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61. 发明申请

US20150113687A1 Fully Digitally Controller for Cantilever-Based Instruments 审中-公开
标题翻译：基于悬臂的仪器的全数字控制器
公开(公告)号：US20150113687A1
公开(公告)日：2015-04-23
申请号：US14590150
申请日：2015-01-06
申请人： OXFORD INSTRUMENTS PLC , OXFORD INSTRUMENTS AFM INC.
发明人： Roger Proksch , Jason Cleveland , Dan Bocek , Todd Day , Mario Viani , Clint Callahan
IPC分类号： G01Q10/00 , G01Q60/24
CPC分类号： G01Q10/06 , B82Y35/00 , G01Q10/00 , G01Q30/04 , G01Q60/24
摘要： A controller for cantilever-based instruments, including atomic force microscopes, molecular force probe instruments, high-resolution profilometers and chemical or biological sensing probes. The controller samples the output of the photo-detector commonly used to detect cantilever deflection in these instruments with a very fast analog/digital converter (ADC). The resulting digitized representation of the output signal is then processed with field programmable gate arrays and digital signal processors without making use of analog electronics. Analog signal processing is inherently noisy while digital calculations are inherently “perfect” in that they do not add any random noise to the measured signal. Processing by field programmable gate arrays and digital signal processors maximizes the flexibility of the controller because it can be varied through programming means, without modification of the controller hardware.
摘要翻译：用于基于悬臂的仪器的控制器，包括原子力显微镜，分子力探针仪器，高分辨率轮廓仪和化学或生物传感探针。控制器采用非常快速的模拟/数字转换器（ADC）对通常用于检测这些仪器中的悬臂偏转的光检测器的输出进行采样。然后，利用现场可编程门阵列和数字信号处理器对输出信号产生的数字化表示进行处理，而不利用模拟电子装置。模拟信号处理本质上是嘈杂的，而数字计算本质上是“完美的”，因为它们不会对测量的信号增加任何随机噪声。通过现场可编程门阵列和数字信号处理器的处理可以最大限度地提高控制器的灵活性，因为它可以通过编程手段进行变化，而无需修改控制器硬件。

62. 发明授权

US09015861B2 Modification of atomic force microscopy tips by deposition of nanoparticles with an aggregate source 有权
标题翻译：通过用聚集源沉积纳米颗粒来改变原子力显微镜尖端
公开(公告)号：US09015861B2
公开(公告)日：2015-04-21
申请号：US13697598
申请日：2011-05-04
申请人： Elisa Leonor Román García , Lidia Martínez Orellana , Mercedes Díaz Lagos , Yves Huttel
发明人： Elisa Leonor Román García , Lidia Martínez Orellana , Mercedes Díaz Lagos , Yves Huttel
IPC分类号： G01Q70/12 , G01Q60/38 , G01Q60/42 , B82Y15/00 , B82Y35/00
CPC分类号： G01Q60/38 , B82Y15/00 , B82Y35/00 , C23C14/22 , G01Q60/42 , G01Q60/56
摘要： The present invention relates to a method for covering Atomic Force Microscopy (AFM) tips by depositing a material in the form of nanoparticles with an aggregate source.
摘要翻译：本发明涉及通过用聚集源沉积纳米颗粒形式的材料来覆盖原子力显微镜（AFM）尖端的方法。

63. 发明授权

US09014231B2 Vertical cavity surface emitting laser nanoscope for near-field applications 有权
标题翻译：垂直腔表面发射激光纳米镜用于近场应用
公开(公告)号：US09014231B2
公开(公告)日：2015-04-21
申请号：US13758820
申请日：2013-02-04
申请人： The Board of Trustees of the Leland Stanford Junior University
发明人： Sonny Vo , James S. Harris, Jr.
IPC分类号： H01S3/08 , H01S5/183 , B82Y20/00 , B82Y35/00 , G01Q60/22 , H01S5/026
CPC分类号： H01S5/18394 , B82Y20/00 , B82Y35/00 , G01Q60/22 , H01S5/026 , H01S5/18341 , H01S5/18391
摘要： A vertical cavity surface emitting laser (VCSEL) nanoscope is provided. The VCSEL nanoscope combines a VCSEL with a nano-scale aperture using a support member to separate the aperture from the VCSEL emission face. The resulting device is a useful near-field probe with a wide variety of applications.
摘要翻译：提供垂直腔表面发射激光（VCSEL）纳米镜。 VCSEL纳米镜使用支撑构件将VCSEL与纳米尺度孔结合，以将孔径与VCSEL发射面分离。所得到的器件是一种有用的近场探头，具有广泛的应用。

