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61. 发明申请

US20060216737A1 Methods for multiplex amplification 审中-公开
标题翻译：多重扩增方法
公开(公告)号：US20060216737A1
公开(公告)日：2006-09-28
申请号：US11372242
申请日：2006-03-08
申请人： John Bodeau , Stephen Gunstream , Mark Oldham
发明人： John Bodeau , Stephen Gunstream , Mark Oldham
IPC分类号： C12Q1/68 , C12P19/34
CPC分类号： C12Q1/6806 , C12Q1/6844 , C12Q1/686 , C12Q2537/143 , C12Q2527/149 , C12Q2527/137 , C12Q2565/501 , C12Q2545/114 , C12Q2565/629
摘要： Methods for multiplex amplification of target nucleic acid sequences are provided.
摘要翻译：提供靶核酸序列的多重扩增方法。

62. 发明申请

US20060138344A1 Spectral calibration method and system for multiple instruments 有权
标题翻译：多种仪器的光谱校准方法和系统
公开(公告)号：US20060138344A1
公开(公告)日：2006-06-29
申请号：US11286071
申请日：2005-11-23
申请人： Stephen Gunstream , Mark Oldham
发明人： Stephen Gunstream , Mark Oldham
IPC分类号： G01N21/64
CPC分类号： G01J1/58 , G01N21/278 , G01N21/6452 , Y10T436/10 , Y10T436/11 , Y10T436/112499 , Y10T436/113332
摘要： Implementations of the present invention describe an apparatus for generating calibration factors for a spectral detector instrument. The calibration factors are derived from a calibration plate containing one or more spectral species in each well of the calibration plate. Each well is then exposed to an excitation source that causes the one or more spectral species in each of the wells to fluoresce. The signal response is measured and associated with each spectral species at each different well position in the calibration plate. Next, the measured signal response from each spectral species at each well position in the calibration plate is compared with a predetermined signal response for each spectral species. The results of this comparison can be used to determine a calibration factor for each well and spectral species to compensate for the difference between the measured signal response and the predetermined signal response.
摘要翻译：本发明的实施方式描述了一种用于产生光谱检测器仪器的校准因子的装置。校准因子来源于校准板的每个孔中含有一个或多个光谱种类的校准板。然后将每个孔暴露于激发源，使得每个孔中的一个或多个光谱物质发荧光。测量信号响应并与校准板中每个不同孔位置处的每个光谱种类相关联。接下来，将来自校准板中每个孔位置处的每个光谱种类的测量信号响应与每个光谱种类的预定信号响应进行比较。该比较的结果可用于确定每个孔和光谱种类的校准因子，以补偿测量的信号响应与预定信号响应之间的差异。

63. 发明申请

US20060094027A1 Multiaxis focusing mechanism for microarray analysis 有权
标题翻译：用于微阵列分析的多轴聚焦机制
公开(公告)号：US20060094027A1
公开(公告)日：2006-05-04
申请号：US10980886
申请日：2004-11-03
申请人： Scott Warren , Louis Hoff , Mark Oldham
发明人： Scott Warren , Louis Hoff , Mark Oldham
IPC分类号： C12Q1/68 , G06F19/00 , G06K9/00
CPC分类号： G06K9/00127 , G06K9/32
摘要： Systems and methods for positioning a multi-featured biological array relative to a signal acquisition device. Detection of the array's positional deviation may be achieved by a calibration beam reflected from the array surface and detected by a position sensitive detector (PSD). The PSD-measured positional deviation can be transformed and used in a control loop to correct for positional variations of the array. The calibration beam and PSD may also be used to detect the array or feature boundaries, thereby allowing lateral centering or positioning of the array relative to the signal acquisition device.
摘要翻译：用于相对于信号采集装置定位多功能生物阵列的系统和方法。通过从阵列表面反射并由位置敏感检测器（PSD）检测的校准光束可以实现阵列位置偏差的检测。可以将PSD测量的位置偏差变换并用于控制回路中以校正阵列的位置变化。校准光束和PSD也可用于检测阵列或特征边界，从而允许阵列相对于信号采集装置的侧向对中或定位。

