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71. 发明授权

US4704469A Preparation of halogenated phenols 失效
标题翻译：卤化酚的制备
公开(公告)号：US4704469A
公开(公告)日：1987-11-03
申请号：US684733
申请日：1984-12-21
申请人： Francesco D. Valle , Aurelio Romeo
发明人： Francesco D. Valle , Aurelio Romeo
IPC分类号： C07C69/84 , C07C27/00 , C07C35/14 , C07C37/62 , C07C39/24 , C07C39/27 , C07C39/28 , C07C39/367 , C07C39/42 , C07C41/01 , C07C43/225 , C07C43/23 , C07C51/00 , C07C65/03 , C07C67/00 , C07C213/00 , C07C213/08 , C07C215/76 , C07C215/78 , C07C301/00 , C07C303/06 , C07C303/22 , C07C303/32 , C07C309/28 , C07C309/42 , C07C69/76
CPC分类号： C07C37/62 , C07C309/00 , C07C37/00
摘要： A method for the preparation of 2-halogenoresorcinols having the following formula I ##STR1## where X represents a halogen atom and R and R.sub.1 may be the same or different and represent a hydrogen atom or a free organic functional or functionally modified group or a hydrocarbon group, which may be substituted by one or more free organic functional or functionally modified groups and R and R.sub.1 jointly may also represent a free organic functional or functionally modified group or a hydrocarbon group which may be substituted by one or more free organic functional or functionally modified groups, and esters, ethers, or salts thereof.The method comprises sulfonating the corresponding resorcinols which do not contain a halogen in the 2-position and then halogenating the sulfonic acids thus obtained. The halogenated sulfonic acids thereby obtained are subsequently protodesulfonated by acid hydrolysis and, if desired, any functional groups which may be present can be modified.
摘要翻译：一种制备具有下式I的2-卤代半乳糖的方法，其中X表示卤素原子，R和R 1可以相同或不同，表示氢原子或游离的有机官能或官能改性基团或可以被一个或多个游离的有机官能或功能修饰的基团取代的烃基，R和R 1共同表示可以被一个或多个游离有机官能团或官能改性的基团取代的游离有机官能团或官能改性基团或烃基，官能改性基团，以及酯，醚或其盐。该方法包括在2-位上磺化对应不含卤素的间苯二酚，然后卤化如此获得的磺酸。由此获得的卤代磺酸随后通过酸水解进行原磺化，如果需要，可以改变可能存在的任何官能团。

72. 发明授权

US4349566A Treatment of arrhythmia with 8-chloro- or 8-bromocoumarin derivatives 失效
标题翻译：用8-氯或8-溴香豆素衍生物治疗心律不齐
公开(公告)号：US4349566A
公开(公告)日：1982-09-14
申请号：US185893
申请日：1980-09-10
申请人： Francesco della Valle
发明人： Francesco della Valle
IPC分类号： A61K31/365 , A61K31/37
CPC分类号： A61K31/365 , Y10S514/821
摘要： A method of treating arrhythmia in mammals which comprises administering 8-chloro- or 8-bromo-3-(.beta.-diethylaminoethyl)-4-methyl-7-ethoxycarbonylmethoxycoumarin (or a pharmaceutically acceptable salt thereof) thereto. When formulated in conventional pharmaceutical preparations, the active ingredient may be administered orally or endovenously.
摘要翻译：一种治疗哺乳动物心律失常的方法，其包括给予8-氯代或8-溴-3-（β-二乙基氨基乙基）-4-甲基-7-乙氧基羰基甲氧基香豆素（或其药学上可接受的盐）。当配制在常规药物制剂中时，活性成分可以口服或内服给药。

