专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

US20100323406A1 MUTANT DNA POLYMERASES AND METHODS OF USE 审中-公开
标题翻译：突变DNA聚合物及其使用方法
公开(公告)号：US20100323406A1
公开(公告)日：2010-12-23
申请号：US12542648
申请日：2009-08-17
申请人： Paolo Vatta , John W. Brandis , Elena V. Bolchakova , Sandra L. Spurgeon
发明人： Paolo Vatta , John W. Brandis , Elena V. Bolchakova , Sandra L. Spurgeon
IPC分类号： C12P19/34 , C12N9/10 , C07H21/04 , C12N15/63 , C12N5/10
CPC分类号： C12N9/1252 , C12Y207/07007
摘要： The present invention provides mutant DNA polymerases, polynucleotides encoding the polymerases, cassettes and vectors including such polynucleotides, and cells containing the polymerases, polynucleotides, cassettes, and/or vectors of the invention. The present invention also provides methods for synthesizing polynucleotides and kits including a DNA polymerase of the invention.
摘要翻译：本发明提供了突变型DNA聚合酶，编码聚合酶的多核苷酸，包含这种多核苷酸的盒和载体，以及含有本发明的聚合酶，多核苷酸，盒和/或载体的细胞。本发明还提供了合成多核苷酸和包含本发明的DNA聚合酶的试剂盒的方法。

2. 发明申请

US20090118485A1 OLIGONUCLEOTIDES AND ANALOGS LABELED WITH ENERGY TRANSFER DYES 审中-公开
标题翻译：标识与能量转运染色体的寡核苷酸和模拟物
公开(公告)号：US20090118485A1
公开(公告)日：2009-05-07
申请号：US12205817
申请日：2008-09-05
申请人： Linda G. LEE , Sandra L. Spurgeon , Barnett B. Rosenblum
发明人： Linda G. LEE , Sandra L. Spurgeon , Barnett B. Rosenblum
IPC分类号： C07H21/00
CPC分类号： C07H21/04 , C07H21/00 , C09B11/24 , C12Q1/6818
摘要： Novel linkers for linking a donor dye to an acceptor dye in an energy transfer fluorescent dye are provided. These linkers faciliate the efficient transfer of energy between a donor and acceptor dye in an energy transfer dye. One of these linkers for linking a donor dye to an acceptor dye in an energy transfer fluorescent dye has the general structure R21Z1C(O)R22R28 where R21 is a C1-5 alkyl attached to the donor dye, C(O) is a carbonyl group, Z1 is either NH, sulfur or oxygen, R22 is a substituent which includes an alkene, diene, alkyne, a five and six membered ring having at least one unsaturated bond or a fused ring structure which is attached to the carbonyl carbon, and R28 includes a functional group which attaches the linker to the acceptor dye.
摘要翻译：提供了用于将供体染料与能量转移荧光染料中的受体染料连接的新型接头。这些连接器有助于在能量转移染料中的供体和受体染料之间的能量的有效转移。用于将供体染料与能量转移荧光染料中的受体染料连接的这些接头之一具有通式结构R21Z1C（O）R22R28，其中R21是与供体染料连接的C 1-5烷基，C（O）是羰基 Z1是NH，硫或氧，R22是包含烯烃，二烯烃，炔烃，具有至少一个不饱和键的五元和六元环或连接到羰基碳上的稠环结构的取代基，R28 包括将接头连接到受体染料的官能团。

