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2. 发明授权

US4900749A Isoprenoidamine compounds useful as antiulcer agents 失效
标题翻译：异戊二烯类化合物可用作抗溃疡剂
公开(公告)号：US4900749A
公开(公告)日：1990-02-13
申请号：US837192
申请日：1986-03-10
申请人： Saichi Matsumoto , Masami Doteuchi , Takuji Mizui , Kentaro Hirai
发明人： Saichi Matsumoto , Masami Doteuchi , Takuji Mizui , Kentaro Hirai
IPC分类号： A61K31/16 , A61K31/165 , A61K31/17 , A61K31/22 , A61K31/335 , A61K31/34 , A61K31/341 , A61K31/357 , A61K31/38 , A61K31/381 , A61K31/40 , A61K31/403 , A61K31/404 , A61K31/415 , A61K31/495 , A61K45/08 , A61P1/04 , C07C67/00 , C07C231/00 , C07C233/05 , C07C233/65 , C07C275/20 , C07C275/24 , C07C275/28 , C07C275/30 , C07C313/00 , C07C317/44 , C07C323/62 , C07C325/00 , C07C327/40 , C07C327/46 , C07C327/50 , C07C331/22 , C07D207/34 , C07D209/18 , C07D209/28 , C07D209/30 , C07D209/42 , C07D213/40 , C07D213/54 , C07D213/56 , C07D213/74 , C07D213/75 , C07D213/81 , C07D213/82 , C07D213/83 , C07D233/54 , C07D233/60 , C07D233/61 , C07D241/12 , C07D241/24 , C07D295/13 , C07D295/15 , C07D295/215 , C07D307/68 , C07D317/58 , C07D333/38 , C07D521/00 , C08B37/16
CPC分类号： C07D213/40 , C07C275/20 , C07C275/24 , C07C275/28 , C07C275/30 , C07C331/22 , C07D207/34 , C07D209/28 , C07D209/30 , C07D213/54 , C07D213/74 , C07D213/75 , C07D213/81 , C07D213/82 , C07D213/83 , C07D231/12 , C07D233/56 , C07D233/64 , C07D241/24 , C07D249/08 , C07D295/13 , C07D295/15 , C07D295/215 , C07D307/68 , C07D317/58 , C07D333/38
摘要： Novel isoprenoidamine compounds (I) which show antiulcer activity are provided. ##STR1##
摘要翻译：提供了具有抗溃疡活性的新型异戊二烯酮化合物（I）。（一）

3. 发明授权

US5091569A Di-tert-butyl(hydroxy)phenylthio substituted hydroxamic acid derivatives 失效
标题翻译：二叔丁基（羟基）苯基取代的羟基酸衍生物
公开(公告)号：US5091569A
公开(公告)日：1992-02-25
申请号：US540625
申请日：1990-06-19
申请人： Saichi Matsumoto , Takuji Mizui , Masami Doteuchi
发明人： Saichi Matsumoto , Takuji Mizui , Masami Doteuchi
IPC分类号： A61K31/165 , A61K31/095 , A61P1/04 , A61P3/06 , A61P3/08 , A61P9/00 , A61P9/10 , A61P11/00 , A61P29/00 , A61P35/00 , A61P37/08 , A61P43/00 , C07C319/20 , C07C323/47 , C07C323/60
CPC分类号： C07C323/47 , C07C323/60
摘要： (Di-tert-butylhydroxyphenyl)thio substituted hydroxamic acid derivatives of the formula: ##STR1## wherein X is straight or branched C.sub.1 to C.sub.15 alkylene which may be attached to Y through phenylene, provided that X is not n-butylmethylene; Y is CO--N(OH) or N(OH)--CO; and R is hydrogen or straight or branched C.sub.1 to C.sub.9 alkyl, C.sub.3 to C.sub.9 cycloalkyl, aryl, or aralkyl, provided that R is not hydrogen when Y--R is N(OH)--CO--R; or a pharmaceutically acceptable salt thereof; useful in treating arteriosclerosis, ulcer, inflammation, allergy, or the like.

