专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

61. 发明授权

US5527945A Diphenylheteroalkyl derivatives, the preparation thereof and drugs and cosmetics prepared therefrom 失效
标题翻译：二苯基杂烷基衍生物，其制备方法和由其制备的药物和化妆品
公开(公告)号：US5527945A
公开(公告)日：1996-06-18
申请号：US297537
申请日：1994-08-31
申请人： Bernd Janssen , Hans-Heiner Wuest
发明人： Bernd Janssen , Hans-Heiner Wuest
IPC分类号： A61K8/33 , A61K8/34 , A61K8/36 , A61K8/37 , A61K8/40 , A61K8/41 , A61K8/42 , A61K8/44 , A61K8/46 , A61K8/67 , A61K31/195 , A61Q19/00 , C07C37/11 , C07C39/17 , C07C43/20 , C07C43/205 , C07C43/21 , C07C43/23 , C07C45/44 , C07C47/575 , C07C51/367 , C07C59/70 , C07C65/21 , C07C65/24 , C07C65/26 , C07C69/76 , C07C69/92 , C07C205/06 , C07C205/34 , C07C205/35 , C07C205/37 , C07C211/60 , C07C217/48 , C07C217/58 , C07C217/76 , C07C217/86 , C07C223/06 , C07C229/38 , C07C229/60 , C07C233/18 , C07C233/25 , C07C233/43 , C07C233/47 , C07C233/48 , C07C233/75 , C07C235/42 , C07C255/51 , C07C255/54 , C07C259/10 , C07C309/42 , C07C317/22 , C07C317/32 , C07C317/44 , C07C323/16 , C07C323/19 , C07C323/20 , C07C323/32 , C07C323/34 , C07C323/36 , C07C323/41 , C07C323/56 , C07C323/62 , C07C327/30 , C07D263/58 , C07D311/72 , C07F9/38 , C07F9/40 , C07C255/49 , A61K31/275 , C07C69/02
CPC分类号： A61K8/46 , A61K8/33 , A61K8/34 , A61K8/36 , A61K8/37 , A61K8/40 , A61K8/41 , A61K8/411 , A61K8/42 , A61K8/445 , A61K8/671 , A61Q19/00 , C07C205/06 , C07C205/34 , C07C205/35 , C07C205/37 , C07C211/60 , C07C217/48 , C07C217/58 , C07C217/76 , C07C217/86 , C07C223/06 , C07C229/38 , C07C229/60 , C07C233/18 , C07C233/25 , C07C233/43 , C07C233/47 , C07C233/48 , C07C233/75 , C07C235/42 , C07C255/54 , C07C259/10 , C07C309/42 , C07C317/22 , C07C317/32 , C07C317/44 , C07C323/16 , C07C323/19 , C07C323/20 , C07C323/32 , C07C323/34 , C07C323/36 , C07C323/41 , C07C323/56 , C07C323/62 , C07C327/30 , C07C37/18 , C07C39/17 , C07C41/26 , C07C43/202 , C07C43/2055 , C07C43/21 , C07C43/23 , C07C45/44 , C07C47/575 , C07C51/367 , C07C65/24 , C07C65/26 , C07C69/76 , C07C69/92 , C07D263/58 , C07D311/58 , C07D311/70 , C07D311/72 , C07D317/22 , C07F9/3834 , C07F9/4021 , C07C2102/10
摘要： Diphenylheteroalkyl derivatives of the formula I ##STR1## where A and R.sup.1 -R.sup.6 have the meanings specified in the description, and the preparation thereof are described.The substances are suitable for controlling diseases and as cosmetic agents.
摘要翻译：描述了其中A和R 1 -R 6具有说明书中规定的含义的式I的（I）的二苯基杂烷基衍生物及其制备。该物质适用于控制疾病和化妆品。

