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61. 发明授权

US07052710B2 Polymer re-inforced anatomically accurate bioactive protheses 失效
公开(公告)号：US07052710B2
公开(公告)日：2006-05-30
申请号：US10615466
申请日：2003-07-08
申请人： Russell A. Giordano , Benjamin M. Wu
发明人： Russell A. Giordano , Benjamin M. Wu
IPC分类号： A61F2/36
CPC分类号： A61F2/2875 , A61F2/2803 , A61F2/3094 , A61F2/30942 , A61F2002/2817 , A61F2002/2835 , A61F2002/30011 , A61F2002/30062 , A61F2002/30677 , A61F2002/30968 , A61F2210/0004 , A61F2250/0023 , A61F2310/00023 , A61F2310/00155 , A61F2310/00203 , A61F2310/00239 , A61F2310/00293 , A61F2310/00329 , A61L27/42 , A61L27/425 , A61L27/46 , B33Y70/00 , B33Y80/00
摘要： Customized implants for use in reconstructive bone surgeries where anatomical accuracy and bone adaptation are important, such as plastic and craniomaxillofacial reconstructions. This implant comprises a porous surface layer and a tough inner core of interpenetrating phase composite. The porous surface layer enhances the biocompatibility, tissue ingrowth, and implant stability. The tough inner core improves the mechanical properties of the implant with a high fracture toughness and a low modulus. The anatomical accuracy of the implants will minimize the intra-operative manipulation required to maintain a stable host bone-implant interface.

62. 发明申请

US20060078590A1 Resorbable ceramic compositions 失效
公开(公告)号：US20060078590A1
公开(公告)日：2006-04-13
申请号：US11222821
申请日：2005-09-12
申请人： Leif Hermansson , Hakan Engqvist
发明人： Leif Hermansson , Hakan Engqvist
IPC分类号： A61F2/00
CPC分类号： C04B28/06 , A61K6/0085 , A61K6/0091 , A61K6/024 , A61K6/0612 , A61K6/0675 , A61K6/0681 , A61L27/12 , A61L27/425 , A61L27/58 , C04B28/02 , C04B28/025 , C04B28/145 , C04B28/344 , C04B2111/00836 , Y02P40/148 , C04B22/143 , C04B7/02 , C04B7/32 , A61K6/083 , C08L33/08
摘要： Ceramic precursor compositions and chemically bonded ceramic (CBC) materials, especially Ca-based, and a composite biomaterial suitable for orthopaedic applications. The CBC-system includes a binding phase (chemical cement) and additional phases with specified chemistry imparting to the biomaterial the ability of initial strength followed by interaction with the body tissue including body liquid, to form a resorbable or partly resorbable biomaterial. The ceramic precursor composition includes at least one silicate with Ca as the main cation with a resorption rate less or equal to that of the bone in-growth rate. The silicate will form the binding phase of the cured material. Implants and surface coated devices are also disclosed. The cured material exhibits a compressive strength exceeding 100 MPa.

