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1. 发明授权

US06191278B1 Water-soluble rhodamine dyes and conjugates thereof 有权
标题翻译：水溶性罗丹明染料及其共轭物
公开(公告)号：US06191278B1
公开(公告)日：2001-02-20
申请号：US09433093
申请日：1999-11-03
申请人： Linda G. Lee , Ronald J. Graham , William E. Werner , Elana Swartzman , Lily Lu
发明人： Linda G. Lee , Ronald J. Graham , William E. Werner , Elana Swartzman , Lily Lu
IPC分类号： C07D49304
CPC分类号： C07D491/04 , C07D311/80 , C07D491/06 , C07H19/207 , C07H21/00 , C09B11/24 , G01N33/582 , G01N2458/00
摘要： The present invention provides novel, water-soluble, red-emitting fluorescent rhodamine dyes and red-emitting fluorescent energy-transfer dye pairs, as well as labeled conjugates comprising the same and methods for their use. The dyes, energy-transfer dye pairs and labeled conjugates are useful in a variety of aqueous-based applications, particularly in assays involving staining of cells, protein binding, and/or analysis of nucleic acids, such as hybridization assays and nucleic acid sequencing.
摘要翻译：本发明提供新颖的水溶性红色荧光罗丹明染料和红色发光荧光能量转移染料对，以及包含其的标记共轭物及其使用方法。染料，能量转移染料对和标记的缀合物可用于各种水基应用，特别是涉及细胞染色，蛋白质结合和/或核酸分析的测定，如杂交测定和核酸测序。

2. 发明授权

US07504496B2 Water-soluble rhodamine dye conjugates 有权
标题翻译：水溶性罗丹明染料共轭物
公开(公告)号：US07504496B2
公开(公告)日：2009-03-17
申请号：US11059035
申请日：2005-02-14
申请人： Linda G. Lee , Ronald J. Graham , William E. Werner , Elana Swartzman , Lily Lu
发明人： Linda G. Lee , Ronald J. Graham , William E. Werner , Elana Swartzman , Lily Lu
IPC分类号： C07G3/00 , C07H21/02 , C07H21/00 , C07H21/04 , C07H19/04 , C12Q1/68
CPC分类号： C07D491/04 , C07D311/80 , C07D491/06 , C07H19/207 , C07H21/00 , C09B11/24 , G01N33/582 , G01N2458/00 , Y10S436/80
摘要： The present invention provides novel, water-soluble, red-emitting fluorescent rhodamine dyes and red-emitting fluorescent energy-transfer dye pairs, as well as labeled conjugates comprising the same and methods for their use. The dyes, energy-transfer dye pairs and labeled conjugates are useful in a variety of aqueous-based applications, particularly in assays involving staining of cells, protein binding, and/or analysis of nucleic acids, such as hybridization assays and nucleic acid sequencing.
摘要翻译：本发明提供新颖的水溶性红色荧光罗丹明染料和红色发光荧光能量转移染料对，以及包含其的标记共轭物及其使用方法。染料，能量转移染料对和标记的缀合物可用于各种水基应用，特别是涉及细胞染色，蛋白质结合和/或核酸分析的测定，如杂交测定和核酸测序。

3. 发明申请

US20110081688A1 Water-Soluble Rhodamine Dyes Conjugates 有权
标题翻译：水溶性罗丹明染料缀合物
公开(公告)号：US20110081688A1
公开(公告)日：2011-04-07
申请号：US12855649
申请日：2010-08-12
申请人： Linda G. Lee , Ronald J. Graham , William E. Werner , Elana Swartzman , Lily Lu
发明人： Linda G. Lee , Ronald J. Graham , William E. Werner , Elana Swartzman , Lily Lu
IPC分类号： C12P19/34 , C07H19/04 , C07D498/14 , C07D498/22
CPC分类号： C07D491/04 , C07D311/80 , C07D491/06 , C07H19/207 , C07H21/00 , C09B11/24 , G01N33/582 , G01N2458/00 , Y10S436/80
摘要： The present invention provides novel, water-soluble, red-emitting fluorescent rhodamine dyes and red-emitting fluorescent energy-transfer dye pairs, as well as labeled conjugates comprising the same and methods for their use. The dyes, energy-transfer dye pairs and labeled conjugates are useful in a variety of aqueous-based applications, particularly in assays involving staining of cells, protein binding, and/or analysis of nucleic acids, such as hybridization assays and nucleic acid sequencing.
摘要翻译：本发明提供新颖的水溶性红色荧光罗丹明染料和红色发光荧光能量转移染料对，以及包含其的标记共轭物及其使用方法。染料，能量转移染料对和标记的缀合物可用于各种水基应用，特别是涉及细胞染色，蛋白质结合和/或核酸分析的测定，如杂交测定和核酸测序。

