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61. 发明授权

US5053524A 3-aminophenylpentane-1,5-diones 失效
标题翻译： 3-氨基戊基-1,5-二酮
公开(公告)号：US5053524A
公开(公告)日：1991-10-01
申请号：US515840
申请日：1990-04-27
申请人： Friedrich-Wilhelm Raulfs , Udo Mayer , Andreas Oberlinner
发明人： Friedrich-Wilhelm Raulfs , Udo Mayer , Andreas Oberlinner
IPC分类号： C07C211/50 , C07C215/70 , C07C225/22 , C07C251/30 , C07C255/24 , C07C255/58 , C07C255/59 , C07D209/86 , C09B55/00
CPC分类号： C07C251/30 , C07C211/50 , C07C215/70 , C07C225/22 , C07C255/24 , C07C255/58 , C07D209/86 , C07C2101/08 , C07C2101/10
摘要： 3-Aminophenylpentane-1,5-diones of the formula I ##STR1## where R.sup.1 and R.sup.2 are, independently of one another, hydrogen, C.sub.1 -C.sub.8 -alkyl, C.sub.4 -C.sub.8 -cycloalkyl, cyano-C.sub.2 -C.sub.4 -alkyl, hydroxy-C.sub.2 -C.sub.4 -alkyl, chloro-C.sub.2 -C.sub.4 -alkyl, phenyl-C.sub.1 -C.sub.2 -alkyl which can be substituted by chlorine, or phenyl which can be substituted by clorine or methyl, or R.sup.1 and R.sup.2 form, together with the nitrogen to which they are bonded, a heterocyclic radical which can contain further hetero atoms,R.sup.3 is hydrogen, fluorine, chlorine, C.sub.1 -C.sub.2 -alkyl or C.sub.2 -C.sub.5 -alkoxy or, if R.sup.3 is ortho to --NR.sup. R.sup.2, R.sup.3 and R.sup.2 together form C.sub.2 -C.sub.4 -alkylene, which can be substituted, or 1,2-phenylene andA is naphthyl or a radical of the formula II ##STR2## where X is hydrogen, fluorine, chlorine, bromine, C.sub.1 -C.sub.5 -alkyl, hydroxyl, C.sub.1 -C.sub.5 -alkoxy, phenoxy, phenyl-C.sub.1 -C.sub.2 -alkoxy, cyano or phenyl andn is 1 or 2,with the proviso that R.sup.1 and R.sup.2 are not both methyl when A is phenyl, are described.
摘要翻译：式I的3-氨基苯基戊-1,5-二酮其中R 1和R 2彼此独立地为氢，C 1 -C 8 - 烷基，C 4 -C 8 - 环烷基，氰基-C 2 -C 4 - 烷基，羟基-C 2 -C 4 - 烷基，氯代-C 2 - C 4 - 烷基，可被氯取代的苯基-C 1 -C 2 - 烷基，或可被氯取代或甲基取代的苯基，或R 1和R 2一起形成与其键合的氮原子可以含有其它杂原子的杂环基，R3是氢，氟，氯，C1-C2-烷基或C2-C5-烷氧基，或者如果R3是-NRR2的邻位，R3和 R2一起形成可被取代的C 2 -C 4亚烷基或1,2-亚苯基，A是萘基或式II的基团其中X是氢，氟，氯，溴，C1- C5-烷基，羟基，C1-C5-烷氧基，苯氧基，苯基-C1-C2-烷氧基，氰基或苯基，n为1或2，条件是当A为苯基时，R1和R2不同时为甲基。

