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71. 发明申请

US20100211132A1 Selectable Boost Converter and Charge Pump for Compliance Voltage Generation in an Implantable Stimulator Device 有权
标题翻译：可选择的升压转换器和电荷泵，用于在植入式刺激器装置中实现合规电压产生
公开(公告)号：US20100211132A1
公开(公告)日：2010-08-19
申请号：US12372501
申请日：2009-02-17
申请人： Kiran Nimmagadda , Md. Mizanur Rahman , Jordi Parramon
发明人： Kiran Nimmagadda , Md. Mizanur Rahman , Jordi Parramon
IPC分类号： A61N1/08
CPC分类号： A61N1/3782 , A61N1/37211 , A61N1/378 , H02M3/07 , H02M3/156 , H02M2001/009
摘要： Improved compliance voltage generation circuitry for a medical device is disclosed. The improved circuitry in one embodiment comprises a boost converter and a charge pump, either of which is capable of generating an appropriate compliance voltage from the voltage of the battery in the device. A telemetry enable signal indicating whether the implant's transmitter, receiver, or both, have been enabled is received. A “boost” signal from compliance voltage monitor-and-adjust logic circuitry is processed with the telemetry enable signal and its inverse to selectively enable either the charge pump or the boost converter: if the telemetry enable signal is not active, the boost converter is used to generate the compliance voltage; if the telemetry enable signal is active, the charge pump is used. Because the charge pump circuitry does not produce a magnetic field, the charge pump will not interfere with magnetically-coupled telemetry between the implant and an external controller. By contrast, the boost converter is allowed to operate during periods of no telemetry, when magnetic interference is not a concern, while obtaining the advantage of higher power efficiency.
摘要翻译：公开了用于医疗装置的改进的顺应性电压产生电路。一个实施例中的改进的电路包括升压转换器和电荷泵，其中任何一个能够从装置中的电池的电压产生适当的顺应性电压。接收到指示植入物的发射器，接收器或两者是否被使能的遥测使能信号。来自合规电压监控调节逻辑电路的“升压”信号通过遥测使能信号进行处理，其反相选择使能电荷泵或升压转换器：如果遥测使能信号无效，升压转换器用于产生合规电压; 如果遥测使能信号有效，则使用电荷泵。由于电荷泵电路不产生磁场，电荷泵不会干扰植入物和外部控制器之间的磁耦合遥测。相比之下，在没有遥测的时期，升压转换器在磁干扰不受关注的同时获得了较高功率效率的优势，允许运行。

72. 发明申请

US20100125315A1 IMPLANTABLE MEDICAL DEVICE THAT USES ELECTRICAL CURRENT STEERING BY MEANS OF OUTPUT IMPEDANCE MODULATION 有权
标题翻译：通过输出阻抗调制方式使用电流转向的可植入医疗器械
公开(公告)号：US20100125315A1
公开(公告)日：2010-05-20
申请号：US12606065
申请日：2009-10-26
申请人： Jordi Parramon , David K.L. Peterson , Kerry Bradley , Rafael Carbunaru , Andrew DiGiore
发明人： Jordi Parramon , David K.L. Peterson , Kerry Bradley , Rafael Carbunaru , Andrew DiGiore
IPC分类号： A61N1/00
CPC分类号： A61N1/36125 , A61N1/0551 , A61N1/36157 , A61N1/36185
摘要： A method and system of providing therapy to a patient implanted with an array of electrodes is provided. Electrical stimulation current is conveyed from at least two of the electrodes to at least one of the electrodes along at least two electrical paths through tissue of the patient, and the electrical stimulation current is shifted between the electrical paths by actively adjusting one or more finite resistances respectively associated with one or more of the electrical paths.
摘要翻译：提供了向植入电极阵列的患者提供治疗的方法和系统。电刺激电流沿着沿着患者组织的至少两条电路径从至少两个电极传送到至少一个电极，并且电刺激电流通过主动调节一个或多个有限电阻而在电路径之间移动分别与一个或多个电路径相关联。