4. 发明授权

US07795042B2 Water-soluble rhodamine dye conjugates 有权
标题翻译：水溶性罗丹明染料共轭物
公开(公告)号：US07795042B2
公开(公告)日：2010-09-14
申请号：US12402634
申请日：2009-03-12
申请人： Linda G. Lee , Ronald J. Graham , William E. Werner , Elana Swartzman , Lily Lu
发明人： Linda G. Lee , Ronald J. Graham , William E. Werner , Elana Swartzman , Lily Lu
IPC分类号： G01N33/53 , C12Q1/68 , C07K2/00 , C07K14/00 , C07H21/02
CPC分类号： C07D491/04 , C07D311/80 , C07D491/06 , C07H19/207 , C07H21/00 , C09B11/24 , G01N33/582 , G01N2458/00 , Y10S436/80
摘要： The present invention provides novel, water-soluble, red-emitting fluorescent rhodamine dyes and red-emitting fluorescent energy-transfer dye pairs, as well as labeled conjugates comprising the same and methods for their use. The dyes, energy-transfer dye pairs and labeled conjugates are useful in a variety of aqueous-based applications, particularly in assays involving staining of cells, protein binding, and/or analysis of nucleic acids, such as hybridization assays and nucleic acid sequencing.
摘要翻译：本发明提供新颖的水溶性红色荧光罗丹明染料和红色发光荧光能量转移染料对，以及包含其的标记共轭物及其使用方法。染料，能量转移染料对和标记的缀合物可用于各种水基应用，特别是涉及细胞染色，蛋白质结合和/或核酸分析的测定，如杂交测定和核酸测序。

5. 发明授权

US06372907B1 Water-soluble rhodamine dye peptide conjugates 有权
标题翻译：水溶性罗丹明染料肽缀合物
公开(公告)号：US06372907B1
公开(公告)日：2002-04-16
申请号：US09661206
申请日：2000-09-14
申请人： Linda G. Lee , Ronald J. Graham , William E. Werner , Elana Swartzman , Lily Lu
发明人： Linda G. Lee , Ronald J. Graham , William E. Werner , Elana Swartzman , Lily Lu
IPC分类号： C07D40500
CPC分类号： C07D491/04 , C07D311/80 , C07D491/06 , C07H19/207 , C07H21/00 , C09B11/24 , G01N33/582 , G01N2458/00 , Y10S436/80
摘要： The present invention provides novel, water-soluble, red-emitting fluorescent rhodamine dyes and red-emitting fluorescent energy-transfer dye pairs, as well as labeled conjugates comprising the same and methods for their use. The dyes, energy-transfer dye pairs and labeled conjugates are useful in a variety of aqueous-based applications, particularly in assays involving staining of cells, protein binding, and/or analysis of nucleic acids, such as hybridization assays and nucleic acid sequencing.
摘要翻译：本发明提供新颖的水溶性红色荧光罗丹明染料和红色发光荧光能量转移染料对，以及包含其的标记共轭物及其使用方法。染料，能量转移染料对和标记的缀合物可用于各种水基应用，特别是涉及细胞染色，蛋白质结合和/或核酸分析的测定，如杂交测定和核酸测序。