62. 发明授权

US5053427A Guanidino-substituted benzopyrans and their use as pharmaceuticals 失效
标题翻译：甘氨酸取代苯并噻唑及其作为药物的用途
公开(公告)号：US5053427A
公开(公告)日：1991-10-01
申请号：US407227
申请日：1989-09-14
申请人： Geoffrey Stemp , Gordon Burrell , David G. Smith
发明人： Geoffrey Stemp , Gordon Burrell , David G. Smith
IPC分类号： A61K31/155 , A61K31/35 , A61K31/352 , A61K31/435 , A61P1/00 , A61P9/00 , A61P9/12 , A61P11/08 , A61P13/02 , A61P15/00 , A61P15/04 , C07C255/59 , C07C255/67 , C07C279/16 , C07C279/28 , C07C335/32 , C07D311/58 , C07D311/68 , C07D405/04 , C07D491/04 , C07D491/052
CPC分类号： C07D405/04 , C07C255/59 , C07C255/67 , C07C279/28 , C07C335/32 , C07D311/68 , C07D491/04 , C07C2102/08
摘要： Compounds of formula (I) and pharmaceutically acceptable salts thereof: ##STR1## wherein a and b together form an --O-- or --CH.sub.2 -- linkage or a bond;either Y is N and R.sub.2 is hydrogen; orY is C-R.sub.1whereineither one of R.sub.1 and R.sub.2 is hydrogen and the other is nitro, cyano, halo, CF.sub.3, formyl, aldoxime, CF.sub.3 O, NO.sub.2 --CH.dbd.CH--, NC--CH.dbd.CH--; a group R.sub.x X-- wherein R.sub.x and C.sub.1-6 alkyl, aryl or heteroaryl either of which may be optionally substituted by one, two or three of C.sub.1-4 alkyl, C.sub.1-4 alkoxy, nitro, halo, CF.sub.3 and cyano; and X is C.dbd.O, O.C.dbd.O, C.dbd.0.0, CHOH, SO, SO.sub.2, 0.SO, 0.SO.sub.2, CONH, 0.CONH, C.dbd.S, 0.C.dbd.S, C.dbd.S.0, CH.SH, SONH, SO.sub.2 NH, 0.SONH, 0.SO.sub.2 NH, CO--CH.dbd.CH, C.dbd.NHOH, C.dbd.NNH.sub.2 ; or a group R.sub.y R.sub.z NZ-- wherein R.sub.y and R.sub.z are independently hydrogen or C.sub.1-6 alkyl and Z is C.dbd.O, SO or SO.sub.2 ; orR.sub.1 is a C.sub.3-8 cycloalkyl group or a C.sub.1-6 alkyl group optionally substituted by a group which is hydroxy, C.sub.1-6 alkoxy, amino optionally substituted by one or two C.sub.1-6 alkyl groups, C.sub.1-7 alkanoylamino, C.sub.3-8 cycloalkyloxy or C.sub.3-8 cycloalkylamino; and R.sub.2 is hydrogen; orone of R.sub.1 and R.sub.2 is nitro, cyano or C.sub.1-3 alkylcarbonyl and the other is a different group selected from nitro, cyano, halo, C.sub.1-3 alkylcarbonyl, methoxy or amino optionally substituted by one or two C.sub.1-6 alkyl or by C.sub.2-7 alkanoyl;either one of R.sub.3 and R.sub.4 is hydrogen or C.sub.1-4 alkyl and the other is C.sub.1-4 alkyl; orR.sub.3 and R.sub.4 together are C.sub.2-5 polymethylene;either R.sub.5 is hydrogen, hydroxy, C.sub.1-6 alkoxy or C.sub.1-7 acyloxy; andR.sub.6 is hydrogen; orR.sub.5 and R.sub.6 together are a bond;either R.sub.7 is hydrogen, C.sub.1-6 alkyl, C.sub.3-6 cycloalkyl, C.sub.2-6 alkenyl or C.sub.2-6 alkynyl; andR.sub.8 is hydrogen or C.sub.1-6 alkyl; orR.sub.7 and R.sub.8 together are C.sub.2-4 polymethylene;R.sub.9 is CN, NO.sub.2, COR.sub.10 or SO.sub.2 R.sub.10 wherein R.sub.10 is C.sub.1-3 alkyl, NH.sub.2, NH(C.sub.1-3 alkyl), CF.sub.3 or phenyl optionally substituted as defined for R.sub.x ; andthe R.sub.8 N(NR.sub.9)NHR.sub.7 moiety is trans to the R.sub.5 group when R.sub.5 is hydroxy, C.sub.1-6 alkoxy or C.sub.1-7 acyloxy;having antihypertensive and/or bronchodilator activity, processes for their preparation and their use as pharmaceuticals.

