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61. 发明授权

US06562864B1 Catechin multimers as therapeutic drug delivery agents 有权
标题翻译：儿茶素多聚体作为治疗药物递送剂
公开(公告)号：US06562864B1
公开(公告)日：2003-05-13
申请号：US10137368
申请日：2002-05-03
申请人： Drake Larson
发明人： Drake Larson
IPC分类号： A61K3135
CPC分类号： A61K31/015 , A61K31/19 , A61K31/192 , A61K31/35 , A61K31/352 , A61K31/355 , A61K31/375 , A61K31/616 , A61K31/685 , A61K33/245 , A61K33/30 , A61K45/06 , A61K47/545 , G01N33/5308 , Y10S514/824 , A61K2300/00
摘要： Described herein are catechin multimers, and particularly substituted catechin multimers, and their use as carrier moieties for the delivery of nucleophilic and cationic bioactive therapeutic agents to target sites in vivo. For example, substituted catechin multimers of the present invention may be administered alone, for the treatment of stenotic vascular diseases and disorders, such as atherosclerosis (also known as arteriosclerosis) and coronary heart disease (also known as coronary artery disease and ischemic heart disease). Alternatively, catechin multimers, substituted and otherwise, may be complexed with nucleophilic and/or cationic bioactive therapeutic agents, such as anti-thrombotic agents, cholesterol lowering agents, anti-plaque agents, anti-cancer agents, chemotherapeutic agents, anti-inflammatory agents, antibiotics, antimicrobials, wound healing agents, and the like, for the treatment of a variety of diseases and disorders, including but not limited to cardiac and vascular stenoses, cancer, inflammatory conditions, neurological conditions, infection, wounds, burns and the like. The catechin multimers, particularly the substituted catechin multimers, described herein have a strong affinity for polar proteins residing in the vascular endothelium as well as cell walls and membranes, and, accordingly, are able to provide targeted delivery of bioactive agents embedded therein and/or complexed therewith so as to potentiate their therapeutic effects. The therapeutic complexes may be pharmaceutically formulated “neat” (e.g., without additives) or with additives such as pharmaceutical carriers, diluents, buffers, adjuvants, excipients, surfactants, and stabilizers.
摘要翻译：本文描述的是儿茶素多聚体，特别是取代的儿茶素多聚体，以及它们作为用于将亲核和阳离子生物活性治疗剂递送到体内靶向部位的载体部分的用途。例如，本发明的取代儿茶素多聚体可以单独施用，用于治疗狭窄的血管疾病和病症，例如动脉粥样硬化（也称为动脉硬化）和冠心病（也称为冠状动脉疾病和缺血性心脏病）。或者，取代或其它方式的儿茶素多聚体可以与亲核和/或阳离子生物活性治疗剂如抗血栓形成剂，胆固醇降低剂，抗斑块剂，抗癌剂，化学治疗剂，抗炎剂，抗生素，抗微生物剂，伤口愈合剂等，用于治疗各种疾病和病症，包括但不限于心脏和血管狭窄，癌症，炎性病症，神经病症，感染，伤口，烧伤等。本文所述的儿茶素多聚体，特别是取代的儿茶素多聚体对驻留在血管内皮以及细胞壁和膜中的极性蛋白质具有强亲和力，因此能够提供嵌入其中的生物活性剂的靶向递送和/或与其复合以增强其治疗效果。治疗复合物可以是药物配制的“纯”（例如，不含添加剂）或添加剂，例如药物载体，稀释剂，缓冲剂，佐剂，赋形剂，表面活性剂和稳定剂。

62. 发明授权

US06489317B1 Method for eradication of Helicobacter pylori 有权
标题翻译：消除幽门螺杆菌的方法
公开(公告)号：US06489317B1
公开(公告)日：2002-12-03
申请号：US09673631
申请日：2000-11-20
申请人： Thomas Julius Borody
发明人： Thomas Julius Borody
IPC分类号： A61K3143
CPC分类号： A61K45/06 , A61K33/245 , Y10S514/819 , Y10S514/925 , Y10S514/926 , Y10S514/927 , Y10S514/928 , A61K31/445 , A61K31/43 , A61K31/65 , A61K2300/00
摘要： The invention provides methods for the treatment and/or prevention of recurrence of a gastrointestinal disorder associated with Helicobacter pylori in a patient requiring said treatment and/or prevention, which comprise administering to the patient a therapeutically effective amount of a first antibiotic which is an ansamycin and a therapeutically effective amount of at least a second antibiotic or antimicrobial agent. The invention also provides pharmaceutical compositions for use in the methods of the invention.
摘要翻译：本发明提供了在需要所述治疗和/或预防的患者中治疗和/或预防与幽门螺杆菌相关的胃肠道疾病复发的方法，其包括向患者施用治疗有效量的第一种抗生素，其为沙霉素和治疗有效量的至少第二抗生素或抗微生物剂。本发明还提供了用于本发明方法的药物组合物。