6. 发明授权

US08030096B2 Water-soluble rhodamine dyes conjugates 有权
标题翻译：水溶性罗丹明染料缀合物
公开(公告)号：US08030096B2
公开(公告)日：2011-10-04
申请号：US12855649
申请日：2010-08-12
申请人： Linda G. Lee , Ronald Graham , Lily Lu , Elana E. Swartzman , William E. Werner
发明人： Linda G. Lee , Ronald Graham , Lily Lu , Elana E. Swartzman , William E. Werner
IPC分类号： G01N33/53 , C12Q1/68 , C07H21/02 , C07H15/00 , C07K2/00
CPC分类号： C07D491/04 , C07D311/80 , C07D491/06 , C07H19/207 , C07H21/00 , C09B11/24 , G01N33/582 , G01N2458/00 , Y10S436/80
摘要： The present invention provides novel, water-soluble, red-emitting fluorescent rhodamine dyes and red-emitting fluorescent energy-transfer dye pairs, as well as labeled conjugates comprising the same and methods for their use. The dyes, energy-transfer dye pairs and labeled conjugates are useful in a variety of aqueous-based applications, particularly in assays involving staining of cells, protein binding, and/or analysis of nucleic acids, such as hybridization assays and nucleic acid sequencing.
摘要翻译：本发明提供新颖的水溶性红色荧光罗丹明染料和红色发光荧光能量转移染料对，以及包含其的标记共轭物及其使用方法。染料，能量转移染料对和标记的缀合物可用于各种水基应用，特别是涉及细胞染色，蛋白质结合和/或核酸分析的测定，如杂交测定和核酸测序。

7. 发明授权

US06248239B1 Effluent collection apparatus and method 失效
标题翻译：流出物收集装置及方法
公开(公告)号：US06248239B1
公开(公告)日：2001-06-19
申请号：US08887350
申请日：1997-07-02
申请人： Kuo-Liang Hsi , Jindong Zhao , Michael Kochersperger , William E. Werner , Pau-Miau Yuan
发明人： Kuo-Liang Hsi , Jindong Zhao , Michael Kochersperger , William E. Werner , Pau-Miau Yuan
IPC分类号： B01D1508
CPC分类号： G01N30/82 , G01N2030/8411 , Y10T436/2575
摘要： The present invention includes a method of analyzing one or more molecular components in a mixture of components. In the method, a mixture of molecular components, i.e., an analyte mixture, is separated on a capillary liquid chromatography column. The component-containing eluate from the column is deposited as a series of discrete, defined-volume microdrops, along a region of an adsorbent collection layer. During the chromatographic separation, the column eluate may also be monitored to detect the presence of separated components in the eluate. The one or more components deposited in the collection layer are then analyzed by selected analytical techniques. In related aspect, the invention includes a method of collecting one or more molecular components derived from a mixture of components, a blotter apparatus useful in the above method, and a system for analyzing one or more molecular components in a mixture of components.
摘要翻译：本发明包括分析组分混合物中的一种或多种分子组分的方法。在该方法中，在毛细管液相色谱柱上分离分子组分的混合物，即分析物混合物。来自柱的含组分的洗脱液沿着吸附剂收集层的区域沉积为一系列离散的限定体积的微滴。在色谱分离期间，还可以监测柱洗脱液以检测洗脱液中分离的组分的存在。然后通过选择的分析技术分析沉积在收集层中的一种或多种组分。在相关方面，本发明包括收集一种或多种衍生自组分混合物的分子组分的方法，可用于上述方法的吸墨装置和用于分析组分混合物中的一种或多种分子组分的系统。

8. 发明授权

US06787030B2 Effluent collection apparatus and method 有权
标题翻译：流出物收集装置及方法
公开(公告)号：US06787030B2
公开(公告)日：2004-09-07
申请号：US10602342
申请日：2003-06-23
申请人： Kuo-Liang Hsi , Jindong Zhao , Michael Kochersperger , William E. Werner , Pau-Miau Yuan
发明人： Kuo-Liang Hsi , Jindong Zhao , Michael Kochersperger , William E. Werner , Pau-Miau Yuan
IPC分类号： B01D1508
CPC分类号： G01N30/82 , G01N2030/8411 , Y10T436/2575
摘要： The present invention includes a method of analyzing one or more molecular components in a mixture of components. In the method, a mixture of molecular components, i.e., an analyte mixture, is separated on a capillary liquid chromatography column. The component-containing eluate from the column is deposited as a series of discrete, defined-volume microdrops, along a region of an adsorbent collection layer. During the chromatographic separation, the column eluate may also-be monitored to detect the presence of separated components in the equate. The one or more components deposited in the collection layer are then analyzed by selected analytical techniques. In related aspect, the invention includes a method of collecting one or more molecular components derived from a mixture of components, a blotter apparatus useful in the above method, and a system for analyzing one or more molecular components in a mixture of components.
摘要翻译：本发明包括分析组分混合物中的一种或多种分子组分的方法。在该方法中，在毛细管液相色谱柱上分离分子组分的混合物，即分析物混合物。来自柱的含组分的洗脱液沿着吸附剂收集层的区域沉积为一系列离散的限定体积的微滴。在色谱分离期间，也可以监测柱洗脱液以检测等分物中分离的组分的存在。然后通过选择的分析技术分析沉积在收集层中的一种或多种组分。在相关方面，本发明包括收集一种或多种衍生自组分混合物的分子组分的方法，可用于上述方法的吸墨装置和用于分析组分混合物中的一种或多种分子组分的系统。

