinylpyrrolidone) polymer hydrogel 失效
标题翻译：含有聚（N-乙烯基吡咯烷酮）聚合物水凝胶的聚氨酯 - 尿素聚合物水凝胶的湿滑粘结水凝胶涂层的方法
公开(公告)号：US5662960A
公开(公告)日：1997-09-02
申请号：US384711
申请日：1995-02-01
申请人： Fritz Hostettler , David Rhum , Michael R. Forman , Michael N. Helmus , Ni Ding
发明人： Fritz Hostettler , David Rhum , Michael R. Forman , Michael N. Helmus , Ni Ding
IPC分类号： A61L29/00 , A61L29/08 , A61L31/00 , A61L31/10 , B05D1/36 , B05D7/00 , B05D7/02 , B05D7/16 , B05D7/24 , C08G18/10 , C08J7/00 , C08J7/04 , B05D3/10 , B05D3/04 , C23C14/02
CPC分类号： B05D7/52 , A61L29/085 , A61L31/10 , B05D7/02 , B05D7/16 , C08G18/10 , C08G2210/00 , C08G2270/00
摘要： A process for preparing coating compositions of a commingled hydrogel of a polyurethane-polyurea polymer hydrogel and a poly(N-vinylpyrrolidone) polymer hydrogel; a process for making materials composed of a polymeric plastic or rubber substrate or a metallic substrate, with a coating of the commingled hydrogel thereon; and a process for making medical devices with a coating of the commingled hydrogel thereon, are disclosed. The coating compositions tenaciously adhere to the substrate materials and medical devices to which they are applied due to bonding of a tie coat to a reactive substrate surface and due to the commingling of the two hydrogel components. The coating compositions and coated materials and medical devices are non-toxic and biocompatible, making them ideally suited for use in applications such as for catheters, catheter balloons and stents. In such applications, the coating compositions, coated materials, and coated medical devices made therefrom demonstrate low coefficients of friction in contact with body fluids, especially blood, as well as a high degree of wear permanence over prolonged use. The commingled hydrogel coatings are capable of being dried to facilitate storage of the devices to which they have been applied, and can be instantly reactivated for later use by exposure to water.
摘要翻译：一种制备聚氨酯 - 聚脲聚合物水凝胶和聚（N-乙烯基吡咯烷酮）聚合物水凝胶的混合水凝胶的涂料组合物的方法; 制造由聚合物塑料或橡胶基材或金属基材组成的材料的方法，其上混合水凝胶的涂层; 并公开了在其上制造混合水凝胶涂层的医疗装置的方法。涂层组合物由于粘结涂层与反应性基底表面的结合以及由于两种水凝胶组分的混合而顽固地粘附到其所施加的基底材料和医疗装置上。涂料组合物和涂覆材料和医疗装置是无毒的和生物相容的，使得它们非常适用于诸如导管，导管气囊和支架的应用。在这种应用中，由其制成的涂料组合物，涂覆的材料和涂覆的医疗装置显示出与体液，特别是血液接触的低摩擦系数，以及长时间使用时的高度的耐磨性。混合的水凝胶涂层能够被干燥以便于其已被施加到的装置的储存，并且可以立即重新激活以供将来通过暴露于水中使用。

73. 发明授权

US09675737B2 Methods of providing antioxidants to a drug containing product 有权
公开(公告)号：US09675737B2
公开(公告)日：2017-06-13
申请号：US12851420
申请日：2010-08-05
申请人： Ni Ding
发明人： Ni Ding
IPC分类号： A01N25/34 , A61F13/00 , B65D81/24 , A61L31/10
CPC分类号： A61L31/10 , Y10T428/1307
摘要： A method of providing an antioxidant to a medical device and a kit are described.

