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61. 发明申请

US20120113419A1 NANOWIRE-BASED SYSTEMS FOR PERFORMING RAMAN SPECTROSCOPY 有权
标题翻译：用于执行拉曼光谱的基于纳米级的系统
公开(公告)号：US20120113419A1
公开(公告)日：2012-05-10
申请号：US13383387
申请日：2009-07-30
申请人： Shih-Yuan Wang , Jingjing Li , Huei Pei Kuo , David A. Fattal , Nobuhiko Kobayashi , Zhiyong Li
发明人： Shih-Yuan Wang , Jingjing Li , Huei Pei Kuo , David A. Fattal , Nobuhiko Kobayashi , Zhiyong Li
IPC分类号： G01J3/44 , B82Y99/00
CPC分类号： G01N21/658 , B82Y15/00 , G01J3/44
摘要： Embodiments of the present invention are directed to nanowire-based systems for performing surface-enhanced Raman spectroscopy. In one embodiment, a system comprises a substrate (102) having a surface and a plurality of tapered nanowires (104) disposed on the surface. Each nanowire has a tapered end directed away from the surface. The system also includes a plurality of nanoparticles (110) disposed near the tapered end of each nanowire. When each nanowire is illuminated with light of a pump wavelength, Raman excitation light is emitted from the tapered end of the nanowire to interact with the nanoparticles and produce enhanced Raman scattered light from molecules located in close proximity to the nanoparticles.
摘要翻译：本发明的实施方案涉及用于进行表面增强拉曼光谱的基于纳米线的系统。在一个实施例中，系统包括具有表面的基板（102）和设置在表面上的多个锥形纳米线（104）。每个纳米线具有远离表面的锥形端。该系统还包括在每个纳米线的锥形端附近设置的多个纳米颗粒（110）。当每个纳米线被泵浦波长的光照射时，拉曼激发光从纳米线的锥形端发射以与纳米颗粒相互作用，并从位于紧邻纳米颗粒的分子产生增强的拉曼散射光。

62. 发明申请

US20120105841A1 APPARATUS FOR PERFORMING SERS 有权
标题翻译：执行人员的设备
公开(公告)号：US20120105841A1
公开(公告)日：2012-05-03
申请号：US12915148
申请日：2010-10-29
申请人： Min Hu , Michael Josef Stuke , Zhiyong Li , Wei Wu , Fung Suong Ou , Shih-Yuan Wang , Lars Helge Thylen
发明人： Min Hu , Michael Josef Stuke , Zhiyong Li , Wei Wu , Fung Suong Ou , Shih-Yuan Wang , Lars Helge Thylen
IPC分类号： G01J3/44
CPC分类号： G01J3/44 , G01N21/658
摘要： An apparatus for performing surface enhanced Raman spectroscopy (SERS) includes a substrate and a plurality of nano-pillars, each of the plurality of nano-pillars having a first end attached to the substrate, a second end located distally from the substrate, and a body portion extending between the first end and the second end, in which the plurality of nano-pillars are arranged in an array on the substrate, and in which each of the plurality of nano-pillars is formed of a polymer material that is functionalized to expand in the presence of a fluid to cause gaps between the plurality of nano-pillars to shrink when the fluid is supplied onto the nano-pillars.
摘要翻译：用于进行表面增强拉曼光谱（SERS）的设备包括基底和多个纳米柱，多个纳米柱中的每一个具有连接到基底的第一端，位于远离基底的第二端，以及主体部分在所述第一端和所述第二端之间延伸，其中所述多个纳米柱以阵列布置在所述基底上，并且所述多个纳米柱中的每一个由聚合物材料形成，所述聚合物材料被官能化为在存在流体的情况下膨胀，以便当将流体供应到纳米支柱上时，使多个纳米柱之间的间隙收缩。

63. 发明申请

US20120105840A1 SENSING DEVICE AND METHOD PRODUCING A RAMAN SIGNAL 有权
标题翻译：感测装置和产生拉曼信号的方法
公开(公告)号：US20120105840A1
公开(公告)日：2012-05-03
申请号：US12914655
申请日：2010-10-28
申请人： Michael Josef Stuke , Shih-Yuan Wang , Zhiyong Li
发明人： Michael Josef Stuke , Shih-Yuan Wang , Zhiyong Li
IPC分类号： G01J3/44 , B82Y15/00
CPC分类号： B82Y15/00 , G01N21/65 , G01N21/658
摘要： A sensing device that produces a Raman signal includes micro-rods or nano-rods arranged on a substrate in a two-dimensional (2D) array, each of the rods having a length in a single row being substantially the same, with the rod length of each row being different from the rod length of each other row. Each row of rods has a respective resonant vibration frequency that varies from row to row. A source of vibration energy, operatively connected to the substrate, excites vibration in each of the rods such that a responding row resonates when an exciting frequency approaches the resonant vibration frequency of the responding row. A method includes exposing the 2D array to a light source and analyzing Raman scattering at each rod of the 2D array to render a Raman map.
摘要翻译：产生拉曼信号的感测装置包括以二维（2D）阵列布置在基底上的微棒或纳米棒，每根棒具有基本上相同的长度，其中棒长度每行的距离与每隔一行的杆长度不同。每排棒具有相应的谐振振动频率，其逐行变化。可操作地连接到基板的振动能量源激发每个杆中的振动，使得当激励频率接近响应行的谐振振动频率时，响应行谐振。一种方法包括将2D阵列暴露于光源并分析2D阵列的每个杆处的拉曼散射以呈现拉曼图。

