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1. 发明授权

US06566516B1 High purity polysaccharide containing a hydrophobic group and process for producing it 有权
标题翻译：含有疏水基团的高纯度多糖及其生产方法
公开(公告)号：US06566516B1
公开(公告)日：2003-05-20
申请号：US09530347
申请日：2000-04-25
申请人： Junzo Sunamoto , Kazunari Akiyoshi , Ryuzo Hosotani , Akio Hayashi , Hiroki Fukui
发明人： Junzo Sunamoto , Kazunari Akiyoshi , Ryuzo Hosotani , Akio Hayashi , Hiroki Fukui
IPC分类号： C07H100
CPC分类号： C08B37/00 , C08B33/00 , C08B37/0021
摘要： A high purity polysaccharide containing hydrophobic group is produced by a process involving a first process step of producing an isocyanate group-containing hydrophobic compound, wherein one mole of a hydroxyl group-containing hydrocarbon having 12-50 carbon atoms or of a sterol is reacted with a diisocyanate represented by OCN—R1—NCO in which R1 is a hydrocarbyl of 1-50 carbon atoms, a second process step of producing the polysaccharide containing hydrophobic group composed of the hydrocarbon group of 12-50 carbon atoms or of the steryl group, wherein the isocyanate group-containing hydrophobic compound obtained in the first process step is reacted with one or more polysaccharides, and a purification step in which the reaction product in the second process step is purified using a solvent based on a ketone.
摘要翻译：含有疏水性基团的高纯度多糖通过涉及制造含异氰酸酯基的疏水性化合物的第一工序的工序来制造，其中1摩尔含有12-50个碳原子的羟基或固醇的烃与由OCN-R1-NCO表示的二异氰酸酯，其中R 1是1-50个碳原子的烃基，制备由12-50个碳原子的烃基或固醇基构成的含有疏水基团的多糖的第二工艺步骤，其中使第一工序中得到的含异氰酸酯基的疏水性化合物与一种或多种多糖反应，其中使用基于酮的溶剂对第二工序中的反应产物进行纯化的纯化工序。

2. 发明授权

US06656481B1 Vaccinal preparations 有权
标题翻译：疫苗制剂
公开(公告)号：US06656481B1
公开(公告)日：2003-12-02
申请号：US09147773
申请日：1999-07-03
申请人： Hiroshi Shiku , Junzo Sunamoto , Hideo Nakamura
发明人： Hiroshi Shiku , Junzo Sunamoto , Hideo Nakamura
IPC分类号： A61K4500
CPC分类号： A61K45/06 , A61K39/00 , A61K39/39 , A61K2039/55555 , A61K2039/55583 , A61K2039/57
摘要： Vaccinal preparations comprising an antigen such as tumor-associated antigens and viral antigens, together with a hydrophobized polysaccharide as adjuvant, e.g., hydrophobized polysaccharides containing a saccharide unit whose primary hydroxyl group is represented by the following formula: —O—(CH2)mCONH(CH2)nNH—CO—O—R wherein R represents an alkyl group or a sterol residue; m represents 0 or 1; and n represents an arbitrary positive integer, at a ratio of one to five units per 100 saccharide units that constitute the polysaccharide, preferably comprising an antigen encapsulated in microparticles of aggregated hydrophobized polysaccharide.
摘要翻译：包含抗原例如肿瘤相关抗原和病毒抗原的疫苗制剂连同疏水化多糖作为佐剂，例如含有主要羟基由下式表示的糖单元的疏水化多糖：-O-（CH 2）m CONH（ CH2）nNH-CO-OR，其中R表示烷基或固醇残基; m表示0或1; n表示任意的正整数，以构成多糖的每100个糖单元为1〜5个单位的比例，优选包含封装在聚集的疏水化多糖的微粒中的抗原。

