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1. 发明授权

US09126050B2 Non-invasive vagus nerve stimulation devices and methods to treat or avert atrial fibrillation 有权
标题翻译：非侵入性迷走神经刺激装置和治疗或避免房颤的方法
公开(公告)号：US09126050B2
公开(公告)日：2015-09-08
申请号：US13736096
申请日：2013-01-08
申请人： Bruce J. Simon , Joseph P. Errico , John T. Raffle
发明人： Bruce J. Simon , Joseph P. Errico , John T. Raffle
IPC分类号： A61N1/36 , A61N1/362
CPC分类号： A61N1/3625 , A61N1/36014 , A61N1/36053 , A61N1/36114 , A61N1/36171 , A61N1/36178 , A61N1/362
摘要： Energy is transmitted noninvasively to a patient using electrode-based stimulation devices or magnetic stimulation devices that are designed to non-invasively stimulate nerves selectively. The devices produce impulses that are used to treat atrial fibrillation, by stimulating a vagus nerve of a patient. The devices are also used to forecast the imminent onset of atrial fibrillation and then avert it by stimulating a vagus nerve.
摘要翻译：使用基于电极的刺激装置或设计成非侵入性地刺激神经的磁刺激装置将能量非侵入地传播给患者。该装置通过刺激患者的迷走神经产生用于治疗房颤的脉冲。这些装置也用于预测心房颤动即将发生，然后通过刺激迷走神经来避免。

2. 发明授权

US08918178B2 Non-invasive vagal nerve stimulation to treat disorders 有权
标题翻译：非侵入性迷走神经刺激治疗疾病
公开(公告)号：US08918178B2
公开(公告)日：2014-12-23
申请号：US13603799
申请日：2012-09-05
申请人： Bruce J. Simon , Joseph P. Errico , John T. Raffle
发明人： Bruce J. Simon , Joseph P. Errico , John T. Raffle
IPC分类号： A61N1/34 , A61N1/40 , A61N1/36 , A61N2/00 , A61N2/02 , A61B5/00
CPC分类号： A61N1/3601 , A61B5/4836 , A61N1/36014 , A61N1/40 , A61N2/006 , A61N2/008 , A61N2/02
摘要： Devices, systems and methods are disclosed for treating a variety of diseases and disorders that are primarily or at least partially driven by an imbalance in neurotransmitters in the brain, such as asthma, COPD, depression, anxiety, epilepsy, fibromyalgia, and the like. The invention involves the use of an energy source comprising magnetic and/or electrical energy that is transmitted non-invasively to, or in close proximity to, a selected nerve to temporarily stimulate, block and/or modulate the signals in the selected nerve such that neural pathways are activated to release inhibitory neurotransmitters in the patient's brain.
摘要翻译：公开了用于治疗主要或至少部分地由脑中的神经递质不平衡驱动的多种疾病和病症的装置，系统和方法，例如哮喘，COPD，抑郁症，焦虑症，癫痫，纤维肌痛等。本发明涉及使用能量源，该能量源包括磁性和/或电能非侵入性或非常接近所选择的神经以暂时刺激，阻断和/或调节选定神经中的信号，使得激活神经通路以释放患者大脑中的抑制性神经递质。

3. 发明授权

US08676330B2 Electrical and magnetic stimulators used to treat migraine/sinus headache and comorbid disorders 有权
标题翻译：用于治疗偏头痛/窦性头痛和并发症的电磁刺激剂
公开(公告)号：US08676330B2
公开(公告)日：2014-03-18
申请号：US13109250
申请日：2011-05-17
申请人： Bruce J. Simon , Joseph P. Errico , John T. Raffle
发明人： Bruce J. Simon , Joseph P. Errico , John T. Raffle
IPC分类号： A61N1/36
CPC分类号： A61N1/36021 , A61N1/0456 , A61N1/36075 , A61N1/40 , A61N2/006 , A61N2/008 , A61N2/02
摘要： Non-invasive electrical nerve stimulation devices and magnetic stimulation devices are disclosed, along with methods of treating medical disorders using energy that is delivered noninvasively by such devices. The disorders comprise migraine and other primary headaches such as cluster headaches, including sinus symptoms that resemble an immune-mediated response (“sinus” headaches), irrespective of whether those symptoms arise from an allergy that is co-morbid with the headache. The disclosed methods may also be used to treat other disorders that may be co-morbid with migraine headaches, such as anxiety disorders. In preferred embodiments of the disclosed methods, one or both of the patient's vagus nerves are stimulated non-invasively. In other embodiments, parts of the sympathetic nervous system and/or the adrenal glands are stimulated.
摘要翻译：公开了非侵入性电神经刺激装置和磁刺激装置，以及使用由这种装置非侵入性地输送的能量来治疗医学病症的方法。这些疾病包括偏头痛和其他原发性头痛，例如丛集性头痛，包括类似于免疫介导的反应（“窦”头痛）的窦性症状，而不管这些症状是否由与头痛并发的过敏引起。所公开的方法还可以用于治疗可能与偏头痛如焦虑症一起并发的其它疾病。在所公开的方法的优选实施例中，患者的迷走神经中的一个或两个被非侵入性地刺激。在其它实施方案中，刺激部分交感神经系统和/或肾上腺。