74. 发明申请

US20110260358A1 Post Electron Beam Conditioning of Polymeric Medical Devices 有权
标题翻译：聚合物医疗器械后电子束调理
公开(公告)号：US20110260358A1
公开(公告)日：2011-10-27
申请号：US13093755
申请日：2011-04-25
申请人： Yungbing Wang , Xiao Ma , Fuh-Wei Tang , Ni Ding
发明人： Yungbing Wang , Xiao Ma , Fuh-Wei Tang , Ni Ding
IPC分类号： B29C71/00
CPC分类号： B29C71/02 , A61F2/82 , A61F2/915 , A61F2002/91558 , A61F2002/91583 , A61F2210/0004 , A61F2240/001 , A61L2/007 , A61L2/08 , A61L2/087 , A61L31/06 , A61L31/148 , A61L2202/21 , A61L2202/24 , A61L2400/18 , B29C35/02 , B29C2035/0877 , B29C2071/022 , B29L2031/753 , C08J7/08 , C08J7/123 , C08J2367/04 , C08L67/04
摘要： Methods are disclosed for conditioning a polymeric stent after sterilization, and/or after crimping and before packaging, such that the properties of the polymeric stent fall within a narrower range of values. The stent is exposed to a controlled temperature at or above ambient for a period of time after radiation sterilization and/or after crimping and before sterilization. As a result, the polymeric stent properties, particularly radial strength and number-average molecular weight of the polymer of the polymeric stent, fall within a narrower range.
摘要翻译：公开了用于在灭菌后和/或在卷曲之后和包装之前调节聚合物支架的方法，使得聚合物支架的性质落在较窄的值范围内。在辐射灭菌后和/或在压接之后和灭菌之前将支架暴露于等于或高于环境的受控温度一段时间。结果，聚合物支架的聚合物支架性质，特别是聚合物支架的聚合物的径向强度和数均分子量落在更窄的范围内。

75. 发明申请

US20110212139A1 HIGH-DENSITY LIPOPROTEIN COATED MEDICAL DEVICES 审中-公开
标题翻译：高密度脂蛋白涂层医疗器械
公开(公告)号：US20110212139A1
公开(公告)日：2011-09-01
申请号：US13102791
申请日：2011-05-06
申请人： Ni Ding
发明人： Ni Ding
IPC分类号： A61F2/82 , A61K38/17 , A61P9/10 , A61P7/02
CPC分类号： A61L31/16 , A61F2/82 , A61K38/1709 , A61L31/10 , A61L2300/252 , A61L2300/416
摘要： Method are disclosed for local and systemic administration HDL, recombinant HDL or HDLm for the prevention, treatment, or amelioration of a vascular disorder, disease or occlusion such as restenosis or vulnerable plaque.
摘要翻译：公开了局部和全身给药HDL，重组HDL或HDLm用于预防，治疗或改善血管疾病，疾病或闭塞如再狭窄或易损斑块的方法。

76. 发明授权

US07923509B2 Drug delivery compositions and medical devices containing block copolymer 有权
标题翻译：药物输送组合物和含有嵌段共聚物的医疗器械
公开(公告)号：US07923509B2
公开(公告)日：2011-04-12
申请号：US12578362
申请日：2009-10-13
申请人： Leonard Pinchuk , Sepideh Hashemi , Marlene C. Schwarz , Kalpana Kamath , Ni Ding
发明人： Leonard Pinchuk , Sepideh Hashemi , Marlene C. Schwarz , Kalpana Kamath , Ni Ding
IPC分类号： C08L53/00 , C08L23/00 , C08L25/02 , C08F8/00
CPC分类号： C08L53/00 , A61L27/16 , A61L27/54 , A61L31/048 , A61L31/10 , A61L31/16 , A61L2300/416 , A61L2300/602 , A61L2300/606 , C08F293/005 , C08F297/00 , C08F297/04 , C08L53/02 , C09D153/00 , C09D153/02 , C08L2666/02
摘要： A composition for delivery of a therapeutic agent is provided. The composition comprises: (a) a biocompatible block copolymer comprising one or more elastomeric blocks and one or more thermoplastic blocks and (b) a therapeutic agent, wherein the block copolymer is loaded with the therapeutic agent. The block copolymer is preferably of the formula X-(AB)n, where A is an elastomeric block, B is a thermoplastic block, n is a positive whole number and X is a seed molecule. The elastomeric blocks are preferably polyolefin blocks, and the thermoplastic blocks are preferably selected from vinyl aromatic blocks and methacrylate blocks. According to another aspect of the invention, a medical device is provided, at least a portion of which is insertable or implantable into the body of a patient. The medical device comprises (a) the above biocompatible block copolymer and (b) a therapeutic agent, wherein the block copolymer is loaded with the therapeutic agent. According to another aspect of the present invention, a method of treatment is provided in which the above device is implanted or inserted into a patient, resulting in the release of therapeutic agent in the patient over an extended period. According to yet another aspect of the invention, a coated medical device is provided which comprises: (a) an intravascular or intervascular medical device and (b) a coating over at least a portion of the intravascular or intervascular a medical device, wherein the coating comprises the above biocompatible block copolymer.
摘要翻译：提供了用于递送治疗剂的组合物。所述组合物包含：（a）包含一种或多种弹性体嵌段和一种或多种热塑性嵌段的生物相容性嵌段共聚物和（b）治疗剂，其中所述嵌段共聚物负载有所述治疗剂。嵌段共聚物优选为式X-（AB）n，其中A为弹性体嵌段，B为热塑性嵌段，n为正整数，X为种子分子。弹性体嵌段优选为聚烯烃嵌段，并且热塑性嵌段优选选自乙烯基芳族嵌段和甲基丙烯酸酯嵌段。根据本发明的另一方面，提供一种医疗装置，其至少一部分可插入或植入患者体内。医疗装置包括（a）上述生物相容性嵌段共聚物和（b）治疗剂，其中嵌段共聚物负载有治疗剂。根据本发明的另一方面，提供了一种治疗方法，其中将上述装置植入或插入患者体内，导致治疗剂在患者体内长时间释放。根据本发明的另一方面，提供了一种涂覆的医疗装置，其包括：（a）血管内或血管内医疗装置和（b）在血管内或血管内至少一部分医疗装置上的涂层，其中所述涂层包括上述生物相容性嵌段共聚物。

