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1. 发明授权

US5919965A Non-nucleotide phosphorus ester oligomers 失效
标题翻译：非核苷酸磷酯低聚物
公开(公告)号：US5919965A
公开(公告)日：1999-07-06
申请号：US374040
申请日：1995-01-18
申请人： Robert Gerard Gentles , Alan F. Cook , Morris Jonathan Rudolph , Reza Fathi
发明人： Robert Gerard Gentles , Alan F. Cook , Morris Jonathan Rudolph , Reza Fathi
IPC分类号： C07B59/00 , C07B61/00 , C07D233/60 , C07F9/141 , C07F9/143 , C07F9/144 , C07F9/145 , C07F9/24 , C07F9/572 , C07F9/58 , C07F9/6506 , C07F9/6509 , C07F9/6539 , C07F9/655 , C07F9/6561 , C07F9/6574 , C07F9/6578 , C07F9/06 , C07D241/04
CPC分类号： C07F9/6578 , C07B59/004 , C07F9/1411 , C07F9/1414 , C07F9/143 , C07F9/144 , C07F9/145 , C07F9/2408 , C07F9/2416 , C07F9/242 , C07F9/5728 , C07F9/582 , C07F9/588 , C07F9/65062 , C07F9/650958 , C07F9/6539 , C07F9/65515 , C07F9/6561 , C07F9/65616 , C40B40/00 , Y02P20/55
摘要： A phosphorus ester oligomer having the structure: ##STR1## wherein A can be the same or different in each monomeric unit and each is independently selected from the group consisting of oxygen, sulfur, lower alkyl, alkyl- or aryl-substituted amino and aminoalkyl; B.sub.1 and B.sub.2 can be the same or different and each is independently selected from hydrogen, lower alkyl, a labelling group, a protecting group, a phosphoramidate or a phosphomonoester; R.sub.1 can be the same or different in each monomeric unit, and in at least one of the non-nucleotide monomeric units, R.sub.1 is independently selected from the group consisting of a condensation product of (i) a non-vicinal diol attached to a hydrogen bond donor functionality; (ii) a hydrogen bond acceptor selected from an ether, a purine or pyrimidine substituted 1,2-diol or a disubstituted heterocycle; (iii) a non-vicinal diol attached to a hydrophobic functionality or a vicinal diol attached to an aliphatic or alicyclic hydrophobic functionality (iv) a diol attached to a ring substituted anionic functionality and (v) a cationic moiety attached to a non-vicinal or alicyclic diol, any of which can further include a detectable label, and n is at least one. Preferred R.sub.1 moieties include condensation products of heterocyclic diols, alicyclic diols, and polycyclic diols. Also the non-nucleotide monomers thereof, combinatorial library mixtures of the oligomers and the use of the oligomers as selective target-binding compounds.
摘要翻译：具有以下结构的磷酯低聚物：其中A可以在每个单体单元中相同或不同，并且各自独立地选自氧，硫，低级烷基，烷基或芳基取代的氨基和氨基烷基; B1和B2可以相同或不同，各自独立地选自氢，低级烷基，标记基团，保护基，氨基磷酸酯或磷酸酯酯; R 1可以在每个单体单元中相同或不同，并且在至少一个非核苷酸单体单元中，R 1独立地选自以下组中的缩合产物：（i）连接于氢的非连位二醇债券供体功能; （ii）选自醚，嘌呤或嘧啶取代的1,2-二醇或二取代杂环的氢键受体; （iii）连接到疏水官能团的非连位二醇或连接到脂族或脂环族疏水官能团的连位二醇（iv）连接到环取代的阴离子官能团上的二醇和（v）连接到非邻位的阳离子部分或脂环族二醇，其中任何一种可以进一步包括可检测标记，并且n是至少一个。优选的R1部分包括杂环二醇，脂环族二醇和多环二醇的缩合产物。还有其非核苷酸单体，低聚物的组合文库混合物以及低聚物作为选择性靶结合化合物的用途。

