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61. 发明授权

US5503973A Method for inhibition of viral morphogenesis 失效
标题翻译：抑制病毒形态发生的方法
公开(公告)号：US5503973A
公开(公告)日：1996-04-02
申请号：US890754
申请日：1992-05-29
申请人： Jeffrey Glenn
发明人： Jeffrey Glenn
IPC分类号： C12N7/04 , A61K31/365 , A61K38/00 , A61K45/00 , A61P31/12 , C07K14/005 , C07K14/08 , C12N7/06 , C12Q1/02 , C12Q1/18 , C12Q1/68 , G01N33/15 , G01N33/50 , G01N33/569 , G01N33/576 , C12Q1/70 , C12N7/01 , A61K35/76
CPC分类号： G01N33/502 , A61K31/365 , A61K38/005 , C07K14/005 , C12N7/00 , C12Q1/18 , C12Q1/6897 , G01N33/5008 , G01N33/5097 , G01N33/56983 , G01N33/5765 , C12N2770/24222 , C12N2770/24263
摘要： Viral morphogenesis, in particular hepatitis D viral morphogenesis, may be inhibited by effecting inhibition of prenylation of at least one viral protein. The use of inhibitors of prenylation, in particular, inhibitors of the mevalonic synthesis pathway and mimics of the prenylation target CXXX (SEQ ID NO:1) box are disclosed.
摘要翻译：病毒形态发生，特别是丙型肝炎病毒形态发生，可能通过抑制至少一种病毒蛋白的异戊烯基化来抑制。公开了使用异戊烯基化抑制剂，特别是甲羟戊酸合成途径的抑制剂和异戊烯化靶向CXXX（SEQ ID NO：1）盒的模拟物。

62. 发明授权

US5501948A Stabilized hepatitis B e antigen suitable for immunoassays 失效
标题翻译：稳定乙型肝炎e抗原适用于免疫测定
公开(公告)号：US5501948A
公开(公告)日：1996-03-26
申请号：US254475
申请日：1994-06-06
申请人： Daniel J. Hicklin , Charles T. Tackney , Harlan W. Waksal
发明人： Daniel J. Hicklin , Charles T. Tackney , Harlan W. Waksal
IPC分类号： C07K14/02 , G01N33/576 , C12Q1/70
CPC分类号： C07K14/005 , G01N33/5762 , C12N2730/10122 , Y10S436/82
摘要： Methods and materials for producing hepatitis virus HBe antigenic proteins useful in immunoassays without the necessity of maintaining these proteins in denaturing environments are disclosed. Assay methods and materials utilizing these HBe proteins are also provided.
摘要翻译：公开了用于免疫测定的肝炎病毒HBe抗原蛋白的生产方法和材料，而不需要在变性环境中维持这些蛋白质。还提供了使用这些HBe蛋白的测定方法和材料。

63. 发明授权

US5445932A Method for detection of a new marker associated with hepatitis delta virus infection 失效
标题翻译：检测与丙型肝炎病毒感染相关的新标记的方法
公开(公告)号：US5445932A
公开(公告)日：1995-08-29
申请号：US976358
申请日：1992-11-17
申请人： Howard A. Fields , Yuri Khudyakov , Michael Favorov
发明人： Howard A. Fields , Yuri Khudyakov , Michael Favorov
IPC分类号： A61K39/00 , C07K14/08 , G01N33/576 , C12Q1/70
CPC分类号： C07K14/005 , G01N33/5767 , A61K39/00 , C12N2760/10122 , Y10S436/82
摘要： Reagents and methods for the detection of a marker which is associated with severe forms of hepatitis delta virus infection are described. A vaccine comprising immunogenically active HDAg' polypeptides is also described.
摘要翻译：描述了用于检测与严重形式的乙型肝炎病毒感染相关的标记物的试剂和方法。还描述了包含免疫原性活性HDAg'多肽的疫苗。