63. 发明申请

US20060002976A1 Absorbable putty-like implants and methods for their use for mechanical hemostasis of bone and for the treatment of osseous defects 有权
标题翻译：可吸收的油灰状植入物及其用于骨骼机械止血和治疗骨缺损的方法
公开(公告)号：US20060002976A1
公开(公告)日：2006-01-05
申请号：US10941889
申请日：2004-09-16
申请人： Richard Kronenthal
发明人： Richard Kronenthal
IPC分类号： A61F2/00
CPC分类号： A61L24/0042 , A61L24/043 , A61L27/425 , A61L27/46 , A61L2400/04 , A61L2430/02
摘要： Two (or more), component, body-implantable, absorbable, biocompatible, putty-like surgical mechanical hemostatic tamponades for use in surgery. Component 1, a carboxylic acid salt bulking material preferably less than 50 micron, preferably the calcium, magnesium, zinc, aluminum, lithium or barium salts of saturated or unsaturated carboxylic acids containing about 6 to 22 carbon atoms. Component 2, a dispersing vehicle, may be esters of C8-C18 monohydric alcohols with C2-C6 aliphatic monocarboxylic acids; C2-C18 monohydric alcohols with polycarboxylic acids; C8-C30 monohydric alcohols; tocopherol and esters thereof with C2-C10 aliphatic monocarboxylic acids or polycarboxylic acids; absorbable 10-14C hydrocarbons; free carboxylic acids such as oleic, linoleic, caprylic, capric, and lauric; dialkyl ethers; alkyl aryl ethers; dialkyl ketones and alkyl aryl ketones; polyhydroxy compounds and esters and ethers thereof; oils such as olive oil and castor oil and triglycerides.
摘要翻译：两个（或更多），组件，可植入人体，可吸收，生物相容，腻子样的手术机械止血栓塞用于手术。组分1，优选小于50微米的羧酸盐膨胀材料，优选含有约6至22个碳原子的饱和或不饱和羧酸的钙，镁，锌，铝，锂或钡盐。组分2，分散载体，可以是C 8 -C 18 -C 18一元醇与C 2 -C 6 - 脂肪族单羧酸; C 2 -C 18一元醇与多元羧酸; C 8 -C 30一元醇; 生育酚及其与C 2 -C 10脂肪族单羧酸或多元羧酸的酯; 可吸收的10-14C碳氢化合物; 游离羧酸如油酸，亚油酸，辛酸，癸酸和月桂酸; 二烷基醚; 烷基芳基醚; 二烷基酮和烷基芳基酮; 多羟基化合物及其酯和醚; 油如橄榄油和蓖麻油以及甘油三酸酯。

64. 发明申请

US20050281856A1 Implantable biostructure comprising an osteoconductive member and an osteoinductive material 审中-公开
标题翻译：包括骨传导构件和骨诱导材料的可植入生物结构
公开(公告)号：US20050281856A1
公开(公告)日：2005-12-22
申请号：US11125336
申请日：2005-05-10
申请人： Jonathan McGlohorn , Sunil Saini , Andrea Caruso , Thomas West , Peter Materna , John Sharobiem , Thomas Bradbury
发明人： Jonathan McGlohorn , Sunil Saini , Andrea Caruso , Thomas West , Peter Materna , John Sharobiem , Thomas Bradbury
IPC分类号： A61F2/00 , A61F2/02 , A61F2/28 , A61F2/30 , A61K31/724 , A61L27/36 , A61L27/42 , A61L27/56
CPC分类号： A61F2/28 , A61F2/30744 , A61F2/30767 , A61F2002/2835 , A61F2002/30059 , A61F2002/30062 , A61F2002/30153 , A61F2002/30154 , A61F2002/30179 , A61F2002/30224 , A61F2002/30225 , A61F2002/30235 , A61F2002/30261 , A61F2002/30263 , A61F2002/30271 , A61F2002/30604 , A61F2002/30677 , A61F2002/30772 , A61F2002/30785 , A61F2002/30795 , A61F2002/30807 , A61F2002/30813 , A61F2002/30815 , A61F2002/30822 , A61F2002/30957 , A61F2002/30985 , A61F2210/0004 , A61F2230/0019 , A61F2230/0021 , A61F2230/0058 , A61F2230/0069 , A61F2230/0082 , A61F2230/0084 , A61F2310/00293 , A61K31/724 , A61L27/3608 , A61L27/365 , A61L27/425 , A61L27/56
摘要： The present invention is directed to a biostructure comprising an osteoconductive member and an osteoinductive material. The osteoinductive material may be located within a cavity in the osteoconductive material. In one aspect of the invention the osteoinductive material is demineralized bone matrix and the osteoconductive member comprises tricalcium phosphate.
摘要翻译：本发明涉及包括骨传导构件和骨诱导材料的生物结构。骨诱导材料可以位于骨传导材料的腔内。在本发明的一个方面，骨诱导材料是去矿物质骨基质，并且骨传导性构件包括磷酸三钙。

