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1. 发明授权

US11982655B2 Analysis apparatus having a plurality of liquid chromatographs and its analysis method 有权
公开(公告)号：US11982655B2
公开(公告)日：2024-05-14
申请号：US17295345
申请日：2019-11-19
申请人： Hitachi High-Tech Corporation
发明人： Daisuke Akieda , Makoto Nogami , Iwao Suzuki , Masako Kawarai , Izumi Ogata , Shinya Ito
IPC分类号： G01N30/86 , G01N30/02 , G01N30/24 , G01N30/34 , G01N30/46 , G01N30/62 , G01N30/72
CPC分类号： G01N30/86 , G01N30/46 , G01N30/466 , G01N30/7233 , G01N2030/027 , G01N30/24 , G01N30/34 , G01N2030/628
摘要： The present invention makes it possible to realize an analysis apparatus having a plurality of liquid chromatographs capable of judging separation performance and the like at the right timing and improving analysis performance early. Analysis starts and a mixed sample is prepared by adding a non-retaining ingredient to a measurement object sample and is introduced into an analysis flow path (S401 to S404). The mixed sample is separated into components by a separation column, the components are outputted as chromatogram data by a detector, and the analysis finishes (S404 to S406). Retention time and peak information are acquired from the chromatogram outputted from the detector, whether or not a measurement result is within an allowable range is judged, and the process shifts to next analysis when the measurement result is within the allowable range (S407 to S409). An amount of transit time t0 of a non-retaining ingredient shifted from an allowable value is confirmed when separation performance is outside an allowable range at step S408 and a separation column replacement instruction is outputted to an output unit when fluctuation of the transit time t0 is within an allowable range (S410, S411). A device maintenance instruction is outputted to the output unit when the fluctuation is outside the allowable range at step S410 (S412).

2. 发明公开

US20240118251A1 Control Method for Automatic Analyzer 审中-公开
公开(公告)号：US20240118251A1
公开(公告)日：2024-04-11
申请号：US18273111
申请日：2022-01-06
申请人： Hitachi High-Tech Corporation
发明人： Takumi YAMADA , Takayuki SUGIME , Naoto SAKAMOTO
IPC分类号： G01N30/86 , G01N30/46 , G01N35/00 , G01N35/10
CPC分类号： G01N30/86 , G01N30/46 , G01N35/0092 , G01N35/10
摘要： [Problem] To provide a control method of avoiding drop of a throughput by solvent substitution and of avoiding increase of a solvent consumption amount in a control method for an automatic analyzer including a liquid chromatograph that includes plural analysis flow passages arranged to be parallel to each other.
[Solution] Which one of plural analysis flow passages 105 to 107 is to be used is determined in introducing plural separation processes using solvents whose kind is different from each other with a time lag relative to one another, and a solvent used in a next separation process executed at timing after starting the plural separation processes determined to be introduced with a time lag relative to one another and each of the solvents used in the plural separation processes determined to be introduced with a time lag relative to one another are compared. Whether or not a solvent substitution process is required for the analysis flow passages 105 to 107 used in the plural separation processes is determined, an analysis flow passage used in the next separation process out of the plural analysis flow passages 105 to 107 is determined according to the determination, and an analysis schedule is prepared.

