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61. 发明申请

US20030180732A1 Methods for generating ligand arrays 失效
标题翻译：产生配体阵列的方法
公开(公告)号：US20030180732A1
公开(公告)日：2003-09-25
申请号：US10106685
申请日：2002-03-25
发明人： John S. Hargreaves
IPC分类号： B05D003/00 , C12Q001/68 , C12M001/34
CPC分类号： C12Q1/6837 , C07H21/04
摘要： Methods of producing ligand arrays, e.g., polypeptide and nucleic acid arrays, as well as the arrays produced thereby, methods for use of the arrays and kits that include the same, are provided. In the subject methods, a substrate having a surface displaying carboxylic ester functional groups that produce surface bound hydroxyl functional groups upon hydrolysis is first provided. Next, the functional groups are hydrolyzed to hydroxyl functional groups. The resultant substrate, optionally after an additional functionalization step, is then contacted with ligands, e.g., via deposition of each different ligand onto a different region of the surface, resulting in covalent attachment of the contacted ligands to the surface.
摘要翻译：提供了制备配体阵列的方法，例如多肽和核酸阵列，以及由此产生的阵列，使用阵列的方法和包括其的试剂盒。在本发明方法中，首先提供具有表现出在水解时产生表面结合的羟基官能团的羧酸酯官能团的表面的基材。接下来，将官能团水解成羟基官能团。然后任选地在另外的官能化步骤之后，将所得底物与配体接触，例如通过将各种不同配体沉积在表面的不同区域上，导致所接触的配体与表面的共价连接。

62. 发明申请

US20030175827A1 Stable thin film dried protein composition or device and related methods 审中-公开
标题翻译：稳定的薄膜干燥蛋白质组合物或装置及相关方法
公开(公告)号：US20030175827A1
公开(公告)日：2003-09-18
申请号：US10098768
申请日：2002-03-14
发明人： Brett A. Stillman , Weiwen Zhao , John L. Tonkinson , Daniel S. Osborn , Debra W. English
IPC分类号： G01N033/53 , G01N033/542 , C12M001/34 , B05D003/00
CPC分类号： G01N33/552
摘要： The present invention relates to methods for making a stable thin film dried protein composition on a surface that has a protein denaturing capability and related devices. A thin film of a biologically active protein containing solution to be dried is deposited on the support surface wherein the film also contains a buffer that maintains the surface pH between about 5.0 and 9.0 during drying under normal pressures and a saccharide in an amount sufficient to stabilize the protein while drying. An advantage of the present invention is that one can make thin film assay devices, such as proteomic microarrays, using supports that normally would not be useful. These supports include modified, chemically derivatized or coated glass substrates.
摘要翻译：本发明涉及在具有蛋白质变性能力的表面上制备稳定的薄膜干燥蛋白质组合物的方法和相关装置。将待干燥的含有生物活性蛋白质的待干燥溶液的薄膜沉积在支撑表面上，其中所述膜还含有缓冲液，所述缓冲液在正常压力下干燥期间将表面pH保持在约5.0和9.0之间，并且糖的量足以稳定蛋白质同时干燥。本发明的一个优点是，可以使用通常不会有用的支持物来制造薄膜测定装置，例如蛋白质组微阵列。这些载体包括改性的，化学衍生的或涂覆的玻璃基材。

