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61. 发明授权

US08691516B2 Mutant microorganism producing succinic acid simultaneously using sucrose and glycerol, and method for preparing succinic acid using same 有权
标题翻译：使用蔗糖和甘油同时生产琥珀酸的突变体微生物，以及使用其制备琥珀酸的方法
公开(公告)号：US08691516B2
公开(公告)日：2014-04-08
申请号：US13819339
申请日：2011-08-30
申请人： Sang Yup Lee , Jeong Wook Lee , Sol Choi , Jongho Yi
发明人： Sang Yup Lee , Jeong Wook Lee , Sol Choi , Jongho Yi
IPC分类号： G01N33/53 , C12N1/20
CPC分类号： C12P7/46 , C12N1/20 , C12N15/52 , C12R1/01
摘要： The present invention relates to a succinic acid-producing mutant microorganism that is able to utilize sucrose and glycerol simultaneously as carbon sources. More particularly, the present invention relates to a succinic acid-producing mutant microorganism that is able to utilize sucrose and glycerol simultaneously for succinic acid production, the mutant organism being obtained by relieving the mechanism of sucrose-mediated catabolite repression of glycerol in a succinic acid-producing microorganism. As described above, when the succinic acid-producing mutant microorganism is cultured, it utilizes sucrose and glycerol simultaneously so that succinic acid can be produced with high productivity in a maximum yield approaching the theoretical yield while the production of byproducts is minimized. In addition, according to the present invention, various reduced chemicals which have been produced in low yields in conventional methods can be more effectively produced.
摘要翻译：本发明涉及能够同时使用蔗糖和甘油作为碳源的产琥珀酸突变体微生物。更具体地，本发明涉及能够同时使用蔗糖和甘油进行琥珀酸生产的产琥珀酸的突变体微生物，其通过减轻甘油在琥珀酸中的蔗糖介导的分解代谢物抑制的机制而获得生产微生物。如上所述，当培养产琥珀酸的突变体微生物时，它同时使用蔗糖和甘油，使得以最大产率接近理论产率的高生产率生产琥珀酸，同时副产物的产生最小化。此外，根据本发明，可以更有效地制造在常规方法中以低收率生产的各种还原化学品。

62. 发明申请

US20140030775A1 RECOMBINANT MICROORGANISM HAVING ABILITY TO PRODUCE [LACTATE-CO-GLYCOLATE] COPOLYMER FROM GLUCOSE, AND METHOD FOR PREPARING [LACTATE-CO-GLYCOLATE] COPOLYMER USING SAME 有权
标题翻译：具有从葡萄糖生产[柠檬酸 - 甘油酯]共聚物的能力的重组微生物以及使用其制备[LACTATE-CO-GLYCOLATE]共聚物的方法
公开(公告)号：US20140030775A1
公开(公告)日：2014-01-30
申请号：US14004437
申请日：2012-03-09
申请人： Sang Yup Lee , Si Jae Park , Seung Hwan Lee , Bong Keun Song , Yu Kyung Jung , Tae Woo Lee
发明人： Sang Yup Lee , Si Jae Park , Seung Hwan Lee , Bong Keun Song , Yu Kyung Jung , Tae Woo Lee
IPC分类号： C12P7/62 , C12N15/70
CPC分类号： C12P7/625 , C12N9/0006 , C12N9/1029 , C12N15/70
摘要： There is provided a recombinant microorganism having producibility of poly(lactate-co-glycolate) from glucose, and more particularly, a recombinant microorganism having producibility of poly(lactate-co-glycolate) without adding an exogenous glycolate precursor, and a method of preparing [poly(preparing lactate-co-glycolate)] using the same. According to the present invention, the poly(lactate-co-glycolate) in which the concentration of the glycolate fraction is high may be prepared at a high concentration without supplying exogenous glyoxylate. Therefore, the present invention may be effectively used for treatment.
摘要翻译：提供了一种具有来自葡萄糖的聚（乳酸 - 共 - 乙醇酸）的生产性的重组微生物，更具体而言，是在不添加外源乙醇酸酯前体的情况下具有聚（乳酸 - 共 - 乙醇酸）的生产性的重组微生物， [聚（制备乳酸 - 共 - 乙醇酸）]。根据本发明，可以高浓度制备其中乙醇酸酯部分浓度高的聚（乳酸 - 共 - 乙醇酸），而不提供外源乙醛酸酯。因此，本发明可以有效地用于治疗。