73. 发明申请

US20100106204A1 SYSTEMS AND METHODS FOR DETECTING A LOSS OF ELECTRICAL CONNECTIVITY BETWEEN COMPONENTS OF IMPLANTABLE MEDICAL LEAD SYSTEMS 失效
标题翻译：用于检测可植入医疗铅系统组成部分之间电气连接性的系统和方法
公开(公告)号：US20100106204A1
公开(公告)日：2010-04-29
申请号：US12258324
申请日：2008-10-24
申请人： Michael A. Moffitt , Christopher B. Gould , Daniel Aghassian , Marco Henry Gin , Jordi Parramon
发明人： Michael A. Moffitt , Christopher B. Gould , Daniel Aghassian , Marco Henry Gin , Jordi Parramon
IPC分类号： A61N1/08 , A61B5/00
CPC分类号： A61N1/37 , A61B2562/227 , A61N1/3706 , A61N1/3752 , A61N2001/083 , H01R13/6683 , H01R2201/12
摘要： A connection monitoring system for an implantable medical lead system includes an implantable lead, a first trial system cable, an external trial system, and a sensor. The lead has a distal end and at least one proximal end. The lead includes a plurality of terminals disposed at each proximal end. The first trial system cable has a distal end and at least one proximal end. The distal end of the first trial system cable is configured and arranged to electrically couple with the lead. The external trial system is configured and arranged to electrically couple with the first trial system cable. The sensor is electrically coupled to the external trial system. The sensor is configured and arranged for detecting a loss of electrical connectivity between the external trial system and the lead when the lead becomes electrically decoupled from the external trial system.
摘要翻译：用于可植入医疗引线系统的连接监视系统包括可植入引线，第一试验系统电缆，外部试验系统和传感器。引线具有远端和至少一个近端。引线包括设置在每个近端处的多个端子。第一试验系统电缆具有远端和至少一个近端。第一试验系统电缆的远端被配置和布置成与引线电耦合。外部试验系统被配置和布置成与第一试验系统电缆电耦合。传感器电耦合到外部试验系统。传感器被配置和布置成用于当引线变得与外部试验系统电隔离时，检测外部试验系统和引线之间的电连接性的损失。

74. 发明授权

US07428438B2 Systems and methods for providing power to a battery in an implantable stimulator 有权
标题翻译：为植入式刺激器中的电池供电的系统和方法
公开(公告)号：US07428438B2
公开(公告)日：2008-09-23
申请号：US11043642
申请日：2005-01-25
申请人： Jordi Parramon , Goran N. Marnfeldt , Rafael Carbunaru , Robert D. Ozawa
发明人： Jordi Parramon , Goran N. Marnfeldt , Rafael Carbunaru , Robert D. Ozawa
IPC分类号： A61N1/00
CPC分类号： A61N1/37223 , A61N1/08 , A61N1/37205 , A61N1/3727 , A61N1/37276 , A61N1/37288 , A61N1/3787 , H04B5/0037 , H04B5/0081 , H04L27/02 , H04L27/10
摘要： An exemplary system for providing power to a rechargeable battery in an implantable stimulator includes a first coil configured to emit a first magnetic field, a coil in the stimulator configured to receive the first magnetic field, and a zero volt recovery (ZVR) circuit in the stimulator configured to use the first magnetic field to cause the coil in the stimulator to be tuned to a frequency of a second magnetic field. The second magnetic field is used to provide the power to recharge the battery. An exemplary method of providing power to recharge a battery in an implantable stimulator includes transmitting a first magnetic field used to provide the power to recharge the battery, transmitting a second magnetic field; and using the second magnetic field to cause a coil in the stimulator to be tuned to a frequency of the first magnetic field.
摘要翻译：用于向可植入刺激器中的可再充电电池供电的示例性系统包括被配置为发射第一磁场的第一线圈，被配置为接收第一磁场的激励器中的线圈，以及零电压恢复（ZVR）电路激励器被配置为使用第一磁场使激励器中的线圈被调谐到第二磁场的频率。第二个磁场用于提供电池给电池充电。提供在可植入刺激器中对电池再充电的示例性方法包括：传输用于提供电力以对电池再充电的第一磁场;发射第二磁场; 并且使用第二磁场使激励器中的线圈被调谐到第一磁场的频率。