65. 发明申请

US20050249773A1 Biocompatible bone implant compositions and methods for repairing a bone defect 审中-公开
标题翻译：生物相容性骨植入物组合物和修复骨缺损的方法
公开(公告)号：US20050249773A1
公开(公告)日：2005-11-10
申请号：US11121831
申请日：2005-05-04
申请人： Fabrizio Maspero , Kurt Ruffieux
发明人： Fabrizio Maspero , Kurt Ruffieux
IPC分类号： A61F2/28 , A61K33/42 , A61L24/00 , A61L27/00 , A61L27/42 , A61L27/50 , A61L27/58
CPC分类号： A61L24/0021 , A61L24/0042 , A61L24/0084 , A61L27/425 , A61L27/502 , A61L27/58 , A61L2430/02
摘要： Moldable bone implants for use in a bone defect or wound include a plurality of biocompatible granules and a biocompatible polymer that together form an implant mass. The polymer is softened with a plasticizer to make the implant mass moldable or flowable. The plasticizer can dissipate or be extracted to cause the implant mass to harden. The implant mass can be shaped in-situ or ex-situ. Implants formed in-situ are shaped by the bone defect or wound. The implant becomes hard through contact with body fluids, which extracts the plasticizer from the implant mass. Bone implants formed ex-situ, such as in a mold, are shaped by a mold, for example, and then hardened by placing the implant mass in contact with a hardening agent, such as water, which extracts the plasticizer from the implant mass. The shaped, hardened implant can be placed into a bone defect of corresponding size and shape.
摘要翻译：用于骨缺损或伤口的可成型骨植入物包括多个生物相容性颗粒和一起形成植入体的生物相容性聚合物。聚合物用增塑剂软化以使植入物模量可模制或流动。增塑剂可以消散或提取，使植入物质变硬。植入物质可以原地或非原位成形。原位形成的植入物通过骨缺损或伤口成形。植入物通过与体液接触而变硬，其从植入体中提取增塑剂。例如在模具中形成的例如在模具中形成的骨植入体通过例如模具成形，然后通过将植入物质与诸如水的固化剂接触而硬化，所述硬化剂从植入物质中提取增塑剂。成形的硬化植入物可以放置成相应尺寸和形状的骨缺损。

66. 发明申请

US20050169965A1 Compounds with improved cartilage-inducing and/or bone-inducing activity 失效
标题翻译：具有改善的软骨诱导和/或骨诱导活性的化合物
公开(公告)号：US20050169965A1
公开(公告)日：2005-08-04
申请号：US11080494
申请日：2005-03-16
申请人： Michael Paulista , Jens Pohl , Joachim Pabst , Helmut Heide
发明人： Michael Paulista , Jens Pohl , Joachim Pabst , Helmut Heide
IPC分类号： C12N15/09 , A61K38/00 , A61K38/18 , A61L27/00 , A61L27/22 , A61L27/42 , C07K14/495 , C07K14/51 , C07K19/00 , A61K38/17 , A61F2/00 , A61K33/42
CPC分类号： A61L27/425 , A61K38/1875 , A61L27/227 , C07K14/495 , C07K14/51
摘要： The present invention concerns a bioactive implant material having a cartilage-inducing and/or bone-inducing activity composed of two components A and B, of which A is a bone-inducing and/or cartilage-inducing protein or protein mixture and preferably one or several proteins from the TGF-β superfamily, preferably MP52 or a DNA sequence coding therefor and B is a carrier matrix composed of calcium phosphate ceramics with an interconnecting microporosity which already alone has bone-inducing properties. The invention additionally concerns the production of these compounds and their use for the treatment of diseases which affect cartilage and/or bones as well as to treat damage to cartilage and/or bone tissue.
摘要翻译：本发明涉及具有由两种组分A和B组成的软骨诱导和/或骨诱导活性的生物活性植入材料，其中A是诱导骨诱导和/或软骨诱导蛋白或蛋白质混合物，优选其中一种或来自TGF-β超家族的几种蛋白质，优选MP52或其编码的DNA序列，B是由磷酸钙陶瓷构成的载体基质，其具有已经单独具有骨诱导性质的互连微孔。本发明还涉及这些化合物的生产及其用于治疗影响软骨和/或骨骼的疾病以及治疗软骨和/或骨组织损伤的用途。