63. 发明申请

US20020114847A1 Wound healing compound 失效
标题翻译：伤口愈合化合物
公开(公告)号：US20020114847A1
公开(公告)日：2002-08-22
申请号：US10125165
申请日：2002-04-18
发明人： Mickey L. Peshoff
IPC分类号： A61K033/32
CPC分类号： A61K31/59 , A61K31/43 , A61K31/545 , A61K31/65 , A61K31/665 , A61K31/7034 , A61K31/7048 , A61K33/30 , A61K45/06 , A61K2300/00 , A61K33/245 , A61K31/355 , A61K31/12 , A61K31/07 , A61K31/00
摘要： This invention pertains to therapeutic antibacterial/antifungal-wound healing compositions comprise a therapeutically effective amount of antibacterial agents and/or antifungal agents and/or wound healing composition alone. In one embodiment, the wound healing composition comprises (a) zinc oxide and (b) fat-soluble vitamins. The therapeutic antibacterial/antifungal-wound healing compositions may be utilized in a wide variety of pharmaceutical products. This invention also relates to methods for preparing and using the antibacterial/antifungal-wound healing compositions and the pharmaceutical products in which the therapeutic compositions may be used.
摘要翻译：本发明涉及治疗性抗菌/抗真菌伤口愈合组合物，其包含单独的治疗有效量的抗菌剂和/或抗真菌剂和/或伤口愈合组合物。在一个实施方案中，伤口愈合组合物包含（a）氧化锌和（b）脂溶性维生素。治疗性抗菌/抗真菌伤口愈合组合物可用于多种药物产品中。本发明还涉及制备和使用抗细菌/抗真菌伤口愈合组合物的方法和其中可以使用治疗组合物的药物产品。

64. 发明授权

US06426085B1 Use of bismuth-containing compounds in topical oral dosage forms for the treatment of halitosis 失效
标题翻译：在局部口服剂型中使用含铋化合物治疗口臭
公开(公告)号：US06426085B1
公开(公告)日：2002-07-30
申请号：US09578824
申请日：2000-05-24
申请人： Narayan K. Athanikar
发明人： Narayan K. Athanikar
IPC分类号： A61K716
CPC分类号： A61Q17/005 , A61K8/19 , A61K8/365 , A61K8/42 , A61K8/49 , A61K8/494 , A61K8/60 , A61K8/64 , A61K8/66 , A61K8/676 , A61K8/88 , A61K8/97 , A61K9/0058 , A61K31/28 , A61K31/29 , A61K31/43 , A61K31/44 , A61K31/485 , A61K31/7135 , A61K33/245 , A61K38/164 , A61K45/06 , A61Q11/00 , A61Q19/00 , Y10S514/90 , Y10S514/901 , Y10S514/902 , A61K2300/00
摘要： This invention provides for a method for treatment of corneal and dermal wounds by administering bismuth compounds in topical dosage forms. Bismuth compounds cause stimulation of release of growth factors in damaged tissue to promote regeneration of epithelial cells and hence accelerate wound healing. These bismuth compounds also have good antimicrobial activity against several anaerobic bacteria involved in diaper rash exacerbation.
摘要翻译：本发明提供了通过以局部剂型施用铋化合物来治疗角膜和皮肤伤口的方法。铋化合物引起受损组织中生长因子释放的刺激，促进上皮细胞的再生，从而加速伤口愈合。这些铋化合物对于涉及尿布疹恶化的几种厌氧细菌也具有良好的抗微生物活性。

