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    • 4. 发明授权
    • Biocompatible bone implant compositions and methods for repairing a bone defect
    • 生物相容性骨植入物组合物和修复骨缺损的方法
    • US08163030B2
    • 2012-04-24
    • US10840041
    • 2004-05-06
    • Fabrizio Alessandro MasperoKurt Ruffieux
    • Fabrizio Alessandro MasperoKurt Ruffieux
    • A61F2/28
    • A61L24/0021A61L24/0042A61L24/0084A61L27/425A61L27/502A61L27/58A61L2430/02
    • Moldable bone implants for use in a bone defect or wound include a plurality of biocompatible granules and a biocompatible polymer that together form an implant mass. The polymer is softened with a plasticizer to make the implant mass moldable. The plasticizer can dissipate or be extracted to cause the implant mass to harden. The implant mass can be shaped in-situ or ex-situ. Implants formed in-situ are shaped by the bone defect or wound. The implant becomes hard through contact with body fluids, which extracts the plasticizer from the implant mass. Bone implants formed ex-situ, such as in a mold, are shaped by a mold, for example, and then hardened by placing the implant mass in contact with a hardening agent, such as water, which extracts the plasticizer from the implant mass. The shaped, hardened implant can be placed into a bone defect of corresponding size and shape.
    • 用于骨缺损或伤口的可成型骨植入物包括多个生物相容性颗粒和一起形成植入体的生物相容性聚合物。 聚合物用增塑剂软化以使植入物模块成型。 增塑剂可以消散或提取,使植入物质变硬。 植入物质可以原地或非原位成形。 原位形成的植入物通过骨缺损或伤口成形。 植入物通过与体液接触而变硬,其从植入体中提取增塑剂。 例如在模具中形成的例如在模具中形成的骨植入体通过例如模具成形,然后通过将植入物质与诸如水的固化剂接触而硬化,所述硬化剂从植入物质中提取增塑剂。 成形的硬化植入物可以放置成相应尺寸和形状的骨缺损。
    • 6. 发明申请
    • Biocompatible bone implant compositions and methods for repairing a bone defect
    • 生物相容性骨植入物组合物和修复骨缺损的方法
    • US20050251266A1
    • 2005-11-10
    • US10840041
    • 2004-05-06
    • Fabrizio MasperoKurt Ruffieux
    • Fabrizio MasperoKurt Ruffieux
    • A61F2/28A61K33/42A61L24/00A61L27/00A61L27/42A61L27/50A61L27/58
    • A61L24/0021A61L24/0042A61L24/0084A61L27/425A61L27/502A61L27/58A61L2430/02
    • Moldable bone implants for use in a bone defect or wound include a plurality of biocompatible granules and a biocompatible polymer that together form an implant mass. The polymer is softened with a plasticizer to make the implant mass moldable. The plasticizer can dissipate or be extracted to cause the implant mass to harden. The implant mass can be shaped in-situ or ex-situ. Implants formed in-situ are shaped by the bone defect or wound. The implant becomes hard through contact with body fluids, which extracts the plasticizer from the implant mass. Bone implants formed ex-situ, such as in a mold, are shaped by a mold, for example, and then hardened by placing the implant mass in contact with a hardening agent, such as water, which extracts the plasticizer from the implant mass. The shaped, hardened implant can be placed into a bone defect of corresponding size and shape.
