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71. 发明申请

US20100292697A1 POLYMERIC PLATE BENDABLE WITHOUT THERMAL ENERGY AND METHODS OF MANUFACTURE 审中-公开
标题翻译：聚合物板可弯曲而不具有热能和制造方法
公开(公告)号：US20100292697A1
公开(公告)日：2010-11-18
申请号：US12780653
申请日：2010-05-14
申请人： Randolf von Oepen , Alexander Tschakaloff
发明人： Randolf von Oepen , Alexander Tschakaloff
IPC分类号： A61B17/80
CPC分类号： A61B17/8085 , A61B2017/00004 , A61B2017/00526 , Y10S606/907
摘要： An implantable plate for providing support to a bone of a subject when affixed thereto includes a polymeric body of a biocompatible polymer having a desired amount of polymer molecule orientation in a first direction so that the plate can be bent to conform with a contour of the bone of the subject. The polymeric body includes a top surface, a bottom surface, and at least one fastener portion. The fastener portion includes a recess and a fastener hold that is configured for receiving a fastener when affixed to the bone of the subject. A method of manufacturing the implantable plate includes: (1) injection molding a biocompatible polymeric composition into a polymeric body within an injection mold; (2) removing the polymeric body from the injection mold; and (3) forming at least one fastener hole within polymeric body.
摘要翻译：用于向被检体的骨骼提供支撑的可植入板，当固定在其上时包括具有在第一方向上具有所需量的聚合物分子取向的生物相容性聚合物的聚合体，使得该板能够弯曲以符合骨骼的轮廓的主题。聚合物主体包括顶表面，底表面和至少一个紧固件部分。紧固件部分包括凹部和紧固件保持件，其被构造成在固定到被检体的骨骼上时接收紧固件。制造可植入板的方法包括：（1）将生物相容性聚合物组合物注塑成注射模具内的聚合体; （2）从注射模具中取出聚合体; 和（3）在聚合物体内形成至少一个紧固件孔。

72. 发明申请

US20100291287A1 POLYMERIC PLATE BENDABLE WITHOUT THERMAL ENERGY AND METHODS OF MANUFACTURE 审中-公开
公开(公告)号：US20100291287A1
公开(公告)日：2010-11-18
申请号：US12780622
申请日：2010-05-14
申请人： Randolf von Oepen , Alexander Tschakaloff
发明人： Randolf von Oepen , Alexander Tschakaloff
IPC分类号： A61K9/56 , B29C45/14
CPC分类号： A61B17/8085 , A61B2017/00004 , A61B2017/00526 , Y10S606/907
摘要： An implantable plate for providing support to a bone of a subject when affixed thereto includes a polymeric body of a biocompatible polymer having a desired amount of polymer molecule orientation in a first direction so that the plate can be bent to conform with a contour of the bone of the subject. The polymeric body includes a top surface, a bottom surface, and at least one fastener portion. The fastener portion includes a recess and a fastener hold that is configured for receiving a fastener when affixed to the bone of the subject. A method of manufacturing the implantable plate includes: (1) injection molding a biocompatible polymeric composition into a polymeric body within an injection mold; (2) removing the polymeric body from the injection mold; and (3) forming at least one fastener hole within polymeric body.

73. 发明申请

US20100023108A1 Multiple Drug Delivery From A Balloon And A Prosthesis 有权
标题翻译：从气球和假体的多个药物递送
公开(公告)号：US20100023108A1
公开(公告)日：2010-01-28
申请号：US12371422
申请日：2009-02-13
申请人： John L. Toner , Sandra E. Burke , Keith R. Cromack , Randolf von Oepen
发明人： John L. Toner , Sandra E. Burke , Keith R. Cromack , Randolf von Oepen
IPC分类号： A61F2/84 , A61F2/82
CPC分类号： A61L31/16 , A61F2/91 , A61F2/958 , A61F2230/0054 , A61F2250/0067 , A61F2310/0097 , A61L29/085 , A61L29/16 , A61L31/10 , A61L2300/606 , A61M25/10 , A61M2025/105
摘要： Disclosed is an interventional device for delivery of therapeutic agents from an angioplasty balloon and from a prosthesis such as an intraluminal stent. The invention also relates to the method of loading the beneficial agents onto the balloon and the device, as well as the method of delivery of the agents from separate surfaces. The invention also relates to an interventional device having a prosthesis surface that is loaded with a first beneficial agent, and a balloon surface loaded with a second beneficial agent. The invention also relates to a method of loading multiple beneficial agents onto the prosthesis surfaces and the balloon surfaces, and to a method of manufacturing an interventional device for the delivery of a first beneficial agent and a second beneficial agent from separate surfaces.
摘要翻译：公开了用于从血管成形术球囊和诸如腔内支架之类的假体递送治疗剂的介入装置。本发明还涉及将有益试剂装载到球囊和装置上的方法以及将试剂从分开的表面递送的方法。本发明还涉及具有装载有第一有益试剂的假体表面的介入装置和装载有第二有益试剂的气囊表面。本发明还涉及一种将多种有益试剂装载到假体表面和球囊表面上的方法，以及制造用于从单独表面递送第一有益试剂和第二有益试剂的介入装置的方法。

