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61. 发明申请

US20130000382A1 METHODOLOGY FOR DETERMINATION OF NITROGEN CONTENT IN NITROCELLULOSE 有权
标题翻译：用于测定硝酸纤维素中氮含量的方法
公开(公告)号：US20130000382A1
公开(公告)日：2013-01-03
申请号：US13175503
申请日：2011-07-01
申请人： Michael T. Combs
发明人： Michael T. Combs
IPC分类号： G01N7/00
CPC分类号： G01N30/86 , C08B5/02 , G01N30/34 , G01N30/50 , G01N30/74 , G01N30/8668 , G01N30/8693 , G01N33/22 , Y10T436/17 , Y10T436/25 , Y10T436/25375 , Y10T436/255
摘要： In at least one embodiment, the invention is directed to a method of determining the nitrogen content in nitrocellulose by High Performance Liquid Chromatography (HPLC). It is within the scope of the invention for the sample of nitrocellulose to be unstable nitrocellulose, unrefined nitrocellulose, or refined nitrocellulose. The sample of nitrocellulose can wet or dry. A sample of nitrocellulose that is wet can be in acid or in water. Before HPLC, the sample is dissolved in a suitable solvent. The nitrogen content of the sample is determined by comparing the retention time of the sample to a graph of retention time to amount of nitrogen due to the linear correlation of retention time and percent nitrogen substitution.
摘要翻译：在至少一个实施方案中，本发明涉及通过高效液相色谱（HPLC）测定硝酸纤维素中的氮含量的方法。硝酸纤维素样品不稳定硝化纤维素，未精制硝酸纤维素或精制硝化纤维素在本发明的范围内。硝酸纤维素样品可以湿润或干燥。湿的硝酸纤维素样品可以在酸或水中。在HPLC之前，将样品溶解在合适的溶剂中。通过将样品的保留时间与保留时间与氮量的比较，由于保留时间和氮取代率的线性相关性，来测定样品的氮含量。

62. 发明申请

US20120103054A1 CALIBRATION METHOD IN MEASUREMENT OF HEMOGLOBIN A1c 有权
标题翻译： HEMOGLOBIN A1c测量中的校准方法
公开(公告)号：US20120103054A1
公开(公告)日：2012-05-03
申请号：US13284132
申请日：2011-10-28
申请人： Koji Sugiyama
发明人： Koji Sugiyama
IPC分类号： G01N33/49 , G01N30/96 , G01N27/447
CPC分类号： G01N30/88 , G01N27/447 , G01N30/86 , G01N30/8665 , G01N33/723 , G01N33/96 , G01N2030/042 , G01N2030/8822
摘要： A calibration method that enables calibration easily in a short time in a measurement of hemoglobin A1c by use of a separation analysis is provided. In a measurement of a hemoglobin A1c amount by use of a separation analysis, a one-point calibration using a single calibration standard is performed to obtain calibration data to be used for correcting a measured value.
摘要翻译：提供了一种通过使用分离分析在短时间内容易地测量血红蛋白A1c的校准方法。在通过分析分析测量血红蛋白A1c量时，使用单一校准标准进行单点校准，以获得用于校正测量值的校准数据。

63. 发明申请

US20070143042A1 Processes and systems for providing analytical device analysis advisory information 审中-公开
标题翻译：提供分析设备分析咨询信息的流程和系统
公开(公告)号：US20070143042A1
公开(公告)日：2007-06-21
申请号：US11305691
申请日：2005-12-16
申请人： Gordon Stewart , Robert Ricker
发明人： Gordon Stewart , Robert Ricker
IPC分类号： G01N11/00
CPC分类号： G01N30/86 , G01N30/8662
摘要： Processes and systems for providing analytical device analysis advisory information are provided. Aspects of the subject processes and systems include use of an advisory module that generates analytical device analysis advisory information based on a sample identifier and instrument parameter. Also provided are computer program products for use in executing the subject processes.
摘要翻译：提供了提供分析设备分析咨询信息的流程和系统。主题过程和系统的方面包括使用基于样本标识符和仪器参数生成分析设备分析咨询信息的咨询模块。还提供了用于执行主题处理的计算机程序产品。

