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    • 72. 发明授权
    • Time-of-flight mass spectrometer with constant flight path length
    • 飞行时间质谱仪具有恒定的飞行路径长度
    • US6049077A
    • 2000-04-11
    • US133868
    • 1998-08-13
    • Jochen Franzen
    • Jochen Franzen
    • H01J49/40
    • H01J49/40
    • The time-of-flight mass spectrometers which must demonstrate a high constancy of the calibrated mass scale even under changeable ambient temperatures and thermal loads due to pumps or electronics. Time-of-flight mass spectrometers calculate the masses of ions from the measured time of flight in a long flight tube that is normally manufactured of stainless steel. These flight tubes are subject to temperature-related length changes which affect the flight time and therefore the mass determination. The thermal expansion of spectrometer parts between ion source and ion detector, thus keeping the flight path for the ions at a constant length. Length compensation can be produced by design of the spacing system made of materials of different thermal expansion coefficients, the length changes of which balance out in opposite directions.
    • 飞行时间质谱仪即使在可变环境温度和由于泵或电子设备造成的热负载的情况下也必须表现出校准质量标度的高恒定性。 飞行时间质谱仪从通常由不锈钢制造的长飞行管中测量的飞行时间计算离子质量。 这些飞行管受到温度相关的长度变化,影响飞行时间,因此影响质量测定。 离子源和离子检测器之间的光谱仪部分的热膨胀,从而保持离子的飞行路径恒定的长度。 长度补偿可以通过设计由不同热膨胀系数的材料制成的间隔系统,其长度变化在相反方向平衡。
    • 73. 发明授权
    • Wide mass range focusing in time-of-flight mass spectrometers
    • 宽质量范围聚焦于飞行时间质谱仪
    • US5969348A
    • 1999-10-19
    • US933862
    • 1997-09-19
    • Jochen Franzen
    • Jochen Franzen
    • H01J49/40B01D59/44H01J49/00
    • H01J49/403
    • The invention relates to measurement methods for time-of-flight mass spectrometers which operate with an ionization of analyte substances adsorbed at the surface of a sample support and an improvement in mass resolution through delayed ion acceleration (or "delayed extraction") in front of the sample support. It particularly relates to velocity focusing for good mass resolution simultaneously for wide ranges of masses within the spectrum.The invention consists of focusing the flight-times of the ions simultaneously for all masses in wide ranges of interest relative to their initial velocity, by allowing the acceleration in the first accelerating region to increase in time after being switched on. Thus a good resolution cannot only be set for one mass on the spectrum but for all masses in wide ranges simultaneously. In computer simulations, provided there is a correlation of space and velocity distribution, focusing of a least first order is obtained simultaneously for all ions.
    • 本发明涉及飞行时间质谱仪的测量方法,其通过吸附在样品载体表面的分析物质的离子化和通过延迟离子加速(或“延迟提取”)提高质量分辨率而工作, 样品支持。 它特别涉及速度聚焦,用于在光谱范围内的宽范围的质量范围内同时获得良好的质量分辨率。 本发明包括通过允许第一加速区域中的加速度在接通之后随时间增加,将离子的飞行时间同时聚焦在相对于其初始速度的广泛范围内的所有质量。 因此,不仅可以在光谱上设置一个质量,而且可以同时为宽范围内的所有质量设置好的分辨率。 在计算机模拟中,只要存在空间和速度分布的相关性,所有离子同时获得最小一阶的聚焦。
    • 75. 发明授权
    • Geometry for a linear time-of-light mass spectrometer with very high
resolution
    • 用于具有非常高分辨率的线性时间光谱质谱仪的几何
    • US5898174A
    • 1999-04-27
    • US925629
    • 1997-09-09
    • Jochen Franzen
    • Jochen Franzen
    • H01J49/16H01J49/40
    • H01J49/40
    • A linear time-of-flight mass spectrometer which operates using ionization of analyte substances adsorbed on a sample support plate and an improvement in mass resolution through delayed acceleration of the ions in front of the sample support plate. The geometric design of the mass spectrometer consists of focusing the flight time of the ions in second or higher order by maintaining geometric requirements for the lengths of acceleration paths in the ion source relative to the field-free flight path length. In computer simulations, resolutions of flight time greater than one million have been obtained even for very high ion masses provided there is a correlation in space and velocity distribution when switching on the acceleration.