64. 发明授权

US5437974A DNA sequence and encoded polypeptide useful in the diagnosis of hepatitis disease 失效
标题翻译： DNA序列和编码的多肽可用于诊断肝炎病毒
公开(公告)号：US5437974A
公开(公告)日：1995-08-01
申请号：US833838
申请日：1992-02-04
申请人： Terence E. Ryan , Badr Saeed , Mark K. Kieselburg , Robert E. Byrne , Priscilla W. Stevens , Terukatsu Arima , John Todd
发明人： Terence E. Ryan , Badr Saeed , Mark K. Kieselburg , Robert E. Byrne , Priscilla W. Stevens , Terukatsu Arima , John Todd
IPC分类号： A61K39/29 , A61K39/00 , A61K39/395 , A61P31/12 , C07K14/005 , C07K14/02 , C07K14/10 , C07K14/18 , C07K16/00 , C12N1/21 , C12N15/09 , C12P21/02 , C12Q1/68 , C12Q1/70 , C12R1/19 , G01N33/53 , G01N33/576
CPC分类号： G01N33/5767 , C07K14/005 , C12Q1/707 , A61K39/00 , C12N2770/24222 , Y10S436/82
摘要： A novel cDNA clone, 20E, has been isolated and characterized as encoding a previously unknown polypeptide antigen recognized by antibodies in the serum of certain patients with non-A non-B hepatitis (NANBH). The nucleic acid sequence is not represented in the genome of the Hepatitis C Virus (HCV). Neither is the nucleic acid sequence represented in the human genome. The data suggest that the RNA sequence corresponding to clone 20E is contained within the genome of an external infective agent other than HCV, and therefore may represent an additional etiologic agent or contributing factor to the development of NANBH in human patients. The 20E nucleic acid and corresponding polypeptide and respective variants thereof will be useful in a variety of procedures directed at prevention and diagnosis of NANBH.
摘要翻译：已经分离了一种新的cDNA克隆20E，并将其表征为编码在某些非A非乙型肝炎（NANBH）患者的血清中由抗体识别的先前未知的多肽抗原。核酸序列不在丙型肝炎病毒（HCV）的基因组中表示。核酸序列也不在人类基因组中表示。数据表明，对应于克隆20E的RNA序列被包含在HCV以外的外部感染因子的基因组中，因此可能代表另外的病原体或人类患者中NANBH发展的促成因子。 20E核酸和相应的多肽及其相应变体可用于针对NANBH的预防和诊断的多种方法。

65. 发明授权

US5350671A HCV immunoassays employing C domain antigens 失效
标题翻译： HCV免疫测定采用C结构域抗原
公开(公告)号：US5350671A
公开(公告)日：1994-09-27
申请号：US103961
申请日：1993-08-09
申请人： Michael Houghton , Qui-Lim Choo , George Kuo
发明人： Michael Houghton , Qui-Lim Choo , George Kuo
IPC分类号： A61K39/00 , C07K14/18 , C07K16/10 , C12Q1/68 , C12Q1/70 , G01N33/576 , C12G1/70 , A61K37/02 , G01N33/543 , C12G1/68
CPC分类号： G01N33/5767 , C07K14/005 , C07K16/109 , C12Q1/701 , C12Q1/707 , A61K39/00 , C07K2319/02 , C07K2319/40 , C12N2770/24222 , Y10S435/975 , Y10S530/812 , Y10S530/826 , Y10S930/223
摘要： Immunoassays for the detection of antibodies to HCV are provided which employ "C" domain antigens. Immunoassay kits comprising such antigens are also provided.
摘要翻译：提供用于检测HCV抗体的免疫测定法，其使用“C”结构域抗原。还提供了包含这种抗原的免疫测定试剂盒。

66. 发明授权

US5316936A Method for preparation of human serum albumin-sensitized sheep erythrocytes (HSA-cell) for detection of pre-S2 antigen 失效
标题翻译：用于检测前S2抗原的人血清白蛋白致敏羊红细胞（HSA细胞）的制备方法
公开(公告)号：US5316936A
公开(公告)日：1994-05-31
申请号：US752850
申请日：1991-08-30
申请人： Jin-Nam Ko , On-Sun Pak
发明人： Jin-Nam Ko , On-Sun Pak
IPC分类号： G01N33/50 , G01N33/576 , A61K35/18
CPC分类号： G01N33/5761 , G01N33/5005 , Y10S436/82
摘要： A method for preparation in a large quantity of human serum albumin-sensitized sheep erythrocytes is described. The sensitized cells are useful for detecting Hepatitis B virus pre-S.sub.2 antigen. The method uses human serum albumin sensitized glutaraldehyde-fixed, sheep erythrocytes in the presence of chromium chloride.
摘要翻译：描述了用于制备大量人血清白蛋白致敏的绵羊红细胞的方法。致敏细胞可用于检测乙型肝炎病毒前S2抗原。该方法使用人血清白蛋白敏化戊二醛固定，绵羊红细胞在氯化铬存在下。