64. 发明申请

US20060122785A1 Constellation mapping and uses thereof 审中-公开
标题翻译：星座映射及其用途
公开(公告)号：US20060122785A1
公开(公告)日：2006-06-08
申请号：US11246463
申请日：2005-10-06
申请人： Paul Kearney , Navdeep Jaitly , Kevin Eng
发明人： Paul Kearney , Navdeep Jaitly , Kevin Eng
IPC分类号： G06F19/00
CPC分类号： H01J49/0027 , G01N27/44773 , G01N30/86 , G16B20/00
摘要： The present invention features computer methods and systems for comparing biomolecules across biological samples. In these methods, mass spectrometry measurements are obtained on biomolecules in two or more samples. These measurements are then processed and analyzed by the methods described herein to render them more comparable. We refer to this technology as “Constellation Mapping” (CM). The resulting data, constellation maps, can be used to compare the abundance of biomolecules across samples, and, when done in real time, can be used to select differentially abundant biomolecules for subsequent LC/MS-MS.
摘要翻译：本发明的特征在于用于比较生物样品上的生物分子的计算机方法和系统。在这些方法中，在两个或多个样品中的生物分子上获得质谱测量。然后通过本文所述的方法对这些测量进行处理和分析，以使它们更可比。我们把这项技术称为“星座映射”（CM）。所得到的数据，星座图可用于比较样品中生物分子的丰度，当实时完成时，可用于选择差异丰富的生物分子用于随后的LC / MS-MS。

65. 发明申请

US20040034513A1 Software for the display of chromatographic separation data 有权
公开(公告)号：US20040034513A1
公开(公告)日：2004-02-19
申请号：US10443657
申请日：2003-05-22
申请人： CALIPER TECHNOLOGIES CORPORATION, a Corporation of the state of Delaware
发明人： Steven J. Gallagher
IPC分类号： G06F017/50
CPC分类号： G01N30/86 , G01N27/44717 , G01N30/8651 , G01N2030/625
摘要： Techniques for displaying chromatographic data using a graphical user interface are provided. Chromatographic separation data that is a series of measurements for a sample at a scanning location over time can be displayed on a display device in a series of bands. Additionally, the series of bands for multiple samples can be aligned on the display device.

66. 发明授权

US06210970B1 Method of diagnosing or categorizing disorders from biochemical profiles 失效
标题翻译：从生化特征诊断或分类疾病的方法
公开(公告)号：US06210970B1
公开(公告)日：2001-04-03
申请号：US08092543
申请日：1993-07-16
申请人： Wayne R. Matson
发明人： Wayne R. Matson
IPC分类号： G01N3348
CPC分类号： G01N33/6896 , G01N30/02 , G01N30/34 , G01N30/64 , G01N30/86 , G01N33/48 , G01N33/6803 , G01N2030/645 , B01D15/36
摘要： A method for diagnosing disorders in a subject organism, in which fluid samples from normal and abnormal organisms are analyzed to generate electrical signal patterns representative of molecular constituents of the samples. A data base of electrical signal patterns representative of frequency distribution of sample constituents from the abnormal organisms having known categories of disorders and control samples from normal organisms are created, and a fluid sample taken from the subject organism is analyzed by comparing it to the data base for conformity to the electrical signal patterns representative of the frequency distribution. The invention has particular applicability to assisting in the diagnosis of degenerative diseases such as Alzheimer's Disease, Parkinson's Disease, Huntington's Disease, schizophrenia, amyotrophic lateral sclerosis and Progressive Supernuclear Palsy.
摘要翻译：用于诊断受试生物体内的病症的方法，其中分析来自正常和异常生物体的流体样品以产生代表样品的分子组分的电信号图谱。产生代表来自具有已知类型的异常生物的异常生物体的样品成分的频率分布的数据库以及来自正常生物体的对照样品的电信号模式的数据库，并且通过将其与数据库进行比较来分析从受试者生物体中获取的流体样品用于符合代表频率分布的电信号模式。本发明特别适用于辅助诊断退行性疾病如阿尔茨海默病，帕金森病，亨廷顿病，精神分裂症，肌萎缩性侧索硬化和进行性超核麻痹。

67. 发明公开

US20240353381A1 MULTI-CORRECTION ANALYSIS METHOD USING CHROMATOGRAPH 审中-公开
公开(公告)号：US20240353381A1
公开(公告)日：2024-10-24
申请号：US18685442
申请日：2021-08-23
申请人： SHIMADZU CORPORATION , Hyogo College of Medicine
发明人： Tomonori YOKOYAMA , Noriyuki OJIMA , Reiko TANAKA , Shin NISHIUMI
IPC分类号： G01N30/86 , G01N30/06 , G01N30/72
CPC分类号： G01N30/86 , G01N30/06 , G01N30/7206
摘要： A multi-correction analysis method for correcting a result of analyzing a large number of object substances contained in a sample using a chromatograph, includes: grouping at least a part of a large number of object substances possibly contained in a sample to be analyzed into groups based on changes in the measured values of the part of the object substances obtained by performing chromatographic analysis of the sample under different analysis conditions, and determining a surrogate substance for each of the groups; and adding the surrogate substance to the sample as an internal standard substance common to the object substances contained in each group, and correcting a measured value of each of the large number of object substances obtained from a result of chromatographic analysis of the sample with a measured value of the internal standard substance corresponding to the group to which the object substance belongs.