2. 发明申请

US20180346815A1 RESVERATROL-BASED FLAME RETARDANT MATERIALS 审中-公开
公开(公告)号：US20180346815A1
公开(公告)日：2018-12-06
申请号：US15609218
申请日：2017-05-31
申请人： International Business Machines Corporation
发明人： SCOTT B. KING , BRANDON M. KOBILKA , JOSEPH KUCZYNSKI , JASON T. WERTZ
IPC分类号： C09K21/12 , C07F9/40 , C08K5/5333 , C09K21/14 , C07F9/12
CPC分类号： C09K21/12 , C07F9/12 , C07F9/141 , C07F9/1411 , C07F9/1412 , C07F9/1414 , C07F9/145 , C07F9/4084 , C08F30/02 , C08F130/02 , C08F230/02 , C08K5/5333 , C08K5/5337 , C08K5/5353 , C08K5/5357 , C08K5/5373 , C09K21/14
摘要： A process of forming a resveratrol-based flame retardant small molecule with a phosphonate/phosphinate molecule that includes a chloride group and a terminal functional group.

3. 发明授权

US3158645A 2, 3, 6-trichlorobenzyl-2, 4-dichlorophenoxy-acetate 失效
标题翻译： 2,3,6-三氯苄基-2,4-二氯苯氧基乙酸酯
公开(公告)号：US3158645A
公开(公告)日：1964-11-24
申请号：US18684462
申请日：1962-04-12
申请人： HOOKER CHEMICAL CORP
发明人： NEWCOMER JACK S , WEIL EDWARD D , EDWIN DORFMAN , JEROME LINDER
IPC分类号： C07C305/18 , C07C327/36 , C07C331/04 , C07C333/20 , C07C381/02 , C07F9/14 , C07F9/141 , C07F9/165
CPC分类号： C07F9/1414 , C07C305/18 , C07C327/36 , C07C331/04 , C07C333/20 , C07C381/02 , C07F9/14 , C07F9/1653

4. 发明授权

US10138423B1 Resveratrol-based flame retardant materials 有权
公开(公告)号：US10138423B1
公开(公告)日：2018-11-27
申请号：US15609218
申请日：2017-05-31
申请人： International Business Machines Corporation
发明人： Scott B. King , Brandon M. Kobilka , Joseph Kuczynski , Jason T. Wertz
IPC分类号： C09K21/12 , C07F9/40 , C08K5/5333 , C09K21/14 , C07F9/12 , C07F9/141 , C08F230/02 , C07F9/145 , C08K5/5337 , C08F130/02 , C08K5/5373 , C08K5/5353 , C08K5/5357 , C08F30/02
CPC分类号： C09K21/12 , C07F9/12 , C07F9/141 , C07F9/1411 , C07F9/1412 , C07F9/1414 , C07F9/145 , C07F9/4084 , C08F30/02 , C08F130/02 , C08F230/02 , C08K5/5333 , C08K5/5337 , C08K5/5353 , C08K5/5357 , C08K5/5373 , C09K21/14
摘要： A process of forming a resveratrol-based flame retardant small molecule with a phosphonate/phosphinate molecule that includes a chloride group and a terminal functional group.

5. 发明申请

US20070135539A1 Macromolecular antioxidants based on sterically hindered phenols and phosphites 有权
标题翻译：基于空间位阻酚和亚磷酸酯的大分子抗氧化剂
公开(公告)号：US20070135539A1
公开(公告)日：2007-06-14
申请号：US11588855
申请日：2006-10-27
申请人： Ashok Cholli , Rajesh Kumar
发明人： Ashok Cholli , Rajesh Kumar
IPC分类号： C08K5/524 , C07F9/6574
CPC分类号： C07F9/1414 , C07F9/1412 , C07F9/145 , C07F9/6571 , C07F9/65746 , C08K5/524 , C08K5/527
摘要： Sterically hindered phenol and phosphite based compounds, represented by a formula selected from I-III: and their use as antioxidants in a wide range of materials including, but not limited to, food, plastics, elastomers, composites and petroleum based products is disclosed herein.
摘要翻译：由选自I-III的式表示的受阻酚和亚磷酸酯基化合物及其作为抗氧化剂在广泛范围的材料中的用途，包括但不限于食品，塑料，弹性体，复合材料和石油基产品。。