75. 发明申请

US20070123938A1 Magnetically coupled microstimulators 失效
标题翻译：磁耦合微型激励器
公开(公告)号：US20070123938A1
公开(公告)日：2007-05-31
申请号：US11291464
申请日：2005-11-30
申请人： Matthew Haller , Jordi Parramon
发明人： Matthew Haller , Jordi Parramon
IPC分类号： A61N1/36
CPC分类号： A61N1/37205 , A61N1/36036 , A61N1/3605 , A61N1/3756
摘要： Disclosed are implantable electronic devices and systems including a pair of microstimulators. The microstimulators include coils that are energized to generate magnetic fields aligned along a common axis.
摘要翻译：公开了包括一对微型激励器的可植入电子设备和系统。微型激励器包括被激励以产生沿公共轴对准的磁场的线圈。

76. 发明申请

US20070097719A1 Cascaded step-up converter and charge pump for efficient compliance voltage generation in an implantable stimulator device 有权
标题翻译：级联升压转换器和电荷泵，用于在可植入的刺激器装置中产生有效的符合电压
公开(公告)号：US20070097719A1
公开(公告)日：2007-05-03
申请号：US11266646
申请日：2005-11-03
申请人： Jordi Parramon , Goran Marnfeldt
发明人： Jordi Parramon , Goran Marnfeldt
IPC分类号： H02J1/10
CPC分类号： H02M3/07 , A61N1/37205 , A61N1/378 , A61N1/3787 , H02M3/155 , H02M2001/007
摘要： Disclosed herein are circuits and methods for generating a compliance voltage from a battery voltage in an implantable stimulator device. In one embodiment, the battery voltage is boosted to form the compliance voltage for driving the current sources (DACs) that provide therapeutic current to the electrodes on the device. Such improved boosting circuitry is preferably cascaded and comprises two stages. The first stage is preferably a step-up converter, which is used to generate an intermediate voltage from the battery voltage. The second stage is preferably a charge pump, which is used to generate the compliance voltage from the intermediate voltage. By splitting the boosting into stages, power efficiency during generation of high voltages is improved compared to the use of step-up converters and resolution in setting the compliance voltage is improved compared to the use of charge pumps alone. Moreover, depending on the compliance voltage to be produced by the boosting circuitry, the various stages can be selectively activated.
摘要翻译：本文公开了用于在可植入刺激器装置中从电池电压产生顺应性电压的电路和方法。在一个实施例中，升高电池电压以形成用于驱动向装置上的电极提供治疗电流的电流源（DAC）的顺应性电压。这种改进的升压电路优选地级联并且包括两个阶段。第一级优选是升压转换器，其用于从电池电压产生中间电压。第二阶段优选为电荷泵，其用于从中间电压产生顺应性电压。通过将升压分为阶段，与使用升压转换器相比，在产生高电压期间的功率效率得到改善，与单独使用电荷泵相比，提高了顺应性电压的分辨率得到改善。此外，根据由升压电路产生的顺应性电压，可以选择性地激活各个级。

