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61. 发明授权

US5288751A [(Substituted) phenyalkyl]furylalkynyl-and [substituted) phenyalkyl] thienylalkynyl-N-hydroxyurea inhibitors or leukotriene biosynthesis 失效
标题翻译： [（取代的）烷基]呋喃基炔基和[取代的]烷基]噻吩基炔基-N-羟基脲抑制剂或白三烯生物合成
公开(公告)号：US5288751A
公开(公告)日：1994-02-22
申请号：US973100
申请日：1992-11-06
申请人： Dee W. Brooks , Andrew O. Stewart , Anwer Basha , Pramila Bhatia , James D. Ratajczyk
发明人： Dee W. Brooks , Andrew O. Stewart , Anwer Basha , Pramila Bhatia , James D. Ratajczyk
IPC分类号： A61K31/17 , A61K31/38 , A61K31/381 , A61K31/425 , A61K31/426 , A61K31/44 , A61K31/4433 , A61P9/00 , A61P9/10 , A61P11/00 , A61P17/00 , A61P25/00 , A61P27/16 , A61P29/00 , A61P37/08 , A61P43/00 , C07C273/18 , C07C275/24 , C07C275/64 , C07D213/61 , C07D277/28 , C07D307/52 , C07D333/20 , C07D333/22 , C07D405/06 , C07D409/04 , C07D409/06 , C07D417/04 , C07D307/36 , A61K31/34
CPC分类号： C07D405/06 , C07C275/64 , C07D213/61 , C07D277/28 , C07D307/52 , C07D333/20 , C07D409/06
摘要： The present invention relates to compounds of the formula ##STR1## and the pharmaceutically acceptable salts thereof wherein Z is selected from optionally substituted phenyl, furyl, thienyl or thiazolyl; which inhibits leukotriene biosynthesis and is useful in the treatment of inflammatory disease states; also disclosed are leukotriene biosynthesis inhibiting compositions and a method for inhibiting 5-lipoxygenase activity and leukotriene biosynthesis.
摘要翻译：本发明涉及式IMA的化合物及其药学上可接受的盐，其中Z选自任选取代的苯基，呋喃基，噻吩基或噻唑基; 其抑制白细胞三烯生物合成并且可用于治疗炎性疾病状态; 还公开了白三烯生物合成抑制组合物和抑制5-脂氧合酶活性和白三烯生物合成的方法。

62. 发明授权

US5191083A Functionalized monomers from 1-(1-isocyanato-1-methlethyl)-3 or 4-(1-methylethenyl) benzene 失效
标题翻译：来自1-（1-异氰酸基-1-甲基乙基）-3或4-（1-甲基乙烯基）苯的官能化单体
公开(公告)号：US5191083A
公开(公告)日：1993-03-02
申请号：US317259
申请日：1989-02-28
申请人： Howard A. Colvin , Kirkwood S. Cottman , Dane K. Parker
发明人： Howard A. Colvin , Kirkwood S. Cottman , Dane K. Parker
IPC分类号： C07C273/18 , C07C275/24 , C07C275/40 , C07D211/46 , C08F12/26 , C08G18/72
CPC分类号： C08G18/728 , C07C273/1827 , C07D211/46 , C08F12/26
摘要： This invention is directed to the preparation of polymerizable monomers that are prepared from 1-(1-isocyanato-1-methylethyl)-3-(1-methylethenyl) benzene (m-TMI) and 1-(1-isocyanato-1-methylethyl)-4-(1-methylethenyl) benzene (p-TMI). The monomers prepared from m- and p-TMI can contain numerous chemical moieties, and when polymerized, produce polymers that have chemically bonded to the polymeric backbone the functional moiety. More specifically, these TMI derived monomers may contain chain breaking antioxidant moieties, peroxide decomposing antioxidant moieties, ultraviolet stabilizing moieties, triplet quenching moieties, and other chemical moieties that are useful in polymers.
摘要翻译：本发明涉及由1-（1-异氰酸基-1-甲基乙基）-3-（1-甲基乙烯基）苯（m-TMI）和1-（1-异氰酸基-1-甲基乙基酯）制备的可聚合单体的制备）-4-（1-甲基乙烯基）苯（p-TMI）。由m-和p-TMI制备的单体可以含有许多化学部分，当聚合时，产生化学键合到聚合物主链功能部分的聚合物。更具体地，这些TMI衍生的单体可以含有断链抗氧化剂部分，过氧化物分解抗氧化剂部分，紫外线稳定部分，三重峰淬灭部分和可用于聚合物的其它化学部分。