6. 发明授权

US2876246A Tris (phenyl chloroethyl) phosphite 失效
标题翻译：亚磷酸三（苯基氯乙基）酯
公开(公告)号：US2876246A
公开(公告)日：1959-03-03
申请号：US53926055
申请日：1955-10-07
申请人： FMC CORP
发明人： PIANFETTI JOHN A , KOSOAPOFF GENNADY M
IPC分类号： C07F9/141 , C10L1/26
CPC分类号： C10L1/2641 , C07F9/1414

7. 发明授权

US4333868A Phosphite ester stabilizers 失效
标题翻译：亚磷酸酯稳定剂
公开(公告)号：US4333868A
公开(公告)日：1982-06-08
申请号：US104502
申请日：1979-12-17
申请人： Andreas Schmidt , Kurt Schwarzenbach
发明人： Andreas Schmidt , Kurt Schwarzenbach
IPC分类号： C10M101/00 , C07C45/00 , C07C47/27 , C07C67/00 , C07C69/00 , C07C215/54 , C07C231/00 , C07C275/24 , C07C323/52 , C07C327/00 , C07C329/06 , C07D251/12 , C07D251/46 , C07D251/52 , C07F7/18 , C07F9/09 , C07F9/141 , C07F9/145 , C07F9/24 , C07F9/32 , C07F9/40 , C07F9/6574 , C08K5/00 , C08K5/13 , C08K5/53 , C08L7/00 , C08L21/00 , C08L23/00 , C08L23/02 , C08L33/00 , C08L33/02 , C08L51/00 , C08L51/02 , C08L77/00 , C08L101/00 , C09K15/00 , C09K15/08 , C09K15/14 , C11B5/00 , C08K5/52
CPC分类号： C07F9/65746 , C07C215/54 , C07C275/24 , C07C323/52 , C07C329/00 , C07C329/06 , C07D251/12 , C07F7/1804 , C07F7/1824 , C07F9/094 , C07F9/1414 , C07F9/145 , C07F9/24 , C07F9/2475 , C07F9/32 , C07F9/40 , C07F9/4006 , C07F9/4087 , C07F9/65742
摘要： Compounds of the formula I ##STR1## in which R.sub.1 and R.sub.2 independently of one another denote alkyl, cycloalkyl or aralkyl, R.sub.3 denotes hydrogen or, conjointly with R.sub.1, denotes tetramethylene, R.sub.4 denotes hydrogen or lower alkyl or, conjointly with R.sub.2, denotes tetramethylene, R.sub.5 denotes hydrogen, alkyl, aralkyl, acyloxyalkyl, oxaalkyl or phenyl, R.sub.6 denotes hydrogen, alkyl, phenyl or the group ##STR2## or, conjointly with R.sub.5, denotes alkylene, R.sub.7 denotes hydrogen, alkyl, phenyl, benzyl or alkylphenyl or, conjointly with R.sub.5 or R.sub.6, denotes alkylene or, conjointly with R.sub.5 and R.sub.6, denotes alkanetriyl, R.sub.5, R.sub.6 and R.sub.7 together containing at least one carbon atom, Y denotes --O-- or --NH--, P denotes 1, 2, 3 or 4 and A denotes hydrogen or a group which is derived from an organic or inorganic oxygen acid A-(OH).sub.p, are suitable for stabilizing organic material against thermo-oxidative degradation.
摘要翻译：其中R 1和R 2彼此独立地表示烷基，环烷基或芳烷基的式I（I）化合物，R 3表示氢，或与R 1一起表示四亚甲基，R 4表示氢或低级烷基，或与R 2 表示四氢烯，R5表示氢，烷基，芳烷基，酰氧基烷基，氧杂烷基或苯基，R6表示氢，烷基，苯基或基团，或与R5相连，表示亚烷基，R7表示氢，烷基，苯基，苄基或烷基苯基或与R 5或R 6一起表示亚烷基，或与R 5和R 6一起表示烷基三乙基，R 5，R 6和R 7一起含有至少一个碳原子，Y表示-O-或-NH-，P表示1,2 ，3或4，A表示氢或衍生自有机或无机氧酸A-（OH）p的基团适于稳定有机材料以防止热氧化降解。