64. 发明申请

US20150081228A1 METHOD AND APPARATUS FOR MEASURING CHARGE AND SIZE OF SINGLE OBJECTS IN A FLUID 有权
标题翻译：用于测量流体中单个物体的电荷和尺寸的方法和装置
公开(公告)号：US20150081228A1
公开(公告)日：2015-03-19
申请号：US14390034
申请日：2013-03-28
申请人： UNIVERSITAT ZURICH
发明人： Madhavi Krishnan
IPC分类号： G01N15/10 , G01N15/02 , G01N25/00
CPC分类号： G01N15/10 , B82Y35/00 , G01N15/0211 , G01N15/0266 , G01N15/1031 , G01N15/1463 , G01N25/00 , G01N2015/0038 , G01N2015/1075 , G01N2015/1087
摘要： In a method for determining charge and/or size of an object (15) suspended in a fluid, the object (15) is introduced, together with the fluid, into an electrostatic trap (1) defining an electrostatic confining potential. The thermal motion of the object (15) in the fluid is observed under influence of the confining potential, and charge and/or size are determined from the observed thermal motion. In particular, the viscous drag on the object yields a measure of its size, while the stiffness of its confinement can be compared with a potential model to reveal the total charge it carries. Also disclosed are an apparatus and software for carrying out the method.
摘要翻译：在用于确定悬浮在流体中的物体（15）的电荷和/或尺寸的方法中，将物体（15）与流体一起引入限定静电限制电位的静电捕获器（1）中。在限制电位的影响下观察流体中物体（15）的热运动，并根据观察到的热运动确定电荷和/或尺寸。特别地，物体上的粘性阻力产生其尺寸的度量，而其约束的刚度可以与潜在的模型进行比较，以显示其承载的总电荷。还公开了用于执行该方法的装置和软件。

65. 发明授权

US08982451B2 Pump probe measuring device 有权
标题翻译：泵探头测量装置
公开(公告)号：US08982451B2
公开(公告)日：2015-03-17
申请号：US14236771
申请日：2012-07-31
申请人： Hidemi Shigekawa , Osamu Takeuchi
发明人： Hidemi Shigekawa , Osamu Takeuchi
IPC分类号： G01N21/55 , G01N21/17 , B82Y35/00 , G01Q60/12
CPC分类号： G01N21/55 , B82Y35/00 , G01N21/1717 , G01N21/636 , G01N2021/1719 , G01N2021/1725 , G01N2021/1789 , G01N2021/1791 , G01N2201/0697 , G01Q60/12 , H01J37/244 , H01J37/26 , H01J2237/24507 , H01J2237/24564 , H01J2237/2818
摘要： A pump probe measuring device (1) comprises: an ultrashort optical pulse laser generator (2) for generating a first ultrashort optical pulse train which is a pump light (3a), second and third ultrashort optical pulse trains (3b), (3c) which are probe lights; an optical shutter unit (6) to which the second and the third ultrashort pulse trains (3b), (3c) are introduced; and a detecting unit (20) including an irradiation optical system (8) for directing the pump light (3a), the first probe light (3b) and the second probe light (3c) to a sample (7), a sensor (11) for detecting a probe signal from the sample (7), and a phase-sensitive detecting means (12) connected to the sensor (11). An optical shutter control unit (10) periodically modulates the delay time of the first probe light (3b) and that of the second probe light (3c) with respect to the pump light (3a), and the modulated first and second probe lights (3a), (3b) illuminate the sample (7) alternately to detect the probe signals from the sample (7) by the phase-sensitive detecting means (12) in synchronization with the periodic modulation signal of the delay time.
摘要翻译：泵探头测量装置（1）包括：超短光脉冲激光发生器（2），用于产生作为泵浦光（3a）的第一超短脉冲串，第二和第三超短脉冲序列（3b），（3c）探针灯; 引入第二和第三超短脉冲串（3b），（3c）的光学快门单元（6）; 以及检测单元（20），包括用于将泵浦光（3a），第一探测光（3b）和第二探测光（3c）引导到样品（7）的照射光学系统（8），传感器（11）），用于检测来自所述样品（7）的探针信号;以及相敏检测装置（12），连接到所述传感器（11）。光学快门控制单元（10）相对于泵浦光（3a）周期性地调制第一探测光（3b）和第二探测光（3c）的延迟时间，以及调制的第一和第二探测光（ 3a），（3b）交替地照射样品（7），以与延迟时间的周期性调制信号同步地由相敏检测装置（12）检测来自采样（7）的探测信号。