3. 发明授权

US4636381A Coated ubidecarenone-containing liposome 失效
标题翻译：涂有含ubidecarenone的脂质体
公开(公告)号：US4636381A
公开(公告)日：1987-01-13
申请号：US497255
申请日：1983-05-19
申请人： Masahiro Takada , Teruaki Yuzuriha , Kouichi Katayama , Junzo Sunamoto
发明人： Masahiro Takada , Teruaki Yuzuriha , Kouichi Katayama , Junzo Sunamoto
IPC分类号： A61K9/127 , A61K31/12 , A61K9/10 , A61K9/52
CPC分类号： A61K9/1271 , A61K31/12 , A61K9/127
摘要： A coated ubidecarenone-containing liposome which comprises the ubidecarenone-containing liposome and a polysaccharide fatty acid ester applied on the surface of the membrane of said liposome, whereby the ubidecarenone can be selectively transferred in high concentrations to the lungs, spleen and kidneys.
摘要翻译：一种包含含ubidecarenone的脂质体，其包含含有含ubidecarenone的脂质体和应用于所述脂质体的膜表面的多糖脂肪酸酯，由此可将所述ubidecarenone以高浓度选择性转移至肺，脾脏和肾脏。

4. 发明申请

US20070042970A1 Folate-modified cholesterol-bearing pullulan as a drug carrier 审中-公开
标题翻译：叶酸修饰的含胆固醇的支链淀粉作为药物载体
公开(公告)号：US20070042970A1
公开(公告)日：2007-02-22
申请号：US11207888
申请日：2005-08-22
申请人： Junzo Sunamoto , Kazutoshi Ushio , Masaaki Hidaka
发明人： Junzo Sunamoto , Kazutoshi Ushio , Masaaki Hidaka
IPC分类号： A61K31/704 , A61K31/7076
CPC分类号： A61K31/704 , A61K9/5161 , A61K31/7076 , A61K47/551 , A61K47/554 , A61K47/61
摘要： Folate modified cholesterol-bearing pullulan (FA-CHP) was synthesized by the reaction of folic acid γ-2-aminoethylamide and 4-nitorophenyl chloroformate-activated cholesterol-bearing pullulan, wherein folate and pullulan are connected through a NH—CH2—CH2—NH group. Approximately 0.5-1 folates are connected per about 100 glycoside units of pullulan. Then, several combinations of FA-CHP, cholesterol-bearing pullulan (CHP) and doxorubicin (DOX) mixture were tested for cancer selective cytotoxicity. A mixture of FA-CHP, CHP and DOX of 1:4:0.02 (weight ratio) gave sharp and selective damage to cells of a human epidermoid cancer KB known as expressing a high level of folate receptor. The same mixture inhibited the growth of HuH7 cells, which is a human hepatocellular carcinoma and is unknown as a folate receptor.
摘要翻译：叶酸修饰的含胆固醇的支链淀粉（FA-CHP）通过叶酸γ-2-氨基乙酰胺和4-硝苯基氯甲酸酯活化的含胆固醇的支链淀粉的反应合成，其中叶酸和支链淀粉通过NH-CH 2个-CH 2 -NH基。每个约100个糖基单位的支链淀粉连接约0.5-1个叶酸盐。然后，测试FA-CHP，含胆固醇的支链淀粉（CHP）和多柔比星（DOX）混合物的几种组合的癌症选择性细胞毒性。 1：4：0.02（重量比）的FA-CHP，CHP和DOX的混合物对称为表达高水平叶酸受体的人表皮样癌细胞的细胞产生明显和选择性的损伤。相同的混合物抑制HuH7细胞的生长，HuH7细胞是人类肝细胞癌，并且作为叶酸受体是未知的。

5. 发明授权

US4997819A Fatty emulsion stabilized by a polysaccharide derivative 失效
标题翻译：通过多糖衍生物稳定的脂肪乳剂
公开(公告)号：US4997819A
公开(公告)日：1991-03-05
申请号：US439810
申请日：1989-11-21
申请人： Shigehiko Yamaguchi , Junzo Sunamoto
发明人： Shigehiko Yamaguchi , Junzo Sunamoto
IPC分类号： A23L29/10 , A23L29/269 , A61K9/10 , A61K9/107 , A61K47/36 , B01F17/00 , B01F17/56 , B01J13/00 , C08B37/00
CPC分类号： C08B37/0018 , A23L29/274 , A61K47/36 , B01F17/0028 , Y10S514/937 , Y10S514/938 , Y10S514/943
摘要： The invention is a fatty emulsion stabilized by a polysaccharide derivative, wherein the fatty emulsion contains a polysaccharide derivative which is substituted by a fatty acid or cholesterol at a proportion of 0.5-5 per 100 of sugar units.

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