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1. 发明授权

US10286212B2 Nerve stimulation methods for averting imminent onset or episode of a disease 有权
公开(公告)号：US10286212B2
公开(公告)日：2019-05-14
申请号：US13357025
申请日：2012-01-24
申请人： Bruce J. Simon , Joseph P. Errico , John T. Raffle
发明人： Bruce J. Simon , Joseph P. Errico , John T. Raffle
IPC分类号： A61N1/36 , A61N2/00
摘要： Transcutaneous electrical and magnetic nerve stimulation devices are disclosed, along with methods of averting imminent medical attacks using energy that is delivered noninvasively by the devices. In particular, the devices and methods involve handheld devices designed to stimulate the vagus nerve of a patient with a signal sufficient to minimize or avert epileptic seizures.

2. 发明授权

US08874227B2 Devices and methods for non-invasive capacitive electrical stimulation and their use for vagus nerve stimulation on the neck of a patient 有权
标题翻译：用于非侵入性电容电刺激的装置和方法及其用于患者颈部的迷走神经刺激
公开(公告)号：US08874227B2
公开(公告)日：2014-10-28
申请号：US13183765
申请日：2011-07-15
申请人： Bruce J. Simon , Joseph P. Errico , John T. Raffle
发明人： Bruce J. Simon , Joseph P. Errico , John T. Raffle
IPC分类号： A61N1/00 , A61N1/40
CPC分类号： A61N1/36021 , A61M21/00 , A61M2021/0022 , A61M2021/0027 , A61M2021/0044 , A61M2021/0072 , A61N1/0456 , A61N1/0496 , A61N1/36014 , A61N1/36025 , A61N1/36053 , A61N1/40
摘要： A non-invasive electrical stimulator shapes an elongated electric field of effect that can be oriented parallel to a long nerve, such as a vagus nerve in a patient's neck, producing a desired physiological response in the patient. The stimulator comprises a source of electrical power, at least one electrode and a continuous electrically conducting medium in contact with the electrodes. The conducting medium is also in contact with an interface element that may conform to the contour of a target body surface of the patient when the interface element is applied to that surface. When the interface element is made of insulating (dielectric) material, and disclosed stimulation waveforms are used, the power source need not supply high voltage, in order to capacitively stimulate the target nerve. The stimulator is configured to produce a peak pulse that is sufficient to produce a physiologically effective electric field in the vicinity of a target nerve, but not to substantially stimulate other nerves and muscles that lie in the vicinity of the target nerve and patient's skin.
摘要翻译：非侵入式电刺激器形成可以平行于长神经（例如患者颈部的迷走神经）定向的细长电场，在患者体内产生所需的生理反应。刺激器包括电源，至少一个电极和与电极接触的连续导电介质。当将界面元件应用于该表面时，导电介质也与接口元件接触，该界面元件可以符合患者的目标体表的轮廓。当界面元件由绝缘（电介质）材料制成并且使用公开的刺激波形时，电源不需要提供高电压，以便电容地刺激目标神经。刺激器被配置为产生峰值脉冲，其足以在目标神经附近产生生理上有效的电场，但是不能基本上刺激位于目标神经和患者皮肤附近的其它神经和肌肉。

