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1. 发明授权

US11858889B2 Compound for modulating DDAH and ADMA levels, as well as methods of using thereof to treat disease 有权
公开(公告)号：US11858889B2
公开(公告)日：2024-01-02
申请号：US17565981
申请日：2021-12-30
申请人： THE TRUSTEES OF INDIANA UNIVERSITY
发明人： Jaipal Singh , Kerry Fowler
IPC分类号： C07D333/24 , C07D263/32 , C07D213/55 , C07D277/30 , C07C63/49 , C07C65/17 , C07D295/088 , C07C65/19 , C07C49/513 , C07C63/64 , C07C65/10 , C07C65/24 , C07C65/40 , C07C211/55 , C07C215/74 , C07C233/65 , C07C233/81 , C07C317/32 , C07C323/62 , C07D209/18 , C07D257/04 , C07D295/16
CPC分类号： C07C65/19 , C07C49/513 , C07C63/49 , C07C63/64 , C07C65/10 , C07C65/17 , C07C65/24 , C07C65/40 , C07C211/55 , C07C215/74 , C07C233/65 , C07C233/81 , C07C317/32 , C07C323/62 , C07D209/18 , C07D213/55 , C07D257/04 , C07D263/32 , C07D277/30 , C07D295/088 , C07D295/16 , C07D333/24 , C07C2601/16 , C07C2602/08
摘要： Disclosed are compounds that can modulate DDAH and the amount of asymmetric dimethylarginine (ADMA) in a subject. Also provided are pharmaceutical compositions comprising these compounds, as well as methods of using these compositions to treat and/or prevent diseases associated with elevated or low levels of DDAH and ADMA.

2. 发明授权

US11802118B2 Methods for extraction, processing, and purification of a selected family of target compounds from cannabis 有权
公开(公告)号：US11802118B2
公开(公告)日：2023-10-31
申请号：US17617341
申请日：2020-06-12
申请人： Nectar Health Sciences Inc.
发明人： Tony Durst , Jay Van Der Vlugt , Amanda Saikaley
IPC分类号： C07D311/80 , C07C211/63 , C07C215/40 , C07D453/04 , C07D487/04 , C07D487/08 , C07C51/43 , C07C65/19
CPC分类号： C07D311/80 , C07C51/43 , C07C65/19 , C07C211/63 , C07C215/40 , C07D453/04 , C07D487/04 , C07D487/08 , C07D311/80 , C07B63/00 , C07D311/80 , C07B63/02
摘要： Disclosed are methods for separating, recovering, and purifying cannabidiolic acid (CBDA) salts from an organic solvent solution comprising a mixture of cannabinoids. The methods comprise solubilizing the mixture of cannabinoids in C5-C7 hydrocarbon solvents, adding thereto a selected amine to thereby precipitate a CBDA-amine salt therefrom, dissolving the recovered CBDA-amine salt in a selected solvent and then adding thereto a selected antisolvent to thereby recrystallizing a purified CBDA-amine salt therefrom. The recrystallized CBDA-amine salt may be decarboxylated to form a mixture of cannabidiol (CBD) and amine. The CBD amine mixture may be acidified to separate the amine from CBD. The recovered CBD may be concentrated to produce a highly purified CBD. Also disclosed are CBDA-amine salts produced with certain amines selected from groups of secondary amines, tertiary amines, diamines, amino alcohols, amino ethers, and highly basic amines.

