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    • 71. 发明授权
    • Protection system for critical memory information
    • 关键记忆体信息保护系统
    • US5668973A
    • 1997-09-16
    • US422435
    • 1995-04-14
    • Peter StutzMartin MullerDaniel Fluckiger
    • Peter StutzMartin MullerDaniel Fluckiger
    • G06F12/14B65G61/00G06Q10/00G06Q50/00G07B17/00G06F12/16G06F13/00
    • G07B17/00193G07B2017/00258G07B2017/00403G07B2017/00967
    • A computer system for protecting memory comprising a processor having address outputs and executing a stored program, a memory having a control input, an address-decoder for providing a control signal to the control input of the memory in response to associated address outputs from the processor, and a window circuit. The window circuit comprises a range detector responsive to the address outputs for generating a range-detection signal indicative of an address from the processor being within a protected range, the protected range non-identical to the entirety of the space of addresses within the memory. Access to memory locations within the protected range is permitted only if a request signal is received from the processor. If the request signal is asserted for an unexpectedly long time an error condition is annunciated, for example the processor is reset.
    • 一种用于保护存储器的计算机系统,包括具有地址输出和执行存储的程序的处理器,具有控制输入的存储器,地址解码器,用于响应于来自处理器的相关联的地址输出向存储器的控制输入提供控制信号 ,和一个窗口电路。 窗口电路包括响应于地址输出的范围检测器,用于产生指示来自处理器的地址在范围检测范围内的范围检测信号,受保护范围与存储器内的地址空间的整体不相同。 仅当从处理器接收到请求信号时才允许访问受保护范围内的存储单元。 如果请求信号在意外长时间被断言,则报告错误状态,例如处理器被复位。
    • 74. 发明授权
    • Hydraulic control device
    • 液压控制装置
    • US5305718A
    • 1994-04-26
    • US64163
    • 1993-05-19
    • Martin Muller
    • Martin Muller
    • F01L1/34F01L1/344
    • F01L1/34406Y10T74/2102
    • The hydraulic control device for rotating the camshaft of an internal combustion engine has a couple member constructed as a piston (25) connected with the sprocket wheel of the camshaft via a spiral toothing and with the camshaft via a straight toothing. A hydraulic body is mounted on at the camshaft and receives a radial piston pump which delivers the pressure medium required for the displacement of the piston. The pressure space is closed by a controllable pressure limiting valve. An electromagnetic valve controls a pressure medium flow to the piston bores of the radial piston pump and the pressure medium is delivered by an external pump. The sprocket wheel and camshaft are rotated relative to one another by the displacement of the piston.
    • PCT No.PCT / DE92 / 00750 Sec。 371日期:1993年5月19日 102(e)日期1993年5月19日PCT提交1992年9月4日PCT公布。 公开号WO93 / 08380 日本1994年4月29日。用于旋转内燃机的凸轮轴的液压控制装置具有构造为通过螺旋齿与凸轮轴的链轮连接的活塞(25)的联接构件,并且通过直线 齿。 液压体安装在凸轮轴上并且接收径向活塞泵,其输送活塞位移所需的压力介质。 压力空间由可控压力限制阀封闭。 电磁阀控制到径向活塞泵的活塞孔的压力介质流,并且压力介质由外部泵输送。 链轮和凸轮轴通过活塞的位移相对于彼此旋转。
    • 75. 发明授权
    • Porphycene compounds for photodynamic therapy
    • 磷光化合物用于光动力疗法
    • US5179120A
    • 1993-01-12
    • US723394
    • 1991-06-28
    • Emanuel VogelClemens RichertThomas BenninghausMartin MullerAlexander D. Cross
    • Emanuel VogelClemens RichertThomas BenninghausMartin MullerAlexander D. Cross
    • A61K31/40A61K41/00A61K49/00A61P7/00A61P17/00A61P35/00C07D20060101C07D209/56C07D487/22
    • C07D487/22A61K41/0057
    • A porphycene having the structure ##STR1## wherein each R.sup.1 is, independently, (a) --(CH.sub.2).sub.n --X, where n=1-4, X is OR.sup.2 and R.sup.2 is C.sub.1-6 alkyl, aralkyl or aryl; CN; OH; OSO.sub.2 R.sup.2 ; NH.sub.2 ; NHR.sup.2 ; NR.sub.2.sup.2 ; SH; SR.sup.2 ; S(O).sub.1-2 R.sup.2 ; COOH; CO.sub.2 R.sup.2 ; C(O)NH.sub.2 ; C(O)NHR.sup.2 ; C(O)NR.sub.2.sup.2 ; halogen; or CHO;(b) --(CH.sub.2).sub.m CH.dbd.CH.sub.2 where m is 0-2; or(c) --(CH.sub.2).sub.n --O--G where G is a mono- or oligosaccharide;(d) --(CH.sub.2).sub.2n --X, where X is an amino acid, oligopeptide covalently bonded by an ether-, ester- or amine-bond or --Y--(CH.sub.2).sub.n -porphycene.sup.2 (porphycene.sup.2 being a compound of the same structure and Y is a direct bond; --O--; or --CH.dbd.CH.sub.2); or(e) where one, two or three of the substituents R.sup.1 are C.sub.1-6 alkyl or aryl and the remaining substituents are as above under (a)-(d), and salts and metal complexes thereof. The porphycene compounds and pharmaceutical compositions containing the compounds are useful in photodynamic therapy treatment of tumors and psoriasis.