63. 发明授权

US5053073A Thiophene derivatives useful as fungicidal, insecticidal or plant growth regulating agents 失效
标题翻译：有害作为杀真菌剂，杀虫剂或植物生长调节剂的噻吩衍生物
公开(公告)号：US5053073A
公开(公告)日：1991-10-01
申请号：US378076
申请日：1989-07-11
申请人： Vivienne M. Anthony , John M. Clough , Paul deFraine , Christopher R. A. Godfrey , Kevin Beautement
发明人： Vivienne M. Anthony , John M. Clough , Paul deFraine , Christopher R. A. Godfrey , Kevin Beautement
IPC分类号： C07C241/00 , A01N37/36 , A01N37/42 , A01N37/44 , A01N37/48 , A01N43/06 , A01N43/08 , A01N43/10 , A01N43/36 , A01N43/38 , A01N43/58 , C07C67/00 , C07C69/734 , C07C201/00 , C07C205/56 , C07C229/64 , C07C233/58 , C07C239/00 , C07C245/06 , C07C251/02 , C07C251/44 , C07C253/00 , C07C255/57 , C07C255/59 , C07C309/63 , C07C313/00 , C07C323/54 , C07D207/32 , C07D207/337 , C07D207/34 , C07D209/18 , C07D307/42 , C07D307/54 , C07D307/79 , C07D333/24 , C07D333/32 , C07D333/34 , C07D333/38 , C07D333/60 , C07F7/18
CPC分类号： C07D207/337 , A01N43/06 , A01N43/36 , A01N43/38 , A01N43/58 , C07D209/18 , C07D307/54 , C07D307/79 , C07D333/24 , C07D333/60
摘要： Compounds of formula (I): ##STR1## and stereoisomers thereof, wherein W is R.sup.1 O.sub.2 C--C.dbd.CH--ZR.sup.2, wherein R.sup.1 and R.sup.2, which are the same or different, are alkyl or fluoroalkyl groups, and Z is either an oxygen or sulphur atom; A is an oxygen or sulphur atom, --NR.sup.3 --, or --CR.sup.4 R.sup.5 --; X, Y and Z.sup.1, which are the same or different, are hydrogen or halogen atoms, or hydroxy, optionally substituted alkyl, optionally substituted cycloalkyl, optionally substituted cycloalkylalkyl, optionally substituted aralkyl, optionally substituted heteroarylalkyl, optionally substituted aryloxyalkyl, optionally substituted heteroaryloxyalkyl, optionally substituted alkenyl, optionally substituted alkynyl, optionally substituted aryl, optionally substituted heteroaryl, optionally substituted alkoxy, optionally substituted arylalkoxy, optionally substituted aryloxy, optionally substituted heteraryloxy, optionally substituted acyloxy, optionally substituted amino, optionally substituted acylamino, optionally substituted arylazo, nitro, cyano, --CO.sub.2 R.sup.6, --CONR.sup.7 R.sup.8, --COR.sup.9 --CR.dbd.NR.sup.10, --CR.dbd.NOR.sup.10 or --N.dbd.CR.sup.11 R.sup.12 groups; or the groups X and Y, when they are in adjacent positions on the ring, optionally join to form a fused ring, either aromatic or aliphatic, optionally containing one or more heteroatoms; and R, R.sup.3, R.sup.4, R.sup.5, R.sup.6, R.sup.7, R.sup.8, R.sup.9, R.sup.10, R.sup.11, and R.sup.12, which are the same or different, are hydrogen atoms (provided that R.sup.4 and R.sup.5 are not hydrogen) or optionally substituted alkyl, optionally substituted cycloalkyl, optionally substituted cycloalkylalkyl, optionally substituted aralkyl, optionally substituted heterarylalkyl, optionally substituted aryloxyalkyl, optionally substituted heteroaryloxyalkyl, optionally substituted alkenyl, optionally substituted alkynyl, optionally substituted aryl or optionally substituted heteroaryl groups; and metal complexes thereof.The compounds are useful in agriculture, especially as fungicides but also as insecticides and plant growth regulators.

