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61. 发明申请

US20150374991A1 TECHNIQUES FOR PLACING MEDICAL LEADS FOR ELECTRICAL STIMULATION OF NERVE TISSUE 审中-公开
公开(公告)号：US20150374991A1
公开(公告)日：2015-12-31
申请号：US14845765
申请日：2015-09-04
申请人： Medtronic, Inc.
发明人： Mary M. Morris , Avram Scheiner , Ruth N. Klepfer , John E. Burnes
IPC分类号： A61N1/36 , A61N1/05
CPC分类号： A61N1/36053 , A61M25/09 , A61N1/05 , A61N1/0551 , A61N1/0558 , A61N1/057 , A61N1/36085 , A61N1/36114 , A61N1/36125 , A61N1/36128
摘要： This disclosure is directed to extra, intra, and transvascular medical lead placement techniques for arranging medical leads and electrical stimulation and/or sensing electrodes proximate nerve tissue within a patient.

62. 发明申请

US20150374296A1 NERVE CUFF STIMULATION ELECTRODE, CONTROL DEVICE FOR A VAGUS NERVE STIMULATION SYSTEM, AND VAGUS NERVE STIMULATION SYSTEM 有权
标题翻译：神经刺激电极，VAGUS神经刺激系统的控制装置和VAGUS神经刺激系统
公开(公告)号：US20150374296A1
公开(公告)日：2015-12-31
申请号：US14745776
申请日：2015-06-22
申请人： BIOTRONIK SE & Co. KG
发明人： Marcelo BARU , Andrew B. KIBLER , Warren DABNEY , Jie LIAN , Christopher MOULDER , Dirk MUESSIG
IPC分类号： A61B5/00 , A61B5/0452 , A61B5/11 , A61B5/042
CPC分类号： A61B5/6877 , A61B5/002 , A61B5/0205 , A61B5/02125 , A61B5/0215 , A61B5/1116 , A61N1/0556 , A61N1/28 , A61N1/36053
摘要： A nerve cuff stimulation electrode for cervical VNS is provided and configured to be arranged so as to at least partially surround or enclose one of the vagus nerves. The cuff stimulation electrode has at least two contacts configured to deliver electric stimulation pulses to a vagus nerve. The cuff stimulation electrode further has or may be attached or connected to a tilt sensor, a kinematic sensor, and/or a pulsation sensor configured to generate a signal representative of arterial and venous pressures. The implantable tilt sensor is configured to output a posture signal indicating a patient's posture, thus allowing discrimination between supine and semi-recumbent or erect postures.
摘要翻译：提供并配置用于颈部VNS的神经套箍刺激电极，以至少部分地围绕或包围迷走神经中的一个。袖带刺激电极具有构造成将电刺激脉冲输送到迷走神经的至少两个触点。袖带刺激电极还具有或可以附接或连接到倾斜传感器，运动学传感器和/或脉动传感器，该传感器构造成产生代表动脉和静脉压的信号。可植入倾斜传感器被配置为输出指示患者姿势的姿势信号，从而允许仰卧位和半卧位或直立姿势之间的区别。