67. 发明授权

US5290684A Permanent human hepatocyte cell line and its use in a liver assist device (LAD) 失效
标题翻译：永久性人肝细胞系及其在肝辅助装置（LAD）中的应用
公开(公告)号：US5290684A
公开(公告)日：1994-03-01
申请号：US965448
申请日：1992-10-23
申请人： James H. Kelly
发明人： James H. Kelly
IPC分类号： C12N3/00 , A61F2/02 , A61M1/36 , C12M3/00 , C12N5/071 , C12N5/09 , C12Q1/18 , C12Q1/70 , G01N33/50 , G01N33/576 , C12Q1/02 , C12N5/00
CPC分类号： A61F2/022 , C12N5/067 , C12N5/0693 , G01N33/5008 , G01N33/576
摘要： Permanent cell lines are provided which display liver-specific biological activity at a level effective to support a subject suffering from hepatic failure or insufficiency. The cells find use in treating various liver disorders. An example of the cell lines is HepG2/C3A deposited under ATCC No. CRL-10741. Methods for use of the cells in liver assist devices and methods for producing liver assist devices are also provided.
摘要翻译：提供永久性细胞系，其显示肝脏特异性生物活性，其水平有效地支持患有肝衰竭或功能不全的受试者。细胞可用于治疗各种肝脏疾病。细胞系的一个实例是根据ATCC编号CRL-10741保藏的HepG2 / C3A。还提供了在肝辅助装置中使用细胞的方法和用于产生肝脏辅助装置的方法。

68. 发明授权

US5244630A Device for performing solid-phase diagnostic assay 失效
标题翻译：用于进行固相诊断测定的装置
公开(公告)号：US5244630A
公开(公告)日：1993-09-14
申请号：US425651
申请日：1989-10-23
申请人： Omar S. Khalil , Charles F. Hanna , Denise G. Huff , Thomas F. Zurek
发明人： Omar S. Khalil , Charles F. Hanna , Denise G. Huff , Thomas F. Zurek
IPC分类号： B01L3/00 , C12M1/34 , G01N21/78 , G01N33/543 , G01N33/576 , G01N33/94 , G01N35/02 , G01N35/10
CPC分类号： B01L3/50255 , G01N33/54313 , G01N33/54366 , G01N33/5762 , G01N33/94 , G01N35/1002 , B01L2300/069 , B01L2300/0829 , B01L2400/0406 , Y10S435/805 , Y10T436/255 , Y10T436/2575
摘要： A disposable device suitable for performing automated solid-phase diagnostic assays which employs microparticles to complex an analyte and where the microparticle complex becomes retained and immobilized on a fibrous matrix such that the presence of analyte on the microparticles can be detached by optical means. A device is disclosed having a plurality of well pairs comprising a sample well for receiving a sample and reagents for forming a reaction mixture, a read well comprising (a) an entrance port and holder for receiving and holding a quantity of sample and assay reagents, (b) a fibrous matrix for retaining and immobilizing microparticle/analyte complexes for detection, said fibrous matrix positioned below said holder, and having an average spatial separation of fibers greater than the average diameter of said microparticles, (c) absorbent material positioned below said fibrous matrix for assisting the flow of sample and assay reagents through said fibrous matrix, (d) walls or ribs for creating a substantially light-tight real surrounding the wells, (e) a vent for venting air entrapped in the absorbent material and which is displaced by fluids absorbed therein, and (f) a passage between the sample well and the read well whereby sample and reaction mixtures can be transferred and washed from said sample well into said read well without being contacted by any apparatus.
摘要翻译：一种适用于执行自动化固相诊断测定的一次性装置，其使用微粒来复合分析物，并且其中微粒复合物保留并固定在纤维基质上，使得微粒上的分析物的存在可以通过光学方式分离。公开了一种具有多个阱对的装置，其包括用于接收样品的样品阱和用于形成反应混合物的试剂，读数井包括（a）用于接收和保持一定量样品和测定试剂的入口和保持器，（b）用于保持和固定用于检测的微粒/分析物复合物的纤维基质，所述纤维基质位于所述保持器下方，并且具有大于所述微粒平均直径的纤维的平均空间分离，（c）位于所述用于辅助样品和测定试剂通过所述纤维基质流动的纤维基质，（d）用于产生围绕所述孔的基本上不透光的真空的壁或肋，（e）用于排出被捕获在吸收材料中的空气的通风口，被吸收在其中的流体所取代，和（f）样品井和读数井之间的通道，从而可以将样品和反应混合物转移并洗涤在不用任何设备接触的情况下，将样品良好地称入所述读取孔中。

