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61. 发明申请

US20110081688A1 Water-Soluble Rhodamine Dyes Conjugates 有权
标题翻译：水溶性罗丹明染料缀合物
公开(公告)号：US20110081688A1
公开(公告)日：2011-04-07
申请号：US12855649
申请日：2010-08-12
申请人： Linda G. Lee , Ronald J. Graham , William E. Werner , Elana Swartzman , Lily Lu
发明人： Linda G. Lee , Ronald J. Graham , William E. Werner , Elana Swartzman , Lily Lu
IPC分类号： C12P19/34 , C07H19/04 , C07D498/14 , C07D498/22
CPC分类号： C07D491/04 , C07D311/80 , C07D491/06 , C07H19/207 , C07H21/00 , C09B11/24 , G01N33/582 , G01N2458/00 , Y10S436/80
摘要： The present invention provides novel, water-soluble, red-emitting fluorescent rhodamine dyes and red-emitting fluorescent energy-transfer dye pairs, as well as labeled conjugates comprising the same and methods for their use. The dyes, energy-transfer dye pairs and labeled conjugates are useful in a variety of aqueous-based applications, particularly in assays involving staining of cells, protein binding, and/or analysis of nucleic acids, such as hybridization assays and nucleic acid sequencing.
摘要翻译：本发明提供新颖的水溶性红色荧光罗丹明染料和红色发光荧光能量转移染料对，以及包含其的标记共轭物及其使用方法。染料，能量转移染料对和标记的缀合物可用于各种水基应用，特别是涉及细胞染色，蛋白质结合和/或核酸分析的测定，如杂交测定和核酸测序。

62. 发明授权

US07795042B2 Water-soluble rhodamine dye conjugates 有权
标题翻译：水溶性罗丹明染料共轭物
公开(公告)号：US07795042B2
公开(公告)日：2010-09-14
申请号：US12402634
申请日：2009-03-12
申请人： Linda G. Lee , Ronald J. Graham , William E. Werner , Elana Swartzman , Lily Lu
发明人： Linda G. Lee , Ronald J. Graham , William E. Werner , Elana Swartzman , Lily Lu
IPC分类号： G01N33/53 , C12Q1/68 , C07K2/00 , C07K14/00 , C07H21/02
CPC分类号： C07D491/04 , C07D311/80 , C07D491/06 , C07H19/207 , C07H21/00 , C09B11/24 , G01N33/582 , G01N2458/00 , Y10S436/80
摘要： The present invention provides novel, water-soluble, red-emitting fluorescent rhodamine dyes and red-emitting fluorescent energy-transfer dye pairs, as well as labeled conjugates comprising the same and methods for their use. The dyes, energy-transfer dye pairs and labeled conjugates are useful in a variety of aqueous-based applications, particularly in assays involving staining of cells, protein binding, and/or analysis of nucleic acids, such as hybridization assays and nucleic acid sequencing.
摘要翻译：本发明提供新颖的水溶性红色荧光罗丹明染料和红色发光荧光能量转移染料对，以及包含其的标记共轭物及其使用方法。染料，能量转移染料对和标记的缀合物可用于各种水基应用，特别是涉及细胞染色，蛋白质结合和/或核酸分析的测定，如杂交测定和核酸测序。

63. 发明申请

US20100047796A1 Reversible Terminator Nucleotides And Methods of Use 失效
标题翻译：可逆终止子核苷酸和使用方法
公开(公告)号：US20100047796A1
公开(公告)日：2010-02-25
申请号：US12493125
申请日：2009-06-26
申请人： Linda G. Lee , Gerald Zon
发明人： Linda G. Lee , Gerald Zon
IPC分类号： C12Q1/68 , C07H21/00 , C12P19/34
CPC分类号： C12Q1/6869 , C12Q2525/101 , C12Q2521/525
摘要： Disclosed herein a reversible terminator nucleotides and methods of use.
摘要翻译：本文公开了可逆终止子核苷酸和使用方法。

64. 发明申请

US20100029923A1 OLIGONUCLEOTIDES AND ANALOGS LABELED WITH ENERGY TRANSFER DYES 有权
标题翻译：标识与能量转运染色体的寡核苷酸和模拟物
公开(公告)号：US20100029923A1
公开(公告)日：2010-02-04
申请号：US12554845
申请日：2009-09-04
申请人： Linda G. Lee , Sandra L. Spurgeon , Barnett B. Rosenblum
发明人： Linda G. Lee , Sandra L. Spurgeon , Barnett B. Rosenblum
IPC分类号： C07H21/04
CPC分类号： C07H21/04 , C07D311/90
摘要： Novel linkers for linking a donor dye to an acceptor dye in an energy transfer fluorescent dye are provided. These linkers facilitate the efficient transfer of energy between a donor and acceptor dye in an energy transfer dye. One of these linkers for linking a donor dye to an acceptor dye in an energy transfer fluorescent dye has the general structure R21Z1C(O)R22R28 where R21 is a C1-5 alkyl attached to the donor dye, C(O) is a carbonyl group, Z1 is either NH, sulfur or oxygen, R22 is a substituent which includes an alkene, diene, alkyne, a five and six membered ring having at least one unsaturated bond or a fused ring structure which is attached to the carbonyl carbon, and R28 includes a functional group which attaches the linker to the acceptor dye.
摘要翻译：提供了用于将供体染料与能量转移荧光染料中的受体染料连接的新型接头。这些接头促进能量转移染料中供体和受体染料之间的能量的有效转移。用于将供体染料与能量转移荧光染料中的受体染料连接的这些接头之一具有通式结构R21Z1C（O）R22R28，其中R21是与供体染料连接的C 1-5烷基，C（O）是羰基 Z1是NH，硫或氧，R22是包含烯烃，二烯烃，炔烃，具有至少一个不饱和键的五元和六元环或连接到羰基碳上的稠环结构的取代基，R28 包括将接头连接到受体染料的官能团。