3. 发明申请

US20170065547A1 Use Of 2,5-Dihydroxybenzene Compounds And Derivatives For The Treatment Of Skin Cancer 审中-公开
标题翻译：使用2,5-二羟基苯化合物和衍生物治疗皮肤癌
公开(公告)号：US20170065547A1
公开(公告)日：2017-03-09
申请号：US15336208
申请日：2016-10-27
申请人： AmDerma Pharmaceuticals, LLC
发明人： Pedro Cuevas Sànchez , Guillermo Gimenez Gallego , Inigo Saenz de Tejada Gorman , Javier Angulo Frutos , Serafin Valverde Lopez , Antonio Romero Garrido , Rosa Maria Lozano Puerto
IPC分类号： A61K31/255 , A61K31/095 , A61K45/06 , A61K31/192 , A61K9/00
CPC分类号： A61K31/255 , A61K9/0014 , A61K31/095 , A61K31/10 , A61K31/185 , A61K31/192 , A61K31/216 , A61K31/222 , A61K31/225 , A61K31/235 , A61K45/06 , C07C57/44 , C07C59/68 , C07C65/03 , C07C65/19 , C07C69/017 , C07C69/84 , C07C309/24 , C07C309/42 , C07C309/68 , C07C309/75 , A61K2300/00
摘要： The present invention relates to the use of a 2,5-dihydroxybenzene derivative of formula (I) or a pharmaceutically acceptable salt, solvate, isomer, or prodrug thereof for the treatment and/or prophylaxis of, inter alia, skin cancer.
摘要翻译：本发明涉及式（I）的2,5-二羟基苯衍生物或其药学上可接受的盐，溶剂化物，异构体或前药在治疗和/或预防皮肤癌中的用途。

4. 发明申请

US20170057941A1 SUBSTITUTED ARYLCYCLOPENTENES AS THERAPEUTIC AGENTS 有权
标题翻译：作为治疗剂代替ARYLCYCLOPENTEN
公开(公告)号：US20170057941A1
公开(公告)日：2017-03-02
申请号：US15088964
申请日：2016-04-01
申请人： Allergan, Inc.
发明人： Yariv Donde , Jeremiah H. Nguyen
IPC分类号： C07D333/40 , C07D333/38 , C07C59/90
CPC分类号： C07D333/40 , C07C59/56 , C07C59/90 , C07C65/19 , C07C323/52 , C07C2601/10 , C07D213/30 , C07D213/55 , C07D277/56 , C07D307/68 , C07D333/24 , C07D333/38 , C07D409/04 , C07D409/10
摘要： Disclosed herein is a compound of the formula Therapeutic methods, compositions, and medicaments, related thereto are also disclosed.
摘要翻译：还公开了与此相关的治疗方法，组合物和药物。

5. 发明申请

US20160287497A1 USE AS A DEODORANT AGENT OF A SALIFIED SALICYLIC ACID DERIVATIVE, ALONE OR IN A MIXTURE 审中-公开
标题翻译：用作均质的酸性衍生物，单独或混合物的去污剂
公开(公告)号：US20160287497A1
公开(公告)日：2016-10-06
申请号：US15036189
申请日：2014-11-13
申请人： L'OREAL
发明人： Maud Brossat , Lucie Tournier-Couturier
IPC分类号： A61K8/368 , A61K8/04 , C07C65/05 , C07C65/19 , A61Q15/00 , A61K8/44
CPC分类号： A61K8/368 , A61K8/046 , A61K8/44 , A61K8/442 , A61K2800/87 , A61Q15/00 , C07C65/05 , C07C65/19
摘要： The invention relates to the use as a deodorant agent of a compound or a mixture of compounds having formula (II): where R denotes a saturated or unsaturated linear or branched hydrocarbon radical comprising from 12 to 20 carbon atoms, where said radical R may comprise one or a plurality of ethylene unsaturations and Cat+ represents a cation or a mixture of cations, organic or inorganic, optionally being + or 2+, independently of the cationic charge and suitable for obtaining electroneutrality of formula (II) along with compositions containing same in a physiologically acceptable medium in association with at least one deodorant agent and/or one antiperspirant agent. The invention also relates to novel compounds and compositions containing same in a physiologically acceptable medium.The invention also relates to a method for treating body odor.
摘要翻译：本发明还涉及一种用于治疗身体气味的方法。