4. 发明授权

US4954514A (Di-tert-butylhydroxyphenyl)thio derivatives and antiarterioschlerosis compositions thereof 失效
标题翻译：（二叔丁基羟基苯基）硫代衍生物及其抗动脉硬化组合物
公开(公告)号：US4954514A
公开(公告)日：1990-09-04
申请号：US451743
申请日：1989-12-18
申请人： Toru Kita , Shuh Narumiya , Masayuki Narisada , Fumrhio Watanabe , Masami Doteuchi , Takuji Mizui
发明人： Toru Kita , Shuh Narumiya , Masayuki Narisada , Fumrhio Watanabe , Masami Doteuchi , Takuji Mizui
IPC分类号： A61K31/165 , A61K31/16 , A61K31/275 , A61K31/41 , A61P1/04 , A61P3/06 , A61P9/10 , A61P29/00 , A61P37/08 , A61P43/00 , C07C323/32 , C07C323/41 , C07C323/60 , C07C323/62 , C07D257/04
CPC分类号： C07D257/04 , C07C323/60
摘要： (Di-tert-butylhydroxyphenyl)thio derivatives of the formula: ##STR1## wherein R is cyano, carbamoyl, or 5-tetrazolyl; n is an integer of 2 to 6; provided that when R is cyano, n is not 2; or a pharmaceutically acceptable salt thereof; useful in treating arterioschlerosis, ulcer, inflammation, allergy, or the like.

5. 发明授权

US5084214A Phenolic thioethers, and their production and use 失效
标题翻译：酚醛树脂及其生产和使用
公开(公告)号：US5084214A
公开(公告)日：1992-01-28
申请号：US359718
申请日：1989-05-31
申请人： Toru Kita , Shuh Narumiya , Masayuki Narisada , Fumihiko Watanabe , Saichi Matsumoto , Masami Doteuchi
发明人： Toru Kita , Shuh Narumiya , Masayuki Narisada , Fumihiko Watanabe , Saichi Matsumoto , Masami Doteuchi
IPC分类号： A61K31/19 , A61K31/22 , A61K31/235 , A61P1/04 , A61P3/06 , A61P9/10 , A61P9/14 , A61P29/00 , A61P37/08 , C07C323/52 , C07C323/54 , C07C323/56
CPC分类号： C07C323/52 , Y02P20/55 , Y10S514/824
摘要： Phenolic thioethers of the formula: ##STR1## wherein R is a hydrogen atom or a protective group for carboxyl, X is a straight or branched C.sub.4 -C.sub.15 alkylene group, a straight or branched C.sub.1 -C.sub.15 alkylene group having a phenylene group or a straight or branched C.sub.2 -C.sub.15 alkenylene group, and their salts, which inhibit the denaturation of low density lipoproteins (LDL) and the incorporation of LDL by macrophages and are useful as anti-arteriosclerosis agents.

