基本信息:
- 专利标题： Coated vascular prosthesis and methods of manufacture and use
- 专利标题（中）：涂层血管假体及其制造和使用方法
- 申请号：US10358348 申请日：2003-02-05
- 公开(公告)号：US20030149471A1 公开(公告)日：2003-08-07
- 发明人： Stephen G. Briana , Ramesh B. Jayaraman
- 主分类号： A61F002/06
- IPC分类号： A61F002/06 ; B05D003/00
摘要：
A method for forming a kink resistant, blood impermeable graft comprises the steps of: providing a crimped substrate of polymer fabric; coating the outer surface of the substrate with a first solution comprising a first polymer and a particulate in a first solvent; allowing the first solution to dry, thereby forming a first coat on the substrate; coating the first coat with a second solution comprising a second polymer in a second solvent; and immersing the coated substrate in a third solvent to precipitate the second polymer from solution, thereby forming a porous second coat. The third solvent also dissolves the salt in the first coat to form pores in the first coat. The first and second polymer solutions do not penetrate to the interior surface of the substrate of the graft. Vascular prostheses made by this method are blood impermeable and kink resistant and are particularly useful as outflow cannulas for ventricular assist devices.
摘要（中）：
用于形成耐扭结的不透血移植物的方法包括以下步骤：提供聚合物织物的卷曲基材; 在第一溶剂中用包含第一聚合物和颗粒的第一溶液涂覆基材的外表面; 使第一溶液干燥，从而在基材上形成第一涂层; 在第二溶剂中用包含第二聚合物的第二溶液涂覆第一涂层; 并将涂布的基材浸渍在第三溶剂中以从溶液中沉淀第二聚合物，从而形成多孔的第二涂层。 第三溶剂也溶解第一涂层中的盐，以在第一涂层中形成孔。 第一和第二聚合物溶液不渗透到移植物的基底的内表面。 通过这种方法制成的血管假体是不透血和抗扭结的，并且特别可用作心室辅助装置的流出插管。