64. 发明授权

US4912135A Amide compounds 失效
标题翻译：酰胺化合物
公开(公告)号：US4912135A
公开(公告)日：1990-03-27
申请号：US263345
申请日：1988-10-27
申请人： Hiroaki Taguchi , Takeo Katsushima , Masakazu Ban , Akihiko Watanabe
发明人： Hiroaki Taguchi , Takeo Katsushima , Masakazu Ban , Akihiko Watanabe
IPC分类号： C07C255/59 , A61K31/165 , A61K31/275 , A61P11/00 , A61P17/00 , A61P27/16 , A61P37/08 , C07C67/00 , C07C231/00 , C07C233/44 , C07C235/16 , C07C235/56 , C07C235/64 , C07C237/30 , C07C237/42 , C07C255/60 , C07C311/29 , C07C311/39 , C07C311/48 , C07C323/59 , C07C323/63
CPC分类号： C07C255/60
摘要： Novel amide compounds of the formula: ##STR1## wherein R.sup.1 is hydrogen, lower alkyl, acetyl, or propionyl; R.sup.2 is hydrogen or chlorine; R.sup.3 is hydrogen or a group of the formula: --CO.sub.2 R.sup.6 (wherein R.sup.6 is hydrogen, lower alkyl or alkali metal); R.sup.4 is hydrogen, trifluoromethyl, cyano, aminocarbonyl, or a group of the formula: --CO.sub.2 R.sup.7 (wherein R.sup.7 is hydrogen, lower alkyl, or alkali metal); R.sup.5 is hydrogen, or a group of the formula: --CO.sub.2 R.sup.8 (wherein R.sup.8 is hydrogen, lower alkyl, or alkali metal), which have excellent anti-allergic activity and are useful for the prophylaxis and treatment of various allergic diseases, and a pharmaceutical composition containing the amide compound as set forth above as an active ingredient.