63. 发明授权

US08494779B2 Method for screening essential metabolites in growth of microorganisms 有权
标题翻译：筛选微生物生长中重要代谢物的方法
公开(公告)号：US08494779B2
公开(公告)日：2013-07-23
申请号：US12519791
申请日：2007-12-21
申请人： Sang Yup Lee , Hawoong Jeong , Tae Yong Kim , Pan-Jun Kim , Kwang Ho Lee
发明人： Sang Yup Lee , Hawoong Jeong , Tae Yong Kim , Pan-Jun Kim , Kwang Ho Lee
IPC分类号： G06F19/10 , G06F19/12
CPC分类号： C12Q1/18 , G01N33/5038
摘要： The present invention disclosed is a method for screening metabolites essential for the growth of microorganism using metabolic flux analysis. More specifically, the present invention relates to the method for screening metabolites essential for the growth of microorganism, by selecting a target microorganism, constructing a metabolic network model of the selected microorganism, inactivating the consumption reaction of each of metabolites in the constructed metabolic network model, analyzing the metabolic flux of the metabolites to select metabolites essential for the growth of the microorganism, and confirming the selected metabolites using the utilization of each of the metabolites, defined as flux sum (Φ). According to the present invention, metabolites essential for the growth of microorganism, and genes involved in the essential metabolites, can be screened in a convenient manner, and drug-target genes against pathogenic microorganisms can be predicted by deleting genes associated with the metabolites screened according to the method.
摘要翻译：所公开的本发明是使用代谢通量分析来筛选微生物生长所必需的代谢物的方法。更具体地说，本发明涉及通过选择靶微生物，构建所选择的微生物的代谢网络模型，在构建的代谢网络模型中灭活各代谢物的消费反应来筛选微生物生长所必需的代谢物的方法分析代谢物的代谢通量以选择对于微生物生长至关重要的代谢物，并且使用定义为通量总和（Phi）的每种代谢物来确认所选择的代谢物。根据本发明，可以以便利的方式筛选微生物生长所必需的代谢物和基本代谢物所涉及的基因，并且可以通过删除与代谢物相关的基因来预测针对病原微生物的药物靶基因的方法。

64. 发明申请

US20110165586A1 Detection Method of Bio-Chemical Material Using Surface-Enhanced Raman Scattering 审中-公开
标题翻译：使用表面增强拉曼散射的生物化学材料的检测方法
公开(公告)号：US20110165586A1
公开(公告)日：2011-07-07
申请号：US12900248
申请日：2010-10-07
申请人： Bongsoo Kim , Taejoon Kang , Ilsun Yoon , Sang Yup Lee , Seung Min Yoo
发明人： Bongsoo Kim , Taejoon Kang , Ilsun Yoon , Sang Yup Lee , Seung Min Yoo
IPC分类号： G01N33/53 , G01N21/00 , G01N33/48
CPC分类号： G01N21/658 , Y10T436/143333
摘要： Provided is a detection method of a biochemical material using surface-enhanced Raman scattering in order to detect the existence of a biochemical material in a target subject or its content therein, more particularly a detection method of a biochemical material facilitating multiplex detection with high-sensitivity, high-reproducibility, high-reliability, and high-precision owing to multiple hot spots formed on the nanowire surface of a single crystal body by the bond of multiple nanoparticles which are physically separated from each other.
摘要翻译：提供了使用表面增强拉曼散射来生物化学材料的检测方法，以检测目标受试者中的生物化学物质的存在或其含量，更具体地说，一种促进多重检测的生化材料的检测方法，具有高灵敏度由于通过物理上彼此分离的多个纳米颗粒的结合而在单晶体的纳米线表面上形成的多个热点，具有高再现性，高可靠性和高精度。