3. 发明授权

US07432058B2 Methods of labeling nucleic acids with energy transfer dyes 有权
标题翻译：用能量转移染料标记核酸的方法
公开(公告)号：US07432058B2
公开(公告)日：2008-10-07
申请号：US11618663
申请日：2006-12-29
申请人： Linda G. Lee , Sandra L. Spurgeon , Barnett Rosenblum
发明人： Linda G. Lee , Sandra L. Spurgeon , Barnett Rosenblum
IPC分类号： C12Q1/68 , C12P19/34 , C07H21/00 , C07H21/02 , C07H21/04 , C07H19/04
CPC分类号： C07H21/04 , C07D311/82 , C07D311/90 , C07D405/12 , C07D405/14 , C07H21/00 , C09B11/04 , C09B11/24 , C09B23/083 , C09B69/00 , C12Q1/6818 , C12Q1/6869 , C12Q2563/107 , C12Q2535/101 , C12Q2565/1015
摘要： Novel linkers for linking a donor dye to an acceptor dye in an energy transfer fluorescent dye are provided. These linkers faciliate the efficient transfer of energy between a donor and acceptor dye in an energy transfer dye. One of these linkers for linking a donor dye to an acceptor dye in an energy transfer fluorescent dye has the general structure R21Z1C(O)R22R28 where R21 is a C1-5 alkyl attached to the donor dye, C(O) is a carbonyl group, Z1 is either NH, sulfur or oxygen, R22 is a substituent which includes an alkene, diene, alkyne, a five and six membered ring having at least one unsaturated bond or a fused ring structure which is attached to the carbonyl carbon, and R28 includes a functional group which attaches the linker to the acceptor dye.
摘要翻译：提供了用于将供体染料与能量转移荧光染料中的受体染料连接的新型接头。这些连接器有助于在能量转移染料中的供体和受体染料之间的能量的有效转移。用于将供体染料与能量转移荧光染料中的受体染料连接的这些接头之一具有通式结构R 21 R 1 C（O）R 22 其中R 21是与供体染料连接的C 1-5烷基，C（O）是羰基（C 1 -C 4）烷基，基团Z 1是NH，硫或氧，R 22是包括烯烃，二烯烃，炔烃，具有至少一个碳原子的五元和六元环的取代基不饱和键或与羰基碳连接的稠合环结构，R 28包括将接头连接于受体染料的官能团。

4. 发明授权

US06849745B2 Energy transfer dyes with enhanced fluorescence 失效
公开(公告)号：US06849745B2
公开(公告)日：2005-02-01
申请号：US10014743
申请日：2001-10-29
申请人： Linda G. Lee , Sandra L. Spurgeon , Barnett Rosenblum
发明人： Linda G. Lee , Sandra L. Spurgeon , Barnett Rosenblum
IPC分类号： C07D231/12 , C07D233/54 , C07D233/60 , C07D261/18 , C07D311/82 , C07H21/00 , C07H21/02 , C07H21/04 , C09B11/04 , C09B11/24 , C09B23/08 , C09B69/00 , C12Q1/68 , G01N33/53
CPC分类号： C07H21/04 , C07D311/82 , C07D311/90 , C07D405/12 , C07D405/14 , C07H21/00 , C09B11/04 , C09B11/24 , C09B23/083 , C09B69/00 , C12Q1/6818 , C12Q1/6869 , C12Q2563/107 , C12Q2535/101 , C12Q2565/1015
摘要： Novel linkers for linking a donor dye to an acceptor dye in an energy transfer fluorescent dye are provided. These linkers faciliate the efficient transfer of energy between a donor and acceptor dye in an energy transfer dye. One of these linkers for linking a donor dye to an acceptor dye in an energy transfer fluorescent dye has the general structure R21Z1C(O)R22R28 where R21 is a C1-5 alkyl attached to the donor dye, C(O) is a carbonyl group, Z1 is either NH, sulfur or oxygen, R22 is a substituent which includes an alkene, diene, alkyne, a five and six membered ring having at least one unsaturated bond or a fused ring structure which is attached to the carbonyl carbon, and R28 includes a functional group which attaches the linker to the acceptor dye.