77. 发明申请

US20050267546A1 Low power loss current digital-to-analog converter used in an implantable pulse generator 有权
标题翻译：用于可植入脉冲发生器的低功耗电流数模转换器
公开(公告)号：US20050267546A1
公开(公告)日：2005-12-01
申请号：US11138632
申请日：2005-05-26
申请人： Jordi Parramon , Yuping He , Kiran Nimmagadda
发明人： Jordi Parramon , Yuping He , Kiran Nimmagadda
IPC分类号： A61N1/18 , A61N1/36
CPC分类号： A61N1/36071 , A61N1/025 , A61N1/36125 , A61N1/378
摘要： In one embodiment, the present invention provides an implantable stimulation device that includes output current sources and/or sinks configured to provide an output current for a load (i.e., tissue). The output path of the output current source or sink comprises a transistor which operates in a linear mode instead of a saturation mode. Because operation in a linear mode results in smaller drain-to-source voltage drops, power consumption in the output current source or sink (and hence in the implantable stimulator) is reduced, reducing battery or other power source requirements. Operation in the linear mode is facilitated in useful embodiments by a load in an input path (into which a reference current is sent) and a load in the output path (which bears the output current). The loads can be active transistors or passive resistors. A feedback circuit (e.g., an operational amplifier) receives voltages that build up across these loads, and sends a control signal to the gate of the transistor to ensure its linear operation.
摘要翻译：在一个实施例中，本发明提供了一种植入式刺激装置，其包括被配置为提供负载（即组织）的输出电流的输出电流源和/或接收器。输出电流源或吸收器的输出路径包括以线性模式而不是饱和模式操作的晶体管。因为在线性模式下的操作会导致较小的漏极 - 源极电压降，所以输出电流源或接收器（以及因此在可植入的刺激器中）的功耗降低，从而减少电池或其他电源要求。在有用的实施例中，通过输入路径（发送参考电流）中的负载和输出路径（承担输出电流）中的负载来促进线性模式的操作。负载可以是有源晶体管或无源电阻。反馈电路（例如，运算放大器）接收跨越这些负载的电压，并将控制信号发送到晶体管的栅极，以确保其线性运行。

78. 发明申请

US20050131496A1 Voltage converter for implantable microstimulator using RF-powering coil 有权
公开(公告)号：US20050131496A1
公开(公告)日：2005-06-16
申请号：US11047052
申请日：2005-01-31
申请人： Jordi Parramon , Matthew Haller
发明人： Jordi Parramon , Matthew Haller
IPC分类号： A61N1/00 , A61N1/08
CPC分类号： A61N1/08 , A61N1/37205 , A61N1/3787
摘要： A combination, voltage converter circuit for use within an implantable device, such as a microstimulator, uses a coil, instead of capacitors, to provide a voltage step up and step down conversion functions. The output voltage is controlled, or adjusted, through duty-cycle modulation. In accordance with one aspect of the invention, applicable to implantable devices having an existing RF coil through which primary or charging power is provided, the existing RF coil is used in a time-multiplexing scheme to provide both the receipt of the RF signal and the voltage conversion function. This minimizes the number of components needed within the device, and thus allows the device to be packaged in a smaller housing or frees up additional space within an existing housing for other circuit components. In accordance with another aspect of the invention, the voltage up/down converter circuit is controlled by a pulse width modulation (PWM) low power control circuit. Such operation allows high efficiencies over a wide range of output voltages and current loads.

79. 发明申请

US20050057905A1 Electronic module design to maximize the volume efficiency in a miniature medical device 有权
标题翻译：电子模块设计，以最大限度地提高微型医疗设备的体积效率
公开(公告)号：US20050057905A1
公开(公告)日：2005-03-17
申请号：US10609452
申请日：2003-06-27
申请人： Tom He , Matthew Haller , Jordi Parramon , Goran Marnfeldt
发明人： Tom He , Matthew Haller , Jordi Parramon , Goran Marnfeldt
IPC分类号： A61N1/36 , A61N1/372 , A61N1/375 , A61N1/378 , H01Q1/24 , H01Q7/08 , H02J7/00 , H02J17/00 , H05K7/06
CPC分类号： A61N1/37276 , A61N1/36007 , A61N1/3605 , A61N1/37205 , A61N1/37217 , A61N1/37223 , A61N1/37229 , A61N1/37235 , A61N1/3727 , A61N1/375 , A61N1/3787 , H01L2224/45144 , H01L2224/45147 , H01L2224/48465 , H01L2224/49175 , H01L2924/00011 , H01L2924/1461 , H01L2924/19105 , H01L2924/19107 , H01L2924/3011 , H01L2924/30111 , H02J7/025 , H02J7/345 , H04B5/0037 , H04B5/0081 , H04L27/02 , H04L27/10 , Y10T29/4902 , Y10T29/49071 , Y10T29/49073 , Y10T29/49128 , Y10T29/4913 , Y10T29/49155 , Y10T29/49169 , Y10T29/49826 , Y10T29/49945 , Y10T29/49968 , Y10T428/12264 , Y10T428/12271 , Y10T428/12347 , Y10T428/12375 , Y10T428/12396 , Y10T428/12535 , Y10T428/12806 , H01L2924/00 , H01L2924/01005 , H01L2924/01033
摘要： Compact electronic modules, which may be used with implantable microstimulators and other medical and non-medical devices, and manufacture/assembly of such modules are described. Component and circuitry designs utilize unique redistribution techniques and attachment methods. A number of component designs and packaging configurations maximize the volume efficiency of electronic modules. Also included are improved processes and systems enabling the manufacture and assembly of such compact packages.
摘要翻译：描述了可与可植入微型刺激器和其他医疗和非医疗装置一起使用的紧凑型电子模块以及这种模块的制造/组装。组件和电路设计采用独特的再分配技术和附件方法。许多组件设计和封装配置使电子模块的体积效率最大化。还包括改进的工艺和系统，能够制造和组装这些紧凑型封装。

