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1. 发明申请

US20100323952A1 Nucleoside Analogs in Combination Therapy of Herpes Simplex Infections 审中-公开
标题翻译：核苷类似物联合治疗单纯疱疹感染
公开(公告)号：US20100323952A1
公开(公告)日：2010-12-23
申请号：US12871563
申请日：2010-08-30
申请人： Malcolm Richard Boyd
发明人： Malcolm Richard Boyd
IPC分类号： A61K38/13
CPC分类号： A61K31/57 , A61K31/522 , A61K31/573 , A61K31/66 , A61K31/675 , A61K38/13 , Y10S514/931 , Y10S514/934 , A61K31/52 , A61K2300/00
摘要： A pharmaceutical product comprising a nucleoside analogue active against herpes simplex virus, such as acyclovir/valaciclovir or peniclovir/famciclovir, and an immunosuppressant, as a combined preparation for simultaneous, separate or sequential use in the treatment and/or prevention of herpes simplex virus infections.
摘要翻译：包含针对单纯疱疹病毒的核苷类似物活性物质的药物产品，例如阿昔洛韦/伐昔洛韦或peniclovir /泛昔洛韦和免疫抑制剂，作为用于同时，分开或顺序用于治疗和/或预防单纯疱疹病毒感染的组合制剂。

2. 发明申请

US20080287389A1 Nucleoside analogs in combination therapy of herpes simplex infections 审中-公开
标题翻译：核苷类似物联合治疗单纯疱疹感染
公开(公告)号：US20080287389A1
公开(公告)日：2008-11-20
申请号：US12217193
申请日：2008-07-02
申请人： Malcolm Richard Boyd
发明人： Malcolm Richard Boyd
IPC分类号： A61K31/70 , A61P31/00
CPC分类号： A61K31/57 , A61K31/522 , A61K31/573 , A61K31/66 , A61K31/675 , A61K38/13 , Y10S514/931 , Y10S514/934 , A61K31/52 , A61K2300/00
摘要： A pharmaceutical product comprising a nucleoside analogue active against herpes simplex virus, such as acyclovir/valaciclovir or peniclovir/famciclovir, and an immunosuppressant, as a combined preparation for simultaneous, separate or sequential use in the treatment and/or prevention of herpes simplex virus infections.
摘要翻译：包含针对单纯疱疹病毒的核苷类似物活性物质的药物产品，例如阿昔洛韦/伐昔洛韦或peniclovir /泛昔洛韦和免疫抑制剂，作为用于同时，分开或顺序用于治疗和/或预防单纯疱疹病毒感染的组合制剂。

3. 发明授权

US07419807B2 Chlamydia protein, gene sequence and uses thereof 失效
标题翻译：衣原体蛋白，基因序列及其用途
公开(公告)号：US07419807B2
公开(公告)日：2008-09-02
申请号：US10701844
申请日：2003-11-04
申请人： W. James Jackson , John L. Pace
发明人： W. James Jackson , John L. Pace
IPC分类号： C12P21/08 , C12N5/12 , C07H21/04 , C07K16/00 , A61K39/118
CPC分类号： G01N33/56927 , A61K38/00 , A61K39/00 , C07K14/295 , C07K16/125 , G01N2333/295 , Y10S514/885 , Y10S514/931 , Y10S514/937 , Y10S530/811 , Y10S530/814 , Y10S530/82
摘要： A high molecular weight (“HMW”) protein of Chlamydia, the amino acid sequence thereof, and antibodies that specifically bind the HMW protein are disclosed as well as the nucleic acid sequence encoding the same. Also disclosed are prophylactic and therapeutic compositions, comprising the HMW protein, a fragment thereof, or an antibody that specifically binds the HMW protein or a portion thereof, or the nucleotide sequence encoding the HMW protein or a fragment thereof, including vaccines.
摘要翻译：公开了衣原体的高分子量（“HMW”）蛋白，其氨基酸序列和特异性结合HMW蛋白的抗体以及编码该HMW蛋白的核酸序列。还公开了包含HMW蛋白，其片段或特异性结合HMW蛋白或其部分的抗体或编码HMW蛋白或其片段（包括疫苗）的核苷酸序列的预防和治疗组合物。