74. 发明申请

US20090282669A1 Method And Apparatus For Reducing Stress During Stent Manufacture 有权
标题翻译：支架制造过程中减轻应力的方法和装置
公开(公告)号：US20090282669A1
公开(公告)日：2009-11-19
申请号：US12119945
申请日：2008-05-13
申请人： Randolf von Oepen , Travis Richard Yribarren , Richard Roy Newhauser , Rainer Bregulla
发明人： Randolf von Oepen , Travis Richard Yribarren , Richard Roy Newhauser , Rainer Bregulla
IPC分类号： B23P17/00 , A61F2/82
CPC分类号： A61F2/91 , A61F2210/0014 , A61F2230/0013 , A61F2230/0054 , A61F2240/001 , Y10T29/49863 , Y10T29/49865 , Y10T29/53657 , Y10T29/53909 , Y10T29/53987 , Y10T29/53996 , Y10T29/54
摘要： The invention relates to a method and apparatus of reducing stress during stent manufacture. Particularly, the invention is directed to a method and apparatus for expanding a stent using primarily radial loads thereby reducing the stresses that are generated due to the axial loads applied during loading of the stent onto a mandrel or other expansion device. The method of the invention provides for the stepwise expansion of shape memory stents, while reducing the overall stresses that the stent encounters, and thereby improving manufacturing yields due to fractured struts during expansion.
摘要翻译：本发明涉及减少支架制造过程中的压力的方法和装置。特别地，本发明涉及一种用于使用主要径向载荷来扩张支架的方法和装置，从而减少由于在将支架装载到心轴或其它扩张装置上时施加的轴向载荷而产生的应力。本发明的方法提供了形状记忆支架的逐步扩张，同时降低了支架遭受的总体应力，从而提高了在扩张期间由于断裂的支柱引起的制造产量。

75. 发明授权

US07578831B2 Balloon catheter 有权
标题翻译：气球导管
公开(公告)号：US07578831B2
公开(公告)日：2009-08-25
申请号：US11474111
申请日：2006-06-23
申请人： Randolf von Oepen , Lorcan Coffey , Thomas Rieth , Travis R. Yribarren , Arik Zucker
发明人： Randolf von Oepen , Lorcan Coffey , Thomas Rieth , Travis R. Yribarren , Arik Zucker
IPC分类号： A61M29/00
CPC分类号： A61M25/10 , A61F2/958 , A61M25/1002 , A61M25/1011 , A61M25/1027 , A61M25/1029 , A61M25/104 , A61M2025/018 , A61M2025/0183 , A61M2025/1045 , A61M2025/1056 , A61M2025/107 , A61M2029/025
摘要： A catheter arrangement is described that is arranged to permit a guide wire or other structure to be fed laterally from the region of an expandable working element. The catheter includes an elongate flexible tubular member and an inflatable structure carried by a distal portion of the flexible tubular member. The flexible tubular member has a guide wire lumen and at least one fluid supply lumen that is in fluid communication with the inflatable structure. The inflatable structure includes at least one, and preferably two, inflatable members (which may take the form of balloons). In the case of two inflatable members, the first and second inflatable members are radially spaced about the guide wire lumen such that at least one gap is formed between the inflatable members. With this arrangement, the distal end of a guide wire may be advanced through the guide lumen and out of a side opening such that the guide wire passes laterally between the first and second inflatable members. With such an arrangement, a guide wire passing out of the side opening in the region between the inflatable members can readily be directed into a second branch of a vessel bifurcation while the device is positioned in a first branch.
摘要翻译：描述了布置成允许导丝或其他结构从可扩张工作元件的区域横向地供给的导管装置。导管包括细长的柔性管状构件和由柔性管状构件的远侧部分承载的可膨胀结构。柔性管状构件具有导丝腔和与可充气结构流体连通的至少一个流体供应腔。可膨胀结构包括至少一个，优选两个可膨胀构件（其可以采取气球的形式）。在两个可膨胀构件的情况下，第一和第二可膨胀构件围绕导丝管腔径向隔开，使得在可膨胀构件之间形成至少一个间隙。通过这种布置，导丝的远端可以通过引导腔前进并且从侧开口排出，使得导丝横向地在第一和第二可膨胀构件之间通过。通过这样的布置，在可膨胀构件之间的区域中的侧开口中的引导线可以容易地被引导到容器分叉的第二分支中，同时装置位于第一分支中。