65. 发明授权

US07553949B2 Reversible terminator nucleotides and methods of use 失效
标题翻译：可逆终止子核苷酸和使用方法
公开(公告)号：US07553949B2
公开(公告)日：2009-06-30
申请号：US11763405
申请日：2007-06-14
申请人： Linda G. Lee , Gerald Zon
发明人： Linda G. Lee , Gerald Zon
IPC分类号： C07H21/00 , C07H21/02 , C12Q1/68 , C12P19/34
CPC分类号： C12Q1/6869 , C12Q2525/101 , C12Q2521/525
摘要： Disclosed herein a reversible terminator nucleotides and methods of use.
摘要翻译：本文公开了可逆终止子核苷酸和使用方法。

66. 发明申请

US20090062543A1 UV EXCITABLE FLUORESCENT ENERGY TRANSFER DYES 审中-公开
标题翻译：紫外线可激活荧光能量转运染料
公开(公告)号：US20090062543A1
公开(公告)日：2009-03-05
申请号：US12176302
申请日：2008-07-18
申请人： Linda G. Lee
发明人： Linda G. Lee
IPC分类号： C07D221/22 , C07D311/80
CPC分类号： C12Q1/6869 , C07H19/10 , C07H19/20 , C07H21/00 , C07H21/04 , C09B11/24 , C12Q1/6818 , C12Q2563/107
摘要： Novel energy transfer dyes which can be used with shorter wavelength light sources are provided. These dyes include a donor dye with an absorption maxima at a wavelength between about 250 to 450 nm and an acceptor dye which is capable of absorbing energy emitted from the donor dye. One of the energy transfer dyes has a donor dye which is a member of a class of dyes having a coumarin or pyrene ring structure and an acceptor dye which is capable of absorbing energy emitted from the donor dye, wherein the donor dye has an absorption maxima between about 250 and 450 nm and the acceptor dye has an emission maxima at a wavelength greater than about 500 nm.
摘要翻译：提供了可用于较短波长光源的新型能量转移染料。这些染料包括在约250至450nm之间的波长处具有最大吸收的供体染料和能够吸收从供体染料发射的能量的受体染料。能量转移染料之一具有供体染料，其是具有香豆素或芘环结构的一类染料的成员和能够吸收从供体染料发射的能量的受体染料，其中供体染料具有吸收最大值在约250和450nm之间，受体染料具有波长大于约500nm的发射最大值。

67. 发明授权

US07402671B2 UV excitable fluorescent energy transfer dyes 有权
标题翻译：紫外线激发荧光能量转移染料
公开(公告)号：US07402671B2
公开(公告)日：2008-07-22
申请号：US11372544
申请日：2006-03-10
申请人： Linda G. Lee
发明人： Linda G. Lee
IPC分类号： C07D213/00 , C07D215/00 , C07D221/22 , C07D263/62 , C12Q1/68 , C07H19/04
CPC分类号： C12Q1/6869 , C07H19/10 , C07H19/20 , C07H21/00 , C07H21/04 , C09B11/24 , C12Q1/6818 , C12Q2563/107
摘要： Novel energy transfer dyes which can be used with shorter wavelength light sources are provided. These dyes include a donor dye with an absorption maxima at a wavelength between about 250 to 450 nm and an acceptor dye which is capable of absorbing energy emitted from the donor dye. One of the energy transfer dyes has a donor dye which is a member of a class of dyes having a coumarin or pyrene ring structure and an acceptor dye which is capable of absorbing energy emitted from the donor dye, wherein the donor dye has an absorption maxima between about 250 and 450 nm and the acceptor dye has an emission maxima at a wavelength greater than about 500 nm.
摘要翻译：提供了可用于较短波长光源的新型能量转移染料。这些染料包括在约250至450nm之间的波长处具有最大吸收的供体染料和能够吸收从供体染料发射的能量的受体染料。能量转移染料之一具有供体染料，其是具有香豆素或芘环结构的一类染料的成员和能够吸收从供体染料发射的能量的受体染料，其中供体染料具有吸收最大值在约250和450nm之间，受体染料具有波长大于约500nm的发射最大值。