68. 发明授权

US11977058B2 Chromatography system 有权
公开(公告)号：US11977058B2
公开(公告)日：2024-05-07
申请号：US16958693
申请日：2018-02-02
申请人： SHIMADZU CORPORATION
发明人： Atsushi Matsudaira
IPC分类号： G01N30/02 , G01N30/06 , G01N30/16 , G01N30/60 , G01N30/86
CPC分类号： G01N30/60 , G01N30/02 , G01N30/06 , G01N30/16 , G01N30/86 , G01N2030/027
摘要： Provided is a chromatography system including a usage information storage device, a column usage information holding part, and a usage information managing part. The usage information storage device is provided corresponding to the analytical column incorporated in the chromatography system and is configured to keep usage information for each corresponding analytical column. The column usage information holding part is provided separately from the analytical column and is configured to keep usage information for each of the analytical columns which may be incorporated in the chromatography system. The usage information managing part is configured to update, at a timing when an analysis process of separating a sample injected into the analysis channel using the analytical column is executed, the usage information kept by the usage information storage device and the usage information kept by the column usage information holding part in association with the analytical column to latest usage information.

69. 发明授权

US11932906B2 System and methods for electrokinetic loading of sub-micron-scale reaction chambers 有权
公开(公告)号：US11932906B2
公开(公告)日：2024-03-19
申请号：US17350509
申请日：2021-06-17
申请人： Quantum-Si Incorporated
发明人： Guojun Chen , Jeremy Lackey , Alexander Goryaynov , Gerard Schmid , Ali Kabiri , Jonathan M. Rothberg , Todd Rearick , Jonathan C. Schultz , Farshid Ghasemi , Keith G. Fife
IPC分类号： C12Q1/6869 , B01L3/00 , C08L1/02 , C12Q1/6806 , G01N21/64 , G01N27/447 , G01N30/86 , G01N30/88
CPC分类号： C12Q1/6869 , B01L3/502761 , B01L3/50857 , C08L1/02 , C12Q1/6806 , G01N21/6428 , G01N21/6454 , G01N27/44743 , G01N27/44782 , G01N30/86 , B01L2200/0647 , B01L2300/0645 , B01L2300/0829 , B01L2300/0864 , B01L2400/0415 , B01L2400/0421 , G01N27/447 , G01N30/88
摘要： Apparatus and techniques for electrokinetic loading of samples of interest into sub-micron-scale reaction chambers are described. Embodiments include an integrated device and related apparatus for analyzing samples in parallel. The integrated device may include at least one reaction chamber formed through a surface of the integrated device and configured to receive a sample of interest, such as a molecule of nucleic acid. The integrated device may further include electrodes patterned adjacent to the reaction chamber that produce one or more electric fields that assist loading the sample into the reaction chamber. The apparatus may further include a sample reservoir having a fluid seal with the surface of the integrated device and configured to hold a suspension containing the samples.

70. 发明授权

US11782034B2 Fraction collector control device and preparative liquid chromatograph 有权
公开(公告)号：US11782034B2
公开(公告)日：2023-10-10
申请号：US16491282
申请日：2017-03-07
申请人： SHIMADZU CORPORATION
发明人： Soichiro Tamaoki , Tsutomu Okoba , Takayuki Iriki , Shiori Ueda
IPC分类号： G01N30/82 , G01N30/86 , G01N30/80 , G01N30/16 , G01N30/02 , G01N30/06
CPC分类号： G01N30/82 , G01N30/80 , G01N30/86 , G01N30/8624 , G01N30/8627 , G01N30/8631 , G01N30/06 , G01N2030/027
摘要： A fraction collector control device includes a peak designation part that displays a chromatogram for setting and requires a user to select at least one peak in the chromatogram for setting, a parameter extraction part that extracts, as a parameter, a signal level and/or a slope at a start point and an end point of each peak designated by a user, and a threshold candidate generation part that generates, based on the parameter extracted by the parameter extraction part, a threshold candidate usable as a common threshold for detecting start points of all peaks designated by a user and a common threshold for detecting end points of all peaks designated by a user.

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