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61. 发明申请

US20080163945A1 Devices and Methods for Flow Control in Microfluidic Structures 有权
标题翻译：微流体结构中流量控制的装置和方法
公开(公告)号：US20080163945A1
公开(公告)日：2008-07-10
申请号：US11960035
申请日：2007-12-19
申请人： James C. Nurse , John R. Van Camp
发明人： James C. Nurse , John R. Van Camp
IPC分类号： F15C1/04 , B81B1/00
CPC分类号： F16K99/0065 , B01L3/502738 , B01L3/502746 , B01L7/52 , B01L2200/0647 , B01L2200/141 , B01L2300/0654 , B01L2300/088 , B01L2400/0672 , B01L2400/086 , F15C3/002 , Y10T137/0318 , Y10T137/1624 , Y10T137/2218 , Y10T137/2224 , Y10T137/309 , Y10T137/4643 , Y10T137/7293 , Y10T137/7736 , Y10T137/7781
摘要： An apparatus for controlling flow in a fluid flow path can include a chamber containing an expandable material, the expandable material being configured to expand out of the chamber into a portion of the fluid flow path so as to at least partially block the fluid flow path. The apparatus also can include at least one structure providing flow communication between the chamber and the fluid flow path. The at least one structure can be configured to pass the expandable material from the chamber to the portion of the fluid flow path during expansion so as to control a rate at which the expandable material expands into the portion of the fluid flow path.
摘要翻译：用于控制流体流动路径中的流动的装置可以包括容纳可膨胀材料的腔室，所述可膨胀材料构造成从所述腔室中扩张到所述流体流动路径的一部分中，以便至少部分地阻挡所述流体流动路径。该装置还可以包括提供腔室和流体流动路径之间的流动连通的至少一个结构。所述至少一个结构可以被配置成在膨胀期间将可膨胀材料从腔室传递到流体流动路径的一部分，以便控制可膨胀材料膨胀到流体流动路径部分中的速率。

62. 发明申请

US20070280858A1 Microchannel device 审中-公开
标题翻译：微通道设备
公开(公告)号：US20070280858A1
公开(公告)日：2007-12-06
申请号：US11594058
申请日：2006-11-08
申请人： Daisuke Nakayama , Ryojiro Akashi
发明人： Daisuke Nakayama , Ryojiro Akashi
IPC分类号： B01L3/02
CPC分类号： F16K99/0036 , B01L3/502738 , B01L2300/1861 , B01L2400/0672 , B01L2400/0677 , F16K99/0001 , F16K99/004 , F16K99/0051 , F16K99/0065 , F16K2099/0074 , F16K2099/0076 , F16K2099/0084
摘要： A microchannel device includes: a microchannel that comprises a stimuli-sensitive gel and is adjusted by giving a stimulation species to the stimuli-sensitive gel.
摘要翻译：微通道装置包括：微通道，其包含刺激敏感性凝胶，并通过向刺激敏感性凝胶提供刺激物质来调节。

63. 发明申请

US20060001010A1 Volume phase transition to induce gel movement 有权
公开(公告)号：US20060001010A1
公开(公告)日：2006-01-05
申请号：US11166164
申请日：2005-06-27
申请人： Lilit Yeghiazarian , Ulrich Wiesner , Carlo Montemagno
发明人： Lilit Yeghiazarian , Ulrich Wiesner , Carlo Montemagno
IPC分类号： H01B1/12
CPC分类号： F04B19/24 , B01L3/50273 , B01L2400/0475 , B01L2400/0478 , B01L2400/0672 , F04B19/006
摘要： Movement of a gel structure is propagated by successively applying external stimuli to cause volume phase transition in the gel structure by alternately causing the gel structure to collapse and swell to move the center of mass of the gel structure in the direction of successive stimuli application. The movement is mediated by confining structure for the gel and anchoring the starting side of the gel in the swelling cycle.