8. 发明授权

US4284829A Hydroxyalkyl and oxoalkyl substituted phenols as analgesics and sedatives 失效
标题翻译：羟烷基和氧代烷基取代酚作为止痛剂和镇静剂
公开(公告)号：US4284829A
公开(公告)日：1981-08-18
申请号：US972595
申请日：1978-12-22
申请人： Thomas H. Althuis , Charles A. Harbert , Michael R. Johnson , Lawrence S. Melvin, Jr.
发明人： Thomas H. Althuis , Charles A. Harbert , Michael R. Johnson , Lawrence S. Melvin, Jr.
IPC分类号： C07C37/055 , C07C39/11 , C07C39/12 , C07C39/367 , C07C41/26 , C07C43/23 , C07C45/44 , C07C45/67 , C07C45/69 , C07C47/277 , C07C49/245 , C07C49/255 , C07D295/15 , C07F9/12 , C07F9/141 , C07C39/06 , C07C39/10 , C07C47/00
CPC分类号： C07D295/15 , C07C37/055 , C07C39/11 , C07C39/12 , C07C39/367 , C07C41/26 , C07C43/23 , C07C45/44 , C07C45/67 , C07C45/69 , C07C47/277 , C07C49/245 , C07C49/255 , C07F9/12 , C07F9/1414
摘要： Compounds useful for pharmacological and medicinal purposes having the formulae ##STR1## wherein R is H, C.sub.1 -C.sub.5 alkanoyl; R.sub.1 is H, benzyl, C.sub.1 14 C.sub.5 alkanoyl, P(O)(OH).sub.2, --CO(CH.sub.2).sub.2 COOH or a basic acyl group; each of R.sub.2 and R.sub.4 is H, C.sub.1 -C.sub.6 alkyl, phenyl, pyridyl or (CH.sub.2).sub.y C.sub.6 H.sub.5 ; y is 1-4; R.sub.3 is H or CH.sub.3 ; Z is C.sub.1 -C.sub.13 alkylene or --(alk.sub.1).sub.m --O--(alk.sub.2).sub.n --; each of (alk.sub.1) and (alk.sub.2) is C.sub.1 -C.sub.13 alkylene with the proviso that the summation of carbon atoms in (alk.sub.1) plus (alk.sub.2) is not greater than 13; each of m and n is 0 or 1; and W is H, pyridyl, phenyl, fluorophenyl or chlorophenyl; intermediates therefor and methods for their preparation and use.
摘要翻译：其中R为H，C 1 -C 5烷酰基，C 1 -C 5烷酰基， R1是H，苄基，C114C5烷酰基，P（O）（OH）2，-CO（CH2）2COOH或碱性酰基; R2和R4各自为H，C1-C6烷基，苯基，吡啶基或（CH2）yC6H5; y为1-4; R3是H或CH3; Z是C1-C13亚烷基或 - （alk1）m-O-（alk2）n-; （alk1）和（alk2）中的每一个是C1-C13亚烷基，条件是（alk1）加（alk2）中的碳原子的总和不大于13; m和n各自为0或1; W为H，吡啶基，苯基，氟苯基或氯苯基; 其中间体及其制备和使用方法。