3. 发明授权

US08868177B2 Non-invasive treatment of neurodegenerative diseases 有权
标题翻译：非侵入性治疗神经退行性疾病
公开(公告)号：US08868177B2
公开(公告)日：2014-10-21
申请号：US13005005
申请日：2011-01-12
申请人： Bruce Simon , Joseph P. Errico , John T. Raffle
发明人： Bruce Simon , Joseph P. Errico , John T. Raffle
IPC分类号： A61N1/36 , A61N2/08 , A61N1/40 , A61N2/02 , A61N2/00
CPC分类号： A61N1/36025 , A61N1/36114 , A61N1/40 , A61N2/002 , A61N2/006 , A61N2/02
摘要： Methods and devices for the non-invasive treatment of neurodegenerative diseases through delivery of energy to target nervous tissue, particularly the vagus nerve. In certain embodiments, the devices include a magnetic stimulator having coils with toroidal windings, which are in contact with an electrically conducting medium that is adapted to conform to the contour of a target body surface of a patient. The coils induce an electric current and/or an electric field within the patient, thereby stimulating nerve fibers within the patient. The stimulation brings about reduction of neuroinflammation in patients suffering from conditions comprising Alzheimer's Disease, Parkinson's Disease, Multiple Sclerosis, postoperative cognitive dysfunction and postoperative delirium.
摘要翻译：通过将能量递送至目标神经组织，特别是迷走神经来非侵入性地治疗神经变性疾病的方法和装置。在某些实施例中，装置包括具有环形绕组的线圈的磁刺激器，其与导电介质接触，导电介质适于符合患者的目标体表的轮廓。线圈在患者体内引起电流和/或电场，从而刺激患者内的神经纤维。刺激导致患有阿尔茨海默病，帕金森病，多发性硬化症，术后认知功能障碍和术后del妄的患者的神经炎症减少。

4. 发明授权

US08840537B2 Non-invasive treatment of bronchial constriction 有权
标题翻译：非侵入性治疗支气管收缩
公开(公告)号：US08840537B2
公开(公告)日：2014-09-23
申请号：US13018558
申请日：2011-02-01
申请人： Bruce J. Simon , Joseph P. Errico , John T. Raffle , Steven Mendez
发明人： Bruce J. Simon , Joseph P. Errico , John T. Raffle , Steven Mendez
IPC分类号： A61N2/02 , A61N5/06 , A61N2/00 , A61H31/00 , A61N1/40 , A61H39/00 , A61H23/00 , A61H23/02 , A61N7/00 , A61N1/36
CPC分类号： A61N2/002 , A61H23/00 , A61H23/004 , A61H23/02 , A61H23/0236 , A61H31/00 , A61H39/002 , A61H2201/123 , A61H2201/1604 , A61H2201/1609 , A61H2201/165 , A61N1/3601 , A61N1/36014 , A61N1/36114 , A61N1/3758 , A61N1/3787 , A61N1/40 , A61N2/006 , A61N2/02 , A61N5/0603 , A61N5/0622 , A61N5/0625 , A61N7/00 , A61N2005/0605 , A61N2005/063 , A61N2007/0026
摘要： Devices, systems and methods for treating bronchial constriction related to asthma, anaphylaxis or chronic obstructive pulmonary disease include non-invasive nerve stimulators. The treatment comprises transmitting impulses of energy non-invasively to selected nerve fibers that are responsible for smooth muscle dilation. The transmitted energy impulses, comprising magnetic and/or electrical, mechanical and/or acoustic, and optical and/or thermal energy, stimulate the selected nerve fibers.
摘要翻译：用于治疗与哮喘，过敏反应或慢性阻塞性肺疾病相关的支气管收缩的装置，系统和方法包括非侵入性神经刺激剂。该治疗包括将能量非侵入性的能量脉冲传递给负责平滑肌扩张的选定神经纤维。包括磁和/或电的机械和/或声学以及光学和/或热能的透射能量脉冲刺激所选择的神经纤维。