67. 发明申请

US20050085922A1 Shaped filler for implantation into a bone void and methods of manufacture and use thereof 审中-公开
标题翻译：用于植入骨空隙的成形填充物及其制造和使用方法
公开(公告)号：US20050085922A1
公开(公告)日：2005-04-21
申请号：US10966113
申请日：2004-10-18
申请人： Ben Shappley , Thomas Bradbury , Peter Materna , Timothy Pryor , John Blum , Ali Recber
发明人： Ben Shappley , Thomas Bradbury , Peter Materna , Timothy Pryor , John Blum , Ali Recber
IPC分类号： A61F2/00 , A61F2/28 , A61F2/30 , A61L27/12 , A61L27/42 , A61L27/56
CPC分类号： A61L27/3608 , A61F2/28 , A61F2002/30011 , A61F2002/3008 , A61F2002/30153 , A61F2002/30158 , A61F2002/3021 , A61F2002/30224 , A61F2002/30225 , A61F2002/30266 , A61F2002/30785 , A61F2002/30787 , A61F2002/30789 , A61F2002/30968 , A61F2002/30985 , A61F2230/0019 , A61F2230/0026 , A61F2230/0067 , A61F2230/0069 , A61F2230/0082 , A61F2250/0023 , A61F2250/0098 , A61F2310/00293 , A61L27/12 , A61L27/365 , A61L27/425 , A61L27/56 , A61L2430/02 , B33Y80/00
摘要： The invention is directed to shaped bone void filler pieces having defined porosity. In embodiments of the invention, the shaped bone void filler pieces are presented substantially as wedges, wafers, and axisymmetric bone void filler pieces. The bone void filler pieces further comprise surface and internal features such as recesses, channels, and/or voids. The bone void filler pieces optionally comprise demineralized bone matrix. The invention further is directed to methods of making and methods of using the bone void filler pieces. In another embodiment of the invention, the bone void filler pieces are produced using three dimensional printing methods. In yet another embodiment of the invention, the bone void filler pieces are manufactured with selected porogens integrated therein, which optionally are decomposed following production through a heat-mediated decomposition process, resulting in voids in the bone void filler spaces previously occupied by the porogen(s).
摘要翻译：本发明涉及具有确定的孔隙度的成形骨空隙填料片。在本发明的实施例中，成形骨空隙填充片基本上呈楔形，晶片和轴对称骨空隙填充片。骨空隙填充片还包括表面和内部特征，例如凹陷，通道和/或空隙。骨空隙填充片任选地包括脱矿质骨基质。本发明进一步涉及使用骨空隙填充片的方法和使用方法。在本发明的另一个实施方案中，使用三维印刷方法制造骨空隙填充片。在本发明的另一个实施方案中，骨空隙填充片用其中整合的选择的致孔剂制造，其任选地通过热介导的分解过程在生产后分解，导致先前由致孔剂占据的骨空隙填料空间中的空隙（ s）。

68. 发明申请

US20050081750A1 Self-hardening calcium phosphate materials with high resistance to fracture, controlled strength histories and tailored macropore formation rates 有权
$Self-hardening calcium phosphate materials with high resistance to fracture, controlled strength histories and tailored macropore formation rates$
公开(公告)号：US20050081750A1
公开(公告)日：2005-04-21
申请号：US10975190
申请日：2004-10-28
申请人： Huakun Xu , Laurence Chow , Shozo Takagi , Frederick Eichmiller
发明人： Huakun Xu , Laurence Chow , Shozo Takagi , Frederick Eichmiller
IPC分类号： A61F2/00 , A61F2/02 , A61F2/28 , A61F2/30 , A61L27/42 , C04B12/02 , C04B28/34
CPC分类号： A61L27/425 , A61F2/28 , A61F2/30965 , A61F2002/2835 , A61F2002/30032 , A61F2002/30062 , A61F2002/30069 , A61F2002/30971 , A61F2210/0004 , A61F2250/003 , A61F2310/00293 , A61L2430/02
摘要： A bone replacement material and therapy comprises the combination of calcium phosphate compounds and two or more soluble fillers in the form of fibers, mesh or other materials which have the dual functions of reinforcing an in vivo implant while dissolving at a programmed rate to form macropores capable of receiving natural bone ingrowth.