4. 发明授权

US07135195B2 Treatment of humans with colloidal silver composition 有权
标题翻译：用胶体银组合物治疗人体
公开(公告)号：US07135195B2
公开(公告)日：2006-11-14
申请号：US10641938
申请日：2003-08-15
申请人： Robert J. Holladay , Herbert Christensen , William D. Moeller
发明人： Robert J. Holladay , Herbert Christensen , William D. Moeller
IPC分类号： A61K33/38 , A61K33/40 , A61K9/10 , A61K9/14 , A01N25/12 , A01N25/26 , A01N59/16 , A01N59/00 , A61P11/00 , A61P13/00 , A61P15/00 , A61P15/02 , A61P17/00 , A61P31/00 , A61P31/02 , A61P31/04 , A61P31/10
CPC分类号： A61K9/0046 , A61K9/0014 , A61K9/0034 , A61K9/0043 , A61K9/0095 , A61K33/38 , A61K33/40 , A61K45/06 , A61K47/10 , A61K47/32 , A61L2/16 , A61L2/186 , A61L2/238 , B01F7/22 , B01F13/0001 , B01F13/0003 , B01J13/0043 , B01J19/087 , B01J19/18 , B01J2219/082 , B01J2219/0835 , B01J2219/0841 , B01J2219/089 , C02F1/4606 , C02F2303/04 , Y10S514/849 , Y10S514/858 , Y10S514/894 , Y10S514/895 , Y10S514/924 , Y10S514/931 , Y10S514/932 , Y10S514/934 , Y10S514/951 , A61K2300/00
摘要： We disclose a colorless composition comprising silver particles and water, wherein said particles comprise an interior of elemental silver and an exterior of ionic silver oxide, wherein the silver particles are present in the water at a level of about 5–40 ppm, and wherein the composition manifests significant antimicrobial properties. Methods of use of the composition are described.
摘要翻译：我们公开了包含银颗粒和水的无色组合物，其中所述颗粒包含元素银的内部和离子氧化银的外部，其中银颗粒以约5-40ppm的水平存在于水中，并且其中组合表现出显着的抗菌性能。描述了组合物的使用方法。

5. 发明授权

US06887843B1 Chlamydia protein, gene sequence and uses thereof 失效
标题翻译：衣原体蛋白，基因序列及其用途
公开(公告)号：US06887843B1
公开(公告)日：2005-05-03
申请号：US09542520
申请日：2000-04-03
申请人： W. James Jackson , John L. Pace
发明人： W. James Jackson , John L. Pace
IPC分类号： G01N33/563 , A61K31/711 , A61K38/00 , A61K39/00 , A61K39/118 , A61K39/395 , A61K39/40 , A61K48/00 , A61P31/04 , A61P43/00 , C07K14/295 , C07K16/12 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/09 , C12Q1/68 , G01N33/569 , G01N33/571 , A01N25/00 , A61K39/02 , A61K39/38
CPC分类号： G01N33/56927 , A61K38/00 , A61K39/00 , C07K14/295 , C07K16/125 , G01N2333/295 , Y10S514/885 , Y10S514/931 , Y10S514/937 , Y10S530/811 , Y10S530/814 , Y10S530/82
摘要： A high molecular weight (“HMW”) protein of Chlamydia, the amino acid sequence thereof, and antibodies that specifically bind the HMW protein are disclosed as well as the nucleic acid sequence encoding the same. Also disclosed are prophylactic and therapeutic compositions, comprising the HMW protein, a fragment thereof, or an antibody that specifically binds the HMW protein or a protein thereof, or the nucleotide sequence encoding the HMW protein or a fragment thereof, including vaccines.
摘要翻译：公开了衣原体的高分子量（“HMW”）蛋白，其氨基酸序列和特异性结合HMW蛋白的抗体以及编码该HMW蛋白的核酸序列。还公开了包含HMW蛋白，其片段或特异性结合HMW蛋白或其蛋白质的抗体或编码HMW蛋白或其片段（包括疫苗）的核苷酸序列的预防和治疗组合物。