63. 发明授权

US5051446A Substituted 3-phenoxy-1-alkoxycarbonylalkylamino-propanol-2-s having beta receptor blocking properties 失效
标题翻译：具有β受体阻断性质的3-苯氧基-1-烷氧基羰基烷基氨基丙醇-2-基的取代基
公开(公告)号：US5051446A
公开(公告)日：1991-09-24
申请号：US323194
申请日：1989-03-13
申请人： Enar I. Carlsson , Bill B. Gustafsson , Bo T. Lungren
发明人： Enar I. Carlsson , Bill B. Gustafsson , Bo T. Lungren
IPC分类号： A61K31/195 , A61K31/215 , A61K31/216 , A61K31/22 , A61K31/275 , A61P9/06 , A61P9/08 , A61P9/10 , C07C67/00 , C07C227/00 , C07C227/08 , C07C227/14 , C07C227/16 , C07C227/18 , C07C229/10 , C07C229/12 , C07C231/00 , C07C231/12 , C07C233/00 , C07C235/06 , C07C235/20 , C07C235/34 , C07C235/46 , C07C255/53 , C07C255/54 , C07C275/24
CPC分类号： C07C255/00 , C07C275/24
摘要： The present invention relates to new compounds of the formula I ##STR1## as well as their preparation, pharmaceutical preparations containing same, and method of treating acute myocardial infarction.The compounds which possess beta-adrenoceptor blocking activity are very shortacting and are preferably intended for treatment of acute myocardial infarction by administration by means of injection.
摘要翻译：本发明涉及式I（I）的新化合物及其制备方法，含有其的药物制剂及治疗急性心肌梗死的方法。具有β-肾上腺素能受体阻断活性的化合物是非常短暂的，并且优选用于通过注射给药治疗急性心肌梗死。

64. 发明授权

US4906767A Monomers with urea groups 失效
标题翻译：尿素组单体
公开(公告)号：US4906767A
公开(公告)日：1990-03-06
申请号：US067883
申请日：1987-06-30
申请人： Lon J. Mathias , David W. Kurz
发明人： Lon J. Mathias , David W. Kurz
IPC分类号： C07C275/20 , C07C275/24 , C07C311/60
CPC分类号： C07C311/60 , C07C275/20 , C07C275/24 , C07C2101/14
摘要： There is disclosed a family of new vinyl monomers capable of forming polymers by free radical polymerization. The vinyl monomer is of the formula ##STR1## wherein R.sub.1 and R.sub.2 are substituted or unsubstituted hydrocarbons, X is O, NH or NR.sub.3, and R.sub.3 is substituted or unsubstituted hydrocarbon.The intermediates in the synthesis of these monomers are new beta-chloroalanine ureas. The polymers are useful in film and fiber formation and display good toughness. These new vinyl monomers also form a cyclic monomer.
摘要翻译：公开了能够通过自由基聚合形成聚合物的新型乙烯基单体族。乙烯基单体具有下式：其中R1和R2是取代或未取代的烃，X是O，NH或NR3，R3是取代或未取代的烃。合成这些单体的中间体是新的β-氯丙氨酸脲。这些聚合物可用于膜和纤维的形成并显示出良好的韧性。这些新的乙烯基单体也形成环状单体。

65. 发明授权

US4900749A Isoprenoidamine compounds useful as antiulcer agents 失效
标题翻译：异戊二烯类化合物可用作抗溃疡剂
公开(公告)号：US4900749A
公开(公告)日：1990-02-13
申请号：US837192
申请日：1986-03-10
申请人： Saichi Matsumoto , Masami Doteuchi , Takuji Mizui , Kentaro Hirai
发明人： Saichi Matsumoto , Masami Doteuchi , Takuji Mizui , Kentaro Hirai
IPC分类号： A61K31/16 , A61K31/165 , A61K31/17 , A61K31/22 , A61K31/335 , A61K31/34 , A61K31/341 , A61K31/357 , A61K31/38 , A61K31/381 , A61K31/40 , A61K31/403 , A61K31/404 , A61K31/415 , A61K31/495 , A61K45/08 , A61P1/04 , C07C67/00 , C07C231/00 , C07C233/05 , C07C233/65 , C07C275/20 , C07C275/24 , C07C275/28 , C07C275/30 , C07C313/00 , C07C317/44 , C07C323/62 , C07C325/00 , C07C327/40 , C07C327/46 , C07C327/50 , C07C331/22 , C07D207/34 , C07D209/18 , C07D209/28 , C07D209/30 , C07D209/42 , C07D213/40 , C07D213/54 , C07D213/56 , C07D213/74 , C07D213/75 , C07D213/81 , C07D213/82 , C07D213/83 , C07D233/54 , C07D233/60 , C07D233/61 , C07D241/12 , C07D241/24 , C07D295/13 , C07D295/15 , C07D295/215 , C07D307/68 , C07D317/58 , C07D333/38 , C07D521/00 , C08B37/16
CPC分类号： C07D213/40 , C07C275/20 , C07C275/24 , C07C275/28 , C07C275/30 , C07C331/22 , C07D207/34 , C07D209/28 , C07D209/30 , C07D213/54 , C07D213/74 , C07D213/75 , C07D213/81 , C07D213/82 , C07D213/83 , C07D231/12 , C07D233/56 , C07D233/64 , C07D241/24 , C07D249/08 , C07D295/13 , C07D295/15 , C07D295/215 , C07D307/68 , C07D317/58 , C07D333/38
摘要： Novel isoprenoidamine compounds (I) which show antiulcer activity are provided. ##STR1##
摘要翻译：提供了具有抗溃疡活性的新型异戊二烯酮化合物（I）。（一）