3. 发明授权

US11854779B2 Systems and methods for reducing lab-to-lab and/or instrument-to-instrument variability of multi-attribute method (MAM) by run-time signal 有权
公开(公告)号：US11854779B2
公开(公告)日：2023-12-26
申请号：US16972742
申请日：2019-06-06
申请人： AMGEN INC.
发明人： Zhongqi Zhang
IPC分类号： H01J49/00 , G01N30/86 , G01N33/68
CPC分类号： H01J49/0009 , G01N30/8665 , G01N30/8696 , H01J49/0036 , G01N30/86 , G01N33/68
摘要： Systems and methods are described for reducing lab-to-lab and/or instrument-to-instrument variability of Multi-Attribute Methods (MAM) analyses via run-time signal intensity calibration. In various aspects, multiple MAM-based instruments each have detectors and different instrument conditions defined by different instrument models or sets of settings. Each MAM-based instrument receives respective samples and a reference standard as a calibrant. Each MAM-based instrument detects, via its detector, sample isoforms of its respective sample and reference standard isoforms of the reference standard. The MAM-based instruments are associated with processor(s) that determine, via respective MAM iterations, correction factors and sample abundance values corresponding to the sample isoforms. The correction factors are based on the reference standard, and the sample abundance values are based on the correction factors. A variance value of the sample abundance values may be reduced based on correction factors of each of the MAM-based instruments.

4. 发明申请

US20180268293A1 ANALYSIS-DATA ANALYZING DEVICE AND ANALYSIS-DATA ANALYZING METHOD 审中-公开
公开(公告)号：US20180268293A1
公开(公告)日：2018-09-20
申请号：US15921107
申请日：2018-03-14
申请人： SHIMADZU CORPORATION
发明人： Akira NODA
IPC分类号： G06N3/08 , G06N5/04 , G06N7/08 , G06F17/18 , G06N3/04
CPC分类号： G06N3/08 , G01N30/86 , G06F17/18 , G06K9/00536 , G06N3/0436 , G06N3/084 , G06N5/048 , G06N7/005 , G06N7/08 , G06N20/10
摘要： Using training data, machine learning is performed to construct a learning model which is a non-linear function for discrimination or regression analysis (S2). A degree of contribution of each input dimension is calculated from a partial differential value of that function. Input dimensions to be invalidated are determined using a threshold defined by a Gaussian distribution function based on the degrees of contribution (S3-S5). Machine learning is once more performed using the training data with the partially-invalidated input dimensions (S6). A new value of the degree of contribution of each input dimension is determined from the obtained learning model, and the degree of contribution is updated using the old and new values (S7-S8). After the processes of Steps S5-S8 are iterated a specified number of times (S9), useful dimensions are determined based on the finally obtained degrees of contribution, and the machine-learning model is constructed (S10).

5. 发明申请

US20180052140A1 MODULAR-TYPE ANALYSIS SYSTEM 审中-公开
公开(公告)号：US20180052140A1
公开(公告)日：2018-02-22
申请号：US15556151
申请日：2015-04-03
申请人： Shimadzu Corporation
发明人： Yusuke YOKOI
IPC分类号： G01N30/24 , G01N35/00
CPC分类号： G01N30/24 , G01N30/02 , G01N30/16 , G01N30/30 , G01N30/86 , G01N30/88 , G01N35/00 , G01N35/00871 , G01N2030/027 , G01N2035/00326 , G01N2035/00891
摘要： Upon receipt of an analysis initiation instruction, regardless of the necessity of any changes in operation at the time of the analysis initiation, an integrated controller (21) of a system control unit (2) notifies other units (3 to 6) of analysis initiation and changes the luminescent color of a state indication LED (25) to blue which is common to each unit. In a liquid supply unit (3) that received a notification of the analysis initiation, a local controller (34) changes the device status to “RUN” and changes the luminescent color of a state indication LED (35) to blue. This is also applies to other units (4 to 6). Upon completion of the analysis, the integrated controller (21) notifies each unit (3 to 6) of the analysis completion and changes the display color of the state indication LED (25) to green. Each unit (3 to 6) also changes the display color of the state indication LED (35 to 65) to green. With this, a user can intuitively grasp that analysis is in progress and the analysis is completed by looking at the luminescent color of the state indication LED (25 to 65).