5. 发明授权

US08676324B2 Electrical and magnetic stimulators used to treat migraine/sinus headache, rhinitis, sinusitis, rhinosinusitis, and comorbid disorders 有权
标题翻译：用于治疗偏头痛/窦性头痛，鼻炎，鼻窦炎，鼻鼻窦炎和合并症的电磁刺激剂
公开(公告)号：US08676324B2
公开(公告)日：2014-03-18
申请号：US13183721
申请日：2011-07-15
申请人： Bruce J. Simon , Joseph P. Errico , John T. Raffle
发明人： Bruce J. Simon , Joseph P. Errico , John T. Raffle
IPC分类号： A61N1/40
CPC分类号： A61N2/006 , A61N1/36021 , A61N1/40 , A61N2/008 , A61N2/02
摘要： Transcutaneous electrical nerve stimulation devices and magnetic stimulation devices are disclosed, along with methods of treating medical disorders using energy that is delivered noninvasively by such devices. The disorders comprise migraine and other primary headaches such as cluster headaches, including nasal or paranasal sinus symptoms that resemble an immune-mediated response (“sinus” headaches). The devices and methods may also be used to treat rhinitis, sinusitis, or rhinosinusitis, irrespective of whether those disorders are co-morbid with a headache. They may also be used to treat other disorders that may be co-morbid with migraine or cluster headaches, such as anxiety disorders. In preferred embodiments of the disclosed methods, one or both of the patient's vagus nerves are stimulated non-invasively. In other embodiments, parts of the sympathetic nervous system and/or the adrenal glands are stimulated.
摘要翻译：公开了经皮电神经刺激装置和磁刺激装置，以及使用通过这种装置非侵入地输送的能量来治疗医学病症的方法。这些疾病包括偏头痛和其他原发性头痛，例如丛集性头痛，包括类似于免疫介导的反应（“窦”头痛）的鼻或鼻旁窦症状。装置和方法也可用于治疗鼻炎，鼻窦炎或鼻鼻窦炎，而不管这些疾病是否与头痛并发症。它们也可用于治疗可能与偏头痛或丛集性头痛如焦虑症共病的其他疾病。在所公开的方法的优选实施例中，患者的迷走神经中的一个或两个被非侵入性地刺激。在其它实施方案中，刺激部分交感神经系统和/或肾上腺。

6. 发明申请

US20130245712A1 NON-INVASIVE VAGAL NERVE STIMULATION TO TREAT DISORDERS 有权
公开(公告)号：US20130245712A1
公开(公告)日：2013-09-19
申请号：US13603810
申请日：2012-09-05
申请人： Bruce J. Simon , Joseph P. Errico , John T. Raffle
发明人： Bruce J. Simon , Joseph P. Errico , John T. Raffle
IPC分类号： A61N1/36
CPC分类号： A61N1/3601 , A61B5/08 , A61B5/082 , A61N1/40 , A61N2/006 , A61N2/008 , A61N2/02
摘要： Devices, systems and methods are disclosed for treating bronchial constriction related to asthma, anaphylaxis, chronic obstructive pulmonary disease (COPD), exercise-induced bronchospasm and post-operative bronchospasm. The treatment comprises transmitting impulses of energy non-invasively to selected nerve fibers that activate neural pathways to reduce the release of acetycholine from airway-related vagal preganglionic neurons within the brain of the patient. The transmitted energy impulses, comprising magnetic and/or electrical energy, stimulate the selected nerve fibers to produce the bronchodilation.

7. 发明申请

US20130245711A1 NON-INVASIVE VAGAL NERVE STIMULATION TO TREAT DISORDERS 有权
公开(公告)号：US20130245711A1
公开(公告)日：2013-09-19
申请号：US13603781
申请日：2012-09-05
申请人： Bruce Simon , Joseph P. Errico , John T. Raffle
发明人： Bruce Simon , Joseph P. Errico , John T. Raffle
IPC分类号： A61N1/36
CPC分类号： A61N1/36014 , A61B5/08 , A61B5/082 , A61N1/0456 , A61N1/3601 , A61N1/40 , A61N2/006 , A61N2/008 , A61N2/02
摘要： Devices, systems and methods are disclosed for treating a variety of diseases and disorders that are primarily or at least partially driven by an imbalance in neurotransmitters in the brain, such as asthma, COPD, depression, anxiety, epilepsy, fibromyalgia, and the like. The invention involves the use of an energy source comprising magnetic and/or electrical energy that is transmitted non-invasively to, or in close proximity to, a selected nerve to temporarily stimulate, block and/or modulate the signals in the selected nerve such that neural pathways are activated to release inhibitory neurotransmitters in the patient's brain.