66. 发明授权

US4730008A Aminophenol derivatives 失效
标题翻译：氨基苯酚衍生物
公开(公告)号：US4730008A
公开(公告)日：1988-03-08
申请号：US817676
申请日：1986-01-10
申请人： Ian F. Skidmore , Harry Finch , Alan Naylor , Lawrence H. C. Lunts , Ian B. Campbell
发明人： Ian F. Skidmore , Harry Finch , Alan Naylor , Lawrence H. C. Lunts , Ian B. Campbell
IPC分类号： A61K31/165 , A61K31/17 , A61K31/195 , A61K31/215 , A61K31/22 , A61K31/235 , A61K31/27 , A61K31/275 , A61K31/335 , A61K31/357 , A61K31/445 , A61K31/535 , A61K31/5375 , A61K31/54 , A61P11/08 , A61P25/02 , C07C67/00 , C07C231/00 , C07C233/43 , C07C233/78 , C07C253/00 , C07C255/37 , C07C255/54 , C07C275/24 , C07C275/32 , C07C275/40 , C07C301/00 , C07C303/40 , C07C307/10 , C07C311/00 , C07C313/00 , C07C315/04 , C07C317/18 , C07D295/08 , C07D317/54 , C07D319/18 , C07C143/74 , A61K31/18
CPC分类号： C07C275/40
摘要： The invention provides compounds of the general formula (I) ##STR1## wherein Ar, R.sup.1, R.sup.2, X, Y and Q are defined in the specification and physiologically acceptable salts and solvates thereof.The compounds have a selective stimulant action at .beta..sub.2 -adrenoreceptors and may be used, inter alia, in the treatment of diseases associated with reversible airways obstruction such as asthma and chronic bronchitis.
摘要翻译：本发明提供通式（I）的化合物其中Ar，R 1，R 2，X，Y和Q在本说明书及其生理上可接受的盐和溶剂合物中定义。这些化合物在β2-肾上腺素受体具有选择性刺激作用，并且可以用于治疗与可逆性气道阻塞如哮喘和慢性支气管炎相关的疾病。