6. 发明授权

US09777818B2 Two-speed drive module 有权
公开(公告)号：US09777818B2
公开(公告)日：2017-10-03
申请号：US14722432
申请日：2015-05-27
申请人： American Axle & Manufacturing, Inc.
发明人： Paul J. Valente , James P. Downs
IPC分类号： F16H48/06 , F16H3/44 , F16H3/66 , F16H3/54 , B60K1/00
CPC分类号： G01N30/74 , B60K2001/001 , F16H3/44 , F16H3/54 , F16H48/06 , F16H2200/0034 , F16H2200/2005 , G01N30/86 , G01N30/8624 , G01N30/8675
摘要： A drive module that includes an electric motor, a differential assembly with a differential input member and a pair of differential output members, a multi-speed transmission assembly, which transmits rotary power between the electric motor and the differential input member, and a pair of axle shafts that are each coupled to an associated one of the differential output members for rotation therewith. The multi-speed transmission assembly and includes a housing, a two-speed planetary transmission stage, a plurality of clutches and a transmission output member that provides rotary power to the differential input member. The two-speed planetary transmission stage has an input sun gear, which is driven by the motor, and employs a set of planet gears having compound planet gears that provide a gear reduction between the sun gear and the transmission output member. The clutches are employed to control an overall reduction ratio.

7. 发明授权

US09417221B2 Food steganography 有权
标题翻译：食品隐写
公开(公告)号：US09417221B2
公开(公告)日：2016-08-16
申请号：US14011421
申请日：2013-08-27
申请人： International Business Machines Corporation
发明人： Kush R. Varshney , Lav R. Varshney
IPC分类号： G01N7/00 , G01N33/00 , G01N33/02 , G01N30/00 , A23L1/30 , A23L1/29 , A23L1/015 , A23L1/22
CPC分类号： A23L27/74 , A23L5/20 , A23L27/84 , A23L33/10 , A23L33/30 , A23V2002/00 , B01F15/00207 , B01F15/0441 , B01F2215/0014 , G01N30/00 , G01N30/86 , G01N30/8651 , G01N33/0001 , G01N33/0004 , G01N33/02 , G01N2030/025
摘要： The present disclosure relates to methods and systems for calculating a food additive. A first method includes identifying chemical compounds of an averse food ingredient, identifying chemical compounds of a flavorful food ingredient and calculating a set of chemical compounds for the food additive such that an olfactory perception of a mixture of the averse food ingredient, the flavorful food ingredient and the food additive is the same as an olfactory perception of only the flavorful food ingredient. A first device includes a database storing information identifying chemical compounds of an averse food ingredient and identifying chemical compounds of a flavorful food ingredient, and a processor for calculating a food additive such that an olfactory perception of flavors of a mixture of the averse food ingredient, the flavorful food ingredient and the food additive is the same as an olfactory perception of only the flavorful food ingredient.
摘要翻译：本公开涉及计算食品添加剂的方法和系统。第一种方法包括鉴定厌食食品成分的化合物，鉴定食用食品成分的化合物，并计算食品添加剂的一组化合物，使得厌食食品成份，美味食品成分食品添加剂与仅有味道的食物成分的嗅觉相同。第一装置包括数据库，其存储识别厌食食品成分的化合物的信息，并鉴定食用食品成分的化合物，以及用于计算食品添加剂的处理器，使得厌食食物成分，美味的食物成分和食品添加剂与仅有味道的食物成分的嗅觉相同。

8. 发明申请

US20160203963A1 Mass Correction 审中-公开
标题翻译：质量纠正
公开(公告)号：US20160203963A1
公开(公告)日：2016-07-14
申请号：US14990928
申请日：2016-01-08
申请人： Micromass UK Limited
发明人： Martin Raymond Green
IPC分类号： H01J49/00 , G01N30/86
CPC分类号： H01J49/0036 , G01N30/86 , G01N30/8679
摘要： Disclosed is a method of mass spectrometry comprising the steps of: providing a library of matrix data, said matrix data comprising one or more physico-chemical properties of one or more matrix components as a function of retention time; chromatographically separating a sample, said sample containing at least some of said matrix components and one or more analyte components; analysing said sample at a plurality of retention times to obtain sample data, said sample data comprising one or more physico-chemical properties of one or more sample components as a function of retention time; and calculating one or more error values as a function of retention time based on a comparison between said sample data and said matrix data.
摘要翻译：公开了一种质谱方法，其包括以下步骤：提供矩阵数据库，所述矩阵数据包括作为保留时间的函数的一个或多个基质成分的一种或多种物理化学性质; 色谱分离样品，所述样品含有至少一些所述基质组分和一种或多种分析物成分; 在多个保留时间分析所述样品以获得样品数据，所述样品数据包括作为保留时间的函数的一种或多种样品组分的一种或多种物理化学性质; 以及基于所述样本数据和所述矩阵数据之间的比较，计算作为保留时间的函数的一个或多个误差值。