4. 发明申请

US20130131753A1 NON-INVASIVE MAGNETIC OR ELECTRICAL NERVE STIMULATION TO TREAT GASTROPARESIS, FUNCTIONAL DYSPEPSIA, AND OTHER FUNCTIONAL GASTROINTESTINAL DISORDERS 有权
标题翻译：非侵入性磁性或电刺激治疗胃肠道功能性功能障碍和其他功能性胃肠疾病
公开(公告)号：US20130131753A1
公开(公告)日：2013-05-23
申请号：US13731035
申请日：2012-12-30
申请人： Bruce J. Simon , Joseph P. Errico , John T. Raffle
发明人： Bruce J. Simon , Joseph P. Errico , John T. Raffle
IPC分类号： A61N1/36
CPC分类号： A61N1/36007 , A61N1/0456 , A61N1/205 , A61N1/36 , A61N1/36014 , A61N1/40 , A61N2/006 , A61N2/02
摘要： Devices, systems and methods are disclosed for treating or preventing gastroparesis, functional dyspepsia, and other functional gastrointestinal disorders. The methods comprise transmitting impulses of energy non-invasively to selected nerve fibers, particularly those in a vagus nerve. The methods provide damaged interstitial cells of Cajal (ICC) with trophic factors via vagal afferent nerve fibers, thereby reversing ICC damage, and as a consequence improving gastric motility. The methods also increase levels of inhibitory neurotransmitters in the brain so as to decrease neural activity within the area postrema, or they deactivate a resting state neural network containing parts of the anterior insula and anterior cingulate cortex, which will thereby reduce abnormal interoception and visceral hypersensitivity.
摘要翻译：公开了用于治疗或预防胃轻瘫，功能性消化不良和其它功能性胃肠道疾病的装置，系统和方法。所述方法包括非侵入性地将能量的脉冲传送到所选择的神经纤维，特别是迷走神经中的神经纤维。该方法通过迷走神经传入神经纤维向营养因子提供Cajal（ICC）受损的间质细胞，从而逆转ICC损伤，从而改善胃动力。这些方法还增加了大脑中抑制性神经递质的含量，从而减少了后期区域的神经活动，或者它们使含有前岛和前扣带皮层部分的静息状态神经网络失活，从而减少异常的接受和内脏超敏反应。

5. 发明申请

US20130066395A1 NERVE STIMULATION METHODS FOR AVERTING IMMINENT ONSET OR EPISODE OF A DISEASE 审中-公开
标题翻译：用于平均静脉注射或感染疾病的神经刺激方法
公开(公告)号：US20130066395A1
公开(公告)日：2013-03-14
申请号：US13655716
申请日：2012-10-19
申请人： Bruce J. Simon , Joseph P. Errico , John T. Raffle
发明人： Bruce J. Simon , Joseph P. Errico , John T. Raffle
IPC分类号： A61N1/36 , A61N1/40
CPC分类号： A61N1/36053 , A61B5/0476 , A61B5/4094 , A61B5/4833 , A61B5/4836 , A61N1/36003 , A61N1/36014 , A61N1/3756 , A61N1/40 , A61N2/006 , A61N2/02
摘要： Transcutaneous electrical and magnetic nerve stimulation devices are disclosed, along with methods of averting imminent medical attacks using energy that is delivered noninvasively by the devices. The attacks comprise asthma attack, epileptic seizure, attacks of migraine headache, transient ischemic attack or stroke, onset of atrial fibrillation, myocardial infarction, onset of ventricular fibrillation or tachycardia, panic attack, and attacks of acute depression. The imminence of an attack is forecasted using grey-box or black-box models as used in control theory. In preferred embodiments of the disclosed methods, a vagus nerve in the neck of a patient is stimulated noninvasively to avert the attack.
摘要翻译：公开了经皮电磁神经刺激装置，以及使用由装置非侵入性地传送的能量来避免即将发生的医疗攻击的方法。袭击包括哮喘发作，癫痫发作，偏头痛，短暂性脑缺血发作或中风发作，心房颤动发作，心肌梗塞，心室颤动或心动过速发作，恐慌发作和急性抑郁症发作。使用控制理论中使用的灰盒或黑盒模型预测攻击的即将发生。在所公开的方法的优选实施例中，患者颈部的迷走神经被非侵入性地刺激以避免攻击。