64. 发明授权

US06821485B2 Method and structure for microfluidic flow guiding 有权
标题翻译：微流体导流的方法和结构
公开(公告)号：US06821485B2
公开(公告)日：2004-11-23
申请号：US10071846
申请日：2002-02-08
申请人： David J. Beebe , Jeffrey S. Moore , Bin Zhao
发明人： David J. Beebe , Jeffrey S. Moore , Bin Zhao
IPC分类号： B01L302
CPC分类号： B82Y30/00 , B01L3/5027 , B01L3/502707 , B01L2300/089 , B01L2400/0672 , Y10T436/11 , Y10T436/117497 , Y10T436/118339 , Y10T436/2575
摘要： A flow of liquids is carried out on a microscale utilizing surface effects to guide the liquid on flow paths to maintain laminar flow. No sidewall confining structure is required, minimizing resistance to flow and allowing laminar flow to be maintained at high flow rates. The guiding structure has flow guiding stripes formed on one or both of facing base and cover surfaces which are wettable by a selected liquid to direct the liquid from a source location to a destination location. The regions adjacent to the guiding stripes on the base and cover surfaces are non-wettable. The smooth interface between the gas and liquid along the flowing stream allows gas-liquid reactions to take place as a function of diffusion across the interface without mixing of the gas and liquid. Liquid-liquid flows may also be guided with such structures.
摘要翻译：使用表面效应在微尺度上进行液体流动以将液体引导到流动路径上以保持层流。不需要侧壁约束结构，使流动阻力最小化，并允许层流维持在高流速。引导结构具有形成在一个或两个相对的基底和盖表面上的流动引导条纹，其可被选定的液体润湿以将液体从源位置引导到目的地位置。在基部和盖表面上与引导条相邻的区域是不可润湿的。沿着流动流动的气体和液体之间的平滑界面允许气 - 液反应作为扩散跨越界面而发生，而不会混合气体和液体。液 - 液流也可以用这种结构引导。

65. 发明授权

US5968746A Method and apparatus for preserving human saliva for testing 失效
标题翻译：用于保存人类唾液进行测试的方法和装置
公开(公告)号：US5968746A
公开(公告)日：1999-10-19
申请号：US978729
申请日：1997-11-26
申请人： David R. Schneider
发明人： David R. Schneider
IPC分类号： G01N33/50 , A61B10/00 , B01L3/00 , C12Q1/24 , C12Q1/32 , C12Q1/68 , C12M1/34 , H01M10/34
CPC分类号： B01L3/502 , A61B10/0051 , C12Q1/32 , B01L2200/16 , B01L2400/0633 , B01L2400/0672 , B01L2400/0683
摘要： A method and apparatus for the preservation of a saliva sample for use in subsequent quantitative chemical assays. The method involves collecting a saliva sample at a location, directly into a specimen cup. The specimen cup contains a predetermined volume of aqueous solution of pH buffered saline and enzymatic inhibitor and is optionally adapted with a constituent compound specific, qualitative test unit.
摘要翻译：用于保存唾液样品以用于随后的定量化学测定的方法和装置。该方法包括将唾液样品直接收集在样品杯中。样品杯含有预定体积的pH缓冲盐水和酶抑制剂的水溶液，并且任选地与组成化合物特异性的定性测试单元相配。

66. 发明申请

US20180156356A1 CAPSULE, IN-LINE MAGNETIC VALVE SYSTEM AND METHOD 审中-公开
公开(公告)号：US20180156356A1
公开(公告)日：2018-06-07
申请号：US15829565
申请日：2017-12-01
申请人： Ahmed Alfadhel , Meng-Chun Hsu , David A. Borkholder
发明人： Ahmed Alfadhel , Meng-Chun Hsu , David A. Borkholder
IPC分类号： F16K99/00 , H01F1/00 , C01G49/08
CPC分类号： F16K99/0053 , B01L3/5023 , B01L3/5027 , B01L3/502738 , B01L2200/026 , B01L2200/147 , B01L2400/043 , B01L2400/0672 , B01L2400/0677 , C01G49/08 , F16K99/0019 , F16K99/0021 , H01F1/0018 , H01F1/44
摘要： A capsule is disclosed which includes a flexible outer shell capable of transforming into an asymmetric shape; an internal medium encapsulated by the outer shell, the medium including a plurality of magnetic particles, wherein the magnetic particles can move in response to an applied magnetic field. A valve system includes an in-line valve sized to fit within a flow channel including a capsule having a flexible outer shell containing an internal medium encapsulated by the outer shell, the medium including a plurality of magnetic particles; and a magnetic field source disposed about the exterior wall of the channel.

67. 发明授权

US09874294B2 Valve with material having modifiable degree of penetrability 有权
公开(公告)号：US09874294B2
公开(公告)日：2018-01-23
申请号：US13375789
申请日：2010-06-02
申请人： Remco Christiaan Den Dulk , Roel Penterman , Menno Willem Jose Prins
发明人： Remco Christiaan Den Dulk , Roel Penterman , Menno Willem Jose Prins
IPC分类号： F16K99/00 , B01L3/00
CPC分类号： F16K99/0001 , B01L3/50273 , B01L3/502738 , B01L2200/0647 , B01L2200/10 , B01L2200/12 , B01L2300/0816 , B01L2300/161 , B01L2400/0672 , B01L2400/0677 , F16K99/0044 , F16K99/0046 , Y10T29/49405
摘要： The invention relates to a valve (2) for controlling a passage of particles from a first region (6) to a second region (7), wherein the valve (2) comprises a valve material (4) having a modifiable degree of penetrability and a valve region (16) comprising the valve material (4), wherein the valve region (16) and the valve material (4) are adapted such that the particles have to penetrate the valve material (4) if the particles pass the valve (2) for being transferred from the first region (6) to the second region (7). The degree of opening of the valve (2) can easily be controlled by modifying the degree of penetrability of the valve material (4), for example, by modifying the temperature of the valve material (4). Moreover, by penetrating the valve material (4) the particles can be separated from other elements like a fluid containing the particles.