63. 发明申请

US20150352352A1 FLEX SAFE SUTURE SLEEVE 审中-公开
标题翻译： FLEX安全套管套
公开(公告)号：US20150352352A1
公开(公告)日：2015-12-10
申请号：US14708714
申请日：2015-05-11
申请人： Cardiac Pacemakers, Inc.
发明人： Brian Soltis , Andrew L. De Kock
IPC分类号： A61N1/05 , B29C45/00 , B29C47/00
CPC分类号： A61N1/0558 , A61N1/0551 , A61N1/36053 , B29C48/001 , B29K2071/00 , B29K2075/00 , B29K2083/00 , B29L2031/753
摘要： A suture sleeve for securing an implantable lead with a suture includes an elongate, tubular body having a proximal end portion with a proximal face, a distal end portion with a distal face, and an exterior surface. The suture sleeve also includes a lumen within the tubular body extending from the proximal end portion to the distal end portion, wherein the lumen is sized to receive the implantable lead. The suture sleeve also includes a nonlinear, inner transition region extending from the lumen to at least one of the proximal face and the distal face of the tubular body, wherein the inner transition region is a curvilinear surface or a chamfered edge having an obtuse angle between adjacent surfaces thereof and is adapted to control the radius of curvature of the implantable lead that bends along the inner transition region.
摘要翻译：用于用缝合线固定可植入引线的缝合套管包括细长的管状体，其具有近端部分，其具有近端面，具有远端面的远端部分和外表面。所述缝合套筒还包括从所述近端部分延伸到所述远端部分的所述管状体内的内腔，其中所述内腔的尺寸被设计成接收所述可植入引线。缝合套管还包括从管腔延伸到管状体的近端面和远端面中的至少一个的非线性内部过渡区域，其中内部过渡区域是曲线表面或倒角边缘，其具有在并且适于控制沿着内部过渡区域弯曲的可植入引线的曲率半径。

64. 发明申请

US20150343222A1 SYSTEMS, METHODS AND DEVICES FOR PAIRED PLASTICITY 审中-公开
标题翻译：用于配对塑料的系统，方法和装置
公开(公告)号：US20150343222A1
公开(公告)日：2015-12-03
申请号：US14809781
申请日：2015-07-27
申请人： MicroTransponder, Inc. , The Board of Regents, The University of Texas System
发明人： Michael P. KILGARD , Larry CAULLER , Navzer ENGINEER , Christa McIntyre Rodriguez , Will ROSELLINI
IPC分类号： A61N1/36 , G09B19/00 , A61N5/06
CPC分类号： A61N1/36167 , A61F11/00 , A61M21/00 , A61M21/02 , A61M2021/0016 , A61M2021/0022 , A61M2021/0027 , A61M2021/0044 , A61M2021/0072 , A61M2021/0077 , A61M2205/3515 , A61M2230/06 , A61M2230/08 , A61M2230/10 , A61M2230/205 , A61M2230/30 , A61M2230/432 , A61M2230/50 , A61M2230/60 , A61M2230/65 , A61N1/36014 , A61N1/36053 , A61N1/36067 , A61N1/36082 , A61N1/36092 , A61N1/361 , A61N1/36103 , A61N1/36139 , A61N5/0618 , A61N5/0622 , G09B19/00 , G09B19/003 , G09B23/28 , H04R25/75
摘要： Systems, methods and devices for paired training include timing controls so that training and neural stimulation can be provided simultaneously. Paired trainings may include therapies, rehabilitation and performance enhancement training Stimulations of nerves such as the vagus nerve that affect subcortical regions such as the nucleus basalis, locus coeruleus or amygdala induce plasticity in the brain, enhancing the effects of a variety of therapies, such as those used to treat tinnitus, stroke, traumatic brain injury and post-traumatic stress disorder.
摘要翻译：用于配对训练的系统，方法和装置包括时间控制，以便可以同时提供训练和神经刺激。配对训练可能包括治疗，康复和性能增强训练神经的刺激，如影响皮质下区域的迷走神经，如基底细胞，基因座或杏仁核诱导脑中的可塑性，增强各种疗法的作用，如那些用于治疗耳鸣，中风，创伤性脑损伤和创伤后应激障碍。