77. 发明申请

US20060246209A1 Fluid treatment of a polymeric coating on an implantable medical device 有权
标题翻译：在可植入医疗设备上的聚合物涂层的流体处理
公开(公告)号：US20060246209A1
公开(公告)日：2006-11-02
申请号：US11395014
申请日：2006-03-31
申请人： Andrew McNiven , Thomas Esbeck , Ni Ding , Stephen Pacetti , Syed Hossainy
发明人： Andrew McNiven , Thomas Esbeck , Ni Ding , Stephen Pacetti , Syed Hossainy
IPC分类号： A61L33/00
CPC分类号： A61L31/10 , A61L31/16 , A61L2300/602 , B05D3/107
摘要： A method for modifying a polymeric coating on an implantable medical device, such as a stent, is disclosed. The method includes application of a fluid to a wet or dry polymeric coating with and without drugs.
摘要翻译：公开了一种用于修改可植入医疗装置（例如支架）上的聚合物涂层的方法。该方法包括将液体施用于具有和不具有药物的湿或干燥聚合物涂层。

78. 发明申请

US20060014720A1 Heparin prodrugs and drug delivery stents formed therefrom 有权
公开(公告)号：US20060014720A1
公开(公告)日：2006-01-19
申请号：US11228420
申请日：2005-09-15
申请人： Syed Hossainy , Ni Ding
发明人： Syed Hossainy , Ni Ding
IPC分类号： A61K31/727 , A61K38/17 , C08B37/10
CPC分类号： A61K31/727 , A61K47/61 , A61L31/10 , A61L31/16 , A61L2300/236 , A61L2300/606 , A61L2300/80 , C08B37/0075 , C09D105/10
摘要： A prodrug comprising a heparin and a drug is provided. The prodrug can be used to form a coating on a medical device. The prodrug can also be used with a polymeric material to form a coating on a medical device. The polymeric material can be a hydrophobic polymer, a hydrophilic polymer, a non-fouling polymer, or combinations thereof. The medical device can be implanted in a human being for the treatment of a disease such as atherosclerosis, thrombosis, restenosis, hemorrhage, vascular dissection or perforation, vascular aneurysm, vulnerable plaque, chronic total occlusion, claudication, anastomotic proliferation for vein and artificial grafts, bile duct obstruction, ureter obstruction, tumor obstruction, or combinations thereof.

