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1. 发明授权

US4574782A Radio frequency-induced hyperthermia for tumor therapy 失效
标题翻译：射频诱导肿瘤治疗热疗
公开(公告)号：US4574782A
公开(公告)日：1986-03-11
申请号：US553376
申请日：1983-11-21
申请人： Nicholas F. Borrelli , Albert A. Luderer , Gerald R. Mansfield , Joseph N. Panzarino
发明人： Nicholas F. Borrelli , Albert A. Luderer , Gerald R. Mansfield , Joseph N. Panzarino
IPC分类号： A61N1/40 , A61B17/52
CPC分类号： A61N1/406
摘要： This invention is directed to a method for reducing the mass of a tumor in animal tissue utilizing localized, magnetically-coupled, RF-induced hyperthermia. The method involves the implanting of a material in and/or closely adjacent to the tumor which is non-toxic to, and preferably inert to and compatible with, normal tissue and which has encapsulated therewithin ferromagnetic particles of such size, amount, composition, and ferromagnetism to develop a heating value of up to about one watt/gram, through essentially only hysteresis heating, under an applied field of about 20 but less than 200 oersteds at a frequency greater than 10 kilohertz and ranging up to about 600 kilohertz, or under an applied field of at least about 2000 oersteds and a frequency below about 40 hertz. Such heating value is sufficient to kill the tumor cells but muscle and nerve response of the animal body to the induced emf is minimized.
摘要翻译：本发明涉及一种利用局部的磁耦合的RF诱导的高热来减少动物组织中肿瘤的质量的方法。该方法包括在与正常组织无毒且优选为惰性和与之相容的肿瘤中和/或紧密邻近的植入材料，并且在其内封装有这样尺寸，数量，组成和在大约10千赫，频率高达约600千赫的频率下，在约20但小于200奥斯特的施加电场下，通过基本上只有滞后加热来产生高达约1瓦特/克的发热值，或在下至少约2000奥斯特的应用场和低于约40赫兹的频率。这样的加热值足以杀死肿瘤细胞，但是动物身体对诱导的emf的肌肉和神经反应最小化。

2. 发明授权

US4297337A Solid-phase immunoassays using magnetic glass 失效
标题翻译：使用磁性玻璃的固相免疫测定
公开(公告)号：US4297337A
公开(公告)日：1981-10-27
申请号：US29576
申请日：1979-04-13
申请人： Gerald R. Mansfield , Karen L. Travis , William P. Vann
发明人： Gerald R. Mansfield , Karen L. Travis , William P. Vann
IPC分类号： H01F1/36 , G01N33/543 , G01N33/551 , G01N33/552 , G01N33/553 , G11B5/706 , G01N33/48 , G01T1/00
CPC分类号： G01N33/54326 , G11B5/70626 , Y10S436/804 , Y10S436/808 , Y10S436/817
摘要： Solid-phase immunoassay procedures employing magnetic glass or crystal-containing material, or a superparamagnetic material formed of magnetic particles dispersed in a non-magnetic matrix, as particulate carrier.
摘要翻译：使用磁性玻璃或含晶体的材料或由分散在非磁性基质中的磁性颗粒形成的超顺磁性材料作为颗粒载体的固相免疫测定方法。

