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1. 发明授权

US11506683B2 Atomic-force microscopy for identification of surfaces 有权
公开(公告)号：US11506683B2
公开(公告)日：2022-11-22
申请号：US17291430
申请日：2019-11-07
申请人： Trustees of Tufts College
发明人： Igor Sokolov , Milos Miljkovic
IPC分类号： G01Q60/34 , G06V20/69 , G01N33/49 , G01N33/574 , G01Q60/42 , G01N33/493
摘要： A method comprises using an atomic-force microscope, acquiring a set of images associated with surfaces, and, using a machine-learning algorithm applied to the images, classifying the surfaces. As a particular example, the classification can be done in a way that relies on surface parameters derived from the images rather than using the images directly.

2. 发明申请

US20220244289A1 AUTOMATED OPTIMIZATION OF AFM LIGHT SOURCE POSITIONING 有权
公开(公告)号：US20220244289A1
公开(公告)日：2022-08-04
申请号：US17591402
申请日：2022-02-02
申请人： Oxford Instruments Asylum Research, Inc.
发明人： Jason Bemis , David Aue , Aleksander Labuda
IPC分类号： G01Q20/02 , G01Q30/02 , G01Q60/42 , G01Q10/06 , G01Q30/04
摘要： An atomic force microscope is provided having a controller configured to store one or more positional parameters output by a sensor assembly when a light spot is located at a first preset position on the surface of the cantilever. The controller is further configured to operate an actuator assembly so as to induce movement of the spot away from the first preset position, to detect said movement of the first spot based on a change in the one or more positional parameters output by the sensor assembly, and to operate an optical assembly in response to the detected movement of the first spot to return the first spot to the first preset position.

3. 发明申请

US20220026463A1 TREATMENT OF LIVING ORGANISMS BASED ON GRAVITATIONAL RESONANCES AND KUKHAREV REGION DATA 有权
公开(公告)号：US20220026463A1
公开(公告)日：2022-01-27
申请号：US17146832
申请日：2021-01-12
申请人： Vadim KUKHAREV
发明人： Vadim KUKHAREV
IPC分类号： G01Q30/14 , G01Q60/42 , A61K41/00
摘要： All fluids, when placed within a Kukharev region at a moment of gravitational resonance, form vibrations of different frequencies within themselves. If, at the same moments of gravitational resonance, forced oscillations of the same frequency are provided as a treatment on a living organism, a double resonance is formed within the fluid, and a sharp increase in the amplitude of oscillations within the fluid formed as a result of the double resonance in turn causes the destruction of the fluid. The method is determined utilizing Kukharev region data on the particular fluid desired to be destroyed or otherwise removed from the living organism. By further fine-tuning the forced oscillation (i.e., the directed radiation), the natural oscillations of the base fluid can be further adjusted to modify the fluid's properties.

4. 发明申请

US20210080413A1 Thermal Analysis for Source Rocks 有权
公开(公告)号：US20210080413A1
公开(公告)日：2021-03-18
申请号：US16569468
申请日：2019-09-12
申请人： Saudi Arabian Oil Company
发明人： Shannon L. Eichmann , Katherine Leigh Hull , Younane N. Abousleiman , David Jacobi
IPC分类号： G01N25/18 , G01Q60/42 , G01Q60/58
摘要： A system and method for evaluating a geological formation including subjecting a source-rock sample from the geological formation to atomic force microscopy (AFM) to determine a thermal property or material property of the source-rock sample. The properties determined may include thermal conductivity or material transition temperature.