6. 发明授权

US4839365A Thienopyridine derivatives useful in treating gastric ulcers 失效
标题翻译：可用于治疗胃溃疡的噻吩并吡啶衍生物
公开(公告)号：US4839365A
公开(公告)日：1989-06-13
申请号：US191057
申请日：1988-05-06
申请人： Kentaro Hirai , Yukio Mizushima , Masami Doteuchi
发明人： Kentaro Hirai , Yukio Mizushima , Masami Doteuchi
IPC分类号： C07D495/04
CPC分类号： C07D495/04
摘要： A compound of the formula: ##STR1## (wherein R.sup.1 is hydrogen, C.sub.1 -C.sub.5 alkyl, C.sub.1 -C.sub.5 alkoxy, C.sub.1 -C.sub.5 alkoxycarbonyl, or trifluoromethyl; R.sup.2 is hydrogen, C.sub.1 -C.sub.5 alkoxycarbonyl, C.sub.6 -C.sub.12 aryloxycarbonyl, C.sub.1 -C.sub.5 alkanoyloxy-C.sub.1 -C.sub.5 alkyl, C.sub.1 -C.sub.5 alkoxycarbonyloxy-C.sub.1 -C.sub.5 alkyl, C.sub.1 -C.sub.5 acylamino-C.sub.1 -C.sub.5 alkyl, 2-hydroxy-1-C.sub.2 -C.sub.5 alkenyl, phthalimido-C.sub.1 -C.sub.5 alkyl, halogeno-C.sub.1 -C.sub.5 alkoxycarbonyl-C.sub.1 -C.sub.5 alkyl, hydroxy-C.sub.1 -C.sub.5 alkyl, C.sub.1 -C.sub.5 alkylthio-C.sub.1 -C.sub.5 alkyl, or C.sub.1 -C.sub.5 alkylsulfinyl-C.sub.1 -C.sub.5 alkyl; ##STR2## m is an integer of 0 or 1; R.sup.3 and R.sup.4 each is hydrogen, halogen, cyano, C.sub.1 -C.sub.5 alkyl, amino, C.sub.1 -C.sub.5 alkoxy, C.sub.6 -C.sub.12 aryl-C.sub.1 -C.sub.5 alkoxy, C.sub.1 -C.sub.5 alkoxycarbonyl, fluoro-C.sub.1 -C.sub.5 alkoxy, C.sub.1 -C.sub.5 alkanoylamino, or carbamoyl) or its salt, being useful as antiulcer agents, is provided.

7. 发明授权

US4318858A Thioethylamide derivatives 失效
标题翻译：硫代乙酰胺衍生物
公开(公告)号：US4318858A
公开(公告)日：1982-03-09
申请号：US212222
申请日：1980-12-02
申请人： Kentaro Hirai , Shigeru Matsutani , Teruyuki Ishiba , Itsuo Makino , Masami Doteuchi , Koichi Otani
发明人： Kentaro Hirai , Shigeru Matsutani , Teruyuki Ishiba , Itsuo Makino , Masami Doteuchi , Koichi Otani
IPC分类号： C07D333/16 , A61K31/34 , A61K31/341 , A61P43/00 , C07D307/52 , C07D307/68 , C07D333/20 , C07D333/38 , C07D405/12 , C07D409/12 , C07D207/04 , C07D333/18
CPC分类号： C07D307/68 , C07D307/52 , C07D333/20 , C07D333/38 , Y10S514/927
摘要： A compound of the formula: ##STR1## [wherein R is dimethylamino or 1-pyrrolidinyl;R.sup.1 and R.sup.2 each is hydrogen or C.sub.1 -C.sub.3 alkyl;R.sup.3 is hydrogen, C.sub.1 -C.sub.3 alkyl (optionally substituted by one member selected from the group consisting of cyano, C.sub.1 -C.sub.3 alkoxy, phenyl, and 5- or 6-membered heterocyclic group), C.sub.3 -C.sub.6 cycloalkyl, C.sub.2 -C.sub.5 alkenyl (optionally substituted by one member selected from the group consisting of C.sub.1 -C.sub.3 alkoxy, phenyl, and phenoxy), C.sub.6 -C.sub.10 aryl (optionally substituted by one or two members selected from the group consisting of hydroxy, halogen, nitro, sulfamoyl, C.sub.1 -C.sub.3 alkyl, C.sub.1 -C.sub.3 alkoxy, C.sub.1 -C.sub.3 alkanoyl, C.sub.2 -C.sub.4 alkoxycarbonyl, C.sub.2 -C.sub.4 dialkylamino, and C.sub.1 -C.sub.3 alkanesulfonyl), or 5- or 6-membered heterocyclic group (optionally substituted by one member selected from the group consisting of oxo, halogen, C.sub.1 -C.sub.3 alkyl, and C.sub.1 -C.sub.3 alkoxy);and X is oxygen or sulfur]and its pharmaceutically acceptable acid addition salts is useful as histamine H.sub.2 blockers.
摘要翻译：下式的化合物：其中R是二甲基氨基或1-吡咯烷基; R1和R2各自为氢或C1-C3烷基; R 3是氢，C 1 -C 3烷基（任选地被选自氰基，C 1 -C 3烷氧基，苯基和5-或6-元杂环基中的一个取代），C 3 -C 6环烷基，C 2 -C 5烯基（任选地被选自C 1 -C 3烷氧基，苯基和苯氧基的一个取代基取代），C 6 -C 10芳基（任选被一个或两个选自羟基，卤素，硝基，氨磺酰基，C1- C 3烷基，C 1 -C 3烷氧基，C 1 -C 3烷酰基，C 2 -C 4烷氧基羰基，C 2 -C 4二烷基氨基和C 1 -C 3烷磺酰基）或5或6元杂环基（任选被一个选自的氧代，卤素，C 1 -C 3烷基和C 1 -C 3烷氧基）; 并且X是氧或硫]，其药学上可接受的酸加成盐可用作组胺H2阻断剂。