6. 发明授权

US06730329B1 Zinc containing compositions for anti-viral use 失效
标题翻译：含锌组合物用于抗病毒用途
公开(公告)号：US06730329B1
公开(公告)日：2004-05-04
申请号：US10083007
申请日：2002-02-26
申请人： Jeffrey B. Smith
发明人： Jeffrey B. Smith
IPC分类号： A61K3160
CPC分类号： A61K9/0014 , A61K9/0034 , A61K31/01 , A61K31/045 , A61K31/05 , A61K31/315 , A61K31/60 , A61K33/30 , A61K36/886 , A61K45/06 , A61K47/06 , A61K47/10 , A61K47/14 , A61K47/44 , Y10S514/886 , Y10S514/887 , Y10S514/931 , Y10S514/932 , Y10S514/933 , Y10S514/934 , Y10S514/937 , Y10S514/938 , Y10S514/939 , Y10S514/944 , Y10S514/967 , Y10S514/969 , Y10S514/97 , A61K2300/00
摘要： One aspect of the invention relates to anti-viral composition containing at least one zinc compound and at least one phenolic antioxidant (and optionally other ingredients such as at least one analgesic) at least one hydrocarbyl containing compound, and water. Another aspect of the invention relates to a method of treating lesionous symptoms of a viral infection involving applying an effective amount of the zinc containing anti-viral composition to the lesions.
摘要翻译：本发明的一个方面涉及含有至少一种锌化合物和至少一种酚类抗氧化剂（和任选的其它成分，例如至少一种止痛剂）至少一种含烃化合物和水的抗病毒组合物。本发明的另一方面涉及一种治疗病毒感染病变症状的方法，其涉及将有效量的含锌抗病毒组合物施用于病变。

7. 发明授权

US06586404B1 Pharmaceutical preparations of glutathione and methods of administration thereof 有权
公开(公告)号：US06586404B1
公开(公告)日：2003-07-01
申请号：US10200852
申请日：2002-07-22
申请人： Harry B. Demopolos , Myron L. Seligman
发明人： Harry B. Demopolos , Myron L. Seligman
IPC分类号： A61K3100
CPC分类号： A61L2/16 , A61K9/0034 , A61K9/0048 , A61K9/4858 , A61K31/195 , A61K31/54 , A61K31/715 , A61K38/063 , A61K45/06 , A61K47/22 , Y10S514/824 , Y10S514/851 , Y10S514/866 , Y10S514/879 , Y10S514/885 , Y10S514/894 , Y10S514/912 , Y10S514/913 , Y10S514/931 , Y10S514/934 , Y10S514/944 , Y10S514/962 , Y10S514/97 , A61K31/165 , A61K2300/00 , A61K31/375
摘要： A method for the administration of glutathione orally comprising the administration of a bolus of glutathione which is pharmaceutically stabilized and encapsulated. The glutathione is administered on an empty stomach. The preferred stabilizer is ascorbic acid.

8. 发明申请

US20020128227A1 Beta-cyclodextrin compositions, and use to prevent transmission of sexually transmitted diseases 有权
标题翻译： β-环糊精组合物，用于预防性传播疾病的传播
公开(公告)号：US20020128227A1
公开(公告)日：2002-09-12
申请号：US09802779
申请日：2001-03-08
发明人： James E. Hildreth
IPC分类号： A61K031/724
CPC分类号： A61K45/06 , A61K9/0034 , A61K31/724 , Y10S514/841 , Y10S514/931 , Y10S514/934 , A61K2300/00
摘要： Methods of reducing the risk of transmission of a sexually transmitted pathogen by contacting the pathogen or cells susceptible to infection by the pathogen with a null-cyclodextrin are provided. Methods for reducing the risk of transmission of a sexually transmitted pathogen to or from a subject by contacting the pathogen or cells susceptible to the pathogen in the subject with a pharmaceutical composition containing a null-cyclodextrin also are provided. Accordingly, pharmaceutical compositions, which include 1) a null-cyclodextrin, which is in an amount that blocks passage of the pathogen through lipid rafts in the membrane of a cell susceptible to the pathogen, and 2) a contraceptive, an agent for treating a sexually transmitted disease, a lubricant, or a combination thereof, are provided, as are composition formulated from a solid substrate that contains an amount of null-cyclodextrin useful for reducing the risk of transmission of a sexually transmitted pathogen.
摘要翻译：提供了通过使病原体或易受病原体感染的细胞与β-环糊精接触来降低性传播病原体传播风险的方法。还提供了通过使受试者中易感染病原体的病原体与含有β-环糊精的药物组合物接触来降低向受试者传播性传播病原体的风险的方法。因此，药物组合物包括1）β-环糊精，其量阻止病原体通过脂质筏在对病原体敏感的细胞膜中，以及2）避孕药，用于治疗提供性传播疾病，润滑剂或其组合，以及由固体底物配制的组合物，其含有一定量的β-环糊精，其可用于降低性传播病原体的传播风险。