65. 发明申请

US20110027845A1 ENHANCED ETHANOL AND BUTANOL PRODUCING MICROORGANISMS AND METHOD FOR PREPARING ETHANOL AND BUTANOL USING THE SAME 审中-公开
标题翻译：生产微生物的增强的乙醇和丁醇和使用它们制备乙醇和丁醇的方法
公开(公告)号：US20110027845A1
公开(公告)日：2011-02-03
申请号：US12809323
申请日：2008-12-22
申请人： Sang Yup Lee , Yu-Sin Jang , Jin Young Lee , Kwang Seop Jung , Jae Hyun Kim
发明人： Sang Yup Lee , Yu-Sin Jang , Jin Young Lee , Kwang Seop Jung , Jae Hyun Kim
IPC分类号： C12P7/16 , C12N1/00 , C12N1/21 , C12P7/06
CPC分类号： C12P7/065 , C12N9/0006 , C12N9/13 , C12P7/16 , Y02E50/10 , Y02E50/17
摘要： The present invention relates to a recombinant microorganism having an enhanced ability to produce ethanol and butanol and a method for preparing ethanol and butanol using the same, and more particularly to a recombinant microorganism having an enhanced ability to produce ethanol and butanol, into which a gene encoding CoA transferase and a gene encoding alcohol/aldehyde dehydrogenase are introduced, and to a method for preparing ethanol and butanol using the same. The recombinant microorganism according to the present invention, obtained by manipulating metabolic pathways of microorganisms, is capable of producing butanol and ethanol exclusively without producing any byproduct, and thus is useful as a microorganism producing industrial solvents and transportation fuel.
摘要翻译：本发明涉及具有提高乙醇和丁醇生产能力的重组微生物，以及使用该重组微生物制备乙醇和丁醇的方法，更具体地说，涉及生产乙醇和丁醇的能力增强的重组微生物，其中基因引入编码CoA转移酶和编码醇/醛脱氢酶的基因，以及使用其制备乙醇和丁醇的方法。根据本发明的通过操纵微生物代谢途径获得的重组微生物能够仅生产丁醇和乙醇而不产生任何副产物，因此可用作产生工业溶剂和运输燃料的微生物。

66. 发明申请

US20100330634A1 Mutants Having Capability To Produce 1, 4-Butanediol And Method For Preparing 1, 4-Butanediol Using The Same 有权
标题翻译：具有生产1,4-丁二醇能力的突变体及其制备1,4-丁二醇的方法
公开(公告)号：US20100330634A1
公开(公告)日：2010-12-30
申请号：US12676840
申请日：2008-08-13
申请人： Si Jae Park , Sang Hyun Lee , Sang Yup Lee , Eun Jeong Lee
发明人： Si Jae Park , Sang Hyun Lee , Sang Yup Lee , Eun Jeong Lee
IPC分类号： C12P7/18 , C12N1/19 , C12N1/15 , C12N1/21 , C07H21/04 , C12N15/63
CPC分类号： C12N15/77 , C12N9/0006 , C12N9/0008 , C12N9/001 , C12N9/13 , C12P7/18 , C12Y101/01061 , C12Y102/01024 , C12Y103/99002
摘要： A mutant capable of producing 1,4-butanediol and a method of preparing 1,4-butanediol using the same are provided. The mutant microorganism is prepared by introducing and amplifying genes encoding enzymes converting succinate into 4-hydroxybutyrate and 4-hydroxybutyrate into 1,4-butanediol in a microorganism capable of producing succinate. The method includes culturing the mutant in a medium containing carbohydrate and obtaining 1,4-butanediol from the culture. Thus, 1,4-butanediol, which is essential in chemical industry, can be prepared in a biological process.
摘要翻译：提供能够生产1,4-丁二醇的突变体和使用其制备1,4-丁二醇的方法。通过在能够产生琥珀酸的微生物中引入和扩增编码将琥珀酸酯转化成4-羟基丁酸酯和4-羟基丁酸酯的基因转化成1,4-丁二醇来制备突变体微生物。该方法包括在含有碳水化合物的培养基中培养该突变体并从培养物中获得1,4-丁二醇。因此，在化学工业中必不可少的1,4-丁二醇可以在生物过程中制备。

67. 发明授权

US07803587B2 Method for developing culture medium using genome information and in silico analysis 有权
标题翻译：使用基因组信息和计算机分析开发培养基的方法
公开(公告)号：US07803587B2
公开(公告)日：2010-09-28
申请号：US11743668
申请日：2007-05-02
申请人： Sang Yup Lee , Ho Nam Chang , Hyohak Song , Tae Yong Kim , Bo-Kyung Choi
发明人： Sang Yup Lee , Ho Nam Chang , Hyohak Song , Tae Yong Kim , Bo-Kyung Choi
IPC分类号： C12P7/44 , C12N1/20 , C12Q1/00 , C12Q1/68 , G06G7/48
CPC分类号： C12N1/20 , C12N5/0018 , C12N2500/32 , C12N2500/38 , C12N2500/40 , C12P7/46 , G06F19/12
摘要： A method for developing a culture medium using genome information and in silico analysis. In one implementation, the method involves developing a minimal synthetic medium, including the steps of constructing a metabolic network using genome information of prokaryotic cell or eukaryotic cell, selecting components of the minimal synthetic medium removing any one among external metabolites from the constructed metabolic network and conducting metabolic flux analysis using in silico simulation, and determining a final culture medium by actual culture.
摘要翻译：使用基因组信息和计算机分析开发培养基的方法。在一个实施方案中，该方法包括开发最小的合成培养基，包括使用原核细胞或真核细胞的基因组信息构建代谢网络的步骤，从构建的代谢网络中选择去除外部代谢物中的任何一种的最小合成培养基的组分，以及使用计算机模拟进行代谢通量分析，并通过实际培养确定最终培养基。