67. 发明授权

US4628112A Amines, processes for their preparation and their use in compositions which can undergo free radical polymerization 失效
标题翻译：胺，它们的制备方法及其在可以进行自由基聚合的组合物中的用途
公开(公告)号：US4628112A
公开(公告)日：1986-12-09
申请号：US675689
申请日：1984-11-28
申请人： Jens Winkel , Gerhard Klein , Helmut-Martin Meier , Carlhans Suling , Dieter Arlt
发明人： Jens Winkel , Gerhard Klein , Helmut-Martin Meier , Carlhans Suling , Dieter Arlt
IPC分类号： C08F20/00 , A61K6/083 , A61L27/00 , C07C67/00 , C07C239/00 , C07C271/16 , C07C275/24 , C08F4/40 , C08F20/34 , C08F20/36 , C07C125/065
CPC分类号： A61K6/083 , C07C275/24 , C08F20/36
摘要： Compounds of the formula ##STR1## in which R represents hydrogen or a methyl group,Y.sup.1 represents an optionally branched alkylene radical with 1 to 6 C atoms,Y.sup.2 represents an optionally branched alkylene radical with 2 to 8 C atoms,X denotes oxygen or an --NH-- group,R.sup.1 and R.sup.2 are identical or different and denote hydrogen, or an alkyl, alkenyl, cycloalkyl, cycloalkenyl, aryl, aralkyl or alkylaryl group which has 1 to 11 C atoms and is optionally substituted by one or more,hydroxyl, amino, epoxide, urethane, urea, ester or ether groups, orR.sup.1 and R.sup.2 together form a 3-membered to 6-membered ring, which optionally contains nitrogen, oxygen or sulphur as hetero-atoms,R.sup.3 has the meaning of R.sup.1 or represents a group ##STR2## or R.sup.2 and R.sup.3, together with the ##STR3## group, form a 5-membered or 6-membered ring, which optionally contains oxygen as a further hetero-atom, andR.sup.4 and R.sup.5 are identical or different and represent hydrogen, an alkyl or alkenyl group which has 1 to 10 C atoms and is optionally substituted by halogen, or halogen,function as activators in the free radical polymerization of olefinically unsaturated monomers.
摘要翻译：其中R表示氢或甲基的式“IMAGE”的化合物，Y1表示具有1至6个C原子的任选支化的亚烷基，Y2表示具有2至8个C原子的任选支化的亚烷基，X表示氧或 -NH-基团，R 1和R 2相同或不同，表示氢或具有1至11个C原子并且任选被一个或多个羟基取代的烷基，烯基，环烷基，环烯基，芳基，芳烷基或烷芳基，氨基，环氧化物，氨基甲酸酯，脲，酯或醚基团，或R 1和R 2一起形成3元至6元环，其任选地含有氮，氧或硫作为杂原子，R 3具有R 1的含义或表示一组或R2和R3与基团一起形成5元或6元环，其任选地含有氧作为另一个杂原子，并且R 4和R 5相同或不同，并且表示氢，具有1至10个C原子的烷基或烯基，并且是op 被卤素或卤素取代，在烯属不饱和单体的自由基聚合中用作活化剂。

68. 发明授权

US4578513A Process for preparing phenylisopropylurea compounds 失效
标题翻译：制备苯基异丙脲化合物的方法
公开(公告)号：US4578513A
公开(公告)日：1986-03-25
申请号：US672038
申请日：1984-11-16
申请人： Balwant Singh , Paul S. Waterman
发明人： Balwant Singh , Paul S. Waterman
IPC分类号： C07B61/00 , B01J27/00 , C07C273/18 , C07C275/24 , C07C275/28 , C07C275/30 , C07C275/34 , C07C127/17
CPC分类号： C07C273/1854
摘要： A new and improved process for making phenylisopropylurea derivatives having the formula: ##STR1## wherein R.sup.1 is selected from hydrogen, halogen, alkyl, alkenyl, haloalkyl or R.sup.2 groups and R.sup.2 is selected from phenyl, alkyl-substituted phenyl alkoxy-substituted phenyl or haloalkyl-substituted phenyl is disclosed. The process comprises reacting a substituted urea of the formula: ##STR2## with an alkenyl aromatic compound of the formula: ##STR3## in a polar aprotic solvent, in the presence of an acid catalyst, preferably, sulfuric acid, substituted sulfonic acids or Lewis acids, and stirring the reaction mixture at a temperature of about 20.degree. to 80.degree. C. until formation of the precipitated phenylisopropylurea derivative is substantially complete.
摘要翻译：制备具有下式的苯基异丙基脲衍生物的新的和改进的方法：其中R1选自氢，卤素，烷基，烯基，卤代烷基或R2基团，R2选自苯基，烷基取代的苯基烷氧基取代的苯基或卤代烷基 - 取代的苯基。该方法包括在极性非质子溶剂中，在酸催化剂，优选硫酸，取代的磺酸或路易斯酸的存在下使下式的取代的脲与下式的链烯基芳族化合物反应：酸，并在约20℃至80℃的温度下搅拌反应混合物，直到形成沉淀的苯基异丙基脲衍生物基本上完成。

