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    • 74. 发明授权
    • Peptides, methods for assaying human pepsinogen I or human pepsin I and assay kits
    • 肽,测定人胃蛋白酶原I或人胃蛋白酶I的方法和测定试剂盒
    • US06407206B1
    • 2002-06-18
    • US09319863
    • 1999-06-14
    • Akio HayashiMasayoshi Matsuo
    • Akio HayashiMasayoshi Matsuo
    • C07K706
    • C07K7/06C12Q1/37C12Q2337/12G01N2333/96472Y02P20/55
    • Peptide substrates, or acid addition salts thereof, wherein said peptide substrate is represented by formula (I): R-X-Pro-Ile-Glu-W-Y-Z  (I) wherein R is a hydrogen, an amino-protective group, or a residue carrying one or two D- or L-amino acids; X is Lys or Arg; W is Phe or Phe(NO2), wherein Phe(NO2) is p-nitrophenylalanine; Y is Phe, Phe(NO2), Tyr, 3,5-diiodotyrosine, norleucine, Leu, Asp(Osbzl) or Met, wherein Obzl is benzyloxy; and Z is an aniline, an aminocoumarin or an aminonapthalene derivative, are disclosed. These compounds are specific substrates for human pepsin I and are useful in assaying the presence of human pepsin I or human pepsinogen I, and useful in diagnosing gastric diseases, such as gastric cancer and gastric ulcer.
    • 肽底物或其酸加成盐,其中所述肽底物由式(I)表示:其中R是氢,氨基保护基或携带一个或两个D-或L-氨基酸的残基; X是Lys或Arg; W是Phe或Phe(NO2),其中Phe(NO2)是对硝基苯丙氨酸; Y是Phe,Phe(NO 2),Tyr,3,5-二碘酪氨酸,正亮氨酸,Leu,Asp(Osbzl)或Met,其中Obzl是苄氧基; Z是苯胺,氨基香豆素或氨基萘衍生物。 这些化合物是人胃蛋白酶I的特异性底物,并且可用于测定人胃蛋白酶I或人胃蛋白酶原I的存在,并且可用于诊断胃癌,例如胃癌和胃溃疡。
    • 76. 发明授权
    • Disc inverting mechanism and disc automatic changer with the mechanism
    • 光盘反转机构和光盘自动更换装置
    • US06304525B1
    • 2001-10-16
    • US09380217
    • 1999-08-27
    • Akio HayashiKoutaro OnsoHitoshi NakamuraKouichi ShibasakiNoritada Kuwayama
    • Akio HayashiKoutaro OnsoHitoshi NakamuraKouichi ShibasakiNoritada Kuwayama
    • G11B1722
    • G11B17/056G11B17/225
    • A rotating frame 22 is supported by a stationary frame 21 rotatably by 180 degrees, and in both side plates 22c of the rotating frame 22, there are formed four pairs of guide grooves 25-28 for guiding pallets 9 and slots 32a-32d for moving claw members 30, 31, said slots corresponding to said guide grooves 25-28. On an inner wall of a rear plate 22b of the rotating frame 22, there is provided an up and down movable member 47 which moves downward together with the claw members 30, 31 when the rotating frame 22 is rotated by 180 degrees. Into the first and third guide grooves 25 and 27, there have been previously inserted empty pallets 9 with such a posture that their front surfaces 11 face downward. By moving the claw members 30, 31 along the slots 32b, 32d, the pallets 9 having discs D placed thereon are drawn into the second and fourth guide grooves 26 and 28 such that these pallets 9 are opposed to the upper empty pallets 9. In this condition, when the rotating frame 22 is rotated by 180 degrees, the discs D are turned-over and are placed on the lower empty pallets 9.
    • 旋转框架22由可旋转180度的固定框架21支撑,并且在旋转框架22的两个侧板22c中形成有四对导向槽25-28,用于引导托盘9和槽32a-32d以移动 爪构件30,31,所述槽对应于所述引导槽25-28。 在旋转框架22的后板22b的内壁上设置有上下可动构件47,当旋转框架22旋转180度时,上下可动构件47与爪构件30,31一起向下移动。 在第一和第三引导槽25和27中,先前插入有空的托盘9,使其前表面11面向下的姿势。 通过沿着槽32b,32d移动爪构件30,31,将具有放置在其上的盘D的托盘9拉入第二和第四引导槽26和28中,使得这些托板9与上空的托盘9相对。 这种情况下,当旋转框架22旋转180度时,盘D被翻转并放置在下空的托盘9上。
    • 77. 发明授权
    • Flame retardant composition
    • 阻燃组合物
    • US06232377B1
    • 2001-05-15
    • US09488449
    • 2000-01-20
    • Akio HayashiKatsuhiro HoritaKoji Ishihara
    • Akio HayashiKatsuhiro HoritaKoji Ishihara
    • C08K534
    • C08K5/34928C08K3/24C08L23/08C08L23/0815C08L51/06C08L2201/02C08L2314/06C08L2666/24C08L2666/04
    • A flame retardant composition comprising (A) about 50 to about 95 percent by weight of at least one ethylene co-polymer selected from an ethylene/vinyl ester copolymer; ethylene/alpha, beta unsaturated carboxylate copolymer; and very low density ethylene/alpha-olefin copolymer; and (B) about 5 to about 50 percent by weight of an ethylene/alpha-olefin copolymer having been prepared with a single site catalyst, and, for each 100 parts by weight of component (A) and component (B) combined, (C) about 2 to about 50 parts by weight of a polyethylene modified with a functional group containing compound; (D) about 5 to about 250 parts by weight of a metal hydrate; (E) about 1 to about 12 parts by weight of a triazine ring containing compound; and (F) about 0.5 to about 5 parts by weight of a flame retardant compound selected from the group consisting of a boron compound, a molybdenum compound, and a silicone.
    • 一种阻燃剂组合物,其包含(A)约50至约95重量%的至少一种选自乙烯/乙烯基酯共聚物的乙烯共聚物; 乙烯/α,β-不饱和羧酸酯共聚物; 和非常低密度的乙烯/α-烯烃共聚物; 和(B)约5至约50重量%的用单中心催化剂制备的乙烯/α-烯烃共聚物,并且对于每100重量份的组分(A)和组分(B)组合,( C)约2至约50重量份用含官能团的化合物改性的聚乙烯;(D)约5至约250重量份的金属水合物;(E)约1至约12重量份的 含三嗪环的化合物; 和(F)约0.5至约5重量份的选自硼化合物,钼化合物和硅氧烷的阻燃化合物。