9. 发明授权

US4283569A Hydroxyalkyl and oxoalkyl substituted phenols as analgesics and sedatives 失效
标题翻译：羟烷基和氧代烷基取代酚作为止痛剂和镇静剂
公开(公告)号：US4283569A
公开(公告)日：1981-08-11
申请号：US832868
申请日：1977-09-13
申请人： Thomas H. Althuis , Charles A. Harbert , Michael R. Johnson , Lawrence S. Melvin, Jr.
发明人： Thomas H. Althuis , Charles A. Harbert , Michael R. Johnson , Lawrence S. Melvin, Jr.
IPC分类号： A61K31/11 , A61K31/05 , A61K31/075 , A61K31/12 , A61K31/325 , A61K31/35 , A61K31/40 , A61K31/44 , A61K31/4409 , A61K31/4418 , A61K31/445 , A61K31/535 , A61P7/10 , A61P25/00 , A61P25/04 , A61P25/20 , C07C27/00 , C07C29/143 , C07C37/00 , C07C37/055 , C07C39/11 , C07C39/12 , C07C39/15 , C07C39/367 , C07C41/00 , C07C41/26 , C07C43/178 , C07C43/23 , C07C45/00 , C07C45/44 , C07C45/67 , C07C47/27 , C07C47/277 , C07C49/20 , C07C49/245 , C07C49/255 , C07C49/76 , C07C67/00 , C07C69/007 , C07C69/017 , C07C69/157 , C07C69/353 , C07C229/06 , C07D213/30 , C07D295/15 , C07F9/09 , C07F9/12 , C07F9/141 , C07C39/06 , C07C39/10
CPC分类号： C07D295/15 , C07C37/055 , C07C39/11 , C07C39/12 , C07C39/367 , C07C41/26 , C07C43/23 , C07C45/44 , C07C45/67 , C07C45/673 , C07C47/277 , C07C49/245 , C07C49/255 , C07F9/094 , C07F9/12 , C07F9/1414
摘要： Compounds useful for pharmacological and medicinal purposes having the formulae ##STR1## wherein R is H, C.sub.1 -C.sub.5 alkanoyl; R.sub.1 is H, benzyl, C.sub.1 -C.sub.5 alkanoyl, P(O)(OH).sub.2, --CO(CH.sub.2).sub.2 COOH or a basic acyl group; each of R.sub.2 and R.sub.4 is H, C.sub.1 -C.sub.6 alkyl, phenyl, pyridyl or (CH.sub.2).sub.y C.sub.6 H.sub.5 ; y is 1-4; R.sub.3 is H or CH.sub.3 ; Z is C.sub.1 -C.sub.13 alkylene or --(alk.sub.1).sub.m --O--(alk.sub.2).sub.n --; each of (alk.sub.1) and (alk.sub.2) is C.sub.1 -C.sub.13 alkylene with the proviso that the summation of carbon atoms in (alk.sub.1) plus (alk.sub.2) is not greater than 13; each of m and n is 0 or 1; and W is H, pyridyl, phenyl, fluorophenyl or chlorophenyl; intermediates therefor and methods for their preparation and use.
摘要翻译：可用于药理学和药物学目的的具有下式的化合物：其中R是H，C 1 -C 5烷酰基; R 1是H，苄基，C 1 -C 5烷酰基，P（O）（OH）2，-CO（CH 2）2 COOH或碱性酰基; R2和R4各自为H，C1-C6烷基，苯基，吡啶基或（CH2）yC6H5; y为1-4; R3为H或CH3; Z是C1-C13亚烷基或 - （alk1）m-O-（alk2）n-; （alk1）和（alk2）中的每一个是C1-C13亚烷基，条件是（alk1）加（alk2）中的碳原子的总和不大于13; m和n各自为0或1; W为H，吡啶基，苯基，氟苯基或氯苯基; 其中间体及其制备和使用方法。

10. 发明授权

US07825260B2 Aminopropanol derivatives as sphingosine-1-phosphate receptor modulators 有权
标题翻译：氨基丙醇衍生物作为鞘氨醇-1-磷酸受体调节剂
公开(公告)号：US07825260B2
公开(公告)日：2010-11-02
申请号：US10554557
申请日：2004-04-29
申请人： Rainer Albert , Claus Ehrhardt , Peter Ettmayer , Klaus Hinterding , Klemens Högenauer , Peter Nussbaumer
发明人： Rainer Albert , Claus Ehrhardt , Peter Ettmayer , Klaus Hinterding , Klemens Högenauer , Peter Nussbaumer
IPC分类号： C07D231/56 , C07D307/00 , C07D307/87 , C09B5/00
CPC分类号： C07F9/65586 , C07C217/64 , C07C2601/14 , C07D231/56 , C07D263/56 , C07D263/57 , C07D307/79 , C07D413/04 , C07F9/1414 , C07F9/6541
摘要： Compounds of formula I, wherein X, a, b, R1, R2, R3, R4 and R5 are as defined in the specification, processes for their production, their uses and pharmaceutical compositions containing them.
摘要翻译：式I化合物，其中X，a，b，R 1，R 2，R 3，R 4和R 5如本说明书中所定义，其制备方法及其用途和含有它们的药物组合物。

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