64. 发明申请

US20120092660A1 APPARATUS FOR PERFORMING SERS 有权
标题翻译：执行人员的设备
公开(公告)号：US20120092660A1
公开(公告)日：2012-04-19
申请号：US12905891
申请日：2010-10-15
申请人： Wei Wu , Zhiyong Li , Shih-Yuan Wang , Michael Josef Stuke , Lars Helge Thylen , Fung Suong Ou , Min Hu
发明人： Wei Wu , Zhiyong Li , Shih-Yuan Wang , Michael Josef Stuke , Lars Helge Thylen , Fung Suong Ou , Min Hu
IPC分类号： G01J3/44
CPC分类号： G01N21/658
摘要： An apparatus for performing SERS includes a substrate and flexible nano-fingers, each of the nano-fingers having a first end attached to the substrate, a free second end, and a body portion extending between the first end and the second end, in which the nano-fingers are arranged in an array on the substrate. The apparatus also includes an active material layer disposed on each of the second ends of the plurality of nano-fingers, in which the nano-fingers are to be in a substantially collapsed state in which the active layers on at least two of the nano-fingers contact each other under dominant attractive forces between the plurality of nano-fingers and in which the active material layers are to repel each other when the active material layers are electrostatically charged.
摘要翻译：用于执行SERS的装置包括基底和柔性纳米指，每个纳米指具有连接到基底的第一端，自由的第二端和在第一端和第二端之间延伸的主体部分，其中纳米手指以阵列排列在基板上。该装置还包括设置在多个纳米手指的每个第二端上的活性材料层，其中纳米指状物将处于基本上塌陷的状态，其中在至少两个纳米手指上的活性层，手指在多个纳米手指之间的主导吸引力下彼此接触，并且当活性材料层被静电充电时，活性材料层将彼此排斥。

65. 发明申请

US20080094620A1 Systems and methods for detection of Raman scattered photons 有权
公开(公告)号：US20080094620A1
公开(公告)日：2008-04-24
申请号：US11584020
申请日：2006-10-20
申请人： Zhiyong Li , Wei Wu , Shih-Yuan Wang
发明人： Zhiyong Li , Wei Wu , Shih-Yuan Wang
IPC分类号： G01J3/44 , G01N21/65
CPC分类号： G01J3/44 , G01N21/658
摘要： Raman spectroscopy systems include an analyte, a radiation source configured to emit incident radiation having a wavelength, and a detector that is capable of detecting only radiation having wavelengths within a detectable range that includes at least one wavelength corresponding to hyper Raman scattered radiation scattered by the analyte. The wavelength of the incident radiation is outside the detectable range. In particular systems, all wavelengths of radiation that are scattered in the direction of the detector impinge on the detector. Raman spectroscopy methods include providing an analyte and irradiating the analyte with incident radiation having a wavelength, providing a detector capable of detecting only wavelengths of radiation within a detectable range that does not include the wavelength of the incident radiation, and detecting Raman scattered radiation scattered by the analyte. A continuous path free of radiation filters may be provided between the analyte and the detector.

66. 发明授权

US07339666B2 Light-amplifying structures and methods for surface-enhanced Raman spectroscopy 有权
标题翻译：用于表面增强拉曼光谱的光放大结构和方法
公开(公告)号：US07339666B2
公开(公告)日：2008-03-04
申请号：US10942079
申请日：2004-09-14
申请人： Shih-Yuan Wang , Zhiyong Li , M. Saif Islam
发明人： Shih-Yuan Wang , Zhiyong Li , M. Saif Islam
IPC分类号： G01J3/44
CPC分类号： G01N21/658
摘要： Structures for amplifying light include a resonant cavity in which an analyte may be positioned. The structures for amplifying light may be used to amplify the incident light employed in surface enhanced Raman spectroscopy (SERS). SERS systems employing the structures for amplifying light of the present invention and methods of performing SERS are also disclosed.
摘要翻译：用于放大光的结构包括其中可以定位分析物的谐振腔。用于放大光的结构可以用于放大表面增强拉曼光谱（SERS）中使用的入射光。还公开了采用本发明的光放大结构的SERS系统和执行SERS的方法。