    • 具有结构的卟菲烯,其中每个R 1独立地为(a) - (CH 2)n -X,其中n = 1-4,X为OR 2,R 2为C 1-6烷基,芳烷基或芳基; CN; 哦; OSO2R2; NH2; NHR2; NR22; SH; SR2; S(O)1-2R2; COOH; CO2R2; C(O)NH 2; C(O)NHR 2; C(O)NR22; 卤素; 或CHO; (b) - (CH 2)m CH = CH 2,其中m是0-2; 或(c) - (CH 2)n -O-G,其中G是单糖或寡糖; (d) - (CH2)2n-X,其中X是氨基酸,通过醚 - ,酯 - 或胺键共价结合的寡肽或-Y-(CH 2)n - 卟吩二(卟吩2是相同的化合物) 结构,Y是直接键; -O-;或-CH = CH 2); 或(e)其中一个,两个或三个取代基R 1为C 1-6烷基或芳基,其余取代基如上述(a) - (d)所述,及其盐和金属络合物。 含有这些化合物的卟吩化合物和药物组合物可用于肿瘤和牛皮癣的光动力疗法治疗。
    • 79. 发明申请
    • ENHANCED PRODUCTION OF PAPILLOMAVIRUS-LIKE PARTICLES WITH A MODIFIED BACULOVIRUS EXPRESSION SYSTEM
    • 用改良的巴氏杆菌表达系统增强具有类似芽胞杆菌的颗粒的生产
    • US20120115207A1
    • 2012-05-10
    • US13257248
    • 2010-03-30
    • Tilo SengerMartin MullerLutz Gissmann
    • Tilo SengerMartin MullerLutz Gissmann
    • C12N7/02C12N15/85C12N5/10
    • C12N15/86A61K39/00A61K2039/5258C12N7/00C12N2710/14143C12N2710/20023
    • The present invention is concerned with the provision of a method for manufacturing papillomavirus like particles (PV-VLP), comprising the steps of a) culturing a host cell lacking protease activity and comprising an expression vector, wherein said expression vector comprises at least one polynucleotide encoding a PV L1 polypeptide, and b) obtaining VLPs from the host cell. Also proposed is a host cell lacking protease activity and comprising an expression vector, wherein said expression vector comprises a polynucleotide encoding at least one PV L1 polypeptide. Furthermore, a method for the manufacture of a pharmaceutical composition for the treatment or prevention of PV-related disease comprising the steps of manufacturing PV-VLPs and the further step of formulating the VLPs as a pharmaceutical composition is proposed as well as an expression vector comprising at least one polynucleotide encoding a PV L1 polypeptide but lacking a functional gene for a v-cath protease.
    • 本发明涉及制备乳头瘤病毒样颗粒(PV-VLP)的方法,其包括以下步骤:a)培养缺乏蛋白酶活性的宿主细胞并包含表达载体,其中所述表达载体包含至少一种多核苷酸 编码PV L1多肽,和b)从宿主细胞获得VLP。 还提出了缺乏蛋白酶活性并包含表达载体的宿主细胞,其中所述表达载体包含编码至少一种PV L1多肽的多核苷酸。 此外,提出了制备用于治疗或预防PV相关疾病的药物组合物的方法,其包括制备PV-VLP的步骤和配制作为药物组合物的VLP的进一步步骤以及包含 编码PV L1多肽的至少一种多核苷酸,但缺乏v-cath蛋白酶的功能基因。
    • 80. 发明申请
    • FAST SEARCH VIEWS OVER BUSINESS OBJECTS
    • 快速搜索查看业务目标
    • US20100049734A1
    • 2010-02-25
    • US12195750
    • 2008-08-21
    • Maic WintelFrank MarkertMartin MullerYe JinThilo Boehm
    • Maic WintelFrank MarkertMartin MullerYe JinThilo Boehm
    • G06F17/30
    • G06Q10/10G06Q10/06
    • A method and means, the method includes selecting a plurality of data sources having attributes to be included in a view entity; defining join conditions on the selected plurality of data sources; defining a set of attributes for the view entity by selecting attributes from the attributes of the plurality of data sources; and saving the view entity. The means includes a graphical user interface having a join builder tool to define join conditions on a selected plurality of data sources each including a pre-defined business object data structure having attributes; a view field definition tool to define a set of attributes for the view entity by selecting attributes from the attributes of the plurality of data sources; and a data source tree tool to display all of the attributes of the plurality of data sources.
    • 一种方法和装置,所述方法包括选择具有要被包括在视图实体中的属性的多个数据源; 在所选择的多个数据源上定义连接条件; 通过从所述多个数据源的属性中选择属性来定义所述视图实体的一组属性; 并保存视图实体。 该装置包括具有连接构建器工具的图形用户界面,用于定义所选择的多个数据源上的连接条件,每个数据源包括具有属性的预定义业务对象数据结构; 视图字段定义工具,用于通过从所述多个数据源的属性中选择属性来定义所述视图实体的一组属性; 以及用于显示多个数据源的所有属性的数据源树工具。