8. 发明授权

US4309433A Pyridinecarbonamido-oxy or thio loweralkyl-1-(diloweralkylaminoloweralkyl)benzene and derivatives thereof, compositions containing same and method of using same 失效
标题翻译：吡啶羰基酰氧基或硫代低级烷基-1-（二低烷基氨基低级烷基）苯及其衍生物，含有它们的组合物及其使用方法
公开(公告)号：US4309433A
公开(公告)日：1982-01-05
申请号：US164016
申请日：1980-06-30
申请人： Kentaro Hirai , Teruyuki Ishiba , Shigeru Matsutani , Itsuo Makino , Toshio Fujishita , Masami Doteuchi , Koichi Otani
发明人： Kentaro Hirai , Teruyuki Ishiba , Shigeru Matsutani , Itsuo Makino , Toshio Fujishita , Masami Doteuchi , Koichi Otani
IPC分类号： C07D295/18 , A61K31/16 , A61K31/165 , A61K31/34 , A61K31/341 , A61K31/40 , A61K31/4015 , A61K31/41 , A61K31/415 , A61K31/42 , A61K31/4245 , A61K31/435 , A61K31/4402 , A61K31/4406 , A61K31/4409 , A61K31/445 , A61K31/455 , A61K31/535 , A61K31/5375 , A61K31/5377 , A61P43/00 , C07C67/00 , C07C231/00 , C07C233/18 , C07C233/20 , C07C233/22 , C07C233/60 , C07C233/69 , C07C235/20 , C07C235/48 , C07C235/72 , C07C237/08 , C07C237/32 , C07C237/42 , C07C239/00 , C07C261/04 , C07C301/00 , C07C311/18 , C07C313/00 , C07C323/29 , C07C323/39 , C07C323/41 , C07C325/00 , C07C327/40 , C07C327/46 , C07C327/48 , C07C327/50 , C07D207/16 , C07D207/28 , C07D211/60 , C07D213/81 , C07D213/82 , C07D233/90 , C07D249/10 , C07D257/04 , C07D261/18 , C07D271/06 , C07D295/08 , C07D295/096 , C07D295/14 , C07D295/15 , C07D307/68 , C07D333/38 , C07D335/06 , C07D498/04 , C07D213/56 , C07D401/10
CPC分类号： C07D213/81 , C07C323/29 , C07D207/16 , C07D207/28 , C07D213/82 , C07D257/04 , C07D261/18 , C07D271/06 , C07D295/096 , C07D295/15 , C07D333/38 , C07D335/06 , Y10S514/927
摘要： An aminoalkylbenzene derivative of the formula: ##STR1## [wherein A is oxygen or sulfur;Y is oxo, thioxo, or cyanoimino;a is an integer of 1 to 3;b is an integer of 0 to 3;c is an integer of 1 to 4;R.sup.1 is alkyl;R.sup.2 is hydrogen or alkyl; orR.sup.1 and R.sup.2 taken together represent pyrrolidinyl;R is hydrogen, cycloalkyl, trihaloalkyl, alkoxy, dialkylamino, aryl, aroyl, heterocyclic group, or a group of the formula: ##STR2## (wherein R.sup.3 is hydrogen, halogen, amino, alkyl, alkylamino, dialkylamino, alkylthio, or aryloxy;R.sup.4 is hydrogen, alkyl, alkenyl, aryl, or heterocyclic group; orR.sup.3 and R.sup.4 taken together represent alkylidene or aralkylidene;with the proviso that the above aryl, aroyl, and heterocyclic group can be substituted by 1 to 3 substituents] and its pharmaceutically acceptable acid addition salts being useful as histamine H.sub.2 blockers, especially peptic ulcer remedies, are provided via several routes.
摘要翻译：下式的氨基烷基苯衍生物：其中A是氧或硫; Y是氧代，硫代或氰基亚氨基; a为1〜3的整数， b为0〜3的整数; c为1〜4的整数， R1是烷基; R2是氢或烷基; 或者R 1和R 2一起代表吡咯烷基; R是氢，环烷基，三卤代烷基，烷氧基，二烷基氨基，芳基，芳酰基，杂环基或下式基团：其中R 3是氢，卤素，氨基，烷基，烷基氨基，二烷基氨基，烷硫基或芳氧基; R4是氢，烷基，烯基，芳基或杂环基;或R3和R4一起代表亚烷基或亚烷叉基;条件是上述芳基，芳酰基和杂环基可以被1至3个取代基取代] 作为组胺H2阻断剂，特别是消化性溃疡治疗剂可用的可接受的酸加成盐通过几种途径提供。

