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    • 62. 发明授权
    • Nano-enhanced Raman spectroscopy substrate packaging structure
    • 纳米增强拉曼光谱基板封装结构
    • US08330951B2
    • 2012-12-11
    • US11413516
    • 2006-04-28
    • Zhiyong LiWilliam M. TongR. Stanley Williams
    • Zhiyong LiWilliam M. TongR. Stanley Williams
    • G01J3/44G01N33/00G01N21/62H01J9/12
    • G01N21/658Y10T428/218Y10T428/28
    • Packaged NERS-active structures are disclosed that include a NERS substrate having a NERS-active structure thereon, and a packaging substrate over the NERS substrate having an opening therethrough, the opening in alignment with the NERS-active structure. A membrane may cover the opening in the packaging substrate. In order to perform nanoenhanced Raman spectroscopy, the membrane may be removed, and an analyte placed on the NERS substrate adjacent the NERS-active structure. The membrane may be replaced with another membrane after the analyte has been placed on the substrate. The membrane may maintain the pristine state of the substrate before it is deployed, and the replacement membrane may preserve the substrate and analyte for archival purposes. Also disclosed are methods for performing NERS with packaged NERS-active structures.
    • 公开了封装的NERS-活性结构,其包括其上具有NERS-活性结构的NERS衬底和在NERS衬底上的具有穿过其中的开口的封装衬底,该开口与NERS-活性结构对准。 膜可以覆盖封装衬底中的开口。 为了进行纳米增强拉曼光谱,可以去除膜,并将分析物放置在邻近NERS-活性结构的NERS衬底上。 在将分析物放置在基底上之后,膜可以用另一膜替代。 膜可以在其被部署之前保持基材的原始状态,并且替换膜可以保留底物和分析物用于归档目的。 还公开了使用封装的NERS-活性结构来执行NERS的方法。
    • 63. 发明授权
    • Compact sensor system
    • 紧凑型传感器系统
    • US08319963B2
    • 2012-11-27
    • US12772063
    • 2010-04-30
    • Min HuWei WuFung Suong OuZhen PengZhiyong LiR. Stanley Williams
    • Min HuWei WuFung Suong OuZhen PengZhiyong LiR. Stanley Williams
    • G01J3/44
    • G01N21/658G01N21/7746
    • A compact sensor system comprising: an analysis cell configured for photon-matter interaction, where photons are received from a light source; and an integrated-optical spectral analyzer configured for identifying a set of frequencies, the integrated-optical spectral analyzer comprising: a waveguide coupled with the analysis cell, the waveguide configured for propagating a set of frequencies through the waveguide; one or more ring resonators coupled with the waveguide, the one or more ring resonators comprising a predetermined bandwidth and configured for capturing the set of frequencies corresponding to frequencies within the predetermined bandwidth; and one or more frequency detectors coupled with the one or more tunable ring resonators, the one or more frequency detectors configured for generating electrical signals that identify each of the set of frequencies.
    • 一种紧凑的传感器系统,包括:配置用于光子 - 物质相互作用的分析单元,其中从光源接收光子; 所述集成光谱分析仪包括:与所述分析单元耦合的波导,所述波导被配置为通过所述波导传播一组频率;以及波导,其被配置为用于识别一组频率。 一个或多个与所述波导耦合的环形谐振器,所述一个或多个环形谐振器包括预定带宽并被配置用于捕获与所述预定带宽内的频率相对应的频率集合; 以及与所述一个或多个可调环形谐振器耦合的一个或多个频率检测器,所述一个或多个频率检测器被配置用于产生标识所述一组频率中的每一个的电信号。
    • 66. 发明授权
    • Vibrating tip surface enhanced Raman spectroscopy
    • 振动尖端表面增强拉曼光谱
    • US08243270B2
    • 2012-08-14
    • US12697156
    • 2010-01-29
    • Huei Pei KuoMichael J. StukeMin HuFung Suong OuShih-Yuan (SY) WangAlexandre M. BratkovskiWei WuZhiyong Li
    • Huei Pei KuoMichael J. StukeMin HuFung Suong OuShih-Yuan (SY) WangAlexandre M. BratkovskiWei WuZhiyong Li
    • G01J3/44
    • G01J3/44
    • A vibrating tip surface enhanced Raman spectroscopy (SERS) apparatus, system and method employ a nano-needle configured to vibrate. The apparatus includes the nano-needle with a substantially sharp tip at a free end opposite an end attached to a substrate. The tip is configured to adsorb an analyte. The apparatus further includes a vibration source configured to provide an alternating current (AC) electric field that induces a vibration of the free end and the tip of the nano-needle. Vibration of the nano-needle under the influence of the AC electric field facilitates detection of a Raman scattering signal from the analyte adsorbed on the nano-needle tip. The system further includes a synchronous detector configured to be gated cooperatively with the vibration of the nano-needle. The method includes inducing the vibration, illuminating the vibrating tip to produce a Raman signal, and detecting the Raman signal using the detector.
    • 振动尖端表面增强拉曼光谱(SERS)装置,系统和方法采用配置为振动的纳米针。 该装置包括在与连接到基底的端相对的自由端处具有基本尖锐的尖端的纳米针。 尖端构造成吸附分析物。 该装置还包括一个被配置为提供交流(AC)电场的振动源,其引起自由端和纳米针的尖端的振动。 在AC电场的影响下,纳米针的振动有助于检测吸附在纳米针尖上的分析物的拉曼散射信号。 该系统还包括配置为与纳米针的振动协同地选通的同步检测器。 该方法包括引起振动,照亮振动尖端以产生拉曼信号,并使用检测器检测拉曼信号。
    • 67. 发明申请
    • RECONFIGURABLE SURFACE ENHANCED RAMAN SPECTROSCOPY APPARATUS, SYSTEM AND METHOD
    • 可重构表面增强拉曼光谱仪,系统和方法
    • US20120188540A1
    • 2012-07-26
    • US13014688
    • 2011-01-26
    • Alexandre M. BratkovskiWei WuZhiyong Li
    • Alexandre M. BratkovskiWei WuZhiyong Li
    • G01J3/44B82Y20/00
    • G01N21/658B82Y20/00
    • A reconfigurable surface enhanced Raman spectroscopy (SERS) apparatus, system and method employ a stimulus responsive material to move nanorods of a plurality between inactive and active configurations. The apparatus includes the plurality of nanorods and the stimulus responsive material. The system further includes a Raman signal detector. The method of reconfigurable SERS includes providing the plurality of nanorods and exposing the stimulus responsive material to a stimulus. The exposure causes a change in one or more of a size, a shape and a volume of the stimulus responsive material that moves the nanorods between the inactive and active configurations. The active configuration facilitates one or both of production and detection of a Raman scattering signal emitted by the analyte.
    • 可重新配置的表面增强拉曼光谱(SERS)装置,系统和方法使用刺激响应材料来移动多个非活动和活动配置之间的纳米棒。 该装置包括多个纳米棒和刺激响应材料。 该系统还包括拉曼信号检测器。 可重新配置的SERS的方法包括提供多个纳米棒并将刺激响应材料暴露于刺激。 暴露导致在非活性和活动配置之间移动纳米棒的刺激响应材料的尺寸,形状和体积中的一种或多种的变化。 活性配置有利于分析物发射的拉曼散射信号的生成和检测中的一个或两个。