73. 发明授权

US10488843B2 Method and system for checking positioning accuracy of a CNC machine 有权
公开(公告)号：US10488843B2
公开(公告)日：2019-11-26
申请号：US15037289
申请日：2015-02-25
申请人： FIDIA S.P.A.
发明人： Mario Vesco , Giuseppe Morfino
IPC分类号： G05B19/401 , G01C5/04 , G01F23/00
CPC分类号： G05B19/401 , G01C5/04 , G01F23/00 , G05B2219/37506 , G05B2219/49195 , G05B2219/50046
摘要： A method for checking positioning accuracy of a CNC machine with a machine tool head and a machine table using an x, y, z coordinate system, the method comprising:

a) arranging a plurality of vessels on the table, the vessels in fluid connection with each other to form a system of vessels, the vessels filled with a liquid,
b) mounting a distance sensor to the tool head,
c) positioning the tool head to a position above the surface of the liquid in one of the vessels,
d) a determining the z coordinate for which the distance sensor touches the surface of the liquid,

or,
for a predetermined position of the tool head in z direction above the liquid, determining the distance between the distance sensor and the liquid;
steps c) and d) are repeated for each vessel to determine a z coordinate of the surface of the liquid.

74. 发明申请

US20130121701A1 OPTICALLY-CONNECTED SYSTEM FOR EXCHANGING DATA AMONG INDUSTRIAL AUTOMATION DEVICES 审中-公开
标题翻译：用于在工业自动化设备中交换数据的光学连接系统
公开(公告)号：US20130121701A1
公开(公告)日：2013-05-16
申请号：US13737571
申请日：2013-01-09
申请人： FIDIA S.P.A.
发明人： Giuseppe Morfino
IPC分类号： H04B10/00
CPC分类号： H04B10/1143 , H04B10/1149 , H04B10/801
摘要： An optically-connected system is disclosed for exchanging data among industrial automation devices, that is composed of a plurality of connection elements, where each element comprises at least two pairs of optical transmitters and receivers on the main side, and one optical receiver on the opposing main side, that are opposite with respect to another pair of transmitters and receivers in a following element; and where each one of the transmitters and receivers is adapted to communicate with industrial automation devices to cooperate for exchanging data between elements, sending one interrogation signal requesting an identity of the receiver and the receiver is adapted to send to each corresponding response signal containing characteristics of the receiver.
摘要翻译：公开了一种用于在工业自动化设备之间交换数据的光学连接系统，其由多个连接元件组成，其中每个元件包括在主侧上的至少两对光发射器和接收器，以及在相对的一个上的一个光接收器主侧相对于下一个元件中的另一对发射器和接收器相反; 并且其中发射器和接收器中的每一个适于与工业自动化设备通信以协作用于在元件之间交换数据，发送请求接收器的身份的一个询问信号和接收器适于发送到每个对应的响应信号，该响应信号包含收件人。

75. 发明申请

US20120290122A1 PREDICTIVE CONTROL AND VIRTUAL DISPLAY SYSTEM FOR A NUMERICALLY CONTROLLED MACHINE TOOL 有权
标题翻译：一种数控机床的预测控制和虚拟显示系统
公开(公告)号：US20120290122A1
公开(公告)日：2012-11-15
申请号：US13561334
申请日：2012-07-30
申请人： Giuseppe MORFINO , Carla FRANCESE , Mario VESCO , Edoardo GHEZZO
发明人： Giuseppe MORFINO , Carla FRANCESE , Mario VESCO , Edoardo GHEZZO
IPC分类号： G05B19/19
CPC分类号： G05B19/4069 , G05B2219/32351 , G05B2219/35304 , G05B2219/35306 , G05B2219/35311 , Y02P90/26
摘要： A numerically controlled machine tool, and method for control thereof, to display virtual two-dimensional future positions to be adopted by a workpiece and by the machine tool in a pre-set predictive time window. The system and method calculate target coordinate values defining positions of the tool along axes of the machine tool on the basis of a machining program. While machining is in progress, a processor receives the calculated target coordinate values to generate and display image data on the basis of the target coordinate values and of stored mathematical models of the machine, of the workpiece, and of the tool.
摘要翻译：一种数控机床及其控制方法，用于在预设的预测时间窗口中显示由工件和机床采用的虚拟二维未来位置。系统和方法基于加工程序计算沿机床轴线定义刀具位置的目标坐标值。在加工过程中，处理器接收计算出的目标坐标值，以根据目标坐标值和机器，工件和工具的存储数学模型生成和显示图像数据。