67. 发明授权

US07245370B2 Nanowires for surface-enhanced Raman scattering molecular sensors 有权
标题翻译：纳米线用于表面增强拉曼散射分子传感器
公开(公告)号：US07245370B2
公开(公告)日：2007-07-17
申请号：US11030733
申请日：2005-01-06
申请人： Alexandre Bratkovski , M. Salf Islam , Theodore I. Kamins , Zhiyong Li , Shih-Yuan Wang
发明人： Alexandre Bratkovski , M. Salf Islam , Theodore I. Kamins , Zhiyong Li , Shih-Yuan Wang
IPC分类号： G01J3/44 , G01N21/65
CPC分类号： G01N21/658
摘要： A SERS-active structure is disclosed that includes a substrate and at least two nanowires disposed on the substrate. Each of the at least two nanowires has a first end and a second end, the first end being attached to the substrate and the second end having a SERS-active tip. A SERS system is also disclosed that includes a SERS-active structure. Also disclosed are methods for forming a SERS-active structure and methods for performing SERS with SERS-active structures.
摘要翻译：公开了一种SERS-活性结构，其包括衬底和设置在衬底上的至少两个纳米线。所述至少两个纳米线中的每一个具有第一端和第二端，所述第一端附接到所述基底，所述第二端具有SERS活性末端。还公开了包括SERS活性结构的SERS系统。还公开了形成SERS活性结构的方法和用SERS活性结构进行SERS的方法。

68. 发明申请

US20060275779A1 Method and apparatus for molecular analysis using nanowires 审中-公开
标题翻译：使用纳米线分子分析的方法和装置
公开(公告)号：US20060275779A1
公开(公告)日：2006-12-07
申请号：US11144588
申请日：2005-06-03
申请人： Zhiyong Li , Shih-Yuan Wang , Wei Wu , M. Islam
发明人： Zhiyong Li , Shih-Yuan Wang , Wei Wu , M. Islam
IPC分类号： C12Q1/68 , C12M1/34
CPC分类号： G01N33/48721 , B82Y5/00 , B82Y15/00
摘要： Devices and methods for detecting the constituent parts of biological polymers are disclosed. A molecular analysis device comprises a molecule sensor and a molecule guide. The molecule sensor comprises a nanowire operably coupling a first terminal and a second terminal and a nitrogenous material disposed on the nanowire. The nitrogenous material is configured to interact with an identifiable configuration of a molecule such that the molecule sensor develops a conductance change responsive to the interaction. The molecule guide is configured for guiding at least a portion of the molecule near the molecule sensor to enable the interaction.
摘要翻译：公开了用于检测生物聚合物的组成部分的装置和方法。分子分析装置包括分子传感器和分子引导件。分子传感器包括可操作地耦合第一端子和第二端子的纳米线和设置在纳米线上的含氮材料。含氮材料被配置为与分子的可识别构型相互作用，使得分子传感器响应于相互作用产生电导变化。分子引导件被配置用于引导分子传感器附近的分子的至少一部分以实现相互作用。

69. 发明申请

US20060243897A1 Composite material lens for optical trapping 审中-公开
标题翻译：用于光学捕获的复合材料透镜
公开(公告)号：US20060243897A1
公开(公告)日：2006-11-02
申请号：US11116657
申请日：2005-04-27
申请人： Shih-Yuan Wang , Zhiyong Li
发明人： Shih-Yuan Wang , Zhiyong Li
IPC分类号： H05H3/04
CPC分类号： G21K1/006
摘要： For manipulation of a specimen, the specimen and a focusing location of a composite material lens are brought into spatial coincidence. The composite material lens has at least one of a negative effective permittivity and a negative effective permeability at a frequency of an applied light beam. The composite material lens focuses the light beam toward the focusing location and forms an optical trap for the specimen.
摘要翻译：对于样品的操作，复合材料透镜的样品和聚焦位置变得空间重合。复合材料透镜在所施加的光束的频率处具有负的有效介电常数和负的有效磁导率中的至少一个。复合材料透镜将光束聚焦到聚焦位置并形成样品的光阱。

70. 发明授权

US07102747B2 In situ excitation for Surface Enhanced Raman Spectroscopy 失效
标题翻译：表面增强拉曼光谱的原位激发
公开(公告)号：US07102747B2
公开(公告)日：2006-09-05
申请号：US10964523
申请日：2004-10-13
申请人： Shih-Yuan Wang , Zhiyong Li , M. Saif Islam
发明人： Shih-Yuan Wang , Zhiyong Li , M. Saif Islam
IPC分类号： G01J3/44 , G01N21/65
CPC分类号： G01N21/658
摘要： Devices, systems, and methods using Surface Enhanced Raman Spectroscopy (SERS) are disclosed. A device for generating Raman scattered radiation comprises a laser source and a SERS-active structure. The laser source may be configured for emanating radiation from an emanating surface or by forming a depression in the laser source, which creates a region of increased evanescent field from the laser source. SERS systems and methods include a device for generating Raman scattered radiation with a detector configured to receive the Raman scattered radiation.
摘要翻译：公开了使用表面增强拉曼光谱（SERS）的器件，系统和方法。用于产生拉曼散射辐射的装置包括激光源和SERS-活性结构。激光源可以被配置用于从发射表面发射辐射，或者通过在激光源中形成凹陷，其产生从激光源增加的渐逝场的区域。 SERS系统和方法包括用配置成接收拉曼散射辐射的检测器产生拉曼散射辐射的装置。

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