80. 发明申请

US20050021108A1 Bi-directional telemetry system for use with microstimulator 有权
标题翻译：用于微型激励器的双向遥测系统
公开(公告)号：US20050021108A1
公开(公告)日：2005-01-27
申请号：US10607962
申请日：2003-06-27
申请人： Daniel Klosterman , Kelly McClure , Goran Marnfeldt , Jordi Parramon , Matthew Haller , Rudolph Park
发明人： Daniel Klosterman , Kelly McClure , Goran Marnfeldt , Jordi Parramon , Matthew Haller , Rudolph Park
IPC分类号： A61N1/36 , A61N1/372 , A61N1/375 , A61N1/378 , H01Q1/24 , H01Q7/08 , H02J7/00 , H02J17/00 , A61N1/08
CPC分类号： A61N1/37276 , A61N1/36007 , A61N1/3605 , A61N1/37205 , A61N1/37217 , A61N1/37223 , A61N1/37229 , A61N1/37235 , A61N1/3727 , A61N1/375 , A61N1/3787 , H01L2224/45144 , H01L2224/45147 , H01L2224/48465 , H01L2224/49175 , H01L2924/00011 , H01L2924/1461 , H01L2924/19105 , H01L2924/19107 , H01L2924/3011 , H01L2924/30111 , H02J7/025 , H02J7/345 , H04B5/0037 , H04B5/0081 , H04L27/02 , H04L27/10 , Y10T29/4902 , Y10T29/49071 , Y10T29/49073 , Y10T29/49128 , Y10T29/4913 , Y10T29/49155 , Y10T29/49169 , Y10T29/49826 , Y10T29/49945 , Y10T29/49968 , Y10T428/12264 , Y10T428/12271 , Y10T428/12347 , Y10T428/12375 , Y10T428/12396 , Y10T428/12535 , Y10T428/12806 , H01L2924/00 , H01L2924/01005 , H01L2924/01033
摘要： An implantable microstimulator configured to be implanted beneath a patient's skin for tissue stimulation employs a bidirectional RF telemetry link for allowing data-containing signals to be sent to and from the implantable microstimulator from at least two external devices. Further, a separate electromagnetic inductive telemetry link allows data containing signals to be sent to the implantable microstimulator from at least one of the two external devices. The RF bidirectional telemetry link allows the microstimulator to inform the patient or clinician regarding the status of the microstimulator device, including the charge level of a power source, and stimulation parameter states. The microstimulator has a cylindrical hermetically sealed case having a length no greater than about 27 mm and a diameter no greater than about 3.3mm. A reference electrode is located on one end of the case and an active electrode is located on the other end of the case.
摘要翻译：配置成植入患者皮肤下方进行组织刺激的可植入微刺激器使用双向RF遥测链路，用于允许从至少两个外部设备向可植入微型激励器发送和从可植入微型激励器发送含数据信号。此外，单独的电磁感应遥测链路允许从两个外部设备中的至少一个将包含信号的数据发送到可植入微型激励器。 RF双向遥测链路允许微刺激器通知患者或临床医生关于微刺激器装置的状态，包括电源的充电水平和刺激参数状态。微型激励器具有圆柱形气密密封的外壳，其长度不大于约27mm，直径不大于约3.3mm。参考电极位于壳体的一端，有源电极位于壳体的另一端。

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