66. 发明申请

US20150074859A1 Low Drift Scanning Probe Microscope 有权
标题翻译：低漂移扫描探针显微镜
公开(公告)号：US20150074859A1
公开(公告)日：2015-03-12
申请号：US14520021
申请日：2014-10-21
申请人： Bruker Nano, Inc.
发明人： Anthonius G. Ruiter , Henry Mittel
IPC分类号： G01Q30/10
CPC分类号： G01Q30/10 , B82Y35/00 , G01Q70/04
摘要： A scanning probe microscope, such as an atomic force microscope, and method including z-stage and a bridge structure. A scanner containing a probe is mounted to the z-stage, which is movable in the z-axis to raise and lower the probe. The method reduces thermal drift of the z-stage and the bridge using a combination of heating elements thermally coupled to the z-stage and the bridge, ambient temperature sensors, and a controller to actively control the heating elements to maintain the bridge and the z-stage at an elevated temperature. Ideally, the temperatures in the system are selected so as to reduce drift between the probe and the sample during AFM scanning, wherein the drift is preferably maintained at less than about 1 nm for an ambient temperature change of about 1° C.
摘要翻译：扫描探针显微镜，例如原子力显微镜，以及包括z级和桥结构的方法。包含探头的扫描器安装在z阶段，z阶可在z轴上移动以升高和降低探针。该方法通过热耦合到z级和桥接器，环境温度传感器和控制器的加热元件的组合来减少z级和桥的热漂移，以主动地控制加热元件以维持桥和z 在高温下。理想地，选择系统中的温度，以便减少在AFM扫描期间探针和样品之间的漂移，其中漂移优选保持在小于约1nm，环境温度变化约为1℃。

67. 发明授权

US08968545B2 Apparatus and method for molecular separation, purification, and sensing 有权
标题翻译：用于分子分离，纯化和感测的装置和方法
公开(公告)号：US08968545B2
公开(公告)日：2015-03-03
申请号：US13437839
申请日：2012-04-02
申请人： Gordon Holt
发明人： Gordon Holt
IPC分类号： G01N27/447 , C12Q1/68 , B82Y35/00 , G01N33/68
CPC分类号： G01N33/68 , B82Y15/00 , B82Y30/00 , B82Y35/00 , C12Q1/68 , G01N27/44791 , G01N33/48721 , G01N33/54346 , G01N33/5438 , Y10S977/852
摘要： Described are devices and methods for forming one or more nanomembranes including electroactive nanomembranes within a nanowell or nanotube, or combinations thereof, in a support material. Nanopores/nanochannels can be formed by the electroactive nanomembrane within corresponding nanowells. The electroactive nanomembrane is capable of controllably altering a dimension, a composition, and/or a variety of properties in response to electrical stimuli. Various embodiments also include devices/systems and methods for using the nanomembrane-containing devices for molecular separation, purification, sensing, etc.
摘要翻译：描述了用于在支撑材料中形成一个或多个纳米膜的装置和方法，包括纳米线或纳米管内的电活性纳米膜或其组合。可以在相应的纳米孔内通过电活性纳米膜形成纳米孔/纳米通道。电活性纳米膜能够可控地改变响应于电刺激的尺寸，组成和/或各种性质。各种实施方案还包括用于使用含纳米膜的装置用于分子分离，纯化，感测等的装置/系统和方法