69. 再颁专利

USRE34312E Process and reagent for the determination of an antibody 失效
公开(公告)号：USRE34312E
公开(公告)日：1993-07-13
申请号：US796545
申请日：1991-11-21
申请人： Thomas Geiger , Wolf D. Engel , Urban Schmitt , Eberhard Maurer , Wolfgang Rudinger , Rolf Deeg
发明人： Thomas Geiger , Wolf D. Engel , Urban Schmitt , Eberhard Maurer , Wolfgang Rudinger , Rolf Deeg
IPC分类号： G01N33/543 , G01N33/576 , G01N33/68
CPC分类号： G01N33/6854 , G01N33/5764 , Y10S435/805 , Y10S435/81 , Y10S436/827
摘要： The present invention provides a process for the determination of an antibody by incubation with three different reagents R.sub.1, R.sub.2 and R.sub.3, of which R.sub. and R.sub.3 are present in liquid phase and are bindable with the antibody, R.sub.2 is present bound to a solid phase and is bindable with R.sub.1 and R.sub.3 carries a label, separation of the solid phase from the liquid phase and measurement of the label in the solid phase, wherein as R.sub.1 there is used a conjugate of a substance specifically recognized by the antibody to be determined and a reaction component of a specific binding system, as R.sub.3 there is used a conjugate of a substance specifically recognized by the antibody to be determined and a label and as R.sub.2 there used the other binding component of the specific binding system. The present invention also provides a composition for the determination of an antibody, wherein it contains two different soluble reagents R.sub.1 and R.sub.3 specifically bindable with the antibody, of which R.sub.1 carries a reaction component of a specific binding system and R.sub.3 carries a label and also a receptor R.sub.2 which is present in solid phase and is bindable with the receptor R.sub.1, the insoluble receptor R.sub.2 and the soluble receptor R.sub.1 being present physically separated from one another.

70. 发明授权

US5204096A Pre-S gene coded peptide hepatitis B immunogens, vaccines, diagnostics, and synthetic lipid vesicle carriers 失效
标题翻译：前S基因编码肽乙型肝炎免疫原，疫苗，诊断和合成脂质囊泡载体
公开(公告)号：US5204096A
公开(公告)日：1993-04-20
申请号：US338028
申请日：1989-04-14
申请人： Alexander R. Neurath , Stephen B. H. Kent
发明人： Alexander R. Neurath , Stephen B. H. Kent
IPC分类号： A61K9/127 , A61K39/00 , A61K47/48 , C07K14/02 , C07K16/08 , G01N33/576
CPC分类号： C07K14/005 , A61K47/48176 , A61K47/48315 , A61K47/48815 , A61K47/48876 , A61K9/1271 , C07K16/082 , G01N33/5764 , A61K39/00 , C12N2730/10122 , Y10S530/81
摘要： A hepatitis B vaccine containing a peptide with an amino acid chain of at least six consecutive amino acids within the pre-S gene coded region of the envelope of hepatitis B virus. The vaccine being free of an amino acid sequence corresponding to the naturally occurring envelope proteins of hepatitis B virus and a physiologically acceptable diluent. The peptide being free or linked to a carrier. The carrier being a conventional carrier or a novel carrier including a lipid vesicle stabilized by cross-linking and having covalently bonded active sites on the outer surface thereon. Such novel carrier being useful not only to link the novel peptide containing an amino acid chain with amino acids within the pre-S gene coded region of the surface antigen or hepatitis B virus, but can also be used to bind synthetic peptide analogues of other viral proteins, as well as bacterial, allergen and parasitic proteins of man and animals. The peptides of the invention can be utilized in diagnostics for the detection of antigens and antibodies.
摘要翻译：一种乙型肝炎疫苗，其含有乙型肝炎病毒包膜前S基因编码区内具有至少六个连续氨基酸的氨基酸链的肽。该疫苗不含对应于乙型肝炎病毒的天然存在的包膜蛋白的氨基酸序列和生理上可接受的稀释剂。肽与载体无关或连接。载体是常规载体或包含通过交联稳定并在其外表面上具有共价键合的活性位点的脂质囊泡的新型载体。这种新型载体不仅用于将含有氨基酸链的新肽与表面抗原或乙型肝炎病毒的S前编码区之前的氨基酸连接，还可用于结合其他病毒的合成肽类似物蛋白质，以及人和动物的细菌，变应原和寄生蛋白。本发明的肽可用于诊断抗原和抗体的检测。

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