6. 发明申请

US20160367808A9 NERVE STIMULATION METHODS FOR AVERTING IMMINENT ONSET OR EPISODE OF A DISEASE 审中-公开
标题翻译：用于平均静脉注射或感染疾病的神经刺激方法
公开(公告)号：US20160367808A9
公开(公告)日：2016-12-22
申请号：US13357025
申请日：2012-01-24
申请人： Bruce J. Simon , Joseph P. Errico , John T. Raffle
发明人： Bruce J. Simon , Joseph P. Errico , John T. Raffle
IPC分类号： A61N1/36 , A61N2/04
CPC分类号： A61N1/36064 , A61N1/36014 , A61N1/36025 , A61N2/006
摘要： Transcutaneous electrical and magnetic nerve stimulation devices are disclosed, along with methods of averting imminent medical attacks using energy that is delivered noninvasively by the devices. In particular, the devices and methods involve handheld devices designed to stimulate the vagus nerve of a patient with a signal sufficient to minimize or avert epileptic seizures.
摘要翻译：公开了经皮电磁神经刺激装置，以及使用由装置非侵入性地传送的能量来避免即将发生的医疗攻击的方法。特别地，装置和方法涉及设计成以足以使癫痫发作最小化或避免的信号刺激患者的迷走神经的手持装置。

7. 发明授权

US09037247B2 Non-invasive treatment of bronchial constriction 有权
标题翻译：非侵入性治疗支气管收缩
公开(公告)号：US09037247B2
公开(公告)日：2015-05-19
申请号：US12859568
申请日：2010-08-19
申请人： Bruce J. Simon , Joseph P. Errico , John T. Raffle , Steven Mendez
发明人： Bruce J. Simon , Joseph P. Errico , John T. Raffle , Steven Mendez
IPC分类号： A61N1/18 , A61N1/36 , A61H23/00 , A61H31/00 , A61H39/00 , A61N1/40 , A61N2/00 , A61N2/02 , A61N5/06 , A61N1/375 , A61N1/378 , A61H23/02 , A61N7/00
CPC分类号： A61N2/002 , A61H23/00 , A61H23/004 , A61H23/02 , A61H23/0236 , A61H31/00 , A61H39/002 , A61H2201/123 , A61H2201/1604 , A61H2201/1609 , A61H2201/165 , A61N1/3601 , A61N1/36014 , A61N1/36114 , A61N1/3758 , A61N1/3787 , A61N1/40 , A61N2/006 , A61N2/02 , A61N5/0603 , A61N5/0622 , A61N5/0625 , A61N7/00 , A61N2005/0605 , A61N2005/063 , A61N2007/0026
摘要： Devices, systems and methods for treating bronchoconstriction associated with asthma, anaphylaxis or chronic obstructive pulmonary disease. The treatment comprises transmitting impulses of energy non-invasively to selected nerve fibers that are responsible for smooth muscle dilation, such as the vagus nerve.
摘要翻译：用于治疗与哮喘，过敏反应或慢性阻塞性肺疾病相关的支气管收缩的装置，系统和方法。该治疗包括将非侵入性能量的脉冲传递给负责平滑肌扩张的选定神经纤维，例如迷走神经。