68. 发明申请

US20100136640A1 ENHANCED BUTANOL PRODUCING MICROORGANISMS AND METHOD FOR PREPARING BUTANOL USING THE SAME 审中-公开
标题翻译：生产微生物的增强的丁醇和使用它们制备丁醇的方法
公开(公告)号：US20100136640A1
公开(公告)日：2010-06-03
申请号：US12519060
申请日：2007-12-14
申请人： Sang Yup Lee , Jin Hwan Park , Eleftherios Terry Papoutsakis
发明人： Sang Yup Lee , Jin Hwan Park , Eleftherios Terry Papoutsakis
IPC分类号： C12P7/16 , C12N1/21 , C12N1/19 , C12N1/15
CPC分类号： C12P7/16 , Y02E50/10
摘要： The present invention relates to a recombinant mutant microorganism having enhanced butanol producing capacity and a method for producing butanol using the same. In the microorganism, genes coding for enzymes responsible for the biosynthesis of lactate, ethanol and/or acetate are deleted or attenuated and genes coding for enzymes involved in butanol biosynthesis are introduced and amplified.
摘要翻译：本发明涉及具有提高的丁醇生产能力的重组突变体微生物和使用其的丁醇生产方法。在微生物中，编码负责乳酸盐，乙醇和/或乙酸盐的生物合成的酶的基因被缺失或减弱，并且引入并扩增了参与丁醇生物合成的酶编码基因。

69. 外观设计

USD613661S1 Vehicle wheel 有权
公开(公告)号：USD613661S1
公开(公告)日：2010-04-13
申请号：US29346184
申请日：2009-10-28
申请人： Sang Yup Lee , Luciano M. Nakamura
设计人： Sang Yup Lee , Luciano M. Nakamura

70. 发明申请

US20100009432A1 CONDUCTIVE CARBON NANOTUBES DOTTED WITH METAL AND METHOD FOR FABRICATING A BIOSENSOR USING THE SAME 失效
标题翻译：带有金属的导电碳纳米管和使用其制造生物传感器的方法
公开(公告)号：US20100009432A1
公开(公告)日：2010-01-14
申请号：US10860544
申请日：2004-06-03
申请人： Sang Yup Lee , Hee Tae Jung , Dae Hwan Jung , Young Koan Ko , Do Hyun Kim , Seok Jae Lee , Byung Hun Kim , Jae Shin Lee
发明人： Sang Yup Lee , Hee Tae Jung , Dae Hwan Jung , Young Koan Ko , Do Hyun Kim , Seok Jae Lee , Byung Hun Kim , Jae Shin Lee
IPC分类号： C12M1/34 , B05D5/12 , B32B37/02 , C12Q1/00 , C12Q1/68 , C07K2/00 , C12Q1/48
CPC分类号： G01N33/5438 , B82Y30/00 , C12Q1/001 , G01N33/551 , Y10S977/742 , Y10S977/745 , Y10S977/746 , Y10S977/747 , Y10S977/748 , Y10T156/10
摘要： Conductive carbon nanotubes (CNTs) obtained by dotting carboxylated CNTs with metal nanocrystals by chemical functional groups, are described, as well as a method for fabricating a pattern or film of the conductive CNTs which involves repeatedly depositing conductive CNTs on a substrate to achieve high surface density. A biosensor is described, in which bioreceptors that bind to target biomolecules are selectively attached to conductive CNTs or a conductive CNT pattern or film. By use of the conductive biosensor, various target biomaterials that bind or react with the bioreceptors can be precisely measured directly or by electrochemical signals at large amounts in one step. Additionally, the biosensor can be used for an electrical detection method capable of providing precise measurement results even with a small amount of source material.
摘要翻译：描述了通过化学官能团将金属纳米晶体的羧化CNT点缀的导电碳纳米管（CNT），以及用于制造导电CNT的图案或膜的方法，其包括在基板上反复沉积导电CNT以实现高表面密度。描述了生物传感器，其中结合靶生物分子的生物感受器选择性地连接到导电CNT或导电CNT图案或膜。通过使用导电生物传感器，可以在一个步骤中直接或通过大量的电化学信号精确测量与生物感受器结合或反应的各种靶生物材料。此外，生物传感器可以用于即使使用少量源材料也能够提供精确测量结果的电检测方法。

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