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1. 发明申请

US20150374296A1 NERVE CUFF STIMULATION ELECTRODE, CONTROL DEVICE FOR A VAGUS NERVE STIMULATION SYSTEM, AND VAGUS NERVE STIMULATION SYSTEM 有权
标题翻译：神经刺激电极，VAGUS神经刺激系统的控制装置和VAGUS神经刺激系统
公开(公告)号：US20150374296A1
公开(公告)日：2015-12-31
申请号：US14745776
申请日：2015-06-22
申请人： BIOTRONIK SE & Co. KG
发明人： Marcelo BARU , Andrew B. KIBLER , Warren DABNEY , Jie LIAN , Christopher MOULDER , Dirk MUESSIG
IPC分类号： A61B5/00 , A61B5/0452 , A61B5/11 , A61B5/042
CPC分类号： A61B5/6877 , A61B5/002 , A61B5/0205 , A61B5/02125 , A61B5/0215 , A61B5/1116 , A61N1/0556 , A61N1/28 , A61N1/36053
摘要： A nerve cuff stimulation electrode for cervical VNS is provided and configured to be arranged so as to at least partially surround or enclose one of the vagus nerves. The cuff stimulation electrode has at least two contacts configured to deliver electric stimulation pulses to a vagus nerve. The cuff stimulation electrode further has or may be attached or connected to a tilt sensor, a kinematic sensor, and/or a pulsation sensor configured to generate a signal representative of arterial and venous pressures. The implantable tilt sensor is configured to output a posture signal indicating a patient's posture, thus allowing discrimination between supine and semi-recumbent or erect postures.
摘要翻译：提供并配置用于颈部VNS的神经套箍刺激电极，以至少部分地围绕或包围迷走神经中的一个。袖带刺激电极具有构造成将电刺激脉冲输送到迷走神经的至少两个触点。袖带刺激电极还具有或可以附接或连接到倾斜传感器，运动学传感器和/或脉动传感器，该传感器构造成产生代表动脉和静脉压的信号。可植入倾斜传感器被配置为输出指示患者姿势的姿势信号，从而允许仰卧位和半卧位或直立姿势之间的区别。

2. 发明申请

US20190175904A1 SPINAL CORD STIMULATION 审中-公开
公开(公告)号：US20190175904A1
公开(公告)日：2019-06-13
申请号：US16218802
申请日：2018-12-13
申请人： BIOTRONIK SE &. Co. KG
发明人： Marcelo BARU , Alan FRYER
IPC分类号： A61N1/05 , A61N1/36
摘要： An implantable pulse generator configured to deliver first and second stimulation pulse trains wherein the first and second trains are delivered simultaneously, are delivered at different frequencies, and are each biphasic, including a stimulation phase followed by a balancing phase.

3. 发明申请

US20160279430A1 IMPLANTABLE STIMULATION DEVICE, STIMULATION SYSTEM AND METHOD FOR DATA COMMUNICATION 审中-公开
标题翻译：可植入刺激装置，刺激系统和数据通信方法
公开(公告)号：US20160279430A1
公开(公告)日：2016-09-29
申请号：US15173404
申请日：2016-06-03
申请人： BIOTRONIK SE & CO. KG
发明人： Marcelo BARU , J. Christopher MOULDER
IPC分类号： A61N1/372 , A61N1/37
CPC分类号： A61N1/37276 , A61N1/3708 , A61N1/37217 , A61N1/3727 , A61N1/378
摘要： An implantable stimulation device including a stimulation module and a data communication module. The stimulation device includes electrodes to delivery stimulation pulses, a voltage source, a DC-blocking capacitor and autoshort switch. The voltage source is connected to the electrodes via stimulation-pulse-switch(s) that controls delivery pacing pulses. The DC-blocking capacitor is connected with the voltage source and an electrode. The autoshort switch allows discharging of the DC-blocking capacitor via the electrodes when closed. The data communication module includes a data transmission control module connected to the autoshort switch and/or the at least one stimulation-pulse-switch, to alternatingly open and close the autoshort switch or the at least one stimulation-pulse-switch respectively, during an autoshort period following the delivery of a stimulation pulse or during a stimulation pulse period, respectively, to modulate an autoshort pulse or a stimulation pulse peak amplitude, respectively.
摘要翻译：一种可植入刺激装置，包括刺激模块和数据通信模块。刺激装置包括用于输送刺激脉冲的电极，电压源，隔直流电容器和自动转换开关。电压源通过控制输送起搏脉冲的刺激脉冲开关连接到电极。隔直流电容器与电压源和电极连接。自动切换开关允许闭合时通过电极放电隔直流电容器。数据通信模块包括连接到自动转换开关和/或至少一个刺激脉冲开关的数据传输控制模块，以分别在自动关闭开关或至少一个刺激脉冲开关期间交替地打开和关闭自动关闭开关或至少一个刺激脉冲开关分别在刺激脉冲传递之后或刺激脉冲周期期间的自动转换期间分别调制自动转换脉冲或刺激脉冲峰值振幅。

4. 发明申请

US20210178161A1 QUASI-ADIABATIC ELECTRICAL STIMULATOR 有权
公开(公告)号：US20210178161A1
公开(公告)日：2021-06-17
申请号：US17116316
申请日：2020-12-09
申请人： BIOTRONIK SE & Co. KG
发明人： Marcelo BARU
IPC分类号： A61N1/36 , A61N1/04 , A61N1/05
摘要： An electrical stimulation system includes a plurality of electrodes, a pulse generator (10) configured to generate a constant current pulse in a stimulation path between at least two electrodes of the plurality of electrodes during an active phase, where the pulse generator is configured to provide an output voltage overhead (V) for generating the constant current pulse. The output voltage (V) tracks a voltage ramp (VTrack) throughout the active phase, where the voltage ramp corresponds to a linear approximation of an accumulated voltage in an effective capacitance (Ceff) of the stimulation path throughout the active phase.

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