9. 发明授权

US4564623A Aminoalkylbenzene derivatives 失效
标题翻译：氨基烷基苯衍生物
公开(公告)号：US4564623A
公开(公告)日：1986-01-14
申请号：US573685
申请日：1984-01-25
申请人： Kentaro Hirai , Teruyuki Ishiba , Shigeru Matsutani , Itsuo Makino , Toshio Fujishita , Masami Doteuchi , Koichi Otani
发明人： Kentaro Hirai , Teruyuki Ishiba , Shigeru Matsutani , Itsuo Makino , Toshio Fujishita , Masami Doteuchi , Koichi Otani
IPC分类号： C07D295/18 , A61K31/16 , A61K31/165 , A61K31/34 , A61K31/341 , A61K31/40 , A61K31/4015 , A61K31/41 , A61K31/415 , A61K31/42 , A61K31/4245 , A61K31/435 , A61K31/4402 , A61K31/4406 , A61K31/4409 , A61K31/445 , A61K31/455 , A61K31/535 , A61K31/5375 , A61K31/5377 , A61P43/00 , C07C67/00 , C07C231/00 , C07C233/18 , C07C233/20 , C07C233/22 , C07C233/60 , C07C233/69 , C07C235/20 , C07C235/48 , C07C235/72 , C07C237/08 , C07C237/32 , C07C237/42 , C07C239/00 , C07C261/04 , C07C301/00 , C07C311/18 , C07C313/00 , C07C323/29 , C07C323/39 , C07C323/41 , C07C325/00 , C07C327/40 , C07C327/46 , C07C327/48 , C07C327/50 , C07D207/16 , C07D207/28 , C07D211/60 , C07D213/81 , C07D213/82 , C07D233/90 , C07D249/10 , C07D257/04 , C07D261/18 , C07D271/06 , C07D295/08 , C07D295/096 , C07D295/14 , C07D295/15 , C07D307/68 , C07D333/38 , C07D335/06 , C07D498/04 , C07D207/04
CPC分类号： C07D213/81 , C07C323/29 , C07D207/16 , C07D207/28 , C07D213/82 , C07D257/04 , C07D261/18 , C07D271/06 , C07D295/096 , C07D295/15 , C07D333/38 , C07D335/06 , Y10S514/927
摘要： An aminoalkylbenzene derivative of the formula: ##STR1## [wherein A is oxygen or sulfur;Y is oxo, thioxo, or cyanoimino;a is an integer of 1 to 3;b is an integer of 0 to 3;c is an integer of 1 to 4;R.sup.1 is alkyl;R.sup.2 is hydrogen or alkyl; orR.sup.1 and R.sup.2 taken together represent pyrrolidinyl;R is hydrogen, cycloaklkyl, trihaloalkyl, alkoxy, dialkylamino, aryl, aroyl, heterocyclic group, or a group of the formula: ##STR2## (wherein R.sup.3 is hydrogen, halogen, amino, alkyl, alkylamino, dialkylamino, alkylthio, or aryloxy;R.sup.4 is hydrogen, alkyl, alkenyl, aryl, or heterocyclic group; orR.sup.3 and R.sup.4 taken together represent alkylidene or aralkylidene);with the proviso that the above aryl, aroyl, and heterocyclic group can be substituted by 1 to 3 substituents] and its pharmaceutically acceptable acid addition salts being useful as histamine H.sub.2 blockers, especially peptic ulcer remedies, are provided via several routes.