65. 发明授权

US4897223A Tri-phenyl methyl color-forming agents 失效
标题翻译：三苯基甲基成色剂
公开(公告)号：US4897223A
公开(公告)日：1990-01-30
申请号：US162531
申请日：1988-03-01
申请人： Udo Eckstein , Hubertus Psaar , Roderich Raue
发明人： Udo Eckstein , Hubertus Psaar , Roderich Raue
IPC分类号： B41M5/00 , B41M5/132 , B41M5/136 , B41M5/20 , B41M5/30 , B41M5/323 , B41M5/34 , C07C255/58 , C07C255/59 , C07D215/14 , C07D241/42 , C07D295/135 , C09B11/00 , C09B11/04 , C09B11/12
CPC分类号： C07D295/135 , B41M5/1366 , B41M5/20 , B41M5/323 , C07C255/00 , C07D215/14 , C07D241/42
摘要： Color-forming agents of the general formula ##STR1## wherein X denotes hydroxyl, alkoxy, alkenyloxy, aralkoxy, cycloalkoxy, aryloxy, acyloxy, alkoxycarbonyloxy, alkylamino, dialkylamino, acylamino, aralkylamino or arylamino,Q denotes cyano, alkoxycarbonyl, aryloxycarbonyl, aralkoxycarbonyl, carbamoyl, N-alkylcarbamoyl, N,N-dialkylcarbamoyl, N-alkyl-N-aryl-carbamoyl, acyl, alkoxysulphonyl, aralkoxysulphonyl, sulphamoyl, N-alkylsulphamoyl, N,N-dialkylsulphamoyl, alkylsulphonyl, arylsulphonyl or aralkylsulphonyl andR denotes alkyl, alkenyl or aralkyl,further isocyclic or heterocyclic rings can be fused on to the rings A, B, C and D, and the cyclic and acyclic radicals and the rings A, B, C and D can carry further substituents, are used for the preparation of pressure-sensitive recording materials.
摘要翻译：通式为（I）的成色剂，其中X表示羟基，烷氧基，烯氧基，芳烷氧基，环烷氧基，芳氧基，酰氧基，烷氧基羰基氧基，烷基氨基，二烷基氨基，酰氨基，芳烷基氨基或芳氨基，Q表示氰基，烷氧基羰基，，芳烷氧基羰基，氨基甲酰基，N-烷基氨基甲酰基，N，N-二烷基氨基甲酰基，N-烷基-N-芳基 - 氨基甲酰基，酰基，烷氧基磺酰基，芳烷基磺酰基，氨磺酰基，N-烷基氨磺酰基，N，N-二烷基氨磺酰基，烷基磺酰基，芳基磺酰基或芳烷基磺酰基和R 表示烷基，烯基或芳烷基，进一步的环或杂环可以稠合在环A，B，C和D上，并且环和无环基和环A，B，C和D可以携带另外的取代基用于制备压敏记录材料。

66. 发明授权

US4845262A Novel arylethanolamines for promoting livestock production 失效
标题翻译：用于促进畜牧生产的新型芳基乙醇胺
公开(公告)号：US4845262A
公开(公告)日：1989-07-04
申请号：US89691
申请日：1987-08-25
申请人： Hans Lindel , Werner Hallenbach , Friedrich Berschauer , Anno de Jong , Martin Scheer
发明人： Hans Lindel , Werner Hallenbach , Friedrich Berschauer , Anno de Jong , Martin Scheer
IPC分类号： A23K1/16 , A61K31/135 , A61K31/275 , A61P3/00 , C07C67/00 , C07C255/58 , C07C255/59 , C07C313/00 , C07C315/04 , C07C317/48 , C07C317/50
CPC分类号： C07C255/00 , A23K20/111
摘要： The growth of livestock is promoted by the novel arylethanolamines of the formula ##STR1## in which R.sup.1 represents cyano,R.sup.2 represents amino, alkylamino or acylamino,R.sup.3 represents hydrogen, halogen, alkyl, halogenoalkyl, alkoxy, halogenoalkoxy, hydroxymethyl, nitro or methylsulphonylmethyl,R.sup.4 represents hydrogen, alkyl or acyl,R.sup.5 represents hydrogen or alkyl,R.sup.6 represents alkyl,n represents 1, 2 or 3,R.sup.7 represents the radicals --COR.sup.9, --O-alkylene-COR.sup.9, -alkylene-R.sup.10 or --O-alkylene-R.sup.10,R.sup.8 represents hydrogen, alkyl or halogen,R.sup.9 represents hydroxyl, alkoxy or the radical --NR.sup.11 R.sup.12,R.sup.10 represents hydroxyl, alkoxy or the radical NR.sup.11 R.sup.12,R.sup.11 represents hydrogen or alkyl, andR.sup.12 represents hydrogen or alkyl,and the physiologically acceptable salts thereof.
摘要翻译：通过式（I）的新型芳基乙醇胺促进家畜的生长，其中R1代表氰基，R2代表氨基，烷基氨基或酰氨基，R3代表氢，卤素，烷基，卤代烷基，烷氧基，卤代烷氧基，羟基甲基，硝基或甲基磺酰基甲基，R 4表示氢，烷基或酰基，R 5表示氢或烷基，R 6表示烷基，n表示1,2或3，R 7表示基团-COR 9，-O-亚烷基-CON 9， - 亚烷基-R 10或-O - 亚烷基-R 10，R 8表示氢，烷基或卤素，R 9表示羟基，烷氧基或基团-NR 11 R 12，R 10表示羟基，烷氧基或基团NR 11 R 12，R 11表示氢或烷基，R 12表示氢或烷基，其可接受的盐。