76. 发明申请

US20030153517A1 Therapeutic use of ganglioside GM1 in the treatment of spinal cord injury 失效
公开(公告)号：US20030153517A1
公开(公告)日：2003-08-14
申请号：US10125810
申请日：2002-04-18
申请人： Fidia, S.p.A.
发明人： Gino Toffano , Alberta Leon , Marino Massarotti
IPC分类号： A61K031/726 , A61K031/57
CPC分类号： A61K31/70
摘要： The invention relates to a method for amelioration of neurological outcome in humans with spinal cord damage by administration of ganglioside GM1. Another object of the present invention is to provide combination therapies for the treatment of spinal cord damage comprised of the administration of the ganglioside GM1 and other drugs which have therapeutical benefit in patients with spinal cord damage, preferably methylprednisolone.

77. 发明授权

US5930143A Equipment for measuring the dimensions of tools of machines for mechanical working 失效
标题翻译：用于测量机械加工机床的尺寸的设备
公开(公告)号：US5930143A
公开(公告)日：1999-07-27
申请号：US942537
申请日：1997-10-01
申请人： Ezio Savazzi
发明人： Ezio Savazzi
IPC分类号： B23Q1/48 , B23Q17/09 , B23Q17/22 , B23Q17/24 , B23Q37/00 , G05B19/401 , G01B11/02
CPC分类号： B23Q17/09 , B23Q1/4809 , B23Q17/2233 , B23Q17/24 , B23Q37/00
摘要： The equipment comprises a main support structure fixable close to the machine and in which a laser source is mounted, and a receiver for providing electrical signals indicative of the strength of laser radiation received. The receiver, in use, is located facing the source at a predetermined distance therefrom so that a field of measurement is defined between them across which the laser beam extends and in which a tool to be measured is movable so as to intercept the laser beam. The receiver is carried by an auxiliary structure connected to the main support structure and movable relative thereto between a retracted rest position, in which the structures present a minimum overall bulk and an extended working position in which the receiver is located facing the source.
摘要翻译：该设备包括可靠近机器固定的主支撑结构，其中安装有激光源，以及接收器，用于提供指示所接收的激光辐射的强度的电信号。使用中的接收器位于与预定距离相对的源处，使得在它们之间限定了激光束延伸的测量区域，并且被测量的工具可移动以便截取激光束。接收器由连接到主支撑结构的辅助结构承载，并且在缩回静止位置之间相对于其移动，其中结构呈现最小总体积和延伸的工作位置，在该延伸工作位置中接收器面向源。

78. 发明授权

US5925626A Hyaluronic acid fractions having pharmaceutical activity, and pharmaceutical compositions containing the same 失效
$Hyaluronic acid fractions having pharmaceutical activity, and pharmaceutical compositions containing the same$
标题翻译：具有药物活性的透明质酸馏分和含有它们的药物组合物
公开(公告)号：US5925626A
公开(公告)日：1999-07-20
申请号：US471016
申请日：1995-06-06
申请人： Francesco della Valle , Aurelio Romeo
发明人： Francesco della Valle , Aurelio Romeo
IPC分类号： C08B37/08 , A61K20060101 , A61K9/00 , A61K9/08 , A61K31/715 , A61K38/18 , A61K45/06 , A61K47/36 , A61P17/00 , A61P27/02 , A61P29/00 , A61P43/00 , C07C20060101 , C08B33/08 , C12S3/02 , A61K31/70 , C07H5/04
CPC分类号： A61K9/0014 , A61K31/715 , A61K38/1808 , A61K45/06 , A61K47/36 , A61K9/0019 , A61K9/0048 , C08B37/0072
摘要： Two pharmaceutically useful fractions of hyaluronic acid are obtained comprising a first fraction with a molecular weight between 50,000 and 100,000 which is useful for wound healing, and a second fraction having a molecular weight between 500,000 and 730,000 which is useful for intraocular and intraarticular injections.
摘要翻译：获得透明质酸的两种药学上可用的级分，其包含分子量在50,000和100,000之间的用于伤口愈合的第一级分，以及分子量在500,000和730,000之间的第二级分，其用于眼内和关节内注射。