10. 发明授权

US4840953A 9-(Substituted thio)-4H-pyrido[1,2,-A]pyrimidin-4-one derivatives 失效
标题翻译： 9-（取代的硫代）-4H-吡啶并[1,2-a]嘧啶-4-酮衍生物
公开(公告)号：US4840953A
公开(公告)日：1989-06-20
申请号：US206665
申请日：1988-06-15
申请人： Shigeru Matsutani , Yukio Mizushima , Masami Doteuchi , Yasunobu Ishihara
发明人： Shigeru Matsutani , Yukio Mizushima , Masami Doteuchi , Yasunobu Ishihara
IPC分类号： C07D471/04
CPC分类号： C07D471/04
摘要： 9-(Substituted thio)-4H-pyrido[1,2-a]pyrimidin-4-one derivatives of the formula: ##STR1## wherein n is 0 or 1, R is --COR.sup.1, --CONR.sup.4 R.sup.5 or --CH.sub.2 R.sup.6, R.sup.1 is C.sub.1 -C.sub.5 alkyl, C.sub.3 -C.sub.7 cycloalkyl, allythio, styryl, phenoxymethyl, thienylmethyl, C.sub.6 -C.sub.10 aryl optionally substituted, benzyl optionally substituted or 5- or 6-membered heterocyclic group optionally substituted, R.sup.2 and R.sup.3 each is hydrogen, C.sub.1 -C.sub.5 alkyl, carboxy, C.sub.2 -C.sub.5 alkoxycarbonyl or benzyloxycarbonyl optionally substituted, R.sup.4 and R.sup.5 each is hydrogen, C.sub.1 -C.sub.5 alkyl, C.sub.3 -C.sub.7 cycloalkyl or phenyl optionally substituted, and R.sup.8 is pyridyl or phenyl optionally substituted) being useful as antiulcer agents are provided through several routes.
摘要翻译： 9-（取代的硫代）-4H-吡啶并[1,2-a]嘧啶-4-酮衍生物其中n为0或1，R为-COR 1，-CONR 4 R 5或-CH 2 R 6 R1是C1-C5烷基，C3-C7环烷基，烯硫基，苯乙烯基，苯氧基甲基，噻吩基甲基，任选取代的C 6 -C 10芳基，任选取代的苄基，或任选被取代的5或6元杂环基，R 2和R 3各自是氢， C 1 -C 5烷基，羧基，C 2 -C 5烷氧基羰基或任选取代的苄氧基羰基，R 4和R 5各自为氢，C 1 -C 5烷基，C 3 -C 7环烷基或任选取代的苯基，R 8为任选取代的吡啶基或苯基）可用作抗溃疡剂代理商通过几条路线提供。

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