62. 发明授权

US5523460A 4-fluorobiphenyl derivatives 失效
标题翻译： 4-氟联苯衍生物
公开(公告)号：US5523460A
公开(公告)日：1996-06-04
申请号：US218186
申请日：1994-03-28
申请人： Masakatsu Matsumoto , Nobuko Watanabe , Eiko Mori , Miwa Ishihara , Tetsuaki Yamaura , Misao Aoyama , Hiroshi Ikawa , Hisako Kobayashi
发明人： Masakatsu Matsumoto , Nobuko Watanabe , Eiko Mori , Miwa Ishihara , Tetsuaki Yamaura , Misao Aoyama , Hiroshi Ikawa , Hisako Kobayashi
IPC分类号： C07C45/44 , C07C45/51 , C07C47/277 , C07C59/64 , C07C69/734 , C07C69/738 , C07C255/37 , C07D307/86 , C07D309/30 , C07D405/12 , C07C69/76 , A01N43/16
CPC分类号： C07D405/12 , C07C255/37 , C07C45/44 , C07C45/516 , C07C47/277 , C07C59/64 , C07C69/734 , C07C69/738 , C07D307/86 , C07D309/30
摘要： A 4-fluorobiphenyl derivative of formula (I), which is useful as a cholesterol lowering agent or a lipid lowering agent because of its strong inhibitory effect on HMG-CoA reductase), and which is also useful as an intermediate for producing the above-mentioned cholesterol lowering agent or lipid lowering agent: ##STR1## wherein A is a .omega.-oxycarbonyldihydroxybutyl group, a tetrahydropyranyl group, a .omega.-oxycarbonyl-3-oxobutyl group, a formyl group, or a cyano group; R.sup.1 is a halogen atom, an alkyl group, or a group represented by R.sup.5 O--, wherein R.sup.5 is a hydrogen atom, or an alkyl group; R.sup.2 is a hydrogen atom, an alkyl group; R.sup.3 is a hydrogen atom, or an alkyl group; R.sup.5 and R.sup.2 may form a five-membered ring or a six-membered ring in combination with the oxygen atoms to which R.sup.5 and R.sup.2 are respectively bonded, and R.sup.5 and R.sup.3 may form a five-membered ring or a six-membered ring in combination with the oxygen atom to which R.sup.5 is bonded.
摘要翻译：由于其对HMG-CoA还原酶具有很强的抑制作用，可用作胆固醇降低剂或降脂剂的式（I）的4-氟联苯衍生物，也可用作制备上述上述胆固醇降低剂或降脂剂：其中A是ω-氧羰基二羟基丁基，四氢吡喃基，ω-氧羰基-3-氧代丁基，甲酰基或氰基的（I） R1是卤原子，烷基或由R5O-表示的基团，其中R5是氢原子或烷基; R2是氢原子，烷基; R3是氢原子或烷基; R5和R2可以与R5和R2分别键合的氧原子结合形成五元环或六元环，R5和R3可以组合形成五元环或六元环与R5键合的氧原子。