68. 发明授权

US09841396B2 Assay devices with integrated sample dilution and dilution verification and methods of using same 有权
公开(公告)号：US09841396B2
公开(公告)日：2017-12-12
申请号：US14702594
申请日：2015-05-01
申请人： Abbott Point of Care Inc.
发明人： Cary James Miller , Graham Davis , Michael Zelin
IPC分类号： G01N27/327 , G01N27/49 , B01L3/00
CPC分类号： G01N33/54373 , B01F11/0071 , B01L3/502 , B01L3/5027 , B01L3/50273 , B01L2200/10 , B01L2200/16 , B01L2300/045 , B01L2300/0645 , B01L2300/0672 , B01L2300/0681 , B01L2300/0816 , B01L2300/0867 , B01L2300/126 , B01L2400/0481 , B01L2400/0672 , G01N21/25 , G01N21/78 , G01N27/02 , G01N27/26 , G01N27/3272 , G01N27/3274 , G01N27/413 , G01N27/49 , G01N33/54366 , G01N33/76
摘要： The invention is to devices and method for rapid determination of analytes in liquid samples by various assays including immunoassays incorporating a sample dilution feature for forming a diluted sample for analysis. The devices and methods also include a dilution verification feature for verifying the degree of dilution of the diluted sample. The devices preferably are capable of being used in the point-of-care diagnostic field is provided.

69. 发明授权

US09802191B2 Disposable, fluid actuated, mechanically driven point-of-care invitro-diagnostic apparatus and method of performing a point-of-care invitro-diagnostic test 有权
公开(公告)号：US09802191B2
公开(公告)日：2017-10-31
申请号：US14745034
申请日：2015-06-19
申请人： David W. Wright
发明人： David W. Wright
IPC分类号： B01L3/00
CPC分类号： B01L3/50273 , B01L2200/16 , B01L2300/0816 , B01L2300/0867 , B01L2300/123 , B01L2400/0481 , B01L2400/0672 , B01L2400/0683
摘要： A portable, disposable in-vitro diagnostic apparatus and method of performing a point-of-care invitro-diagnostic test is provided. The apparatus has a body with at least one chamber containing an actuator member. The chamber is in fluid communication with an upstream first fluid channel and a downstream second fluid channel. The actuator member has a compressed, deactivated state and an expanded, activated state. The actuator member transitions from the compressed, deactivated state to the expanded, activated state upon contact with fluid flowing through the first fluid channel. The actuator member pumps fluid outwardly from the first chamber through the second fluid channel during the transition from its compressed, deactivated state to its expanded, activated state. The pumped fluid can be channeled to other chambers within the body and/or to an analysis chamber within the body for study.

70. 发明授权

US09346046B2 Sintered porous plastic plug for serological pipette 有权
标题翻译：用于血清移液管的烧结多孔塑料塞
公开(公告)号：US09346046B2
公开(公告)日：2016-05-24
申请号：US14379132
申请日：2013-03-05
申请人： Porex Corporation
发明人： Edward Jino Kim , Christopher Lynch , Shivananada Patrick , Guoqiang Mao
IPC分类号： B01L3/02 , B23P19/04
CPC分类号： B01L3/0275 , B01L2200/025 , B01L2200/0684 , B01L2200/0689 , B01L2200/141 , B01L2300/0681 , B01L2300/069 , B01L2300/0832 , B01L2400/0672 , B23P19/04 , Y10T29/49945
摘要： The present invention provides sintered porous plastic plugs for use in filtered serological pipettes which facilitate manufacture or assembly of the filtered serological pipettes. In one embodiment, a sintered porous plastic plug of the present invention comprises plastic and a cylindrical body, a first end and a second end, the first end having a cross-sectional area less than the cross-sectional area of the cylindrical body, and the second end having a cross-sectional area less than the cross-sectional area of the cylindrical body.
摘要翻译：本发明提供用于过滤血清移液管的烧结多孔塑料塞，其有助于过滤血清移液管的制造或装配。在一个实施例中，本发明的烧结多孔塑料塞包括塑料和圆筒体，第一端和第二端，第一端的横截面面积小于圆柱体的横截面面积;以及所述第二端的横截面面积小于所述圆柱体的横截面面积。

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