76. 发明申请

US20070293846A1 Dual Lumen Guidewire Support Catheter 有权
标题翻译：双腔导丝支撑导管
公开(公告)号：US20070293846A1
公开(公告)日：2007-12-20
申请号：US11738382
申请日：2007-04-20
申请人： Randolf von Oepen , James Jacobs , Richard Newhauser
发明人： Randolf von Oepen , James Jacobs , Richard Newhauser
IPC分类号： A61M25/098
CPC分类号： A61M25/0029 , A61M25/0071 , A61M2025/0037 , A61M2025/0183 , A61M2025/107
摘要： A dual lumen guidewire support catheter for accurately crossing a chronic total occlusion in a vessel is disclosed. The dual lumen guidewire support catheter includes a first lumen portion and a second lumen portion sharing a common side and a common distal end. The first lumen portion can be a rapid exchange or over-the-wire portion, while the second lumen portion is an over the wire portion. One or both of the portions can include a discontinuity to enable removal of a guidewire following placement through or at an occlusion or lesion.
摘要翻译：公开了用于准确地穿过血管中的慢性完全闭塞的双腔导丝支撑导管。所述双腔导丝支撑导管包括共享共同侧和共同远端的第一腔部分和第二腔部分。第一管腔部分可以是快速交换或线上部分，而第二管腔部分在线部分之上。这些部分中的一个或两个可以包括不连续性，以便能够在放置穿过或闭塞或损伤之后移除导丝。

77. 发明申请

US20070021772A1 MEDICAL DEVICE BALLOON 有权
标题翻译：医疗器械气球
公开(公告)号：US20070021772A1
公开(公告)日：2007-01-25
申请号：US11456487
申请日：2006-07-10
申请人： Randolf von Oepen , Travis Yribarren
发明人： Randolf von Oepen , Travis Yribarren
IPC分类号： A61M29/00
CPC分类号： A61M29/02 , A61L29/06 , A61L29/148 , A61M25/0045 , A61M25/10 , Y10T428/1334 , C08L67/04
摘要： The present invention relates to medical devices that can be placed in bodily conduits. The invention particularly relates to balloons and catheters using such balloons for administering treatments to widen constricted passages, deliver therapeutic agents, deliver endoprosthesis' or perform other medical procedures. The balloon catheter can include an expandable balloon disposed adjacent a distal end of an elongated catheter shaft. The balloon can be constructed of a novel absorbable biomaterial.
摘要翻译：本发明涉及可以放置在身体管道中的医疗装置。本发明特别涉及使用这种气球的气球和导管，用于施用治疗以扩大收缩的通道，递送治疗剂，递送内用假体或执行其它医疗程序。气囊导管可以包括邻近细长导管轴的远端设置的可膨胀气囊。气球可以由新颖的可吸收生物材料构成。