69. 发明授权

US4333868A Phosphite ester stabilizers 失效
标题翻译：亚磷酸酯稳定剂
公开(公告)号：US4333868A
公开(公告)日：1982-06-08
申请号：US104502
申请日：1979-12-17
申请人： Andreas Schmidt , Kurt Schwarzenbach
发明人： Andreas Schmidt , Kurt Schwarzenbach
IPC分类号： C10M101/00 , C07C45/00 , C07C47/27 , C07C67/00 , C07C69/00 , C07C215/54 , C07C231/00 , C07C275/24 , C07C323/52 , C07C327/00 , C07C329/06 , C07D251/12 , C07D251/46 , C07D251/52 , C07F7/18 , C07F9/09 , C07F9/141 , C07F9/145 , C07F9/24 , C07F9/32 , C07F9/40 , C07F9/6574 , C08K5/00 , C08K5/13 , C08K5/53 , C08L7/00 , C08L21/00 , C08L23/00 , C08L23/02 , C08L33/00 , C08L33/02 , C08L51/00 , C08L51/02 , C08L77/00 , C08L101/00 , C09K15/00 , C09K15/08 , C09K15/14 , C11B5/00 , C08K5/52
CPC分类号： C07F9/65746 , C07C215/54 , C07C275/24 , C07C323/52 , C07C329/00 , C07C329/06 , C07D251/12 , C07F7/1804 , C07F7/1824 , C07F9/094 , C07F9/1414 , C07F9/145 , C07F9/24 , C07F9/2475 , C07F9/32 , C07F9/40 , C07F9/4006 , C07F9/4087 , C07F9/65742
摘要： Compounds of the formula I ##STR1## in which R.sub.1 and R.sub.2 independently of one another denote alkyl, cycloalkyl or aralkyl, R.sub.3 denotes hydrogen or, conjointly with R.sub.1, denotes tetramethylene, R.sub.4 denotes hydrogen or lower alkyl or, conjointly with R.sub.2, denotes tetramethylene, R.sub.5 denotes hydrogen, alkyl, aralkyl, acyloxyalkyl, oxaalkyl or phenyl, R.sub.6 denotes hydrogen, alkyl, phenyl or the group ##STR2## or, conjointly with R.sub.5, denotes alkylene, R.sub.7 denotes hydrogen, alkyl, phenyl, benzyl or alkylphenyl or, conjointly with R.sub.5 or R.sub.6, denotes alkylene or, conjointly with R.sub.5 and R.sub.6, denotes alkanetriyl, R.sub.5, R.sub.6 and R.sub.7 together containing at least one carbon atom, Y denotes --O-- or --NH--, P denotes 1, 2, 3 or 4 and A denotes hydrogen or a group which is derived from an organic or inorganic oxygen acid A-(OH).sub.p, are suitable for stabilizing organic material against thermo-oxidative degradation.
摘要翻译：其中R 1和R 2彼此独立地表示烷基，环烷基或芳烷基的式I（I）化合物，R 3表示氢，或与R 1一起表示四亚甲基，R 4表示氢或低级烷基，或与R 2 表示四氢烯，R5表示氢，烷基，芳烷基，酰氧基烷基，氧杂烷基或苯基，R6表示氢，烷基，苯基或基团，或与R5相连，表示亚烷基，R7表示氢，烷基，苯基，苄基或烷基苯基或与R 5或R 6一起表示亚烷基，或与R 5和R 6一起表示烷基三乙基，R 5，R 6和R 7一起含有至少一个碳原子，Y表示-O-或-NH-，P表示1,2 ，3或4，A表示氢或衍生自有机或无机氧酸A-（OH）p的基团适于稳定有机材料以防止热氧化降解。

70. 发明授权

US4248967A Enzymic complexes adapted to convert racemic hydantoins into optically active aminoacids, and their applications 失效
标题翻译：适用于将外消旋乙内酰脲转化为光学活性氨基酸的酶复合物及其应用
公开(公告)号：US4248967A
公开(公告)日：1981-02-03
申请号：US885194
申请日：1978-03-10
申请人： Aurelio Viglia , Eugenio Fascetti , Elena Perricone , Ludwig Degen
发明人： Aurelio Viglia , Eugenio Fascetti , Elena Perricone , Ludwig Degen
IPC分类号： C12P13/00 , C07C273/18 , C07C275/24 , C12P13/04 , C12P41/00 , C12R1/07 , C07B19/02
CPC分类号： C12P13/04 , C07C273/1854 , Y10S435/832 , Y10S435/833
摘要： Enzymic complexes deriving from micro-organisms belonging to the Bacillaceae family using an hydantoin or a derivative thereof as inductor of the enzymic activity are used for hydrolysing racemic hydantoins into optically active aminoacids. The method of preparation is an enzymic hydrolysis fostered by the enzyme deriving from such special micro-organisms. The hydrolysis can be effected at a comparatively high temperature, which can reach even 60.degree. C.
摘要翻译：使用乙内酰脲或其衍生物作为酶活性的电感器衍生自属于芽孢杆菌科的微生物的酶复合物用于将外消旋乙内酰脲水解成光学活性的氨基酸。制备方法是由这种特殊微生物衍生的酶促进的酶水解。水解可以在比较高的温度下进行，甚至可以达到60℃。

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