8. 发明申请

US20110125213A1 NON-INVASIVE TREATMENT OF BRONCHIAL CONSTRICTION 有权
标题翻译：非正式协商的协商处理
公开(公告)号：US20110125213A1
公开(公告)日：2011-05-26
申请号：US13018558
申请日：2011-02-01
申请人： Bruce J. Simon , Joseph P. Errico , John T. Raffle , Steven Mendez
发明人： Bruce J. Simon , Joseph P. Errico , John T. Raffle , Steven Mendez
IPC分类号： A61N1/36
CPC分类号： A61N2/002 , A61H23/00 , A61H23/004 , A61H23/02 , A61H23/0236 , A61H31/00 , A61H39/002 , A61H2201/123 , A61H2201/1604 , A61H2201/1609 , A61H2201/165 , A61N1/3601 , A61N1/36014 , A61N1/36114 , A61N1/3758 , A61N1/3787 , A61N1/40 , A61N2/006 , A61N2/02 , A61N5/0603 , A61N5/0622 , A61N5/0625 , A61N7/00 , A61N2005/0605 , A61N2005/063 , A61N2007/0026
摘要： Devices, systems and methods are disclosed for treating bronchial constriction related to asthma, anaphylaxis or chronic obstructive pulmonary disease. The treatment comprises transmitting impulses of energy non-invasively to selected nerve fibers that are responsible for smooth muscle dilation. The transmitted energy impulses, comprising magnetic and/or electrical, mechanical and/or acoustic, and optical and/or thermal energy, stimulate the selected nerve fibers.
摘要翻译：公开了用于治疗与哮喘，过敏反应或慢性阻塞性肺疾病相关的支气管收缩的装置，系统和方法。该治疗包括将能量非侵入性的能量脉冲传递给负责平滑肌扩张的选定神经纤维。包括磁和/或电的机械和/或声学以及光学和/或热能的透射能量脉冲刺激所选择的神经纤维。

9. 发明授权

US10286212B2 Nerve stimulation methods for averting imminent onset or episode of a disease 有权
公开(公告)号：US10286212B2
公开(公告)日：2019-05-14
申请号：US13357025
申请日：2012-01-24
申请人： Bruce J. Simon , Joseph P. Errico , John T. Raffle
发明人： Bruce J. Simon , Joseph P. Errico , John T. Raffle
IPC分类号： A61N1/36 , A61N2/00
摘要： Transcutaneous electrical and magnetic nerve stimulation devices are disclosed, along with methods of averting imminent medical attacks using energy that is delivered noninvasively by the devices. In particular, the devices and methods involve handheld devices designed to stimulate the vagus nerve of a patient with a signal sufficient to minimize or avert epileptic seizures.

10. 发明授权

US08874227B2 Devices and methods for non-invasive capacitive electrical stimulation and their use for vagus nerve stimulation on the neck of a patient 有权
标题翻译：用于非侵入性电容电刺激的装置和方法及其用于患者颈部的迷走神经刺激
公开(公告)号：US08874227B2
公开(公告)日：2014-10-28
申请号：US13183765
申请日：2011-07-15
申请人： Bruce J. Simon , Joseph P. Errico , John T. Raffle
发明人： Bruce J. Simon , Joseph P. Errico , John T. Raffle
IPC分类号： A61N1/00 , A61N1/40
CPC分类号： A61N1/36021 , A61M21/00 , A61M2021/0022 , A61M2021/0027 , A61M2021/0044 , A61M2021/0072 , A61N1/0456 , A61N1/0496 , A61N1/36014 , A61N1/36025 , A61N1/36053 , A61N1/40
摘要： A non-invasive electrical stimulator shapes an elongated electric field of effect that can be oriented parallel to a long nerve, such as a vagus nerve in a patient's neck, producing a desired physiological response in the patient. The stimulator comprises a source of electrical power, at least one electrode and a continuous electrically conducting medium in contact with the electrodes. The conducting medium is also in contact with an interface element that may conform to the contour of a target body surface of the patient when the interface element is applied to that surface. When the interface element is made of insulating (dielectric) material, and disclosed stimulation waveforms are used, the power source need not supply high voltage, in order to capacitively stimulate the target nerve. The stimulator is configured to produce a peak pulse that is sufficient to produce a physiologically effective electric field in the vicinity of a target nerve, but not to substantially stimulate other nerves and muscles that lie in the vicinity of the target nerve and patient's skin.
摘要翻译：非侵入式电刺激器形成可以平行于长神经（例如患者颈部的迷走神经）定向的细长电场，在患者体内产生所需的生理反应。刺激器包括电源，至少一个电极和与电极接触的连续导电介质。当将界面元件应用于该表面时，导电介质也与接口元件接触，该界面元件可以符合患者的目标体表的轮廓。当界面元件由绝缘（电介质）材料制成并且使用公开的刺激波形时，电源不需要提供高电压，以便电容地刺激目标神经。刺激器被配置为产生峰值脉冲，其足以在目标神经附近产生生理上有效的电场，但是不能基本上刺激位于目标神经和患者皮肤附近的其它神经和肌肉。

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