3. 发明授权

US4395271A Method for making porous magnetic glass and crystal-containing structures 失效
标题翻译：制造多孔磁性玻璃和含晶体结构的方法
公开(公告)号：US4395271A
公开(公告)日：1983-07-26
申请号：US148260
申请日：1980-05-09
申请人： George H. Beall , Gerald R. Mansfield , Jan W. H. Schreurs
发明人： George H. Beall , Gerald R. Mansfield , Jan W. H. Schreurs
IPC分类号： B03C1/01 , C03C3/089 , C03C10/00 , C03C11/00 , H01F1/37 , C03C3/22 , C03C15/00
CPC分类号： B03C1/01 , C03C10/0081 , C03C11/005 , C03C3/089 , H01F1/37
摘要： The present invention provides a method for making porous bodies of magnetic glass and/or crystal-containing materials having magnetic crystals incorporated therein with dimensions less than about 1000A. Preferably, the crystals have dimensions less than 500A such that the porous bodies demonstrate essential superparamagnetic behavior. The method involves preparing a body which, upon heat treatment, will separate into at least two vitreous phases and at least one crystal phase. One of the vitreous phases is etched away leaving a structure remaining which contains said magnetic crystals. When present as fine particles, the porous magnetic bodies are especially suitable for use in biological assays.
摘要翻译：本发明提供了一种制造具有小于约1000A的尺寸的磁性玻璃和/或含晶体材料的多孔体的方法，该方法结合有磁性晶体。优选地，晶体的尺寸小于500A，使得多孔体显示出基本的超顺磁性。该方法包括制备在热处理时将分离成至少两个玻璃相和至少一个结晶相的主体。蚀刻玻璃质相中的一个，剩下包含所述磁性晶体的结构。当作为细颗粒存在时，多孔磁性体特别适用于生物测定。

4. 发明授权

US4248174A Control system for a slide centrifuge 失效
标题翻译：滑动离心机控制系统
公开(公告)号：US4248174A
公开(公告)日：1981-02-03
申请号：US21768
申请日：1979-03-19
申请人： Robert C. Beaty , Gerald R. Mansfield
发明人： Robert C. Beaty , Gerald R. Mansfield
IPC分类号： G01N1/28 , G01N21/00 , B05C11/02 , G01N21/24
CPC分类号： G01N1/2813 , G01N2001/2846
摘要： A control system for a slide centrifuge includes a ratio checking circuit which produces a signal when the ratio between the light passing through the slide and the rate of change of this light passes through a predetermined critical value. When this ratio passes through the critical valve, spinning is stopped. This effectively stops spinning when the rate of reduction of blood cell density on the slide slows, thereby producing better slides for clinical analysis.
摘要翻译：用于滑动离心机的控制系统包括比例检查电路，当比较通过滑块的光与该光的变化率之间的比率通过预定的临界值时，产生信号。当该比例通过临界阀时，停止旋转。当载玻片上血细胞密度降低的速度减慢时，可有效地停止旋转，从而生成更好的载玻片进行临床分析。

5. 发明授权

US4233169A Porous magnetic glass structure 失效
标题翻译：多孔磁性玻璃结构
公开(公告)号：US4233169A
公开(公告)日：1980-11-11
申请号：US29577
申请日：1979-04-13
申请人： George H. Beall , Gerald R. Mansfield , Jan W. H. Schreurs
发明人： George H. Beall , Gerald R. Mansfield , Jan W. H. Schreurs
IPC分类号： H01F1/34 , C03B32/02 , C03C3/06 , C03C3/064 , C03C3/072 , C03C3/089 , C03C3/097 , C03C3/108 , C03C4/00 , C03C10/00 , C03C10/02 , C03C10/04 , C03C11/00 , C03C15/00 , H01F1/37 , C03C3/22 , C04B35/26
CPC分类号： C03C10/0081 , C03C11/005 , C03C3/089 , H01F1/37 , Y10S428/90 , Y10T428/2982
摘要： The present invention provides a method for making porous bodies of magnetic glass and/or crystal-containing materials having magnetic crystals incorporated therein with dimensions less than about 1000A. Preferably, the crystals have dimensions less than 500A such that the porous bodies demonstrate essential superparamagnetic behavior. The method involves preparing a body which, upon heat treatment, will separate into at least two vitreous phases and at least one crystal phase. One of the vitreous phases is etched away leaving a structure remaining which contains said magnetic crystals. When present as fine particles, the porous magnetic bodies are especially suitable for use in biological assays.
摘要翻译：本发明提供了一种制造具有小于约1000A的尺寸的磁性玻璃和/或含晶体材料的多孔体的方法，该方法结合在其中。优选地，晶体的尺寸小于500A，使得多孔体显示出基本的超顺磁性。该方法包括制备在热处理时将分离成至少两个玻璃相和至少一个结晶相的主体。蚀刻玻璃质相中的一个，剩下包含所述磁性晶体的结构。当作为细颗粒存在时，多孔磁性体特别适用于生物测定。