5. 发明授权

US06335440B1 Method for detecting oligonucleotides using energy transfer dyes with long stoke shift 有权
标题翻译：使用能量转移染料长时间移动检测寡核苷酸的方法
公开(公告)号：US06335440B1
公开(公告)日：2002-01-01
申请号：US09272097
申请日：1999-03-18
申请人： Linda G. Lee , Sandra L. Spurgeon , Barnett Rosenblum
发明人： Linda G. Lee , Sandra L. Spurgeon , Barnett Rosenblum
IPC分类号： C07H2104
CPC分类号： C07H21/04 , C07D311/82 , C07D311/90 , C07D405/12 , C07D405/14 , C07H21/00 , C09B11/04 , C09B11/24 , C09B23/083 , C09B69/00 , C12Q1/6818 , C12Q1/6869 , C12Q2563/107 , C12Q2535/101 , C12Q2565/1015
摘要： Novel linkers for linking a donor dye to an acceptor dye in an energy transfer fluorescent dye are provided. These linkers faciliate the efficient transfer of energy between a donor and acceptor dye in an energy transfer dye. One of these linkers for linking a donor dye to an acceptor dye in an energy transfer fluorescent dye has the general structure R21Z1C(O)R22R26 where R21 is a C1-5 alkyl attached to the donor dye, C(O) is a carbonyl group, Z1 is either NH, sulfur or oxygen, R22 is a substituent which includes an alkene, diene, alkyne, a five and six membered ring having at least one unsaturated bond or a fused ring structure which is attached to the carbonyl carbon, and R28 includes a functional group which attaches the linker to the acceptor dye.
摘要翻译：提供了用于将供体染料与能量转移荧光染料中的受体染料连接的新型接头。这些连接器有助于在能量转移染料中的供体和受体染料之间的能量的有效转移。用于将能量转移荧光染料中的供体染料与受体染料连接的这些接头之一具有通式结构R21Z1C（O）R22R26，其中R21是与供体染料连接的C 1-5烷基，C（O）是羰基 Z1是NH，硫或氧，R22是包含烯烃，二烯烃，炔烃，具有至少一个不饱和键的五元和六元环或连接到羰基碳上的稠环结构的取代基，R28 包括将接头连接到受体染料的官能团。

6. 发明申请

US20100280246A1 ENERGY TRANSFER DYES WITH ENHANCED FLUORESCENCE 审中-公开
标题翻译：能量转运与增强荧光
公开(公告)号：US20100280246A1
公开(公告)日：2010-11-04
申请号：US11617650
申请日：2006-12-28
申请人： Linda G. Lee , Sandra L. Spurgeon , Barnett Rosenblum
发明人： Linda G. Lee , Sandra L. Spurgeon , Barnett Rosenblum
IPC分类号： C07D311/82 , C07D401/00 , C07D407/12 , C07D407/14 , C07D491/16
CPC分类号： C07H21/04 , C07D311/82 , C07D311/90 , C07D405/12 , C07D405/14 , C07H21/00 , C09B11/04 , C09B11/24 , C09B23/083 , C09B69/00 , C12Q1/6818 , C12Q1/6869 , C12Q2563/107 , C12Q2535/101 , C12Q2565/1015
摘要： Novel linkers for linking a donor dye to an acceptor dye in an energy transfer fluorescent dye are provided. These linkers facilitate the efficient transfer of energy between a donor and acceptor dye in an energy transfer dye. One of these linkers for linking a donor dye to an acceptor dye in an energy transfer fluorescent dye has the general structure R21Z1C(O)R22R28 where R21 is a C1-5 alkyl attached to the donor dye, C(O) is a carbonyl group, Z1 is either NH, sulfur or oxygen, R22 is a substituent which includes an alkene, diene, alkyne, a five and six membered ring having at least one unsaturated bond or a fused ring structure which is attached to the carbonyl carbon, and R28 includes a functional group which attaches the linker to the acceptor dye.
摘要翻译：提供了用于将供体染料与能量转移荧光染料中的受体染料连接的新型接头。这些接头促进能量转移染料中供体和受体染料之间的能量的有效转移。用于将供体染料与能量转移荧光染料中的受体染料连接的这些接头之一具有通式结构R21Z1C（O）R22R28，其中R21是与供体染料连接的C 1-5烷基，C（O）是羰基 Z1是NH，硫或氧，R22是包含烯烃，二烯烃，炔烃，具有至少一个不饱和键的五元和六元环或连接到羰基碳上的稠环结构的取代基，R28 包括将接头连接到受体染料的官能团。