78. 发明申请

US20070016241A1 Balloon catheter 有权
标题翻译：气球导管
公开(公告)号：US20070016241A1
公开(公告)日：2007-01-18
申请号：US11474111
申请日：2006-06-23
申请人： Randolf von Oepen , Lorcan Coffey , Thomas Rieth , Travis Yribarren , Arik Zucker
发明人： Randolf von Oepen , Lorcan Coffey , Thomas Rieth , Travis Yribarren , Arik Zucker
IPC分类号： A61M29/00
CPC分类号： A61M25/10 , A61F2/958 , A61M25/1002 , A61M25/1011 , A61M25/1027 , A61M25/1029 , A61M25/104 , A61M2025/018 , A61M2025/0183 , A61M2025/1045 , A61M2025/1056 , A61M2025/107 , A61M2029/025
摘要： A catheter arrangement is described that is arranged to permit a guide wire or other structure to be fed laterally from the region of an expandable working element. The catheter includes an elongate flexible tubular member and an inflatable structure carried by a distal portion of the flexible tubular member. The flexible tubular member has a guide wire lumen and at least one fluid supply lumen that is in fluid communication with the inflatable structure. The inflatable structure includes at least one, and preferably two, inflatable members (which may take the form of balloons). In the case of two inflatable members, the first and second inflatable members are radially spaced about the guide wire lumen such that at least one gap is formed between the inflatable members. With this arrangement, the distal end of a guide wire may be advanced through the guide lumen and out of a side opening such that the guide wire passes laterally between the first and second inflatable members. With such an arrangement, a guide wire passing out of the side opening in the region between the inflatable members can readily be directed into a second branch of a vessel bifurcation while the device is positioned in a first branch.
摘要翻译：描述了布置成允许导丝或其他结构从可扩张工作元件的区域横向地供给的导管装置。导管包括细长的柔性管状构件和由柔性管状构件的远侧部分承载的可膨胀结构。柔性管状构件具有导丝腔和与可充气结构流体连通的至少一个流体供应腔。可膨胀结构包括至少一个，优选两个可膨胀构件（其可以采取气球的形式）。在两个可膨胀构件的情况下，第一和第二可膨胀构件围绕导丝管腔径向隔开，使得在可膨胀构件之间形成至少一个间隙。通过这种布置，导丝的远端可以通过引导腔前进并且从侧开口排出，使得导丝横向地在第一和第二可膨胀构件之间通过。通过这样的布置，在可膨胀构件之间的区域中的侧开口中的引导线可以容易地被引导到容器分叉的第二分支中，同时装置位于第一分支中。

79. 发明授权

US06193747B1 Stent 有权
标题翻译：支架
公开(公告)号：US06193747B1
公开(公告)日：2001-02-27
申请号：US09171293
申请日：1998-10-16
申请人： Randolf von Oepen
发明人： Randolf von Oepen
IPC分类号： A61F200
CPC分类号： A61F2/91 , A61F2/915 , A61F2002/91525 , A61F2002/91533 , A61F2002/91541 , A61F2002/91558 , A61F2230/0054
摘要： A stent (1) has a tubular flexible body (2) with the wall (3) having a web structure (4). The web structure (4) of the wall (3) has cells formed by a pair of adjacent sinuous web patterns (5,6) that are interconnected by linking elements (22) to form elastic elements.
摘要翻译：支架（1）具有管状柔性体（2），壁（3）具有腹板结构（4）。壁（3）的网状结构（4）具有由一对相邻的弯曲网状图案（5,6）形成的单元，其通过连接元件（22）互连以形成弹性元件。

80. 发明申请

US20180126095A1 METHODS, SYSTEMS, AND DEVICES FOR SEALING AND FLUSHING A DELIVERY SYSTEM 审中-公开
公开(公告)号：US20180126095A1
公开(公告)日：2018-05-10
申请号：US15661988
申请日：2017-07-27
申请人： Randolf von Oepen , Sean A. McNiven , Francisco Valencia
发明人： Randolf von Oepen , Sean A. McNiven , Francisco Valencia
IPC分类号： A61M5/36 , A61M25/09 , A61M25/00 , A61M39/22
摘要： A method for sealing and flushing a delivery member includes sealing one or more lumens and flushing air from the one or more lumens. An interventional device delivery system includes a handle assembly and a delivery member. The handle assembly includes a catheter holder with a passageway therethrough. A flush block is associated with the catheter holder and has a flush port and a flush chamber. The delivery member is associated with the handle assembly and includes a plurality of catheters. At least one of the catheters has a proximal end disposed within the passageway in the catheter holder and is in fluid communication with the flush chamber.

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