79. 发明授权

US5849717A O-sulfated gangliosides and lyso-ganglioside derivatives 失效
标题翻译： O-硫酸化神经节苷脂和溶血神经节苷脂衍生物
公开(公告)号：US5849717A
公开(公告)日：1998-12-15
申请号：US530275
申请日：1996-01-31
申请人： Aurelio Romeo , Gunter Kirschner , Carlo Chizzolini , Hari Manev , Laura Facci
发明人： Aurelio Romeo , Gunter Kirschner , Carlo Chizzolini , Hari Manev , Laura Facci
IPC分类号： C07H15/10 , A61K31/70 , C07H15/00
CPC分类号： C07H15/10
摘要： Disclosed are derivatives of gangliosides and of N-acyl-N-lyso-gangliosides, of N'-acyl-N'-lyso-gangliosides and N,N'-di- or poly-acyl-N,N'-di-lyso-gangliosides, in which at least one of the hydroxyl groups in the saccharide, sialic or ceramide residues is esterified with sulfuric acid, functional derivatives thereof, and their salts with either inorganic or organic bases and the acid addition salts, except persulfated derivatives at the hydroxyl, sialic and ceramide groups of the GM.sub.1, GD.sub.1a, GD.sub.1b and GT.sub.1b gangliosides. Such compounds have antineurotoxic and neurotogenic activity and may therefore be used in pharmaceutical preparations. Also a marked modulating effect on the expression of the CD.sub.4 molecule in immune system cells has been shown.
摘要翻译： PCT No.PCT / US94 / 01965。 371日期1996年1月31日 102（e）日期1996年1月31日PCT 1994年3月4日PCT公布。出版物WO94 / 20515 PCT 日期1994年9月15日公开是神经节苷脂和N-酰基-N-溶解神经节苷脂的衍生物，N'-酰基-N'-溶解神经节苷脂和N，N'-二 - 或多酰基-N，N 其中糖，唾液酸或神经酰胺残基中的至少一个羟基被硫酸酯化，其功能衍生物及其与无机或有机碱和酸加成盐形成的盐 - 二溶神经节苷脂，除了GM1，GD1a，GD1b和GT1b神经节苷脂的羟基，唾液酸和神经酰胺基团的过硫酸化衍生物外。这些化合物具有抗神经毒性和神经生成活性，因此可用于药物制剂。已经显示出对免疫系统细胞中CD4分子的表达的显着调节作用。

80. 发明授权

US5792858A Lysosphingolipid derivatives 失效
公开(公告)号：US5792858A
公开(公告)日：1998-08-11
申请号：US628344
申请日：1996-04-05
申请人： Francesco Della Valle , Aurelio Romeo
发明人： Francesco Della Valle , Aurelio Romeo
IPC分类号： A61K31/16 , A61K31/275 , A61K31/685 , A61K31/70 , A61K31/7028 , A61P25/00 , A61P25/28 , C07C215/24 , C07C233/18 , C07C233/20 , C07C235/08 , C07C237/22 , C07C255/19 , C07C323/58 , C07F9/10 , C07H15/04 , C07H15/10 , C07H11/00 , C07F9/02
CPC分类号： C07H15/04 , C07C215/24 , C07C233/18 , C07C233/20 , C07C235/08 , C07C237/22 , C07C255/19 , C07C323/58 , C07F9/10 , C07H15/10
摘要： Novel derivatives of lysophingolipids free from sialic acids which are N-acyllysosphingolipids having one of the two formulae: ##STR1## in which -A- stands for the group --CH.dbd.CH-- or --CH.sub.2 --CH.sub.2 --, n.sub.1 is a whole number of between 6 and 18, n.sub.2 is a whole number of between 11 and 15, X is a hydrogen atom or the residue of a monosaccharide or a disaccharide or phosphorylcholine and R represents an alkyl radical derived from a saturated or unsaturated aliphatic carboxylic acid having from 2 to 24 carbon atoms substituted by one or more polar groups. The lysosphingolipid derivatives of the invention exhibit an inhibiting action on protein-kinase C activation and, thus, can be utilized in therapies for various pathologies of the nervous system.

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