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    • 66. 发明授权
    • Polysaccharide conjugates of biomolecules
    • 生物分子的多糖共轭物
    • US06949524B2
    • 2005-09-27
    • US10188578
    • 2002-07-02
    • Rajendra SinghHarshvardhan Mehta
    • Rajendra SinghHarshvardhan Mehta
    • A01N43/16G01N33/564A61K31/715C08B37/00
    • C08B37/0021A01N43/16C08H1/00G01N33/564G01N2333/988
    • Compounds that are modified polysaccharides having pendant aldehyde functionalities are disclosed. Each of the aldehyde functionalities is attached through a linker to a position corresponding to a hydrogen atom of a different hydroxyl group of unmodified polysaccharide. Also disclosed is a method for introducing an amine-reactive functionality into a dextran. The method comprises (a) reacting the dextran with an alkylating agent having a functionality that reacts with an hydroxyl group of the dextran thereby forming an alkylated dextran wherein the alkylating agent has an olefin group and (b) treating the alkylated dextran to convert the olefin group to an amine-reactive functionality. A polysaccharide can be conjugated to a biomolecule by carrying out the above method and reacting the amine-reactive functionality with an amine functionality on the biomolecule to produce polysaccharide conjugated to the biomolecule.
    • 公开了具有侧醛官能团的改性多糖的化合物。 每个醛官能团通过接头连接到对应于未修饰多糖的不同羟基的氢原子的位置。 还公开了将胺反应性功能引入葡聚糖的方法。 该方法包括(a)使葡聚糖与具有与葡聚糖羟基反应的官能团的烷基化剂反应,从而形成烷基化葡聚糖,其中烷基化剂具有烯烃基团,和(b)处理烷基化葡聚糖以转化烯烃 与胺反应性官能团。 通过进行上述方法并使胺反应性官能团与胺官能团在生物分子上反应以产生与生物分子缀合的多糖,可以将多糖与生物分子缀合。
    • 68. 发明授权
    • Process for depositing a material on a substrate using light energy
    • 使用光能在基板上沉积材料的工艺
    • US5820942A
    • 1998-10-13
    • US770907
    • 1996-12-20
    • Rajendra SinghRahul Sharangpani
    • Rajendra SinghRahul Sharangpani
    • C08F2/48H01L21/316
    • H01L21/316
    • The present invention is generally directed to a process and a system for transforming a liquid into a solid material using light energy. In particular, a solution containing a parent material in a liquid form is atomized in a reaction vessel and directed towards a substrate. The atomized liquid is exposed to light energy which causes the parent material to form a solid coating on a substrate. The light energy can be provided from one or more lamps and preferably includes ultraviolet light. Although the process of the present invention is well suited for use in many different and various applications, one exemplary application is in depositing a dielectric material on a substrate to be used in the manufacture of integrated circuit chips.
    • 本发明一般涉及使用光能将液体转变为固体材料的方法和系统。 特别地,含有液体形式的母体材料的溶液在反应容器中被雾化并且指向基底。 雾化的液体暴露于光能,这导致母体材料在基底上形成固体涂层。 光能可以由一个或多个灯提供,并且优选地包括紫外光。 尽管本发明的方法非常适用于许多不同的和各种应用,但是一个示例性的应用是将电介质材料沉积在用于制造集成电路芯片的基板上。