65. 发明申请

US20150297889A1 DEVICES AND METHODS FOR NON-INVASIVE CAPACITIVE ELECTRICAL STIMULATION AND THEIR USE FOR VAGUS NERVE STIMULATION ON THE NECK OF A PATIENT 有权
标题翻译：非侵入性电刺激的装置和方法及其对患者NECK刺激的VAGUS神经刺激的使用
公开(公告)号：US20150297889A1
公开(公告)日：2015-10-22
申请号：US14753160
申请日：2015-06-29
申请人： Electrocore, LLC
发明人： Bruce J. Simon , Joseph P. Errico , John T. Raffle
IPC分类号： A61N1/36 , A61N1/04
CPC分类号： A61N1/36021 , A61M21/00 , A61M2021/0022 , A61M2021/0027 , A61M2021/0044 , A61M2021/0072 , A61N1/0456 , A61N1/0496 , A61N1/36014 , A61N1/36025 , A61N1/36053 , A61N1/40
摘要： A non-invasive electrical stimulator shapes an elongated electric field of effect that can be oriented parallel to a long nerve, such as a vagus nerve in a patient's neck, producing a desired physiological response in the patient. The stimulator comprises a source of electrical power, at least one electrode and a continuous electrically conducting medium in contact with the electrodes. The conducting medium is also in contact with an interface element that may conform to the contour of a target body surface of the patient when the interface element is applied to that surface. When the interface element is made of insulating (dielectric) material, and disclosed stimulation waveforms are used, the power source need not supply high voltage, in order to capacitively stimulate the target nerve. The stimulator produces a peak pulse that is sufficient to produce a physiologically effective electric field in the vicinity of a target nerve.
摘要翻译：非侵入式电刺激器形成可以平行于长神经（例如患者颈部的迷走神经）定向的细长电场，在患者体内产生所需的生理反应。刺激器包括电源，至少一个电极和与电极接触的连续导电介质。当将界面元件应用于该表面时，导电介质也与接口元件接触，该界面元件可以符合患者的目标体表的轮廓。当界面元件由绝缘（电介质）材料制成并且使用公开的刺激波形时，电源不需要提供高电压，以便电容地刺激目标神经。刺激器产生足以在目标神经附近产生生理有效电场的峰值脉冲。

66. 发明申请

US20150265836A1 ELECTRICAL AND MAGNETIC STIMULATORS USED TO TREAT MIGRAINE/SINUS HEADACHE, RHINITIS, SINUSITIS, RHINOSINUSITIS, AND COMORBID DISORDERS 审中-公开
标题翻译：电磁刺激仪用于治疗癫痫病/ SIN US HE E，，S，，S，ERS ERS ERS ERS ERS ERS ERS ERS ERS ERS ERS ERS ERS ERS ERS
公开(公告)号：US20150265836A1
公开(公告)日：2015-09-24
申请号：US14217762
申请日：2014-03-18
申请人： ElectroCore, LLC
发明人： Bruce J. Simon , Joseph P. Errico , John T. Raffle
IPC分类号： A61N1/36 , A61N2/02 , A61N2/00
CPC分类号： A61N1/0456 , A61N1/36014 , A61N1/36021 , A61N1/36025 , A61N1/36053 , A61N1/40 , A61N2/002 , A61N2/006 , A61N2/008 , A61N2/02
摘要： Transcutaneous electrical nerve stimulation devices and magnetic stimulation devices are disclosed, along with methods of treating medical disorders using energy that is delivered noninvasively by such devices. The disorders comprise migraine and other primary headaches such as cluster headaches, including nasal or paranasal sinus symptoms that resemble an immune-mediated response (“sinus” headaches). The devices and methods may also be used to treat rhinitis, sinusitis, or rhinosinusitis, irrespective of whether those disorders are co-morbid with a headache. They may also be used to treat other disorders that may be co-morbid with migraine or cluster headaches, such as anxiety disorders. In preferred embodiments of the disclosed methods, one or both of the patient's vagus nerves are stimulated non-invasively. In other embodiments, parts of the sympathetic nervous system and/or the adrenal glands are stimulated.
摘要翻译：公开了经皮电神经刺激装置和磁刺激装置，以及使用通过这种装置非侵入地输送的能量来治疗医学病症的方法。这些疾病包括偏头痛和其他原发性头痛，例如丛集性头痛，包括类似于免疫介导的反应（“窦”头痛）的鼻或鼻旁窦症状。装置和方法也可用于治疗鼻炎，鼻窦炎或鼻鼻窦炎，而不管这些疾病是否与头痛并发症。它们也可用于治疗可能与偏头痛或丛集性头痛如焦虑症共病的其他疾病。在所公开的方法的优选实施例中，患者的迷走神经中的一个或两个被非侵入性地刺激。在其它实施方案中，刺激部分交感神经系统和/或肾上腺。