68. 发明授权

US07388092B2 Oligonucleotides and analogs labeled with energy transfer dyes 失效
标题翻译：用能量转移染料标记的寡核苷酸和类似物
公开(公告)号：US07388092B2
公开(公告)日：2008-06-17
申请号：US11617665
申请日：2006-12-28
申请人： Linda G. Lee , Sandra L. Spurgeon , Barnett Rosenblum
发明人： Linda G. Lee , Sandra L. Spurgeon , Barnett Rosenblum
IPC分类号： C07H21/04 , C07H19/04 , C12Q1/68
CPC分类号： C07H21/04 , C07H21/00 , C09B11/24 , C12Q1/6818
摘要： Novel linkers for linking a donor dye to an acceptor dye in an energy transfer fluorescent dye are provided. These linkers faciliate the efficient transfer of energy between a donor and acceptor dye in an energy transfer dye. One of these linkers for linking a donor dye to an acceptor dye in an energy transfer fluorescent dye has the general structure R21Z1C(O)R22R28 where R21 is a C1-5 alkyl attached to the donor dye, C(O) is a carbonyl group, Z1 is either NH, sulfur or oxygen, R22 is a substituent which includes an alkene, diene, alkyne, a five and six membered ring having at least one unsaturated bond or a fused ring structure which is attached to the carbonyl carbon, and R28 includes a functional group which attaches the linker to the acceptor dye.
摘要翻译：提供了用于将供体染料与能量转移荧光染料中的受体染料连接的新型接头。这些连接器有助于在能量转移染料中的供体和受体染料之间的能量的有效转移。用于将供体染料与能量转移荧光染料中的受体染料连接的这些接头之一具有通式结构R 21 R 1 C（O）R 22 其中R 21是与供体染料连接的C 1-5烷基，C（O）是羰基（C 1 -C 4）烷基，基团Z 1是NH，硫或氧，R 22是包括烯烃，二烯烃，炔烃，具有至少一个碳原子的五元和六元环的取代基不饱和键或与羰基碳连接的稠合环结构，R 28包括将接头连接于受体染料的官能团。

69. 发明授权

US06448407B1 Atropisomers of asymmetric xanthene fluorescent dyes and methods of DNA sequencing and fragment analysis 失效
标题翻译：不对称呫吨荧光染料的倾向异构体和DNA测序和片段分析方法
公开(公告)号：US06448407B1
公开(公告)日：2002-09-10
申请号：US09704966
申请日：2000-11-01
申请人： Linda G. Lee , Meng C. Taing , Barnett B. Rosenblum
发明人： Linda G. Lee , Meng C. Taing , Barnett B. Rosenblum
IPC分类号： C07D31182
CPC分类号： C07H19/10 , C07H19/20 , C07H21/00 , C07H21/04 , C09B11/08 , C09B11/24 , G01N33/533
摘要： Substantially pure atropisomers of xanthene compounds are disclosed. A variety of molecular biology applications utilize atropisomeric xanthene fluorescent dyes as labels for substrates such as nucleotides, nucleosides, polynucleotides, polypeptides and carbohydrates. Methods include DNA sequencing, DNA fragment analysis, PCR, SNP analysis, oligonucleotide ligation, amplification, minisequencing, and primer extension.
摘要翻译：公开了呫吨化合物的基本纯的阻转异构体。各种分子生物学应用利用无异构呫吨荧光染料作为底物的标记，例如核苷酸，核苷，多核苷酸，多肽和碳水化合物。方法包括DNA测序，DNA片段分析，PCR，SNP分析，寡核苷酸连接，扩增，minisequencing和引物延伸。

70. 发明授权

US06372907B1 Water-soluble rhodamine dye peptide conjugates 有权
标题翻译：水溶性罗丹明染料肽缀合物
公开(公告)号：US06372907B1
公开(公告)日：2002-04-16
申请号：US09661206
申请日：2000-09-14
申请人： Linda G. Lee , Ronald J. Graham , William E. Werner , Elana Swartzman , Lily Lu
发明人： Linda G. Lee , Ronald J. Graham , William E. Werner , Elana Swartzman , Lily Lu
IPC分类号： C07D40500
CPC分类号： C07D491/04 , C07D311/80 , C07D491/06 , C07H19/207 , C07H21/00 , C09B11/24 , G01N33/582 , G01N2458/00 , Y10S436/80
摘要： The present invention provides novel, water-soluble, red-emitting fluorescent rhodamine dyes and red-emitting fluorescent energy-transfer dye pairs, as well as labeled conjugates comprising the same and methods for their use. The dyes, energy-transfer dye pairs and labeled conjugates are useful in a variety of aqueous-based applications, particularly in assays involving staining of cells, protein binding, and/or analysis of nucleic acids, such as hybridization assays and nucleic acid sequencing.
摘要翻译：本发明提供新颖的水溶性红色荧光罗丹明染料和红色发光荧光能量转移染料对，以及包含其的标记共轭物及其使用方法。染料，能量转移染料对和标记的缀合物可用于各种水基应用，特别是涉及细胞染色，蛋白质结合和/或核酸分析的测定，如杂交测定和核酸测序。

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