79. 发明申请

US20050215722A1 Drug delivery compositions and medical devices containing block copolymer 有权
标题翻译：药物输送组合物和含有嵌段共聚物的医疗器械
公开(公告)号：US20050215722A1
公开(公告)日：2005-09-29
申请号：US11057870
申请日：2005-02-14
申请人： Leonard Pinchunk , Sepideh Hashemi , Marlene Schwarz , Kalpana Kamath , Ni Ding
发明人： Leonard Pinchunk , Sepideh Hashemi , Marlene Schwarz , Kalpana Kamath , Ni Ding
IPC分类号： A61K47/32 , A61K9/22 , A61K31/337 , A61K35/12 , A61K45/00 , A61K47/34 , A61K47/36 , A61K47/38 , A61K47/42 , A61K48/00 , A61L27/16 , A61L27/54 , A61L31/04 , A61L31/10 , A61L31/16 , A61M37/00 , C08F2/00 , C08F293/00 , C08F297/00 , C08F297/04 , C08L53/00 , C08L53/02 , C09D153/00 , C09D153/02
CPC分类号： C08L53/00 , A61L27/16 , A61L27/54 , A61L31/048 , A61L31/10 , A61L31/16 , A61L2300/416 , A61L2300/602 , A61L2300/606 , C08F293/005 , C08F297/00 , C08F297/04 , C08L53/02 , C09D153/00 , C09D153/02 , C08L2666/02
摘要： A composition for delivery of a therapeutic agent is provided. The composition comprises: (a) a biocompatible block copolymer comprising one or more elastomeric blocks and one or more thermoplastic blocks and (b) a therapeutic agent, wherein the block copolymer is loaded with the therapeutic agent. The block copolymer is preferably of the formula X—(AB)n, where A is an elastomeric block, B is a thermoplastic block, n is a positive whole number and X is a seed molecule. The elastomeric blocks are preferably polyolefin blocks, and the thermoplastic blocks are preferably selected from vinyl aromatic blocks and methacrylate blocks. According to another aspect of the invention, a medical device is provided, at least a portion of which is insertable or implantable into the body of a patient. The medical device comprises (a) the above biocompatible block copolymer and (b) a therapeutic agent, wherein the block copolymer is loaded with the therapeutic agent. According to another aspect of the present invention, a method of treatment is provided in which the above device is implanted or inserted into a patient, resulting in the release of therapeutic agent in the patient over an extended period. According to yet another aspect of the invention, a coated medical device is provided which comprises: (a) an intravascular or intervascular medical device and (b) a coating over at least a portion of the intravascular or intervascular a medical device, wherein the coating comprises the above biocompatible block copolymer.
摘要翻译：提供了用于递送治疗剂的组合物。所述组合物包含：（a）包含一种或多种弹性体嵌段和一种或多种热塑性嵌段的生物相容性嵌段共聚物和（b）治疗剂，其中所述嵌段共聚物负载有所述治疗剂。嵌段共聚物优选为式X-（AB）n N，其中A为弹性体嵌段，B为热塑性嵌段，n为正整数，X为种子分子。弹性体嵌段优选为聚烯烃嵌段，并且热塑性嵌段优选选自乙烯基芳族嵌段和甲基丙烯酸酯嵌段。根据本发明的另一方面，提供一种医疗装置，其至少一部分可插入或植入患者体内。医疗装置包括（a）上述生物相容性嵌段共聚物和（b）治疗剂，其中嵌段共聚物负载有治疗剂。根据本发明的另一方面，提供了一种治疗方法，其中将上述装置植入或插入患者体内，导致治疗剂在患者体内长时间释放。根据本发明的另一方面，提供了一种涂覆的医疗装置，其包括：（a）血管内或血管内医疗装置和（b）在血管内或血管内至少一部分医疗装置上的涂层，其中所述涂层包括上述生物相容性嵌段共聚物。

80. 发明申请

US20050208093A1 Phosphoryl choline coating compositions 审中-公开
标题翻译：磷酰胆碱涂层组合物
公开(公告)号：US20050208093A1
公开(公告)日：2005-09-22
申请号：US10807362
申请日：2004-03-22
申请人： Thierry Glauser , Stephen Pacetti , Syed Hossainy , Ni Ding
发明人： Thierry Glauser , Stephen Pacetti , Syed Hossainy , Ni Ding
IPC分类号： A61L27/34 , A61L31/10 , C08G63/91 , A61K31/785 , A61K31/765 , C08G63/48
CPC分类号： A61L31/10 , A61L27/34 , A61L31/148 , A61L31/16 , A61L33/0011 , A61L33/08 , A61L2300/40 , A61L2300/42 , A61L2300/604 , A61L2300/606 , A61L2400/18 , C08L33/14
摘要： A polymer comprising phospholipid moieties and a biocompatible polymer backbone, a composition comprising the polymer and optionally a bioactive agent, an implantable devices such as a DES comprising thereon a coating comprising the polymer and optionally a bioactive agent, and a method of using the device for the treatment of a disorder in a human being are provided.
摘要翻译：包含磷脂部分和生物相容性聚合物骨架的聚合物，包含聚合物和任选的生物活性剂的组合物，可植入装置，例如包含其上的包含聚合物和任选的生物活性剂的涂层的DES，以及使用该装置的方法提供了人类疾病的治疗。

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