9. 发明授权

US06331618B1 Compositions of solvents and high concentrations of nucleic acid analogs 有权
标题翻译：溶剂和高浓度核酸类似物的组成
公开(公告)号：US06331618B1
公开(公告)日：2001-12-18
申请号：US09311079
申请日：1999-05-13
申请人： William Bloch , William E. Werner , Michael Egholm , Rene L. Myers
发明人： William Bloch , William E. Werner , Michael Egholm , Rene L. Myers
IPC分类号： C07H2100
CPC分类号： C12N15/1003 , C12Q1/6806 , C12Q2525/107 , C12Q2525/101
摘要： The invention provides compositions and methods suitable for dissolving nucleic acid analogs with uncharged, neutral backbones at high concentrations at approximately neutral pH. By using the compositions of the invention, which include a polar, aprotic solvent, concentrations of nucleic acid analogs such as PNA can be achieved in the range of approximately 1 &mgr;M to 10 mM.
摘要翻译：本发明提供了适合于在大约中性pH下以高浓度溶解具有不带电的中性骨架的核酸类似物的组合物和方法。通过使用包括极性的非质子溶剂的本发明的组合物，可以在约1μM至10mM的范围内实现核酸类似物（例如PNA）的浓度。

10. 发明授权

US06582597B2 Effluent collection apparatus and method 有权
标题翻译：流出物收集装置及方法
公开(公告)号：US06582597B2
公开(公告)日：2003-06-24
申请号：US09885292
申请日：2001-06-19
申请人： Kuo-Liang Hsi , Jindong Zhao , Michael Kochersperger , William E. Werner , Pau-Miau Yuan
发明人： Kuo-Liang Hsi , Jindong Zhao , Michael Kochersperger , William E. Werner , Pau-Miau Yuan
IPC分类号： B01D1508
CPC分类号： G01N30/82 , G01N2030/8411 , Y10T436/2575
摘要： The present invention includes a method of analyzing one or more molecular components in a mixture of components. In the method, a mixture of molecular components, i.e., an analyte mixture, is separated on a capillary liquid chromatography column. The component-containing eluate from the column is deposited as a series of discrete, defined-volume microdrops, along a region of an adsorbent collection layer. During the chromatographic separation, the column eluate may also be monitored to detect the presence of separated components in the eluate. The one or more components deposited in the collection layer are then analyzed by selected analytical techniques. In related aspect, the invention includes a method of collecting one or more molecular components derived from a mixture of components, a blotter apparatus useful in the above method, and a system for analyzing one or more molecular components in a mixture of components.
摘要翻译：本发明包括分析组分混合物中的一种或多种分子组分的方法。在该方法中，在毛细管液相色谱柱上分离分子组分的混合物，即分析物混合物。来自柱的含组分的洗脱液沿着吸附剂收集层的区域沉积为一系列离散的限定体积的微滴。在色谱分离期间，还可以监测柱洗脱液以检测洗脱液中分离的组分的存在。然后通过选择的分析技术分析沉积在收集层中的一种或多种组分。在相关方面，本发明包括收集一种或多种衍生自组分混合物的分子组分的方法，可用于上述方法的吸墨装置和用于分析组分混合物中的一种或多种分子组分的系统。

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