7. 发明授权

US07449298B2 Methods of analyzing polynucleotides employing energy transfer dyes 失效
标题翻译：使用能量转移染料分析多核苷酸的方法
公开(公告)号：US07449298B2
公开(公告)日：2008-11-11
申请号：US11618679
申请日：2006-12-29
申请人： Linda G. Lee , Sandra L. Spurgeon , Barnett Rosenblum
发明人： Linda G. Lee , Sandra L. Spurgeon , Barnett Rosenblum
IPC分类号： C12Q1/68 , C12P19/34 , C07H21/02 , C07H21/04
CPC分类号： C07H21/04 , C07H21/00 , C09B11/24 , C12Q1/6818
摘要： Novel linkers for linking a donor dye to an acceptor dye in an energy transfer fluorescent dye are provided. These linkers faciliate the efficient transfer of energy between a donor and acceptor dye in an energy transfer dye. One of these linkers for linking a donor dye to an acceptor dye in an energy transfer fluorescent dye has the general structure R21Z1C(O)R22R28 where R21 is a C1-5 alkyl attached to the donor dye, C(O) is a carbonyl group, Z1 is either NH, sulfur or oxygen, R22 is a substituent which includes an alkene, diene, alkyne, a five and six membered ring having at least one unsaturated bond or a fused ring structure which is attached to the carbonyl carbon, and R28 includes a functional group which attaches the linker to the acceptor dye.
摘要翻译：提供了用于将供体染料与能量转移荧光染料中的受体染料连接的新型接头。这些连接器有助于在能量转移染料中的供体和受体染料之间的能量的有效转移。用于将供体染料与能量转移荧光染料中的受体染料连接的这些接头之一具有通式结构R 21 R 1 C（O）R 22 其中R 21是与供体染料连接的C 1-5烷基，C（O）是羰基（C 1 -C 4）烷基，基团Z 1是NH，硫或氧，R 22是包括烯烃，二烯烃，炔烃，具有至少一个碳原子的五元和六元环的取代基不饱和键或与羰基碳连接的稠合环结构，R 28包括将接头连接于受体染料的官能团。

8. 发明授权

US07449149B2 Kits useful for sequencing nucleic acids 失效
标题翻译：用于测序核酸的试剂盒
公开(公告)号：US07449149B2
公开(公告)日：2008-11-11
申请号：US11618688
申请日：2006-12-29
申请人： Linda G. Lee , Sandra L. Spurgeon , Barnett Rosenblum
发明人： Linda G. Lee , Sandra L. Spurgeon , Barnett Rosenblum
IPC分类号： G01N15/06 , C12P19/34 , C12Q1/68 , C07H21/00
CPC分类号： C07H21/04 , C07H21/00 , C09B11/24 , C12Q1/6818
摘要： Novel linkers for linking a donor dye to an acceptor dye in an energy transfer fluorescent dye are provided. These linkers facilitate the efficient transfer of energy between a donor and acceptor dye in an energy transfer dye. One of these linkers for linking a donor dye to an acceptor dye in an energy transfer fluorescent dye has the general structure R21Z1C(O)R22R28 where R21 is a C1-5 alkyl attached to the donor dye, C(O) is a carbonyl group, Z1 is either NH, sulfur or oxygen, R22 is a substituent which includes an alkene, diene, alkyne, a five and six membered ring having at least one unsaturated bond or a fused ring structure which is attached to the carbonyl carbon, and R28 includes a functional group which attaches the linker to the acceptor dye.
摘要翻译：提供了用于将供体染料与能量转移荧光染料中的受体染料连接的新型接头。这些接头促进能量转移染料中供体和受体染料之间的能量的有效转移。用于将供体染料与能量转移荧光染料中的受体染料连接的这些接头之一具有通式结构R 21 R 1 C（O）R 22 其中R 21是与供体染料连接的C 1-5烷基，C（O）是羰基（C 1 -C 4）烷基，基团Z 1是NH，硫或氧，R 22是包括烯烃，二烯烃，炔烃，具有至少一个碳原子的五元和六元环的取代基不饱和键或与羰基碳连接的稠合环结构，R 28包括将接头连接于受体染料的官能团。