65. 发明授权

US06380248B1 Metal-thiols as immunomodulating agents 有权
标题翻译：金属硫醇作为免疫调节剂
公开(公告)号：US06380248B1
公开(公告)日：2002-04-30
申请号：US09601491
申请日：2000-12-14
申请人： Philip Domenico , Dhanonjoy Saha
发明人： Philip Domenico , Dhanonjoy Saha
IPC分类号： A61K3129
CPC分类号： A61K33/36 , A61K31/095 , A61K31/145 , A61K31/28 , A61K31/285 , A61K31/29 , A61K31/433 , A61K31/53 , A61K33/24 , A61K33/245 , A61K47/54 , A61K47/547
摘要： A method is described to treat or prevent sepsis and septic shock in a subject by administering a Group V metal chelated by a complexing agent such as thiol compounds in the form of a metal:complexing agent, wherein the metal is selected from the group consisting of bismuth, antimony and arsenic. Methods for modulating the immune system are also disclosed.
摘要翻译：描述了一种治疗或预防受试者败血症和败血症休克的方法，该方法是通过施用由络合剂螯合的第V族金属，例如金属络合剂形式的硫醇化合物，其中金属选自铋，锑和砷。还公开了调节免疫系统的方法。

66. 发明授权

US06362169B1 Antibacterial compositions with synergistic effect, drugs and remedies for digestive diseases containing the same, process for the production thereof and preparations associated therewith 失效
标题翻译：具有协同效应的抗菌组合物，含有其的消化疾病的药物和补救剂，其生产方法和与其相关的制剂
公开(公告)号：US06362169B1
公开(公告)日：2002-03-26
申请号：US09622712
申请日：2000-08-22
申请人： Kenji Fujii , Katsuji Yamashita , Kazunori Hosoe , Takayoshi Hidaka
发明人： Kenji Fujii , Katsuji Yamashita , Kazunori Hosoe , Takayoshi Hidaka
IPC分类号： A61K3170
CPC分类号： A61K45/00 , A61K31/395 , A61K31/415 , A61K31/44 , A61K31/60 , A61K33/245 , A61K2300/00
摘要： Antibacterial compositions comprising (1) a rifamycin derivative represented by the formula (I) or its physiologically acceptable salt, and (2) a proton pump inhibitor (a) or a bismuth preparation (b) wherein the components (1) and (2) are used in such amounts as producing a synergistic effect against Helicobacter pylori, drugs and remedies for digestive organ diseases which contain the antibacterial compositions, process for producing them, and pharmaceutical preparations related to the antibacterial compositions. The compositions can be administered to patients with digestive diseases caused by infection of Helicobacter pylori in a smaller dose and at a lower administration frequency as compared with conventional remedies.
摘要翻译：抗菌组合物，其包含（1）由式（I）表示的利福霉素衍生物或其生理学上可接受的盐，和（2）质子泵抑制剂（a）或铋制剂（b），其中组分（1）和（2）用于产生对幽门螺杆菌的协同效应，含有抗菌组合物的消化器官疾病的药物和补救剂，其制备方法和与抗菌组合物相关的药物制剂。与常规治疗相比，组合物可以以较小的剂量和较低的施用频率施用于由幽门螺杆菌感染引起的消化系统疾病的患者。

67. 发明授权

US06340469B1 System for prophylactic treatment of mammary disorders 有权
标题翻译：乳腺疾病预防系统
公开(公告)号：US06340469B1
公开(公告)日：2002-01-22
申请号：US09694676
申请日：2000-10-24
申请人： Vincent McNally , James Patrick Morgan
发明人： Vincent McNally , James Patrick Morgan
IPC分类号： A23K118
CPC分类号： A61K33/245 , A01J7/04 , A23K50/10 , A61K9/0041 , A61K9/06 , A61K31/20 , A61K47/02 , A61K47/06
摘要： An antiinfective-free formulation for prophylactic treatment of mastitis in dry cows comprises a seal formulation having approximately 65% by weight of bismuth sub-nitrate in a gel based on aluminum stearate. The seal formulation is prepared by adding the bismuth sub-nitrate to the gel base in at least two separate stages.
摘要翻译：用于在干牛中预防乳腺炎的抗感冒制剂包括在基于硬脂酸铝的凝胶中具有约65重量％的亚硝酸铋的密封制剂。通过在至少两个分开的阶段向凝胶基质中加入亚硝酸铋制备密封制剂。

