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61. 发明授权

US6160087A Peptides having an amino acid sequence from the fimbrial protein of porphyromonas gingivalis and their uses 失效
标题翻译：具有牙龈卟啉单胞菌蛋白质的氨基酸序列的肽及其用途
公开(公告)号：US6160087A
公开(公告)日：2000-12-12
申请号：US619557
申请日：1996-03-27
申请人： Tomohiko Ogawa
发明人： Tomohiko Ogawa
IPC分类号： A61K39/02 , A61K8/64 , A61K31/70 , A61K35/74 , A61K38/00 , A61K39/00 , A61K39/40 , A61P1/02 , A61Q11/00 , C07K7/06 , C07K14/195 , C07K14/41 , C07K17/00 , G01N33/569
CPC分类号： G01N33/56955 , A61K8/64 , A61K38/00 , A61K39/00 , A61Q11/00 , C07K14/195 , Y02P20/55
摘要： There are provided peptides (each having 5 to 10 amino acid residues) corresponding to fragments derived from the amino acid sequence of the 41 kD sub-unit protein constituting the fimbriae of Porphyromonas gingivalis, or salts of the peptides. Further provided are compositions for diagnosis of periodontal disease containing them, vaccines for prophylaxis of periodontal disease containing part of them, and the oral compositions for prophylaxis or treatment of periodontal disease containing antibodies obtained by immunizing animals with the peptides.Peptides are provided which are lowered in nonspecific reactivity and can be used more safely for the above compositions, compared to the above protein and peptides therefrom having 20 amino acid residues.
摘要翻译： PCT No.PCT / JP94 / 01589 Sec。 371日期：1996年3月27日 102（e）1996年3月27日PCT 1994年9月28日PCT公布。公开号WO95 / 09181 日期1995年04月6日提供了相应于构成牙龈卟啉单胞菌的41kD亚单位蛋白质的氨基酸序列的片段或肽的盐，每个肽具有5至10个氨基酸残基。进一步提供了用于诊断含有它们的牙周病的组合物，用于预防含有部分牙周病的疫苗，以及用于通过用肽免疫动物获得的含有抗体的牙周病的口腔组合物。与上述蛋白质和其具有20个氨基酸残基的肽相比，提供了以非特异性反应性降低的肽并且可以更安全地用于上述组合物。

62. 发明授权

US6015681A Rapid immunoassay for cariogenic bacteria 失效
标题翻译：快速免疫测定致龋细菌
公开(公告)号：US6015681A
公开(公告)日：2000-01-18
申请号：US766203
申请日：1996-12-12
申请人： Stephen Alden Ralls , Lloyd Grant Simonson
发明人： Stephen Alden Ralls , Lloyd Grant Simonson
IPC分类号： G01N33/569 , G01N33/554 , G01N33/53 , G01N33/537 , G01N33/543
CPC分类号： G01N33/56955 , G01N33/56944 , G01N2333/315 , G01N2333/335 , G01N2333/36 , Y10S435/975
摘要： An assay method and kit for detecting specific oral cariogenic bacteria, ., mutans streptococci, Lactobacillus sp. and Actinomyces sp., separately or in combination, comprising gathering a sample suspected of containing cariogenic bacteria; treating the sample with a stripping buffer to remove host antibodies from bacteria present in the sample; retaining the treated bacteria on a blocked solid phase substrate; reacting the retained bacteria with a primary antibody specific for the desired cariogenic bacteria; reacting the primary antibody with a conjugated label producing a detectable signal; and detecting the signal whereby the presence of the desired cariogenic bacteria is determined in the sample. The device for conducting these assays is a frame or support which holds a solid substrate capable of retaining the bacteria of interest while permitting drainage of other materials or fluids away from the retained bacteria.
摘要翻译：用于检测特定口腔致龋细菌的测定方法和试剂盒，例如变形链球菌，乳杆菌属（Lactobacillus sp。和放线菌属（Actinomyces sp。）分开或组合，包括收集怀疑含有致龋细菌的样品; 用剥离缓冲液处理样品以除去样品中存在的细菌的宿主抗体; 将经处理的细菌保留在封闭的固相底物上; 使所保留的细菌与所需致龋细菌特异性的一级抗体反应; 使一次抗体与产生可检测信号的共轭标记反应; 并检测信号，由此在样品中确定所需致龋菌的存在。用于进行这些测定的装置是一种框架或支撑体，其保持固体基底，其能够保留感兴趣的细菌，同时允许其它材料或流体从保留的细菌排出。

63. 发明授权

US5399484A Use of blocking protein with high pH extraction in method to determine a microorganism associated with periodontal disease and kit useful therefor 失效
标题翻译：在方法中使用具有高pH提取的阻断蛋白来测定与牙周病相关的微生物和用于其的试剂盒
公开(公告)号：US5399484A
公开(公告)日：1995-03-21
申请号：US773064
申请日：1991-10-08
申请人： Bradley P. Boyer , Paul B. Contestable , Brian A. Snyder
发明人： Bradley P. Boyer , Paul B. Contestable , Brian A. Snyder
IPC分类号： G01N33/531 , G01N33/53 , G01N33/569
CPC分类号： G01N33/56955 , G01N33/5306 , Y10S435/961 , Y10S435/962 , Y10S435/975
摘要： A method has been developed for determining microorganisms associated with periodontal diseases which is highly sensitive and shows very low background and cross-reactivity among various closely related antigens. Antigen is extracted at relatively high pH, and either before or immediately after extraction, the antigen-containing specimen is mixed with a blocking composition having at least about 0.2 weight percent of a non-immunoreactive blocking protein. The pH of the resulting mixture is kept high when contacted with the antibodies specific to the antigen of interest. The compositions and components needed for the assay can be supplied in a diagnostic test kit.
摘要翻译：已经开发了一种用于确定与牙周疾病相关的微生物的方法，所述微生物是高度敏感的并且在各种紧密相关的抗原之间显示非常低的背景和交叉反应性。抗原在相对高的pH下提取，并且在提取之前或之后，将含抗原的样品与具有至少约0.2重量％的非免疫反应性阻断蛋白的封闭组合物混合。当与感兴趣的抗原特异的抗体接触时，所得混合物的pH保持较高。测定所需的组合物和组分可以在诊断测试试剂盒中提供。

64. 发明授权

US5212061A Direct binding assay for the determination of a bacteroids organism 失效
标题翻译：用于确定细菌生物有机体的直接结合测定
公开(公告)号：US5212061A
公开(公告)日：1993-05-18
申请号：US468045
申请日：1990-01-22
申请人： Brian A. Snyder , Paul B. Contestable , Catherine T. Abrams , Joseph J. Zambon , Homer S. Reynolds
发明人： Brian A. Snyder , Paul B. Contestable , Catherine T. Abrams , Joseph J. Zambon , Homer S. Reynolds
IPC分类号： G01N33/569
CPC分类号： G01N33/56955 , Y10S435/961 , Y10S435/962
摘要： Antigens extracted from one or more serotypes of a Bacteroides microorganism are rapidly and sensitively detected when directly bound to a water-insoluble substrate. The bound antigens are detected by forming an immunological complex on the substrate when the antigen reacts with the appropriate antibody. The antibody-antigen complex can be detected directly or by means of a second antibody which is directed to the Bacteroides antibody. The entire assay can be carried out at room temperature in less than about 15 minutes.

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