63. 发明申请

US20030175702A1 Sorting and immobilization system for nucleic acids using synthetic binding systems 失效
标题翻译：使用合成结合系统的核酸分选和固定系统
公开(公告)号：US20030175702A1
公开(公告)日：2003-09-18
申请号：US09910469
申请日：2001-07-19
发明人： Markus Schweitzer , Richard R. Anderson , Michael Fiechtner , Jochen Muller , Stefan Raddatz , Christoph Brucher , Norbert Windhab , Jill Orwick , Eberhard Schneider , Marc Pignot , Stefan Kienle
IPC分类号： C12Q001/68 , C12M001/34 , B05D003/00
CPC分类号： C07H21/00 , B01J19/0046 , B01J2219/00608 , B01J2219/00617 , B01J2219/00626 , B01J2219/0063 , B01J2219/00637 , B01J2219/00653 , B01J2219/00659 , B01J2219/00722 , C12Q1/6837 , G01N33/54353 , C12Q2565/518 , C12Q2525/117 , C12Q2525/113
摘要： The present invention relates to conjugates of synthetic binding units and nucleic acids. The present invention also relates to methods for sorting and immobilizing nucleic acids on support materials using such conjugates by specific molecular addressing of the nucleic acids mediated by the synthetic binding systems. Particularly, the present invention also relates to novel methods of utilizing conjugates of synthetic binding units and nucleic acids to in active electronic array systems to produce novel array constructs from the conjugates, and the use of such constructs in various nucleic acid assay formats. In addition, the present invention relates to various novel forms of such conjugates, improved methods of making solid phase synthesized conjugates, and improved methods of conjugating pre-synthesized synthetic binding units and nucleic acids. The present invention also relates to the use of conjugates of synthetic binding units and nucleic acids as substrates for various enzymatic reactions, including nucleic acid amplification reactions.
摘要翻译：本发明涉及合成结合单元和核酸的缀合物。本发明还涉及使用这种共轭物通过由合成结合系统介导的核酸的特异性分子寻址来分选和固定核酸的载体材料的方法。特别地，本发明还涉及利用合成结合单元和核酸的缀合物在活性电子阵列体系中从缀合物产生新型阵列构建体的新方法，以及以各种核酸测定形式使用这种构建体。此外，本发明涉及这种缀合物的各种新型形式，制备固相合成的缀合物的改进方法，以及与预合成的合成结合单元和核酸缀合的改进方法。本发明还涉及合成结合单元和核酸的缀合物作为各种酶反应的底物的用途，包括核酸扩增反应。

64. 发明申请

US20030164299A1 Cathodic electrodeposition coating agents containing bismuth complexes, preparation and use thereof 失效
标题翻译：含有铋络合物的阴极电沉积涂层剂，其制备和用途
公开(公告)号：US20030164299A1
公开(公告)日：2003-09-04
申请号：US10090654
申请日：2002-03-04
发明人： Ulrich Hermann , Walter Kuehhirt , Rudolf Schipfer
IPC分类号： B05D003/00 , C25D015/00
CPC分类号： C08G18/0814 , C08G18/4045 , C08G18/8064 , C08K5/0091 , C09D5/4492
摘要： Waterborne CED coating agents containing resin solids and optionally pigments, fillers and/or conventional coating additives, wherein said CED coating agents contain at least one bismuth complex with ligands selected from the group consisting of hydroxyquinolines, 1,2-dioximes, 1,3-dioximes, and N,Nnull-diarylthiocarbazides and combinations thereof in an amount of 0.1 wt. % to 2.5 wt. %, calculated as bismuth and based on the resin solids.
摘要翻译：含有树脂固体和任选的颜料，填料和/或常规涂料添加剂的水性CED涂层剂，其中所述CED涂层剂含有选自羟基喹啉，1,2-二肟，1,3-二氧杂环己烷，二肟和N，N'-二芳基硫代卡巴肼及其组合，其量为0.1wt。％至2.5重量％％，以铋计算，并基于树脂固体。

65. 发明申请

US20030157265A1 Reaction vessel of oxidization and decomposition processing equipment by supercritical water and method for manufacturing the same 失效
标题翻译：超临界水氧化分解加工设备的反应容器及其制造方法
公开(公告)号：US20030157265A1
公开(公告)日：2003-08-21
申请号：US10383919
申请日：2003-03-07
申请人： Furuyametal Co., Ltd.
发明人： Takahito Furuya , Takayuki Shimamune
IPC分类号： B05D003/00 , B32B015/04
CPC分类号： B01J19/006 , B01J3/008 , B01J19/02 , B01J2219/00777 , B01J2219/0218 , B01J2219/0231 , B01J2219/024 , Y02P20/544 , Y10T428/12007
摘要： Disclosed is a reaction vessel used for oxidizing and decomposing equipment suitable for processing with supercritical water, and methods of manufacturing the reaction vessel. The reaction vessel comprises an oxide film containing a platinum group metal oxide, for example having a fine crystalline structure, and a high corrosion resistance in both oxidizing and reducing atmosphere. The film is formed on a surface of the vessel by performing a pyrolysis reaction in an atmosphere containing water vapor. The oxide film is comprised of at least one platinum group metal oxide selected from Ir, Ru or Rh oxide, and a platinum group metal selected from Ti and Ta.
摘要翻译：公开了用于氧化和分解适用于超临界水处理的设备的反应容器，以及制造反应容器的方法。反应容器包括含有铂族金属氧化物的氧化物膜，例如具有微细的结晶结构，并且在氧化还原气氛中都具有高耐腐蚀性。通过在含有水蒸汽的气氛中进行热解反应，在容器的表面形成膜。氧化膜由选自Ir，Ru或Rh氧化物中的至少一种铂族金属氧化物和选自Ti和Ta的铂族金属组成。