6. 发明授权

US09376367B2 Cannabinoid carboxylic acids, salts of cannabinoid carboxylic acids, and the production and uses of same 有权
标题翻译：大麻素羧酸，大麻素羧酸的盐及其生产和用途
公开(公告)号：US09376367B2
公开(公告)日：2016-06-28
申请号：US14348459
申请日：2012-10-01
申请人： The Health Concept GmbH
发明人： Thomas Herkenroth , Christian Steup
IPC分类号： C07C65/19 , C07C51/493 , C07C51/41 , C07D311/80 , C07C51/42
CPC分类号： C07C65/19 , C07C51/412 , C07C51/42 , C07C51/493 , C07D311/80
摘要： The invention relates to a compound selected from the group consisting of all stereoisomers and their mixtures of the compounds of general formulas (1)-(4), in which R1 is a straight-chained, branched or cyclic hydrocarbon group with up to 12 C-atoms and X+ is selected from the group consisting of H+, NH4+, mono, di or trivalent metal cations, NH4+, primary, secondary, tertiary or quaternary organic ammonium ions with up to 48 C-atoms, which can carry even more functional groups, hydrazinium ion (N2H5+), hydroxylammonium ion (NH3OH+), guanidinium ion (CN3H6+), and organic derivatives of (N2H5+), NH3OH+, and CN3H6+, which can carry even more functional groups, and similar. A method is also provided for producing these compounds, comprising the following steps: producing synthetic cannabinoid carboxylic acids in a chemical reaction, or extracting natural cannabinoid carboxylic acids from plant material or cell cultures of Cannabis sativa, and adding a suitable inorganic base, a suitable organic base and/or a suitable inorganic or organic salt in a suitable solvent, to the cannabinoid carboxylic acids or cannabinoid carboxylic acid-rich extracts produced in this manner.
摘要翻译：本发明涉及一种选自所有立体异构体及其通式（1） - （4）的化合物的混合物的化合物，其中R 1是具有至多12个碳原子的直链，支链或环状烃基原子和X +选自H +，NH4 +，单，二价或三价金属阳离子，NH4 +，具有多达48个C原子的伯，仲，叔或季有机铵离子，其可以携带甚至更多的官能团，肼离子（N2H5 +），羟铵离子（NH3OH +），胍离子（CN3H6 +）和（N2H5 +），NH3OH +和CN3H6 +的有机衍生物，其可携带更多的官能团等。还提供了一种制备这些化合物的方法，包括以下步骤：在化学反应中生产合成的大麻素羧酸，或从大麻植物材料或细胞培养物中提取天然大麻素羧酸，并加入合适的无机碱，合适的有机碱和/或合适的无机或有机盐在合适的溶剂中加入到以这种方式制备的大麻素羧酸或大麻素富含羧酸的提取物中。