9. 发明授权

US07399854B2 Regents labeled with energy transfer dyes 有权
标题翻译：标有能量转移染料的摄政
公开(公告)号：US07399854B2
公开(公告)日：2008-07-15
申请号：US11617660
申请日：2006-12-28
申请人： Linda G. Lee , Sandra L. Spurgeon , Barnett Rosenblum
发明人： Linda G. Lee , Sandra L. Spurgeon , Barnett Rosenblum
IPC分类号： C07H19/04 , C07D311/82 , C07D311/78
CPC分类号： C07H21/04 , C07D311/82 , C07D311/90 , C07D405/12 , C07D405/14 , C07H21/00 , C09B11/04 , C09B11/24 , C09B23/083 , C09B69/00 , C12Q1/6818 , C12Q1/6869 , C12Q2563/107 , C12Q2535/101 , C12Q2565/1015
摘要： Novel linkers for linking a donor dye to an acceptor dye in an energy transfer fluorescent dye are provided. These linkers faciliate the efficient transfer of energy between a donor and acceptor dye in an energy transfer dye. One of these linkers for linking a donor dye to an acceptor dye in an energy transfer fluorescent dye has the general structure R21Z1C(O)R22R28 where R21 is a C1-5 alkyl attached to the donor dye, C(O) is a carbonyl group, Z1 is either NH, sulfur or oxygen, R22 is a substituent which includes an alkene, diene, alkyne, a five and six membered ring having at least one unsaturated bond or a fused ring structure which is attached to the carbonyl carbon, and R28 includes a functional group which attaches the linker to the acceptor dye.
摘要翻译：提供了用于将供体染料与能量转移荧光染料中的受体染料连接的新型接头。这些连接器有助于在能量转移染料中的供体和受体染料之间的能量的有效转移。用于将供体染料与能量转移荧光染料中的受体染料连接的这些接头之一具有通式结构R 21 R 1 C（O）R 22 其中R 21是与供体染料连接的C 1-5烷基，C（O）是羰基（C 1 -C 4）烷基，基团Z 1是NH，硫或氧，R 22是包括烯烃，二烯烃，炔烃，具有至少一个碳原子的五元和六元环的取代基不饱和键或与羰基碳连接的稠合环结构，R 28包括将接头连接于受体染料的官能团。

10. 发明授权

US07169939B2 Energy transfer dyes with enhanced fluorescence 有权
标题翻译：能量转移染料具有增强的荧光
公开(公告)号：US07169939B2
公开(公告)日：2007-01-30
申请号：US10788836
申请日：2004-02-26
申请人： Linda G. Lee , Sandra L. Spurgeon , Barnett Rosenblum
发明人： Linda G. Lee , Sandra L. Spurgeon , Barnett Rosenblum
IPC分类号： C07D311/82 , C07H21/02 , C07H19/04 , C12Q1/68
CPC分类号： C07H21/04 , C07D311/82 , C07D311/90 , C07D405/12 , C07D405/14 , C07H21/00 , C09B11/04 , C09B11/24 , C09B23/083 , C09B69/00 , C12Q1/6818 , C12Q1/6869 , C12Q2563/107 , C12Q2535/101 , C12Q2565/1015
摘要： Novel linkers for linking a donor dye to an acceptor dye in an energy transfer fluorescent dye are provided. These linkers faciliate the efficient transfer of energy between a donor and acceptor dye in an energy transfer dye. One of these linkers for linking a donor dye to an acceptor dye in an energy transfer fluorescent dye has the general structure R21Z1C(O)R22R28 where R21 is a C1-5 alkyl attached to the donor dye, C(O) is a carbonyl group, Z1 is either NH, sulfur or oxygen, R22 is a substituent which includes an alkene, diene, alkyne, a five and six membered ring having at least one unsaturated bond or a fused ring structure which is attached to the carbonyl carbon, and R28 includes a functional group which attaches the linker to the acceptor dye.
摘要翻译：提供了用于将供体染料与能量转移荧光染料中的受体染料连接的新型接头。这些连接器有助于在能量转移染料中的供体和受体染料之间的能量的有效转移。用于将供体染料与能量转移荧光染料中的受体染料连接的这些接头之一具有通式结构R 21 R 1 C（O）R 22 其中R 21是与供体染料连接的C 1-5烷基，C（O）是羰基（C 1 -C 4）烷基，基团Z 1是NH，硫或氧，R 22是包括烯烃，二烯烃，炔烃，具有至少一个碳原子的五元和六元环的取代基不饱和键或与羰基碳连接的稠合环结构，R 28包括将接头连接于受体染料的官能团。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式