68. 发明授权

US08959661B2 Atomic force microscope probe, method for preparing same, and uses thereof 有权
标题翻译：原子力显微镜探针，其制备方法及其应用
公开(公告)号：US08959661B2
公开(公告)日：2015-02-17
申请号：US13997139
申请日：2011-12-20
申请人： Jérôme Polesel-Maris , Thomas Berthelot , Pascal Viel
发明人： Jérôme Polesel-Maris , Thomas Berthelot , Pascal Viel
IPC分类号： G01Q60/24 , G01Q60/38 , G01Q10/04 , G01Q20/04 , G01Q60/42 , B82Y35/00
CPC分类号： G01Q60/38 , B82Y35/00 , G01Q10/045 , G01Q20/04 , G01Q60/42
摘要： An atomic force microscope probe comprising a piezo-electric resonator provided with two electrodes and coated with an insulating layer and a tip attached on the coated resonator and functionalized with at least one group or molecule of interest is disclosed. The disclosed technology also relates to preparation method and to different uses thereof.
摘要翻译：公开了一种原子力显微镜探针，其包括设置有两个电极并涂覆有绝缘层的压电谐振器和附着在涂覆的谐振器上的末端，并且用至少一个感兴趣的组或分子进行官能化。所公开的技术还涉及制备方法及其不同用途。

69. 发明授权

US08955161B2 Peakforce photothermal-based detection of IR nanoabsorption 有权
标题翻译：峰值光热探测IR纳米吸收
公开(公告)号：US08955161B2
公开(公告)日：2015-02-10
申请号：US14217099
申请日：2014-03-17
申请人： Bruker Nano, Inc.
发明人： Gregory O. Andreev
IPC分类号： G01Q60/24 , G01Q60/04 , G01N13/16 , G01N21/35 , G01Q30/20
CPC分类号： G01N21/171 , B82Y35/00 , G01N21/3563 , G01N2201/06113 , G01N2201/10 , G01N2201/12 , G01Q30/02 , G01Q30/20 , G01Q60/32
摘要： An apparatus and method of performing photothermal chemical nanoidentification of a sample includes positioning a tip of a probe at a region of interest of the sample, with the tip-sample separation being less than about 10 nm. Then, IR electromagnetic energy having a selected frequency, ω, is directed towards the tip. Using PFT mode AFM operation, absorption of the energy at the region of interest is identified. Calorimetry may also be performed with the photothermal PFT system.
摘要翻译：进行样品的光热化学纳米识别的装置和方法包括将探针的尖端定位在样品的感兴趣区域，尖端样品分离小于约10nm。然后，具有选定频率ω的IR电磁能量指向尖端。使用PFT模式AFM操作，识别感兴趣区域的能量的吸收。光热法还可以用光热PFT系统进行。

70. 发明授权

US08945912B2 DNA sequencing and amplification systems using nanoscale field effect sensor arrays 有权
标题翻译：使用纳米尺度场效应传感器阵列的DNA测序和扩增系统
公开(公告)号：US08945912B2
公开(公告)日：2015-02-03
申请号：US13120710
申请日：2009-09-29
申请人： Rashid Bashir , Ashraf Alam , Demir Akin , Oguz Hasan Elibol , Bobby Reddy , Donald E. Bergstrom , Yi-Shao Liu
发明人： Rashid Bashir , Ashraf Alam , Demir Akin , Oguz Hasan Elibol , Bobby Reddy , Donald E. Bergstrom , Yi-Shao Liu
IPC分类号： C12M1/36 , C12P19/34 , G01N27/414 , C40B20/00 , B82Y15/00 , B82Y35/00
CPC分类号： G01N27/414 , B82Y15/00 , B82Y35/00 , G01N27/4145 , G01N27/4148
摘要： In one aspect, described herein are field effect chemical sensor devices useful for chemical and/or biochemical sensing. Also provided herein are methods for single molecule detection. In another aspect, described herein are methods useful for amplification of target molecules by PCR.
摘要翻译：在一个方面，本文描述了可用于化学和/或生物化学感测的场效应化学传感器装置。本文还提供了用于单分子检测的方法。在另一方面，本文所述是通过PCR扩增靶分子的方法。

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