5. 发明授权

US10330581B2 Debris removal from high aspect structures 有权
公开(公告)号：US10330581B2
公开(公告)日：2019-06-25
申请号：US15160302
申请日：2016-05-20
申请人： RAVE LLC
发明人： Tod Evan Robinson , Bernabe J. Arruza , Kenneth Gilbert Roessler , David Brinkley , Jeffrey E. Leclaire
IPC分类号： B08B6/00 , B08B7/00 , B08B9/087 , G01N15/14 , G01N15/10 , B08B1/00 , G03F7/20 , G03F1/82 , G03F1/84 , G03F7/00 , G01Q80/00 , G01Q20/02 , G01Q60/42 , G01Q70/12
摘要： A debris collection and metrology system for collecting and analyzing debris from a tip used in nanomachining processes, the system including an irradiation source, an irradiation detector, an actuator, and a controller. The irradiation source is operable to direct incident irradiation onto the tip, and the irradiation detector is operable to receive a sample irradiation from the tip, the sample irradiation being generated as a result of the direct incident irradiation being applied onto the tip. The controller is operatively coupled to an actuator system and the irradiation detector, and the controller is operable to receive a first signal based on a first response of the irradiation detector to the sample irradiation, and the controller is operable to effect relative motion between the tip and at least one of the irradiation source and the irradiation detector based on the first signal.

6. 发明授权

US10073057B2 Micro magnetic trap and process for evaluating forces with pico Newton resolution 有权
公开(公告)号：US10073057B2
公开(公告)日：2018-09-11
申请号：US15182457
申请日：2016-06-14
申请人： Universidad de Santiago de Chile
发明人： Francisco Esteban Melo Hurtado , Romina Waleska Muñoz Buzeta , Felipe Andrés Aguilar Sandoval
IPC分类号： G01Q60/54 , G01N27/72 , G01Q60/42
CPC分类号： G01N27/72 , G01Q60/42 , G01Q60/54
摘要： Micro magnetic trap comprising a holder and a sample cell on said holder (5); means for providing a controllable homogeneous magnetic field (3) surrounding the sample cell; a modified micro-cantilever comprising a cantilever (1) having dimensions in the micron range and at least three paramagnetic microbeads with a diameter from 1 to 3 microns (2) attached to a bendable tip of the micro-cantilever such that they form a triangular arrangement; means for measuring the deflection of the micro-cantilever when the latter is in use (4). The trap does not require a specific surface functionalization in order to ensure an appropriate and selective linkage to a particular molecule.

7. 发明授权

US09880088B2 Force-clamp spectrometer with functionalized cantilever tip 有权
公开(公告)号：US09880088B2
公开(公告)日：2018-01-30
申请号：US13741208
申请日：2013-01-14
申请人： THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK
发明人： Julio M. Fernandez , Raul Perez-Jimenez , Pallav Kosuri
IPC分类号： G01N29/22 , G01N21/01 , G01N29/02 , B82Y35/00 , G01N19/04 , G01Q60/42
CPC分类号： G01N21/01 , B82Y35/00 , G01N19/04 , G01N29/022 , G01Q60/42
摘要： The disclosed subject matter relates to a force-clamp spectrometer that enables operation in constant force mode and allows for automated data acquisition and analysis, using feedback electronics and software. The disclosed subject matter also relates to methods of using the force-clamp spectrometer for the measurement of the dynamics of chemical reactions. The methods may include, but are not limited to, the measurement of the dynamics of substrate folding and unfolding, as well as bond cleavage and bond formation.