8. 发明申请

US20130238050A1 NON-INVASIVE VAGAL NERVE STIMULATION TO TREAT DISORDERS 有权
公开(公告)号：US20130238050A1
公开(公告)日：2013-09-12
申请号：US13603852
申请日：2012-09-05
申请人： Bruce Simon , Joseph P. Errico , John T. Raffle
发明人： Bruce Simon , Joseph P. Errico , John T. Raffle
IPC分类号： A61N1/36
CPC分类号： A61N1/3601 , A61B5/4836 , A61N1/36014 , A61N1/40 , A61N2/006 , A61N2/008 , A61N2/02
摘要： Devices, systems and methods are disclosed for treating a variety of diseases and disorders that are primarily or at least partially driven by an imbalance in neurotransmitters in the brain, such as asthma, COPD, depression, anxiety, epilepsy, fibromyalgia, and the like. The invention involves the use of an energy source comprising magnetic and/or electrical energy that is transmitted non-invasively to, or in close proximity to, a selected nerve to temporarily stimulate, block and/or modulate the signals in the selected nerve such that neural pathways are activated to release inhibitory neurotransmitters in the patient's brain.

9. 发明授权

US08496608B2 Systems and methods for treating obesity and type 2 diabetes 有权
标题翻译：用于治疗肥胖和2型糖尿病的系统和方法
公开(公告)号：US08496608B2
公开(公告)日：2013-07-30
申请号：US12702449
申请日：2010-02-09
申请人： Attila A. Priplata , Joseph P. Errico , John T. Raffle , Jonathan David Gardiner
发明人： Attila A. Priplata , Joseph P. Errico , John T. Raffle , Jonathan David Gardiner
IPC分类号： A61M5/00 , A61F2/04
CPC分类号： A61F5/0076 , A61B17/3468 , A61B2017/00557 , A61B2017/00818 , A61F5/004 , A61F5/0079 , A61F2002/045 , A61M25/04 , A61M27/002 , A61M39/00 , A61M39/10
摘要： The present invention provides systems and methods for treating wounds in patients who lack the innate ability to regulate glucose (e.g., diabetic patients). In one aspect of the invention, a method includes positioning an internal bypass device within the duodenum to inhibit contact between chyme passing therethrough and an internal wall of the duodenum and maintaining the internal bypass device within the duodenum for a sufficient period of time to decrease insulin resistance and reduce a blood glucose level in the patient. The internal bypass device increases peripheral blood flow and elevates an immune system response to accelerate healing of the wound.
摘要翻译：本发明提供了在缺乏调节葡萄糖的先天能力的患者（例如糖尿病患者）中治疗伤口的系统和方法。在本发明的一个方面，一种方法包括将内部旁路装置定位在十二指肠内，以阻止通过其中的食糜与十二指肠内壁之间的接触，并将内部旁路装置保持在十二指肠内足够的时间段以减少胰岛素阻力并降低患者血糖水平。内部旁路装置增加外周血流量并提高免疫系统响应，以加速伤口愈合。

10. 发明申请

US20130131746A1 NON-INVASIVE VAGUS NERVE STIMULATION DEVICES AND METHODS TO TREAT OR AVERT ATRIAL FIBRILLATION 有权
公开(公告)号：US20130131746A1
公开(公告)日：2013-05-23
申请号：US13736096
申请日：2013-01-08
申请人： Bruce J. Simon , Joseph P. Errico , John T. Raffle
发明人： Bruce J. Simon , Joseph P. Errico , John T. Raffle
IPC分类号： A61N1/362
CPC分类号： A61N1/3625 , A61N1/36014 , A61N1/36053 , A61N1/36114 , A61N1/36171 , A61N1/36178 , A61N1/362
摘要： Energy is transmitted noninvasively to a patient using electrode-based stimulation devices or magnetic stimulation devices that are designed to non-invasively stimulate nerves selectively. The devices produce impulses that are used to treat atrial fibrillation, by stimulating a vagus nerve of a patient. The devices are also used to forecast the imminent onset of atrial fibrillation and then avert it by stimulating a vagus nerve.

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