7. 发明授权

US09359298B2 Cajanine structure analogous compound, preparation method and use 有权
标题翻译：卡氨酸结构类似化合物，制备方法和用途
公开(公告)号：US09359298B2
公开(公告)日：2016-06-07
申请号：US14368066
申请日：2012-12-18
申请人： INSTITUTE OF MEDICINAL BIOTECHNOLOGY, CHINESE ACADEMY OF MEDICAL SCIENCES
发明人： Zhuorong Li , Xingyue Ji , Situ Xue , Guanghui Zheng , Yuhuan Li , Peizhen Tao , Jiandong Jiang
IPC分类号： C07D213/30 , C07D213/68 , C07D213/55 , C07D213/64 , C07D213/65 , C07D213/69 , C07C65/28 , C07C69/92 , C07C51/09 , C07C65/105 , C07C65/19 , C07C43/215 , C07C43/23 , C07D213/80 , C07D311/58 , C07C275/00 , C07C275/54 , C07C279/22 , C07C281/02 , C07D333/16 , C07D333/24 , C07D233/60 , C07D233/90 , C07C217/20 , C07C217/22 , C07D241/04 , C07C229/08 , C07C235/46 , C07C235/62 , C07C235/64 , C07D207/16 , C07D211/58 , C07C69/157 , C07C69/36 , C07C39/21 , C07C51/353 , C07C51/36 , C07C41/18 , C07C67/30 , C07C231/12
CPC分类号： C07D213/30 , C07C39/21 , C07C41/18 , C07C43/215 , C07C43/23 , C07C51/09 , C07C51/353 , C07C51/36 , C07C65/105 , C07C65/19 , C07C65/28 , C07C67/30 , C07C69/157 , C07C69/36 , C07C69/92 , C07C217/20 , C07C217/22 , C07C229/08 , C07C231/12 , C07C235/46 , C07C235/62 , C07C235/64 , C07C275/00 , C07C275/54 , C07C279/22 , C07C281/02 , C07C2601/02 , C07C2601/14 , C07D207/16 , C07D211/58 , C07D213/55 , C07D213/64 , C07D213/65 , C07D213/68 , C07D213/69 , C07D213/80 , C07D233/60 , C07D233/90 , C07D241/04 , C07D311/58 , C07D333/16 , C07D333/24 , C07C65/24
摘要： Provided are cajanine structure analogous compounds, synthesis method and pharmacological effects thereof, the compounds of the present invention having the structure as represented by general formulas I, II, III, IV and V. Also provided are pharmaceutical compositions containing the compounds as active ingredient, and uses thereof; the compounds of the present invention having the pharmacological activities such as anti-virus, anti-virus-infection, nerve protection, anti-metabolic-diseases and the like. Also provided is a chemical total synthesis preparation method of the natural products cajanine, cajanine A and cajanine C. The present invention lays a foundation for the in-depth study and development of the compounds as clinical drugs in the future.
摘要翻译：本发明提供的是具有由通式I，II，III，IV和V表示的结构的本发明化合物的cajanine结构类似化合物，其合成方法和药理作用。还提供了含有化合物作为活性成分的药物组合物，及其用途; 具有抗病毒，抗病毒感染，神经保护，抗代谢疾病等药理活性的本发明化合物。还提供了天然产物cajanine，cajanine A和cajanine C的化学全合成制备方法。本发明为将来化合物作为临床药物的深入研究奠定了基础。

8. 发明申请

US20150038567A1 Cannabinoid Carboxylic Acids, Salts of Cannabinoid Carboxylic Acids, and the Production and Uses of Same 有权
标题翻译：大麻类羧酸，大麻素羧酸的盐及其生产和用途
公开(公告)号：US20150038567A1
公开(公告)日：2015-02-05
申请号：US14348459
申请日：2012-10-01
申请人： THE HEALTH CONCEPT GMBH
发明人： Thomas Herkenroth , Christian Steup
IPC分类号： C07C65/19 , C07C51/493 , C07C51/41 , C07D311/80 , C07C51/42
CPC分类号： C07C65/19 , C07C51/412 , C07C51/42 , C07C51/493 , C07D311/80
摘要： The invention relates to a compound selected from the group consisting of all stereoisomers and their mixtures of the compounds of general formulas (1)-(4), in which R1 is a straight-chained, branched or cyclic hydrocarbon group with up to 12 C-atoms and X+ is selected from the group consisting of H+, NH4+, mono, di or trivalent metal cations, NH4+, primary, secondary, tertiary or quaternary organic ammonium ions with up to 48 C-atoms, which can carry even more functional groups, hydrazinium ion (N2H5+), hydroxylammonium ion (NH3OH+), guanidinium ion (CN3H6+), and organic derivatives of (N2H5+), NH3OH+, and CN3H6+, which can carry even more functional groups, and similar. A method is also provided for producing these compounds, comprising the following steps: producing synthetic cannabinoid carboxylic acids in a chemical reaction, or extracting natural cannabinoid carboxylic acids from plant material or cell cultures of Cannabis sativa, and adding a suitable inorganic base, a suitable organic base and/or a suitable inorganic or organic salt in a suitable solvent, to the cannabinoid carboxylic acids or cannabinoid carboxylic acid-rich extracts produced in this manner.
摘要翻译：本发明涉及一种选自所有立体异构体及其通式（1） - （4）的化合物的混合物的化合物，其中R 1是具有至多12个碳原子的直链，支链或环状烃基原子和X +选自H +，NH4 +，单，二价或三价金属阳离子，NH4 +，具有多达48个C原子的伯，仲，叔或季有机铵离子，其可以携带甚至更多的官能团，肼离子（N2H5 +），羟铵离子（NH3OH +），胍离子（CN3H6 +）和（N2H5 +），NH3OH +和CN3H6 +的有机衍生物，其可携带更多的官能团等。还提供了一种制备这些化合物的方法，包括以下步骤：在化学反应中生产合成的大麻素羧酸，或从大麻植物材料或细胞培养物中提取天然大麻素羧酸，并加入合适的无机碱，合适的有机碱和/或合适的无机或有机盐在合适的溶剂中加入到以这种方式制备的大麻素羧酸或大麻素富含羧酸的提取物中。