8. 发明授权

US09018018B2 Method and apparatus for determining the cell activation of a target cell by an activator 有权
标题翻译：用于通过活化剂确定靶细胞的细胞活化的方法和装置
公开(公告)号：US09018018B2
公开(公告)日：2015-04-28
申请号：US12486674
申请日：2009-06-17
申请人： Matthias Amrein , Yan Shi
发明人： Matthias Amrein , Yan Shi
IPC分类号： G01N33/00 , G01Q60/42 , B82Y35/00 , G01N33/50 , G01Q20/00
CPC分类号： G01Q60/42 , B82Y35/00 , G01N33/5008 , G01Q20/00
摘要： The invention relates to a method and a device for determining the cell activation of a target cell by an activator, said method having the following steps: provision of a probe measuring device with a probe sample arrangement having a measuring probe and a sample holder; loading of the probe sample arrangement with a target cell and with an activator assigned to the target cell, the measuring probe being loaded with the activator, and the sample holder being loaded with the target cell, or vice versa; relative mutual displacement of the measuring probe and the sample holder until contact is made between the target cell and the activator by means of a displacement apparatus of the probe measuring device; recording of measurement values, indicating binding between the target cell and the activator, for the measuring probe with the probe measuring device during the relative displacement of the measuring probe and the sample holder; and determination of a dimension for the cell activation of the target cell from the measurement values recorded.
摘要翻译：本发明涉及一种用于通过活化剂确定靶细胞的细胞活化的方法和装置，所述方法具有以下步骤：提供具有测量探针和样品架的探针样品装置的探针测量装置; 将探针样品装置与目标细胞装载并分配给目标细胞的激活剂，测量探针装载有活化剂，并且样品保持器装载目标细胞，反之亦然; 通过探头测量装置的位移装置接触测量探针和样品架之间的相对相互位移，直到目标单元与激活器接触; 在测量探头和样品架的相对位移期间，使用探针测量装置记录测量值，指示目标单元和激活器之间的结合; 以及从记录的测量值确定靶细胞的细胞活化的维度。

9. 发明授权

US08975215B2 Methods for producing surface bound oligonucleotide on solid substrate and uses thereof 有权
标题翻译：在固体底物上制备表面结合寡核苷酸的方法及其用途
公开(公告)号：US08975215B2
公开(公告)日：2015-03-10
申请号：US12619233
申请日：2009-11-16
申请人： Joon Won Park , Bong Jin Hong , Duk Hoe Kim
发明人： Joon Won Park , Bong Jin Hong , Duk Hoe Kim
IPC分类号： C40B50/14 , B82Y15/00 , B82Y35/00 , C12Q1/68 , G01Q60/42
CPC分类号： B82Y15/00 , B82Y35/00 , C12Q1/6834 , G01Q60/42 , Y10T436/143333 , C12Q2565/601
摘要： The present invention relates to methods for producing an oligonucleotide on a solid substrate surface and methods for using the same. Some aspects of the invention provide methods for selecting a single DNA molecule reproducibily with an atomic force microscope (AFM).
摘要翻译：本发明涉及在固体基质表面上制备寡核苷酸的方法及其使用方法。本发明的一些方面提供了用原子力显微镜（AFM）重复选择单个DNA分子的方法。

10. 发明授权

US5388323A Method of forming a probe for an atomic force microscope 失效
标题翻译：形成原子力显微镜探针的方法
公开(公告)号：US5388323A
公开(公告)日：1995-02-14
申请号：US263117
申请日：1994-06-21
申请人： Theresa J. Hopson , Ronald N. Legge , Juan P. Carrejo
发明人： Theresa J. Hopson , Ronald N. Legge , Juan P. Carrejo
IPC分类号： G01Q60/40 , G01N25/72 , G01Q30/08 , G01Q60/02 , G01Q60/38 , G01Q60/42 , G01Q60/58 , G01Q70/06 , G01R3/00 , G01K1/14
CPC分类号： G01Q60/38 , B82Y35/00 , G01N25/72 , G01Q60/02 , G01Q60/58 , Y10S977/867 , Y10T29/49007
摘要： A probe (10,30,40) for forming images of surfaces (11) facilitates simultaneous formation of both thermal and atomic force microsocopy images. The probe (10,30,40) includes a heat sensing assembly (15) that has a heat sensing element (19,38,42). An electrically isolating and thermally conductive tip (22,48) projects from the heat sensing assembly. The probe (10) also has a reflective element (24) that is positioned between a first end of the heat sensing assembly (15) and the electrically isolating and thermally conductive tip (22).
摘要翻译：用于形成表面（11）的图像的探针（10,30,40）有助于同时形成热和原子力微透镜图像。探针（10,30,40）包括具有热传感元件（19,38,42）的热敏组件（15）。电绝缘和导热尖端（22,48）从热敏组件突出。探针（10）还具有位于热敏组件（15）的第一端和电绝缘和导热尖端（22）之间的反射元件（24）。

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