63. 发明授权

US5489592A 3,4-dihydro-4-oxo-3-(2-propenyl)-1-phthalazineacetic acids and derivatives, their preparations and medicines containing them 失效
标题翻译： 3,4-二氢-4-氧代-3-（2-丙烯基）-1-酞嗪乙酸及其衍生物，其制剂和含有它们的药物
公开(公告)号：US5489592A
公开(公告)日：1996-02-06
申请号：US211427
申请日：1994-06-20
申请人： Francois Collonges , Herve Dumas , Philippe Durbin , Daniel Guerrier
发明人： Francois Collonges , Herve Dumas , Philippe Durbin , Daniel Guerrier
IPC分类号： A61K31/50 , A61P3/08 , A61P13/02 , A61P15/00 , A61P25/02 , A61P27/02 , A61P27/12 , A61P43/00 , C07C17/00 , C07C17/14 , C07C17/16 , C07C17/26 , C07C17/38 , C07C22/04 , C07C22/08 , C07C25/02 , C07C25/13 , C07C25/24 , C07C45/44 , C07C45/56 , C07D237/32 , C07D241/44 , C07D333/12 , C07D409/06
CPC分类号： C07D409/06 , C07C17/00 , C07C17/14 , C07C17/16 , C07C17/2635 , C07C17/38 , C07C22/04 , C07C22/08 , C07C25/02 , C07C25/24 , C07C45/44 , C07C45/565 , C07D237/32 , C07D333/12
摘要： Novel 3,4-dihydro-4-oxo-3(prop-2-enyl)-1-phtalazineacetic acids and derivatives of formula (I) ##STR1## in which R.sub.1 R.sub.2 and R.sub.3 are the same or different and stand for H, a halogen or a linear or branched aliphatic, saturated or unsaturated radical, substituted or not by at least one halogen or R.sub.4 residue such as defined below, except when R.sub.4 is H; R.sub.4 and R.sub.5 are the same or different and stand for H, a linear or branched aliphatic radical, saturated or unsaturated, an aryl or heteroaryl radical, said radicals being substituted or not by at least one grouping such as fluorine, chlorine, bromine, methyl or trifluoromethyl, where R.sub.4 and R.sub.5 do not simultaneously denote H; R.sub.6 stands for hydroxy or alkoxy radical; R.sub.7 stands for H, a halogen, a linear or branched aliphatic saturated or unsaturated radical, an alkoxy radical, said radicals being substituted or not by analiphatic or halogenated radical, a nitro group, a substituted or unsubstituted amino group, S(O)n R.sub.8 or a cyano group; n is equal to 0,1 or 2; R.sub.8 is an aliphatic, linear or branched radical, an aryl or heteroaryl radical, an amino radical, said radicals being substituted or not by an aliphatic or halogenated radical. This invention also relates to the optional tautomeric forms of said acids and their pharmaceutically acceptable base addition salts. Also described is a process for preparing said compounds and the drugs containing same.
摘要翻译： PCT No.PCT / FR92 / 00920 Sec。 371日期：1994年6月20日 102（e）日期1994年6月20日PCT提交1992年10月2日PCT公布。公开号WO93 / 07109 日期1994年4月15日。新型3,4-二氢-4-氧代-3（丙-2-烯基）-1-对乙酰乙酸及式（I）的衍生物其中R1R2和R3相同或不同的，代表H，卤素或直链或支链的脂肪族，饱和或不饱和基团，除非是R4是H，而是被至少一个卤素或R4残基取代或不被定义如下。 R 4和R 5相同或不同，代表H，直链或支链脂族基团，饱和或不饱和的芳基或杂芳基，所述基团被至少一个基团取代，例如氟，氯，溴，甲基或三氟甲基，其中R 4和R 5不同时表示H; R6代表羟基或烷氧基; R7代表H，卤素，直链或支链脂族饱和或不饱和基团，烷氧基，所述基团被脂肪族或卤代基团取代，或不被取代或未取代的氨基取代或未取代的氨基S（O）n R8或氰基; n等于0,1或2; R 8是脂族，直链或支链基团，芳基或杂芳基，氨基，所述基团被脂肪族或卤代基取代。本发明还涉及所述酸及其药学上可接受的碱加成盐的任选互变异构形式。还描述了制备所述化合物和含有它们的药物的方法。

64. 发明授权

US5449686A Compounds useful for treating allergic or inflammatory diseases 失效
标题翻译：可用于治疗过敏性或炎性疾病的化合物
公开(公告)号：US5449686A
公开(公告)日：1995-09-12
申请号：US313095
申请日：1994-09-29
申请人： Siegfried B. Christensen, IV , Paul E. Bender , Cornelia J. Forster
发明人： Siegfried B. Christensen, IV , Paul E. Bender , Cornelia J. Forster
IPC分类号： C07D295/00 , A61K31/12 , A61K31/24 , A61K31/275 , A61K31/33 , A61P11/06 , A61P29/00 , A61P37/08 , C07C45/44 , C07C45/51 , C07C45/71 , C07C47/47 , C07C47/575 , C07C49/603 , C07C49/613 , C07C49/753 , C07C49/757 , C07C233/56 , C07C235/82 , C07C251/42 , C07C255/46 , C07C255/54 , C07C255/64 , C07D213/00 , C07D215/00 , C07D233/00 , C07D239/00 , C07D257/00 , C07D261/00 , C07D263/00 , C07D277/00 , C07D307/00 , C07D309/00 , C07F7/08
CPC分类号： C07C255/46 , C07C233/56 , C07C235/82 , C07C45/44 , C07C45/515 , C07C45/71 , C07C47/47 , C07C47/575 , C07C49/753 , C07C49/757 , C07C2101/02 , C07C2101/08 , C07C2101/14
摘要： Novel cyclohexanes of Formulas (I) and (II) ##STR1## are described herein. They inhibit the production of Tumor Necrosis Factor and are useful in the treatment of disease states mediated or exacerbated by TNF production; these compounds are also useful in the mediation or inhibition of enzymatic or catalytic activity of phosphodiesterase V.
摘要翻译：式（I）和（II）的新型环己烷在本文中描述。它们抑制肿瘤坏死因子的产生，可用于治疗由TNF产生介导或加重的疾病状态; 这些化合物也可用于调节或抑制磷酸二酯酶V的酶促或催化活性。