67. 发明授权

US09126050B2 Non-invasive vagus nerve stimulation devices and methods to treat or avert atrial fibrillation 有权
标题翻译：非侵入性迷走神经刺激装置和治疗或避免房颤的方法
公开(公告)号：US09126050B2
公开(公告)日：2015-09-08
申请号：US13736096
申请日：2013-01-08
申请人： Bruce J. Simon , Joseph P. Errico , John T. Raffle
发明人： Bruce J. Simon , Joseph P. Errico , John T. Raffle
IPC分类号： A61N1/36 , A61N1/362
CPC分类号： A61N1/3625 , A61N1/36014 , A61N1/36053 , A61N1/36114 , A61N1/36171 , A61N1/36178 , A61N1/362
摘要： Energy is transmitted noninvasively to a patient using electrode-based stimulation devices or magnetic stimulation devices that are designed to non-invasively stimulate nerves selectively. The devices produce impulses that are used to treat atrial fibrillation, by stimulating a vagus nerve of a patient. The devices are also used to forecast the imminent onset of atrial fibrillation and then avert it by stimulating a vagus nerve.
摘要翻译：使用基于电极的刺激装置或设计成非侵入性地刺激神经的磁刺激装置将能量非侵入地传播给患者。该装置通过刺激患者的迷走神经产生用于治疗房颤的脉冲。这些装置也用于预测心房颤动即将发生，然后通过刺激迷走神经来避免。

68. 发明授权

US09126044B2 Autonomic modulation using transient response with intermittent neural stimulation 有权
标题翻译：使用间歇神经刺激的瞬态响应的自主调制
公开(公告)号：US09126044B2
公开(公告)日：2015-09-08
申请号：US13086806
申请日：2011-04-14
申请人： Andrew P. Kramer , Jason J. Hamann
发明人： Andrew P. Kramer , Jason J. Hamann
IPC分类号： A61N1/36 , A61N1/05
CPC分类号： A61N1/36139 , A61N1/0551 , A61N1/36053 , A61N1/36114 , A61N1/36117
摘要： In various method embodiments for operating an implantable neural stimulator to deliver a neural stimulation therapy to an autonomic neural target, the method comprises using the implantable neural stimulator to deliver the neural stimulation therapy to the autonomic neural target, and evaluating an evoked response to the neural stimulation bursts. The neural stimulation therapy includes a plurality of neural stimulation bursts where each neural stimulation burst includes a plurality of neural stimulation pulses and successive neural stimulation bursts are separated by a time without neural stimulation pulses. Evaluating the evoked response includes sensing the evoked response to the neural stimulation bursts where sensing the evoked response includes sensing at least one physiological parameter affected by the neural stimulation bursts, comparing the sensed evoked response against a baseline, and determining if the evoked response substantially returns to the baseline between neural stimulation bursts.
摘要翻译：在用于操作可植入神经刺激器以将神经刺激疗法递送至自主神经靶标的各种方法实施例中，该方法包括使用可植入神经刺激器将神经刺激疗法递送至自主神经靶标，以及评估对神经元的诱发反应刺激爆发。神经刺激治疗包括多个神经刺激脉冲串，其中每个神经刺激脉冲串包括多个神经刺激脉冲，并且连续神经刺激脉冲串在没有神经刺激脉冲的情况下被分离一段时间。评估诱发反应包括感测对神经刺激突发的诱发反应，其中感测诱发反应包括感测受神经刺激突发影响的至少一个生理参数，将感测的诱发反应与基线进行比较，以及确定诱发反应是否基本上返回到神经刺激爆发之间的基线。