9. 发明授权

US06350467B1 Pharmaceutical preparations of glutathione and methods of administration thereof 有权
标题翻译：谷胱甘肽的药物制剂及其施用方法
公开(公告)号：US06350467B1
公开(公告)日：2002-02-26
申请号：US09331947
申请日：1999-06-28
申请人： Harry B. Demopoulos , Myron L. Seligman
发明人： Harry B. Demopoulos , Myron L. Seligman
IPC分类号： A61K920
CPC分类号： A61L2/16 , A61K9/0034 , A61K9/0048 , A61K9/4858 , A61K31/195 , A61K31/54 , A61K31/715 , A61K38/063 , A61K45/06 , A61K47/22 , Y10S514/824 , Y10S514/851 , Y10S514/866 , Y10S514/879 , Y10S514/885 , Y10S514/894 , Y10S514/912 , Y10S514/913 , Y10S514/931 , Y10S514/934 , Y10S514/944 , Y10S514/962 , Y10S514/97 , A61K31/165 , A61K2300/00 , A61K31/375
摘要： A method of increasing glutathione levels in mammalian cells comprising administering an oral bolus of encapsulated pharmaceutically stabilized glutathione in a rapidly dissolving formulation to a mammal on an empty stomach. Pharmaceutical formulations including glutathione are also disclosed.
摘要翻译：一种在哺乳动物细胞中增加谷胱甘肽水平的方法，包括在空腹时向快速溶解的制剂中向哺乳动物施用口服胶囊化药物稳定的谷胱甘肽。还公开了包括谷胱甘肽的药物制剂。

10. 发明授权

US06316433B1 Method for treatment of bacterial infections with once or twice-weekly administered rifalazil 有权
标题翻译：用一周或两周施用的里法拉唑治疗细菌感染的方法
公开(公告)号：US06316433B1
公开(公告)日：2001-11-13
申请号：US09464353
申请日：1999-12-15
申请人： Lynn M. Rose , David J. Porubek , Alan B. Montgomery
发明人： Lynn M. Rose , David J. Porubek , Alan B. Montgomery
IPC分类号： A61K3133
CPC分类号： A61K31/538 , A61K31/00 , A61K31/70 , C10M101/025 , C10M103/06 , C10M105/14 , C10M105/24 , C10M107/34 , C10M107/36 , C10M111/00 , C10M2201/0603 , C10M2201/0613 , C10M2201/0623 , C10M2201/0653 , C10M2201/0663 , C10M2201/0803 , C10M2201/0853 , C10M2201/0863 , C10M2201/0873 , C10M2201/1006 , C10M2201/1023 , C10M2201/1033 , C10M2201/1053 , C10M2201/123 , C10M2205/143 , C10M2205/163 , C10M2205/173 , C10M2205/183 , C10M2207/0225 , C10M2207/1203 , C10M2207/1213 , C10M2207/1253 , C10M2207/163 , C10M2207/183 , C10M2207/203 , C10M2207/243 , C10M2209/1033 , C10M2209/1045 , C10M2209/1055 , C10M2209/1065 , C10M2209/1075 , C10M2209/1085 , C10M2209/1095 , C10M2209/123 , Y10S514/924 , Y10S514/931 , A61K2300/00
摘要： A method for treatment of bacterial infections with rifalazil administered once-weekly or twice-weekly. A method for treatment of tuberculosis caused by Mycobacterium tuberculosis, infections caused by Mycobacterium avium complex, infections caused by Chlamydia pneumoniae and infections caused by Helicobacter pylori by administering to a patient suffering from the bacterial infection 1-100 mg of rifalazil once or twice a week. In this dose regimen, the treatment is fast, efficacious and eliminates undesirable secondary symptoms observed with daily doses of 1-50 mg of rifalazil.
摘要翻译：一种每周或每周两次施用利福拉齐治疗细菌感染的方法。一种治疗由结核分枝杆菌引起的结核病，由分枝杆菌复合体引起的感染，肺炎衣原体引起的感染和幽门螺杆菌感染引起的感染的方法，通过对患有细菌感染的患者施用1-100mg的利福拉齐，每周一次或两次。在这种剂量方案中，治疗是快速，有效的，并且消除了每日剂量的1-50mg利福肼的不期望的继发症状。

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