67. 发明授权

US4839364A 9-Amino-3,4-dihydroacridines and related compounds useful for enhancing memory 失效
标题翻译： 9-氨基-3,4-二氢吖啶和有助于增强记忆的相关化合物
公开(公告)号：US4839364A
公开(公告)日：1989-06-13
申请号：US7885
申请日：1987-01-28
申请人： Gregory M. Shutske , Frank A. Pierrat
发明人： Gregory M. Shutske , Frank A. Pierrat
IPC分类号： C07C255/42 , A61K31/435 , A61K31/47 , C07C20060101 , C07C67/00 , C07C253/00 , C07C255/58 , C07C255/59 , C07C255/60 , C07D219/08 , C07D219/10 , C07D219/12 , C07D221/16 , C07D409/12
CPC分类号： C07D409/12 , C07C255/00 , C07D219/10 , C07D219/12 , C07D221/16
摘要： There are disclosed compounds having the formula ##STR1## wherein n is 1, 2 or 3; X is hydrogen, loweralkyl, loweralkoxy, halogen, hydroxy, nitro, trifluoromethyl, NHCOR.sub.2 where R.sub.2 is loweralkyl, or NR.sub.3 R.sub.4 where R.sub.3 and R.sub.4 are independently hydrogen or loweralkyl; R is hydrogen or loweralkyl; R.sub.1 is hydrogen, loweralkyl, diloweralkylaminoloweralkyl, arylloweralkyl, diarylloweralkyl, furylloweralkyl, thienylloweralkyl, oxygen-bridged arylloweralkyl, oxygen-bridged diarylloweralkyl, oxygen-bridged furylloweralkyl or oxygen-bridged thienylloweralkyl; Y is C.dbd.O or CR.sub.5 OH where R.sub.5 is hydrogen or loweralkyl; Z is CH.sub.2 or C.dbd.CR.sub.6 R.sub.7 where R.sub.6 and R.sub.7 are independently hydrogen or loweralkyl; or Y and Z taken together is CR.sub.5 .dbd.Ch where CR.sub.5 and CH correspond to Y and Z respectively; an optical antipode thereof, or a pharmaceutically acceptable acid addition salt thereof, which are useful for enhancing memory, methods for synthesizing them, and pharmaceutical compositions comprising an effective memory enhancing amount of such a compound.
摘要翻译：公开了具有式“IMAGE”的化合物，其中n为1,2或3; X是氢，低级烷基，低级烷氧基，卤素，羟基，硝基，三氟甲基，NHCOR 2，其中R2是低级烷基，或NR3R4，其中R3和R4独立地是氢或低级烷基; R是氢或低级烷基; R 1是氢，低级烷基，二低级烷基氨基低级烷基，芳基低级烷基，二芳基低级烷基，呋喃基烷基，噻吩基低级烷基，氧桥连的芳基低级烷基，氧桥连的二芳基低级烷基，氧桥连的呋喃基低级烷基或氧桥连的噻吩基低级烷基。 Y是C = O或CR5OH，其中R5是氢或低级烷基; Z是CH 2或C = CR 6 R 7，其中R 6和R 7独立地是氢或低级烷基; 或Y和Z一起为CR5 = Ch，其中CR5和CH分别对应于Y和Z; 可用于增强记忆力的光学对映体或其药学上可接受的酸加成盐，以及合成它们的方法和包含有效记忆增加量的这种化合物的药物组合物。