    • 线性飞行时间质谱仪,其使用吸附在样品支持板上的分析物质的电离进行操作,并且通过样品支撑板前面的离子的延迟加速提高质量分辨率。 质谱仪的几何设计包括通过保持离子源相对于无场飞行路径长度的加速度路径的长度的几何要求,将离子的飞行时间以二次或更高次序进行聚焦。 在计算机模拟中,即使对于非常高的离子质量,飞行时间大于一百万的分辨率也可以获得,只要开启加速度时空间和速度分布有相关性。
    • 76. 发明授权
    • Method and device for orthogonal ion injection into a time-of-flight
mass spectrometer
    • 用于正交离子注入飞行时间质谱仪的方法和装置
    • US5763878A
    • 1998-06-09
    • US620803
    • 1996-03-28
    • Jochen Franzen
    • Jochen Franzen
    • H01J49/04H01J49/40H01J49/42B01D59/44H01J49/00
    • H01J49/423H01J49/401
    • The invention relates to methods and devices for the orthogonal injection of ions into a time-of-flight mass spectrometer, whereby the ions preferably originate from ion sources which are located outside of the vacuum system of the mass spectrometer. The invention consists of first introducing the ions into a multipole rod arrangement with extended pole rods which stretches orthogonally to the flight direction of the ions in the time-of-flight spectrometer, and then outpulsing the ions by means of a rapid change of the electrical field, perpendicular to the rod direction, through the intermediate space between two rods. The multipole arrangement can take the form of an ion storage device by fitting reflectors to the ends. The multipole arrangement can be filled with the aid of another multipole arrangement which takes the form of an ion guide. Damping of the ion oscillations with the aid of a collision gas leads to a collection of ions in a very thin thread on the axis of the multipole arrangement, providing the time-of-flight spectrometer with an excellent mass resolving power due to the uniform initial energy and low energy spread of the ions.
    • 本发明涉及用于将离子正交注入飞行时间质谱仪的方法和装置,其中离子优选源自位于质谱仪真空系统外部的离子源。 本发明包括首先将离子引入具有延伸极杆的多极杆装置中,其延伸的极杆与飞行时间分光计中的离子的飞行方向正交地延伸,然后通过电气的快速变化使离子脉冲离开 垂直于杆方向,通过两个杆之间的中间空间。 通过将反射器装配到端部,多极排列可以采用离子存储装置的形式。 可以借助于采用离子导向器形式的另一多极装置来填充多极装置。 借助碰撞气体对离子振荡的阻尼导致多极排列轴线上非常薄的螺纹中的离子的集合,为飞行时间谱仪提供了优异的质量分辨能力,由于均匀的初始 能量和低能量的离子扩散。
    • 80. 发明授权
    • Ejection of ions from ion traps by combined electrical dipole and
quadrupole fields
    • 通过组合电偶极子和四极场从离子阱中吸出离子
    • US5468957A
    • 1995-11-21
    • US245967
    • 1994-05-19
    • Jochen Franzen
    • Jochen Franzen
    • H01J49/42
    • H01J49/424H01J49/427
    • The invention relates to an improved method and an apparatus for the mass-sequential ejection of ions from an RF quadrupole ion trap by electrical alternating fields which are generated in addition to the quadrupolar RF storage field and with different frequencies to it. In contrast to the already known ejection by a pure dipole field, the ions are here essentially ejected by a quadrupole field. The ions leave the ion trap through a perforated end cap and can be detected outside it with conventional means. A weak dipole field undertakes only excitation of the secular oscillation at the center, the amplitude increasing in linear manner in the stationary case. The more intense quadrupole field undertakes further widening of the oscillations with exponential growth in amplitudes. The dipole field is generated by an alternating voltage between the two end caps, while the quadrupole field is generated by an alternating voltage between the end caps on the one hand and the ring electrode on the other. The method is of particular use for the ions of very high masses ranging from approximately 5,000 u to 50,000 u. With the same mass resolution, it permits mass spectra to be recorded considerably quicker than the hitherto conventional use of pure dipole fields.
    • 本发明涉及一种改进的方法和装置,用于通过除了四极RF存储场之外产生并具有不同频率的电交变场来大规模地从RF四极离子阱捕获离子。 与通过纯偶极子场已知的射出相反,这里的离子基本上被四极场喷射。 离子通过穿孔端盖离开离子阱,并可以用常规方法在其外部检测。 弱偶极场只对中心的长期振荡进行激励,在静止情况下振幅以线性方式增加。 更强烈的四极场进一步扩大振幅,幅度呈指数增长。 偶极场由两个端盖之间的交流电压产生,而四极场由一端的端盖和另一端的环形电极之间的交流电压产生。 该方法特别适用于大约5,000u至50,000u的非常高质量的离子。 以相同的质量分辨率,它允许比迄今传统使用纯偶极子场快得多的质谱。