66. 发明申请

US20030152938A1 RET oligonucleotide microchip and method for detecting hereditary cancer employing same 审中-公开
标题翻译： RET寡核苷酸微芯片和用于检测使用其的遗传性癌症的方法
公开(公告)号：US20030152938A1
公开(公告)日：2003-08-14
申请号：US10117586
申请日：2002-04-05
发明人： Jae-Gahb Park , Il-Jin Kim , Hio Chung Kang , Jae-Hyun Park
IPC分类号： C12Q001/68 , C07H021/04 , C12P019/34 , B05D003/00 , C12M001/34
CPC分类号： C12Q1/6883 , C12Q2600/156
摘要： The present invention relates to an RET oligonucleotide microchip for detecting mutation in the mutational hot spot regions of RET gene, a manufacturing process thereof and a method for detecting hereditary cancer employing same, wherein specific oligonucleotides are selectively designed to detect various missense mutations at the mutational hot spots of RET gene.
摘要翻译：本发明涉及用于检测RET基因的突变热点区域中的突变的RET寡核苷酸微芯片，其制备方法和使用其的遗传性癌症检测方法，其中特异性寡核苷酸被选择性地设计用于检测突变型的遗传性突变 RET基因的热点。

67. 发明申请

US20030152756A1 Method and apparatus for processing three-dimensional structure, method for producing three-dimensional shape product and three-dimensional structure 有权
标题翻译：三维结构处理方法及装置，三维形状产品制作方法及三维结构
公开(公告)号：US20030152756A1
公开(公告)日：2003-08-14
申请号：US10321635
申请日：2002-12-18
发明人： Yasufumi Yamada , Katsumi Midorikawa , Hiroshi Kumagai
IPC分类号： B32B009/00 , B05D003/00
CPC分类号： G11B7/125 , B23K26/009 , B23K26/066 , B23K26/18 , B29C33/3857 , B29C64/129 , B81B2203/033 , B81B2203/0392 , B81C1/00103 , B81C99/009 , B81C2201/0143 , G02B5/1857 , G03H2001/0478 , G11B7/261 , Y10S428/913 , Y10T428/12389 , Y10T428/12396 , Y10T428/24917 , Y10T428/24926 , Y10T428/24942 , Y10T428/31623
摘要： Disclosed is a method for processing a three-dimensional structure having a fine three-dimensional shape and a smooth surface is disclosed in which the three-dimensional structure is usable for an optical device. The process method comprises the steps of depositing a thin layer for absorption of laser light on a flat substrate; depositing a transparent layer on the thin layer for absorption of laser light; and irradiating a process laser light, passing through the transparent layer; in which pulse injection energy of the process laser light is set to be the same as or smaller than the maximum pulse injection energy capable of exposing a surface of the thin layer in front in the incident direction of the process laser light, and to be set the same as or greater than the minimum pulse injection energy capable of removing the transparent layer in rear in the incident direction of the process laser light.
摘要翻译：公开了一种用于处理三维结构可用于光学装置的三维形状和光滑表面的三维结构的方法。该方法包括以下步骤：在平坦的基底上沉积用于吸收激光的薄层; 在薄层上沉积透明层以吸收激光; 并照射通过透明层的工艺激光; 其中将工艺激光的脉冲注入能量设定为与能够在工艺激光的入射方向上的前面暴露薄层的表面的最大脉冲注入能量相同或更小，并设定与能够沿着工艺激光的入射方向去除后方的透明层的最小脉冲注入能量相同或者更大。