68. 发明授权

US4603209A Fluorescent indicator dyes for calcium ions 失效
标题翻译：用于钙离子的荧光指示剂染料
公开(公告)号：US4603209A
公开(公告)日：1986-07-29
申请号：US648649
申请日：1984-09-07
申请人： Roger Y. Tsien , Grzegorz Grynkiewicz
发明人： Roger Y. Tsien , Grzegorz Grynkiewicz
IPC分类号： A61K38/00 , A61K38/22 , A61P5/00 , C07C229/18 , C07C229/52 , C07C237/30 , C07C255/59 , C07C309/49 , C07C311/39 , C07C317/32 , C07D209/08 , C07D209/14 , C07D215/40 , C07D307/79 , C07D307/82 , C07D413/04 , C07K7/23 , G01N21/78 , G01N33/84 , C07C101/447 , C07D307/87
CPC分类号： C07D307/79 , C07D209/08 , C07D215/40 , C07D413/04 , Y10S436/80
摘要： The present invention discloses a new class of highly fluorescent indicator dyes that are specific for calcium ions. The new fluorescent indicator dyes combine a stilbene-type fluorophore with a tetracarboxylate parent Ca.sup.2+ chelating compound having the octacoordinate pattern of liganding groups characteristic of EGTA and BAPTA. Preferred forms contain extra heterocyclic bridges to reinforce the ethylenic bond of the stilbene and to reduce hydrophobicity. Compared to their widely used predecessor, "quin2", the new dyes offer up to thirty-fold brighter fluorescence, major changes in wavelength (not just intensity) upon Ca.sup.2+ binding, slightly lower affinities for Ca.sup.2+, slightly longer wavelengths of excitation, and considerably improved selectivity for Ca.sup.2+ over other divalent cations. These properties, particularly the wavelength sensitivity to Ca.sup.2+, make the dyes useful indicators for many intracellular applications, especially in single cells, adherent cell layers, or bulk tissues.The present invention also discloses an improved method for synthesizing alpha-acyloxyalkyl bromides wherein the bromides so synthesized are free of contaminating bis(1-bromoalkyl)ether. The improved method is exemplified herein in the synthesis of acetoxymethyl bromide, a compound useful in preparing the acetoxymethyl esters disclosed herein as novel Ca.sup.2+ specific fluorescent indicators.
摘要翻译：本发明公开了一类对钙离子具有特异性的高荧光指示剂染料。新的荧光指示剂染料将二苯乙烯型荧光团与具有EGTA和BAPTA特征的连接组的八配位图案的四羧酸母体Ca 2+螯合化合物结合。优选的形式包含额外的杂环桥，以加强1,2-二苯乙烯的烯键并降低疏水性。与其广泛使用的前身“quin2”相比，新型染料提供高达三十倍的荧光，Ca2 +结合时的波长（不仅仅是强度）的主要变化，Ca2 +的亲和力略低，激发波长稍长，提高Ca2 +对其他二价阳离子的选择性。这些性质，特别是对Ca2 +的波长敏感性，使得染料对于许多细胞内应用尤其是在单细胞，贴壁细胞层或体组织中是有用的指标。本发明还公开了一种合成α-酰氧基烷基溴化物的改进方法，其中如此合成的溴化物没有污染的双（1-溴烷基）醚。改进的方法在本文中示例性地合成乙酰氧甲基溴，其是可用于制备本文公开的乙酰氧基甲酯作为新型Ca 2+特异性荧光指示剂的化合物。