69. 发明授权

US06881227B2 Hydroxylapatite material containing tricalcium phosphate with microporous structure 有权
标题翻译：含有磷酸三钙的羟基磷灰石材料具有微孔结构
公开(公告)号：US06881227B2
公开(公告)日：2005-04-19
申请号：US10121642
申请日：2002-04-12
申请人： Margarita Jordanova-Spassova
发明人： Margarita Jordanova-Spassova
IPC分类号： C01B25/32 , A61F2/28
CPC分类号： C01B25/32 , A61L27/425
摘要： The invention relates to a hydroxylapatite material containing phosphate wherein the microporous structure of algae hard-tissue raw material is retained in the end product and which can be obtained by reacting an organic compound devoid of algae hard-tissue in an alkaline aqueous phosphate solution by adding magnesium ions at an elevated temperature. The invention also relates to a method for the production of said hydroxylapatite material containing tricalcium phosphate, which is characterized in that it is especially well resorbed in the body, is especially suitable as a bone substitute material or as a carrier material for active ingredients. Said material can also be used as a filter material.
摘要翻译：本发明涉及含有磷酸盐的羟基磷灰石，其中藻类硬组织原料的微孔结构保留在最终产物中，可通过在碱性磷酸水溶液中添加不含藻类硬组织的有机化合物，镁离子在升高的温度。本发明还涉及一种生产含有磷酸三钙的羟基磷灰石材料的方法，其特征在于其在体内特别好地吸收，特别适合作为骨替代材料或作为活性成分的载体材料。所述材料也可以用作过滤材料。

70. 发明授权

US06863899B2 Composite shaped bodies and methods for their production and use 有权
标题翻译：复合成型体及其生产和使用方法
公开(公告)号：US06863899B2
公开(公告)日：2005-03-08
申请号：US10165629
申请日：2002-06-07
申请人： Antony Koblish , Ronald Sapieszko , David Dychala , Erik Erbe
发明人： Antony Koblish , Ronald Sapieszko , David Dychala , Erik Erbe
IPC分类号： A61L27/00 , A61B17/64 , A61B17/70 , A61B17/74 , A61B17/80 , A61B17/86 , A61C8/00 , A61F2/00 , A61F2/28 , A61F2/30 , A61F2/32 , A61F2/36 , A61F2/38 , A61F2/44 , A61K9/14 , A61L27/02 , A61L27/12 , A61L27/42 , A61L27/56 , A61F13/00 , A61K7/16
CPC分类号： A61F2/28 , A61B17/64 , A61B17/70 , A61B17/742 , A61B17/80 , A61B17/866 , A61C8/0012 , A61F2/2803 , A61F2/2875 , A61F2/3094 , A61F2/32 , A61F2/38 , A61F2/3872 , A61F2/3877 , A61F2/389 , A61F2/4455 , A61F2/446 , A61F2/4465 , A61F2/447 , A61F2002/2825 , A61F2002/2882 , A61F2002/30187 , A61F2002/3895 , A61F2002/448 , A61F2230/0034 , A61L27/02 , A61L27/12 , A61L27/425 , A61L27/56
摘要： Shaped, composite bodies are provided. One portion of the shaped bodies comprises an RPR-derived porous inorganic material, preferably a calcium phosphate. Another portion of the composite bodies is a different solid material, preferably metal, glass, ceramic or polymeric. The shaped bodies are especially suitable for orthopaedic and other surgical use.
摘要翻译：提供成形的复合材料。成形体的一部分包括RPR衍生的多孔无机材料，优选磷酸钙。复合体的另一部分是不同的固体材料，优选金属，玻璃，陶瓷或聚合物。成形体特别适用于骨科和其他外科用途。

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