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    • 71. 发明授权
    • Radio frequency-induced hyperthermia for tumor therapy
    • 射频诱导肿瘤治疗热疗
    • US4574782A
    • 1986-03-11
    • US553376
    • 1983-11-21
    • Nicholas F. BorrelliAlbert A. LudererGerald R. MansfieldJoseph N. Panzarino
    • Nicholas F. BorrelliAlbert A. LudererGerald R. MansfieldJoseph N. Panzarino
    • A61N1/40A61B17/52
    • A61N1/406
    • This invention is directed to a method for reducing the mass of a tumor in animal tissue utilizing localized, magnetically-coupled, RF-induced hyperthermia. The method involves the implanting of a material in and/or closely adjacent to the tumor which is non-toxic to, and preferably inert to and compatible with, normal tissue and which has encapsulated therewithin ferromagnetic particles of such size, amount, composition, and ferromagnetism to develop a heating value of up to about one watt/gram, through essentially only hysteresis heating, under an applied field of about 20 but less than 200 oersteds at a frequency greater than 10 kilohertz and ranging up to about 600 kilohertz, or under an applied field of at least about 2000 oersteds and a frequency below about 40 hertz. Such heating value is sufficient to kill the tumor cells but muscle and nerve response of the animal body to the induced emf is minimized.
    • 本发明涉及一种利用局部的磁耦合的RF诱导的高热来减少动物组织中肿瘤的质量的方法。 该方法包括在与正常组织无毒且优选为惰性和与之相容的肿瘤中和/或紧密邻近的植入材料,并且在其内封装有这样尺寸,数量,组成和 在大约10千赫,频率高达约600千赫的频率下,在约20但小于200奥斯特的施加电场下,通过基本上只有滞后加热来产生高达约1瓦特/克的发热值,或在下 至少约2000奥斯特的应用场和低于约40赫兹的频率。 这样的加热值足以杀死肿瘤细胞,但是动物身体对诱导的emf的肌肉和神经反应最小化。