65. 发明授权

US5256694A Diarylacetylenes, their preparation and their use 失效
标题翻译：二芳基乙炔，其制备及其用途
公开(公告)号：US5256694A
公开(公告)日：1993-10-26
申请号：US888691
申请日：1992-05-22
申请人： Hans-Heiner Wuest , Fritz-Frieder Frickel , Axel Nuerrenbach
发明人： Hans-Heiner Wuest , Fritz-Frieder Frickel , Axel Nuerrenbach
IPC分类号： A61K31/235 , C07C33/38 , C07C43/168 , C07C43/215 , C07C45/44 , C07C45/68 , C07C47/548 , C07C47/57 , C07C47/575 , C07C49/683 , C07C49/747 , C07C49/755 , C07C49/757 , C07C49/798 , C07C49/835 , C07C49/84 , C07C57/50 , C07C63/66 , C07C63/74 , C07C65/19 , C07C65/28 , C07C65/38 , C07C69/612 , C07D257/04 , C07C69/76
CPC分类号： C07D257/04 , C07C255/00 , C07C33/38 , C07C43/168 , C07C43/215 , C07C45/44 , C07C45/68 , C07C47/548 , C07C47/57 , C07C47/575 , C07C49/683 , C07C49/747 , C07C49/755 , C07C49/757 , C07C49/798 , C07C49/835 , C07C49/84 , C07C57/50 , C07C63/66 , C07C63/74 , C07C65/19 , C07C65/28 , C07C65/38
摘要： Novel diarylacetylenes of the formula I ##STR1## where A, R.sup.1, R.sup.2, R.sup.3, R.sup.4, R.sup.5 and R.sup.6 have the meanings stated in the description, are useful for the treatment of disorders.
摘要翻译：式I的新型二芳基乙炔，其中A，R1，R2，R3，R4，R5和R6具有说明书中所述的含义，可用于治疗疾病。

66. 发明授权

US5248823A Diphenylheteroalkyl derivatives, the preparation thereof and drugs and cosmetics prepared therefrom 失效
标题翻译：二苯基杂烷基衍生物，其制备方法和由其制备的药物和化妆品
公开(公告)号：US5248823A
公开(公告)日：1993-09-28
申请号：US985934
申请日：1992-12-04
申请人： Bernd Janssen , Hans-Heiner Wuest
发明人： Bernd Janssen , Hans-Heiner Wuest
IPC分类号： A61K8/33 , A61K8/34 , A61K8/36 , A61K8/37 , A61K8/40 , A61K8/41 , A61K8/42 , A61K8/44 , A61K8/46 , A61Q19/00 , C07C39/17 , C07C43/20 , C07C43/205 , C07C43/21 , C07C43/23 , C07C45/44 , C07C47/575 , C07C65/24 , C07C65/26 , C07C69/76 , C07C69/92 , C07C205/06 , C07C205/34 , C07C205/37 , C07C211/60 , C07C217/48 , C07C217/58 , C07C217/76 , C07C217/86 , C07C223/06 , C07C229/38 , C07C229/60 , C07C233/18 , C07C233/25 , C07C233/43 , C07C233/47 , C07C233/48 , C07C233/75 , C07C235/42 , C07C235/46 , C07C255/54 , C07C259/10 , C07C309/42 , C07C317/22 , C07C317/44 , C07C323/16 , C07C323/20 , C07C323/32 , C07C323/41 , C07C323/56 , C07C323/62 , C07D311/72 , C07F9/38 , C07F9/40
CPC分类号： C07F9/3834 , A61K8/33 , A61K8/34 , A61K8/36 , A61K8/37 , A61K8/40 , A61K8/41 , A61K8/411 , A61K8/42 , A61K8/445 , A61K8/46 , A61Q19/00 , C07C205/06 , C07C205/34 , C07C205/37 , C07C211/60 , C07C217/48 , C07C217/58 , C07C217/76 , C07C217/86 , C07C223/06 , C07C229/38 , C07C229/60 , C07C233/18 , C07C233/25 , C07C233/43 , C07C233/47 , C07C233/48 , C07C233/75 , C07C235/42 , C07C255/54 , C07C259/10 , C07C309/42 , C07C317/22 , C07C317/44 , C07C323/16 , C07C323/20 , C07C323/32 , C07C323/41 , C07C323/56 , C07C323/62 , C07C39/17 , C07C43/202 , C07C43/2055 , C07C43/21 , C07C43/23 , C07C45/44 , C07C47/575 , C07C65/24 , C07C65/26 , C07C69/76 , C07C69/92 , C07D311/72 , C07F9/4021 , C07C2102/10
摘要： Diphenylheteroalkyl derivatives of the formula I ##STR1## where A and R.sup.1 -R.sup.6 have the meanings specified in the description, and the preparation thereof are described.The substances are suitable for controlling diseases and as cosmetic agents.
摘要翻译：描述了其中A和R 1 -R 6具有说明书中规定的含义的式I的（I）的二苯基杂烷基衍生物及其制备。该物质适用于控制疾病和化妆品。