9. 发明申请

US20140128466A1 COMPOUNDS FOR USE IN THE TREATMENT OF INFLAMMATORY BOWEL DISEASE 有权
标题翻译：用于治疗炎症性皮肤病的化合物
公开(公告)号：US20140128466A1
公开(公告)日：2014-05-08
申请号：US14124937
申请日：2012-07-20
申请人： Neil Frankish , Helen Sheridan
发明人： Neil Frankish , Helen Sheridan
IPC分类号： C07C65/19 , C07C215/06
CPC分类号： C07C65/19 , A61K9/0095 , A61K31/192 , A61K47/26 , A61K47/38 , C07B2200/07 , C07C215/06
摘要： Described are compounds of the structural formula (I): Also provided are pharmacologically acceptable isomers and salts of the compound of (I). The compounds are useful in the treatment of inflammatory bowel disease.
摘要翻译：描述了结构式（I）的化合物：还提供了（I）化合物的药学上可接受的异构体和盐。该化合物可用于治疗炎症性肠病。

10. 发明授权

US08492367B2 Use of 2,5-dihydroxybenzene compounds and derivatives for the treatment of rosacea 有权
公开(公告)号：US08492367B2
公开(公告)日：2013-07-23
申请号：US13154164
申请日：2011-06-06
申请人： Pedro Cuevas Sánchez , Guillermo Gimenez Gallego , Javier Angulo Frutos , Serafin Valverde Lopez , Antonio Romero Garrido , Rosa Maria Lozano Puerto
发明人： Pedro Cuevas Sánchez , Guillermo Gimenez Gallego , Inigo Saenz de Tejada Gorman , Javier Angulo Frutos , Serafin Valverde Lopez , Antonio Romero Garrido , Rosa Maria Lozano Puerto
IPC分类号： A01N37/36 , A01N45/00 , A01N41/02 , A01N37/10 , A01N37/02 , A61K31/56 , A61K31/255 , A61K31/235 , A61K31/22 , A61K37/19
CPC分类号： A61K31/255 , A61K9/0014 , A61K31/095 , A61K31/10 , A61K31/185 , A61K31/192 , A61K31/216 , A61K31/222 , A61K31/225 , A61K31/235 , A61K45/06 , C07C57/44 , C07C59/68 , C07C65/03 , C07C65/19 , C07C69/017 , C07C69/84 , C07C309/24 , C07C309/42 , C07C309/68 , C07C309/75 , A61K2300/00
摘要： The present invention relates to the use of a 2,5-dihydroxybenzene derivative of formula (I) or a pharmaceutically acceptable salt, solvate, isomer, or prodrug thereof for the treatment and/or prophylaxis of, inter alia, rosacea.

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