68. 发明申请

US20030152693A1 Methods of applying a coating to an optical surface 审中-公开
标题翻译：将涂层施加到光学表面的方法
公开(公告)号：US20030152693A1
公开(公告)日：2003-08-14
申请号：US10075637
申请日：2002-02-12
发明人： Kai C. Su , Richard Lu , William M. Hung , Guigui Wang
IPC分类号： B05D005/06 , B05D003/00
CPC分类号： G02B1/10 , B05C1/02 , B05C1/06 , B05D1/28 , B05D3/029
摘要： A method for applying a coating to an optical surface of an optical device. In one embodiment, the method includes the steps of placing a coating solution in a cliche of a cliche plate, transferring the coating solution from the cliche to deformable body of a transfer pad, and pressing the transfer pad to the optical surface so as to transfer the coating solution from the deformable body of the transfer pad to the optical surface. The method further includes a step of irradiating the coating solution associated with the optical surface at a wavelength of microwave so as to form a coating layer on the optical surface. The coating layer can be further cured to form a desired coating on a proper optical surface. The optical device can be an optical lens having at least one optical surface, or a mold that can be used to produce an optical lens. In other words, the present invention allows a coating to be applied directly to an optical surface of an optical lens. Alternatively, a coating can be first applied to an optical surface of at least one mold and then be transferred to an optical surface of an optical lens during casting process.
摘要翻译：一种将涂层施加到光学装置的光学表面的方法。在一个实施方案中，该方法包括以下步骤：将涂布溶液放置在陈列板的陈列架中，将涂布溶液从胶版转移到转印垫的变形体，并将转印垫按压到光学表面以便转印涂层溶液从转印垫的可变形体到光学表面。该方法还包括以微波波长照射与光学表面相关联的涂布溶液以在光学表面上形成涂层的步骤。涂层可以进一步固化以在合适的光学表面上形成所需的涂层。光学装置可以是具有至少一个光学表面的光学透镜，或者可以用于制造光学透镜的模具。换句话说，本发明允许将涂层直接施加到光学透镜的光学表面。或者，可以首先将涂层施加到至少一个模具的光学表面，然后在铸造过程中转移到光学透镜的光学表面。

69. 发明申请

US20030149471A1 Coated vascular prosthesis and methods of manufacture and use 审中-公开
标题翻译：涂层血管假体及其制造和使用方法
公开(公告)号：US20030149471A1
公开(公告)日：2003-08-07
申请号：US10358348
申请日：2003-02-05
发明人： Stephen G. Briana , Ramesh B. Jayaraman
IPC分类号： A61F002/06 , B05D003/00
CPC分类号： A61L27/507 , A61L27/34 , A61L27/56
摘要： A method for forming a kink resistant, blood impermeable graft comprises the steps of: providing a crimped substrate of polymer fabric; coating the outer surface of the substrate with a first solution comprising a first polymer and a particulate in a first solvent; allowing the first solution to dry, thereby forming a first coat on the substrate; coating the first coat with a second solution comprising a second polymer in a second solvent; and immersing the coated substrate in a third solvent to precipitate the second polymer from solution, thereby forming a porous second coat. The third solvent also dissolves the salt in the first coat to form pores in the first coat. The first and second polymer solutions do not penetrate to the interior surface of the substrate of the graft. Vascular prostheses made by this method are blood impermeable and kink resistant and are particularly useful as outflow cannulas for ventricular assist devices.
摘要翻译：用于形成耐扭结的不透血移植物的方法包括以下步骤：提供聚合物织物的卷曲基材; 在第一溶剂中用包含第一聚合物和颗粒的第一溶液涂覆基材的外表面; 使第一溶液干燥，从而在基材上形成第一涂层; 在第二溶剂中用包含第二聚合物的第二溶液涂覆第一涂层; 并将涂布的基材浸渍在第三溶剂中以从溶液中沉淀第二聚合物，从而形成多孔的第二涂层。第三溶剂也溶解第一涂层中的盐，以在第一涂层中形成孔。第一和第二聚合物溶液不渗透到移植物的基底的内表面。通过这种方法制成的血管假体是不透血和抗扭结的，并且特别可用作心室辅助装置的流出插管。

70. 发明申请

US20030148304A1 Method for immobilisation 审中-公开
标题翻译：固定方法
公开(公告)号：US20030148304A1
公开(公告)日：2003-08-07
申请号：US10165642
申请日：2002-06-07
发明人： Zicai Liang , Anil Kumar
IPC分类号： C12Q001/68 , B05D003/00 , C07H021/02 , C07H021/04 , C12M001/34 , C07K014/00
CPC分类号： C40B40/06 , C07H21/00 , C07H21/04 , C40B50/18
摘要： A method for immobilisation of nucleic acids onto glass and silicon surfaces is described, wherein said nucleic acids are immobilised onto unmodified glass and other silicon surfaces. A new class of modified nucleic acids, namely silanised nucleic acids, and methods of preparing such modified nucleic acids, as well as a method for producing DNA chips of various density with only end-attachment of DNA applied, are also described.
摘要翻译：描述了将核酸固定在玻璃和硅表面上的方法，其中所述核酸固定在未改性的玻璃和其它硅表面上。还描述了一类新的修饰的核酸，即硅烷化的核酸，以及制备这种修饰的核酸的方法，以及用于生产仅具有DNA末端附着的各种密度的DNA芯片的方法。

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