    • 用于骨缺损或伤口的可成型骨植入物包括多个生物相容性颗粒和一起形成植入体的生物相容性聚合物。 聚合物用增塑剂软化以使植入物模块成型。 增塑剂可以消散或提取,使植入物质变硬。 植入物质可以原地或非原位成形。 原位形成的植入物通过骨缺损或伤口成形。 植入物通过与体液接触而变硬,其从植入体中提取增塑剂。 例如在模具中形成的例如在模具中形成的骨植入体通过例如模具成形,然后通过将植入物质与诸如水的固化剂接触而硬化,所述硬化剂从植入物质中提取增塑剂。 成形的硬化植入物可以放置成相应尺寸和形状的骨缺损。
    • 8. 发明申请
    • VEHICLE HAVING A PEDAL DRIVE AND A REVERSE GEAR MECHANISM
    • 具有踏板驱动和反转齿轮机构的车辆
    • US20140251709A1
    • 2014-09-11
    • US14239436
    • 2011-08-17
    • Kurt Ruffieux
    • Kurt Ruffieux
    • B62M1/36B62M6/45B62M6/50B62M6/40
    • B62M1/36B62M6/40B62M6/45B62M6/50B62M11/00
    • A vehicle that includes a vehicle frame having a steering device, a first vehicle wheel fastened to the steering device, one or more second vehicle wheels fastened to the vehicle frame, a braking device, and a drive device having a pedal crank that can be driven by pedals. The vehicle further includes a freewheel clutch and an optionally engageable reverse gear mechanism. When the freewheel clutch is in an engaged state in a drive mode during the forward movement of the pedals, force is transmitted from the drive device to at least the second vehicle wheel. The freewheel clutch can be switched from the drive mode into a braking mode when the reverse gear mechanism is in the engaged state so that, in the braking mode, the pedal crank and the at least one second vehicle wheel are connected to each other in a torsionally rigid manner.
    • 一种车辆,包括具有转向装置的车架,固定到转向装置的第一车轮,固定到车架的一个或多个第二车轮,制动装置和具有可驱动的踏板曲柄的驱动装置 通过踏板 车辆还包括自由轮离合器和可选地可接合的倒档齿轮机构。 当飞轮离合器在踏板的向前运动期间处于驱动模式的接合状态时,力从驱动装置传递到至少第二车轮。 当倒档齿轮机构处于接合状态时,自由轮离合器可以从驱动模式切换到制动模式,使得在制动模式下,踏板曲柄和至少一个第二车轮彼此连接 扭转僵硬的方式。
    • 10. 发明申请
    • DEVICE FOR THE PROPULSION AND ECCENTRIC BRAKING OF A VEHICLE
    • 车辆的推进和偏心制动装置
    • US20140300078A1
    • 2014-10-09
    • US14239457
    • 2011-08-17
    • Kurt RuffieuxStefan StahlAndreas Kaiser
    • Kurt RuffieuxStefan StahlAndreas Kaiser
    • B62M9/06B62L5/00
    • B62M9/06B60T1/062B62L5/00B62L5/006B62M1/36B62M11/00B62M11/16F16H3/005
    • A device for the propulsion and eccentric braking of a vehicle having a pedal drive, which includes a first shaft, a drive mechanism including one or a plurality of chain wheels, belt pulleys or elements of a Cardan drive, a second hollow shaft arranged concentrically about the first shaft mounted into a rear wheel, a freewheel clutch mounted between the first shaft and the drive mechanism, and an optionally engageable reverse gear mechanism mounted between the first and the second shaft. The first and the second shafts are connected to each other in a torsionally rigid manner when the reverse gear mechanism is in the engaged and disengaged state. The freewheel clutch prevents a rotation of the drive mechanism relative to the first shaft in a clockwise direction and is in a freewheeling state when the drive mechanism rotates in a counter-clockwise direction relative to the first shaft.
    • 一种用于具有踏板驱动器的车辆的推进和偏心制动的装置,其包括第一轴,包括一个或多个链轮的驱动机构,皮带轮或卡丹驱动器的元件,第二中空轴同心地布置 安装在后轮中的第一轴,安装在第一轴和驱动机构之间的自由轮离合器,以及安装在第一和第二轴之间的可选择地接合的倒档齿轮机构。 当倒档齿轮机构处于接合和脱离状态时,第一和第二轴以扭转刚性的方式相互连接。 自由轮离合器防止驱动机构相对于第一轴沿顺时针方向旋转,并且当驱动机构相对于第一轴沿逆时针方向旋转时处于续流状态。