67. 发明授权

US5214187A Benzonitriles, benzaldehydes and benzyl alcohols 失效
公开(公告)号：US5214187A
公开(公告)日：1993-05-25
申请号：US946586
申请日：1992-09-18
申请人： Bernd Wolf , Hans Theobald , Norbert Goetz
发明人： Bernd Wolf , Hans Theobald , Norbert Goetz
IPC分类号： C07C25/02 , C07C25/18 , C07C25/22 , C07C25/24 , C07C33/20 , C07C33/30 , C07C33/34 , C07C33/46 , C07C33/50 , C07C45/44 , C07C47/542 , C07C47/546 , C07C47/548 , C07C47/55 , C07C255/50
CPC分类号： C07C33/20 , C07C25/02 , C07C25/18 , C07C25/22 , C07C25/24 , C07C255/50 , C07C33/30 , C07C33/34 , C07C33/46 , C07C33/50 , C07C45/44 , C07C47/542 , C07C47/546 , C07C47/548 , C07C47/55 , C07C2101/02 , C07C2101/08 , C07C2101/10 , C07C2101/14 , C07C2101/16 , C07C2101/18 , C07C2102/42
摘要： Novel benzonitriles, benzaldehydes and benzyl alcohols of the formula I ##STR1## where R.sup.1 is methyl or ethyl, R.sup.2 is alkyl, alkenyl, cycloalkyl, cycloalkenyl, bicycloalkyl, bicycloalkenyl, or C.sub.1 -C.sub.5 -alkyl-substituted cycloalkyl, cycloalkenyl, bicycloalkyl or bicycloalkenyl, X is hydrogen, chlorine or fluorine and Z is --CN, CHO or ##STR2## where R.sup.3 is hydrogen, cyano, C.sub.2 -C.sub.4 -alkynyl, C.sub.2 -C.sub.4 -alkenyl or C.sub.1 -C.sub.4 -alkyl, with the proviso that R.sup.2 is not --CH.sub.2 --CH.dbd.CH--B when B is hydrogen, alkyl or alkenyl and at the same time R.sup.1 is methyl and Z is ##STR3## and with the proviso that R.sup.2 is not methyl or ethyl when R.sup.1 is methyl and at the same time Z is ##STR4## and furthermore with the proviso that R.sup.2 is not methyl when R.sup.1 is methyl or ethyl and at the same time Z is --CN or --CHO.

70. 发明授权

US5034537A Leukotriene antagonists 失效
标题翻译：白三烯拮抗剂
公开(公告)号：US5034537A
公开(公告)日：1991-07-23
申请号：US476992
申请日：1990-02-08
申请人： James S. Frazee
发明人： James S. Frazee
IPC分类号： C07C45/44 , C07C45/56 , C07C45/62 , C07C45/68 , C07C47/542 , C07C47/546 , C07C47/548 , C07C47/55 , C07C255/33 , C07C323/56 , C07C323/60 , C07C323/66 , C07C323/67 , C07D233/84 , C07D257/04
CPC分类号： C07D257/04 , C07C255/33 , C07C323/56 , C07C323/60 , C07C323/66 , C07C323/67 , C07C45/44 , C07C45/56 , C07C45/62 , C07C45/68 , C07C47/542 , C07C47/546 , C07C47/548 , C07C47/55 , C07D233/84
摘要： This invention relates to (R)-.alpha.-methyl-4-halobenzenemethanamine salts of epimers of acids of the formula ##STR1## and the use of these salts to separate these epimers. These acids are leukotriene antagonists.
摘要翻译：本发明涉及式（α）的酸的差向异构体的（R）-α-甲基-4-卤代苯甲胺盐，以及这些盐用于分离这些差向异构体。这些酸是白三烯拮抗剂。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式