69. 发明授权

US4420308A Process for the production of reserve effects on polyester textiles and polyester/cellulose mixed fibre textiles: discharge printing with disperse azo dye with alkyl or alkoxy carbonyl, cyand and hydroxy phenyl group 失效
标题翻译：生产聚酯纺织品和聚酯/纤维素混纺纤维纺织品的储备效果的方法：用分散偶氮染料与烷基或烷氧基羰基，环烷基和羟基苯基进行放电印刷
公开(公告)号：US4420308A
公开(公告)日：1983-12-13
申请号：US384074
申请日：1982-06-01
申请人： Ulrich Buhler , Horst Kindler , Klaus Kuhlein , Maria Kallay , Uwe Kosubek , Rudolf Lowenfeld , Kurt Roth
发明人： Ulrich Buhler , Horst Kindler , Klaus Kuhlein , Maria Kallay , Uwe Kosubek , Rudolf Lowenfeld , Kurt Roth
IPC分类号： C07C255/58 , C07C255/59 , C08K5/23 , C09B29/01 , C09B29/08 , C09B43/42 , C10L1/22 , D06P1/18 , D06P3/26 , D06P3/42 , D06P3/54 , D06P3/72 , D06P5/12 , D06P5/15 , D06P5/17
CPC分类号： C07C255/00 , C09B29/0003 , C09B43/42 , D06P5/12 , D06P5/17 , Y10S8/922
摘要： In a process known per se for the preparation of white patterns or patterns of various colors on a colored substrate on textile materials comprising hydrophobic synthetic fibres or on textile materials based on mixed fibres composed of polyester and cellulose comprising discharge printing wherein a discharge reserving agent based on an alkali or on sulphites, the improvement which comprises employing as the dischargeable disperse dyestuffs having the formula I ##STR1## in which R and K have the meanings given in claim 1.
摘要翻译：在本申请中已知的用于制备包含疏水性合成纤维的纺织材料上的着色基材上的白色图案或各种颜色的图案的方法或基于由聚酯和纤维素组成的混合纤维的纺织材料，其包括放电印刷，其中基于排出保留剂的在碱或亚硫酸盐上，其改进包括使用具有式I（I）的可排出分散染料，其中R和K具有权利要求1中给出的含义。

70. 发明授权

US4411899A Substituted derivatives of amino alkane diols as gastric secretion inhibitors 失效
标题翻译：氨基烷二醇的取代衍生物作为胃分泌抑制剂
公开(公告)号：US4411899A
公开(公告)日：1983-10-25
申请号：US332691
申请日：1981-12-21
申请人： John J. Baldwin , William C. Lumma, Jr.
发明人： John J. Baldwin , William C. Lumma, Jr.
IPC分类号： A61K31/155 , A61K31/42 , A61K31/421 , A61K31/425 , A61K31/426 , A61K31/433 , A61P1/04 , A61P43/00 , C07C45/71 , C07C67/00 , C07C213/00 , C07C217/56 , C07C217/84 , C07C229/30 , C07C235/46 , C07C237/16 , C07C237/20 , C07C239/00 , C07C253/00 , C07C255/30 , C07C255/59 , C07C257/14 , C07C279/10 , C07C279/28 , C07C301/00 , C07C307/02 , C07C311/00 , C07D209/48 , C07D213/64 , C07D233/70 , C07D263/04 , C07D263/16 , C07D263/58 , C07D275/02 , C07D275/03 , C07D277/20 , C07D277/28 , C07D277/34 , C07D277/56 , C07D285/10 , C07D403/14 , C07D417/12 , C07D417/14 , A61K31/535
CPC分类号： C07D209/48 , C07C279/10 , C07C279/28 , C07C45/71 , C07D213/64 , C07D233/70 , C07D263/04 , C07D263/58 , C07D275/03 , C07D277/34 , C07D277/56 , C07D285/10 , C07D403/14 , C07D417/12
摘要： There are disclosed substituted derivatives of amino alkane diols and related compounds as well as processes for the preparation of such compounds. These compounds are useful for the suppression of gastric acid secretions in mammals and compositions for such uses are also disclosed.
摘要翻译：公开了氨基烷烃二醇和相关化合物的取代衍生物以及这些化合物的制备方法。这些化合物可用于抑制哺乳动物中的胃酸分泌物，并且也公开了用于这些用途的组合物。

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