69. 发明申请

US20150246242A1 SYSTEM AND METHOD FOR OPTOGENETIC THERAPY 审中-公开
标题翻译：用于OPTOGENETIC治疗的系统和方法
公开(公告)号：US20150246242A1
公开(公告)日：2015-09-03
申请号：US14445993
申请日：2014-07-29
申请人： Circuit Therapeutics, Inc.
发明人： Scott Delp , Karl Deisseroth , Dan Andersen
IPC分类号： A61N5/06 , A61K38/16
CPC分类号： A61N5/0601 , A61B17/00234 , A61B17/3403 , A61B2017/3413 , A61K38/16 , A61K38/164 , A61K38/168 , A61K38/177 , A61K41/00 , A61K41/0057 , A61K48/00 , A61K48/0075 , A61M5/142 , A61M5/20 , A61M25/0105 , A61M25/0147 , A61M37/0015 , A61M2037/0023 , A61M2037/0061 , A61M2205/3576 , A61M2205/50 , A61N1/0551 , A61N1/3605 , A61N1/36053 , A61N5/062 , A61N5/0622 , A61N2005/0612 , A61N2005/0626 , A61N2005/0627 , A61N2005/063 , A61N2005/0631 , A61N2005/0643 , A61N2005/0651 , A61N2005/0653 , A61N2005/0665 , A61N2005/067
摘要： Configurations are described for utilizing light-activated proteins within cell membranes and subcellular regions to assist with medical treatment paradigms, such as hypertension treatment via anatomically specific and temporally precise modulation of renal plexus activity. The invention provides for proteins, nucleic acids, vectors and methods for genetically targeted expression of light-sensitive proteins to specific cells or defined cell populations. In particular the invention provides systems, devices, and methods for millisecond-timescale temporal control of certain cell activities using moderate light intensities, such as the generation or inhibition of electrical spikes in nerve cells and other excitable cells.
摘要翻译：描述了在细胞膜和亚细胞区域内利用光激活蛋白质的配置来帮助医学治疗范例，例如通过解剖特异性和时间上精确调节肾丛活性的高血压治疗。本发明提供了蛋白质，核酸，载体和用于将光敏感蛋白基因表达的方法用于特定细胞或确定的细胞群体。特别地，本发明提供了使用中等光强度（诸如神经细胞和其它可兴奋细胞中的电尖峰的产生或抑制）对某些细胞活动进行毫秒级时间控制的系统，装置和方法。

70. 发明授权

US09108041B2 Microburst electrical stimulation of cranial nerves for the treatment of medical conditions 有权
标题翻译：微创电刺激颅神经治疗医疗状况
公开(公告)号：US09108041B2
公开(公告)日：2015-08-18
申请号：US14089185
申请日：2013-11-25
申请人： CATHOLIC HEALTHCARE WEST
发明人： Arthur D. Craig
IPC分类号： A61N1/06 , A61N1/05 , A61N1/36 , A61B5/0476
CPC分类号： A61N1/36139 , A61B5/0476 , A61B5/4094 , A61N1/0551 , A61N1/3605 , A61N1/36053 , A61N1/36064 , A61N1/36082 , A61N1/36114 , A61N1/36178
摘要： Disclosed herein are methods for treating a medical condition in a patient using an implantable medical device by applying an electrical signal characterized by having a number of pulses per microburst, an interpulse interval, a microburst duration, and an interburst period to a portion of a cranial nerve of said patient, wherein at least one of the number of pulses per microburst, the interpulse interval, the microburst duration, or the interburst period is selected to enhance cranial nerve evoked potentials.
摘要翻译：本文公开的方法是使用可植入医疗装置来治疗患者的医疗状况的方法，通过施加电信号，其特征在于每个微爆发具有多个脉冲，脉冲间隔，微爆发持续时间和突发间期，所述患者的神经，其中选择每微爆发的脉冲数，脉冲间隔，微爆发持续时间或突发间期中的至少一个以增强颅神经诱发电位。

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