9. 发明申请

US20160195500A1 CHROMATOGRAPHIC DEVICE AND METHOD 审中-公开
标题翻译：色谱装置和方法
公开(公告)号：US20160195500A1
公开(公告)日：2016-07-07
申请号：US14901613
申请日：2014-06-26
申请人： Ruprecht-Karts-Universitat Heidelberg
发明人： Oliver TRAPP , Alexander F SIEGLE
IPC分类号： G01N30/16 , G01N30/86
CPC分类号： G01N30/16 , G01N24/08 , G01N30/86 , G01N30/8658 , G01N30/8675 , G01N30/8696 , G01N2030/027 , G01R33/448
摘要： A chromatographic device for analysing multiple samples comprises a separator for separating the multiple samples, an injector unit for injecting the multiple samples into the separator, the injector unit being provided as regular injector unit for single-sample chromatography, a detector for detecting signals of the multiple samples after they are separated by the separator, a sequence generator for generating a specific binary sequence for each of the multiple samples, a controller that controls the injector unit so that each of the multiple samples is injected into the separator in pulses corresponding to its specific binary sequence, and a decomposer for decomposing the detected signals of the multiple samples by identifying the specific binary sequences in the detected signals.
摘要翻译：用于分析多个样品的色谱装置包括用于分离多个样品的分离器，用于将多个样品注入分离器的注射器单元，注射器单元作为用于单样品层析的常规注射器单元提供，检测器用于检测在由分离器分离后的多个样品，用于为多个样品中的每一个产生特定二进制序列的序列发生器，控制器，其控制注射器单元，使得将多个样品中的每一个以与其对应的脉冲相对应的脉冲注入分离器特定二进制序列，以及分解器，用于通过识别检测到的信号中的特定二进制序列来分解多个样本的检测信号。

10. 发明申请

US20160153945A1 METHOD AND KIT FOR THE IDENTIFICATION OF COMPOUNDS IN AN ORGANIC MIXTURE 审中-公开
标题翻译：用于鉴定有机混合物中化合物的方法和试剂盒
公开(公告)号：US20160153945A1
公开(公告)日：2016-06-02
申请号：US14905489
申请日：2014-07-18
申请人： TOTAL S.A.
发明人： Daniel DESSORT , Jacques BICKERT
IPC分类号： G01N30/86 , G01N30/14 , G01N30/72
CPC分类号： G01N30/86 , G01N30/14 , G01N30/72 , G01N30/7206 , G01N30/8675 , G01N2030/025 , G01N2030/884
摘要： The present disclosure relates to a method for constituting a collection of chromatograms of a reference mixture of organic compounds. The present disclosure also relates to a method for the identification of compounds in a sample of an organic mixture using a collection of chromatograms. A kit is also provided for the identification of at least one compound in a sample from an organic mixture. The method and kit belong to the field of analytical chemistry.
摘要翻译：本公开涉及构成有机化合物的参考混合物的色谱图的集合的方法。本公开还涉及使用色谱图的集合来鉴定有机混合物样品中化合物的方法。还提供了用于鉴定来自有机混合物的样品中至少一种化合物的试剂盒。该方法和试剂盒属于分析化学领域。

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