6. 发明授权

US4183973A Control system for a slide centrifuge 失效
标题翻译：滑动离心机控制系统
公开(公告)号：US4183973A
公开(公告)日：1980-01-15
申请号：US895595
申请日：1978-04-12
申请人： Robert C. Beaty , Gerald R. Mansfield
发明人： Robert C. Beaty , Gerald R. Mansfield
IPC分类号： B04B5/04 , B04B9/10 , G01N1/28 , G01N21/00 , G01N21/24
CPC分类号： B04B9/10 , B04B5/04 , G01N1/2813 , G01N2001/2846
摘要： A control system for a slide centrifuge includes a ratio checking circuit which produces a signal when the ratio between the light passing through the slide and the rate of change of this light passes through a predetermined critical value. When this ratio passes through the critical value, spinning is stopped. This effectively stops spinning when the rate of reduction of blood cell density on the slide slows, thereby producing better slides for clinical analysis.
摘要翻译：用于滑动离心机的控制系统包括比例检查电路，当比较通过滑块的光与该光的变化率之间的比率通过预定的临界值时，产生信号。当该比率通过临界值时，停止旋转。当载玻片上血细胞密度降低的速度减慢时，可有效地停止旋转，从而生成更好的载玻片进行临床分析。

7. 发明授权

US4420689A Multi-anode deep well radiation detector 失效
标题翻译：多阳极深井辐射探测器
公开(公告)号：US4420689A
公开(公告)日：1983-12-13
申请号：US333629
申请日：1981-12-22
申请人： Arthur H. Rogers , Kevin J. Sullivan , Gerald R. Mansfield
发明人： Arthur H. Rogers , Kevin J. Sullivan , Gerald R. Mansfield
IPC分类号： G01T1/18 , H01J47/06
CPC分类号： H01J47/065
摘要： An inner and outer cylindrical cathode are concentrically positioned about a vertical center axis. Vertical anode electrodes extend parallel to the center axis and are symmetrically arranged around the inter-cylinder space between the cathodes. The ends of the anode wires are supported by a pair of insulator rings mounted near the top and bottom of the cathode cylinders. A collection voltage applied to each anode wire for establishing an inward radial E field to the inner cathode cylinder and an outward radial E field to the outer cathode cylinder. The anode-cathode assembly is mounted within a housing containing a conversion gas. A radioactive sample is inserted into the inner cathode which functions as a tubular, deep well radiation window between the sample environment and the conversion gas environment. A portion of the gamma radiations passing through the inter-cylinder region interact with the conversion gas to produce free electrons which are accelerated by the E fields and collected on the anode wires. The extremely small diameter of the anode wires intensifies the electric fields proximate each wire causing avalanche multiplication of the free electrons resulting in a detectable charge pulse.
摘要翻译：内圆柱形阴极和外圆柱形阴极围绕垂直中心轴线同心定位。垂直阳极电极平行于中心轴线延伸，并且围绕阴极之间的气缸间间隔对称地布置。阳极线的端部由安装在阴极筒的顶部和底部附近的一对绝缘体环支撑。施加到每个阳极线的收集电压，以建立到内阴极筒的向内径向E场和向外部阴极筒的向外径向E场。阳极 - 阴极组件安装在包含转化气体的壳体内。将放射性样品插入内阴极，其作用在样品环境和转化气体环境之间的管状深井辐射窗口。通过气缸间区域的伽马辐射的一部分与转化气体相互作用以产生由E场加速并收集在阳极线上的自由电子。阳极线的非常小的直径增强了每个线附近的电场，导致自由电子的雪崩倍增，产生可检测的充电脉冲。

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