68. 发明申请

US20010021403A1 Coated chewing gum products containing various antacids 失效
标题翻译：含有各种抗酸剂的涂布口香糖产品
公开(公告)号：US20010021403A1
公开(公告)日：2001-09-13
申请号：US09747323
申请日：2000-12-22
发明人： Daniel J. Zyck , Michael J. Greenberg , David G. Barkalow , Scott W. Marske , Philip G. Schnell , Philip Mazzone
IPC分类号： A23G003/30
CPC分类号： A23G4/06 , A23G4/00 , A23G4/025 , A23G4/064 , A23G4/068 , A23G4/10 , A23G4/126 , A23G4/20 , A61K9/0058 , A61K9/2086 , A61K9/209 , A61K31/341 , A61K31/415 , A61K31/426 , A61K33/06 , A61K33/12 , A61K33/245 , A61K33/42 , A61K2300/00
摘要： A method of making antacid coated chewing gum products comprises the steps of providing chewing gum cores; providing a coating syrup comprising a bulk sweetener and a neutralizing antacid suspended in the coating syrup, the coating syrup containing from about 25% to about 50% by weight of the solids in the syrup of a neutralizing antacid, selected from the group consisting of aluminum salts, bismuth salts, magnesium salts, sodium bicarbonate, potassium bicarbonate, potassium citrate, sodium potassium tartrate, tricalcium phosphate and mixtures thereof, and applying the coating syrup to the cores and drying the syrup to produce a coating on the cores. Methods of use of the product to provide relief in the gastrointestinal tract are also included.
摘要翻译：制备抗酸包衣口香糖产品的方法包括提供口香糖核心的步骤; 提供包含悬浮在涂覆糖浆中的增量甜味剂和中和抗酸剂的涂料糖浆，所述涂布浆液含有约25％至约50％重量的中和抗酸剂糖浆中的固体，所述中和抗酸剂选自铝盐，铋盐，镁盐，碳酸氢钠，碳酸氢钾，柠檬酸钾，酒石酸钠钾，磷酸三钙及其混合物，并将涂覆糖浆施加到芯上并干燥糖浆以在芯上产生涂层。还包括使用该产品在胃肠道中提供缓解的方法。

69. 发明授权

US06258385B1 Tetrasilver tetroxide treatment for skin conditions 失效
标题翻译：四氯化钛治疗皮肤病
公开(公告)号：US06258385B1
公开(公告)日：2001-07-10
申请号：US09552172
申请日：2000-04-18
申请人： Marvin S. Antelman
发明人： Marvin S. Antelman
IPC分类号： A61K3338
CPC分类号： A61Q19/00 , A61K8/0208 , A61K8/19 , A61K9/0014 , A61K9/06 , A61K33/245 , A61K33/26 , A61K33/32 , A61K33/34 , A61K33/38 , A61K47/02 , A61Q1/12 , Y10S514/859 , Y10S514/861 , Y10S514/863 , Y10S514/925 , Y10S514/928 , Y10S514/931 , Y10S514/934 , Y10S514/937 , Y10S514/938 , Y10S514/969
摘要： The invention relates to the use of electron active molecular crystals comprising tetrasilver tetroxide (Ag4O4) for the treatment and cure of dermatological skin conditions (diseases) ranging from dermatitis, acne and psoiasis to herpes and skin ulcers.
摘要翻译：本发明涉及包含四氧化四砷（Ag 4 O 4）的电子活性分子晶体用于治疗和治愈皮炎，痤疮和皮疹的皮肤病学皮肤病（疾病）到疱疹和皮肤溃疡。

70. 发明授权

US6051604A Methods and compositions for the prevention and treatment of gastrointestinal disorders 失效
标题翻译：用于预防和治疗胃肠道疾病的方法和组合物
公开(公告)号：US6051604A
公开(公告)日：2000-04-18
申请号：US569033
申请日：1995-12-07
申请人： Jamesina Anne Fitzgerald
发明人： Jamesina Anne Fitzgerald
IPC分类号： A61K31/415 , A61K31/43 , A61K31/60 , A61K33/24 , A01N55/02 , A01N33/02 , A01N59/16
CPC分类号： A61K31/43 , A61K31/415 , A61K31/60 , A61K31/70 , A61K33/245
摘要： The subject invention encompasses methods for prevention and treatment of a human or lower animal subject having a gastrointestinal disorder caused or mediated by one or more intestinal helminths comprising administering to the subject bismuth and one or more antimicrobials. The subject invention also encompasses compositions comprising bismuth and one or more antimicrobials for the prevention and treatment of a human or lower animal subject having a gastrointestinal disorder caused or mediated by one or more intestinal helminths.
摘要翻译：本发明包括用于预防和治疗由一种或多种肠蠕虫引起或介导的胃肠道疾病的人或低级动物受试者的方法，其包括向受试者施用铋和一种或多种抗微生物剂。本发明还包括包含铋和一种或多种抗微生物剂的组合物，用于预防和治疗由一种或多种肠蠕虫引起或介导的具有胃肠道疾病的人或低等动物受试者。

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