64. 发明申请

US20060024690A1 Normalization of data using controls 审中-公开
标题翻译：使用控件归一化数据
公开(公告)号：US20060024690A1
公开(公告)日：2006-02-02
申请号：US11086260
申请日：2005-03-22
申请人： H. Kao , Ian Harding , Kathleen Hayashibara , Achim Karger , Fiona Laird Hyland , Mark Oldham , Omead Ostadan , Mark Pratt , Junko Stevens , Austin Tomaney , Greg Young
发明人： H. Kao , Ian Harding , Kathleen Hayashibara , Achim Karger , Fiona Laird Hyland , Mark Oldham , Omead Ostadan , Mark Pratt , Junko Stevens , Austin Tomaney , Greg Young
IPC分类号： C12Q1/68 , G06F19/00 , G01N33/48 , G01N33/50
CPC分类号： G01N35/028 , B01L3/0293 , B01L3/5025 , B01L3/50851 , B01L3/50853 , B01L3/563 , B01L7/52 , B01L9/523 , B01L9/56 , B01L2200/021 , B01L2200/025 , B01L2200/0605 , B01L2200/0642 , B01L2200/0689 , B01L2300/022 , B01L2300/044 , B01L2300/046 , B01L2300/0829 , B01L2300/0851 , B01L2300/0864 , B01L2300/1805 , B01L2400/0406 , B01L2400/0409 , B01L2400/0487 , C12Q1/686 , C12Q2600/166 , G01N21/274 , G01N21/6428 , G01N21/6452 , G01N35/0099 , G01N2035/00356 , G01N2035/042 , G16H10/40 , H04N5/361 , H04N5/367 , C12Q2545/113
摘要： A method of using a standard to correct for variability in sample handling, can comprise (a) adding a template of known concentration to an assay comprising a sample; (b) preamplifying the assay; (c) amplifying the assay; (d) collecting data during the amplifying; and (e) correcting the data using a comparison of data collected from the template to data collected from the sample.
摘要翻译：使用标准来校正样品处理的变异性的方法可以包括（a）将已知浓度的模板加入到包含样品的测定中; （b）预扩增测定; （c）扩增测定; （d）放大期间收集数据; 和（e）使用从模板收集的数据与从样本收集的数据的比较来校正数据。

65. 发明申请

US20050279949A1 Temperature control for light-emitting diode stabilization 审中-公开
标题翻译：温度控制用于发光二极管稳定
公开(公告)号：US20050279949A1
公开(公告)日：2005-12-22
申请号：US10981440
申请日：2004-11-04
申请人： Mark Oldham , Vinod Mirchandani
发明人： Mark Oldham , Vinod Mirchandani
IPC分类号： F21V9/16 , G01N21/01 , G01N21/64
CPC分类号： G01N21/64 , F21K9/00 , F21K9/64 , F21V29/54 , F21V29/677 , F21V29/74 , F21Y2115/10 , G01J3/0286 , G01J3/10 , G01N21/645 , G01N21/6452 , G01N2021/6439 , G01N2201/06113 , G01N2201/062 , G01N2201/0638 , G01N2201/1211 , G05D23/1919 , G05D23/20
摘要： A system is provided that includes a light-emitting diode (LED); a temperature sensor in thermal contact with the LED and capable of measuring an operating temperature and generating an operating temperature signal; and a temperature regulating system capable of receiving the operating temperature signal and regulating the operating temperature based on the operating temperature signal. A method for stabilizing the temperature of an LED is provided. A method is provided that includes providing a system comprising an LED, a reaction region, and a sample in the reaction region; generating excitation beams with the LED; directing excitation beams to the sample; detecting an optical property of the sample to obtain detection data; measuring the operating temperature of the light emitting diode; and adjusting the detection data of an excitation beam characteristic shift related to the operating temperature, when the LED is operated at the operating temperature to generate the excitation beams.
摘要翻译：提供一种包括发光二极管（LED）的系统; 与LED热接触的温度传感器，能够测量工作温度并产生工作温度信号; 以及能够基于工作温度信号接收工作温度信号和调节工作温度的温度调节系统。提供了一种用于稳定LED的温度的方法。提供了一种方法，其包括在反应区域中提供包括LED，反应区域和样品的系统; 用LED产生激励光束; 将激发光束引导到样品; 检测样品的光学特性以获得检测数据; 测量发光二极管的工作温度; 并且当LED在操作温度下操作以产生激发光束时，调整与工作温度相关的激发光束特性偏移的检测数据。

66. 发明申请

US20050269530A1 Combination reader 失效
标题翻译：组合阅读器
公开(公告)号：US20050269530A1
公开(公告)日：2005-12-08
申请号：US11188243
申请日：2005-07-22
申请人： Mark Oldham , Howard King , Douwe Haga , Tracy Ferea
发明人： Mark Oldham , Howard King , Douwe Haga , Tracy Ferea
IPC分类号： G01N21/64 , G01V8/00
CPC分类号： G01N21/76 , G01J3/10 , G01J3/4406 , G01N21/6428 , G01N21/645 , G01N21/6452 , G01N21/6456 , G01N2201/062 , G01N2201/0627 , G01N2201/0633 , G01N2201/0634
摘要： An apparatus for imaging an array of a plurality of features associated with a sample tile. The apparatus can comprise a stage that supports the sample tile in an illumination region, and an illumination source having a plurality of LEDs adapted to emit light. At least a portion of the light can illuminate the illumination region. Additionally, the apparatus can comprise an image collecting device adapted to selectively collect images of either a first signal when the illumination source is illuminating the illumination region, or a second signal absent illumination of the illumination region. The first signal can have wavelengths effectively different from the wavelengths of the portion of the light emitted by the LEDs that illuminates the illumination region.
摘要翻译：一种用于对与样本瓦片相关联的多个特征的阵列进行成像的装置。该装置可以包括在照明区域中支撑样品瓦片的平台和具有适于发光的多个LED的照明源。光的至少一部分可以照亮照明区域。另外，该装置可以包括图像采集装置，适于当照明源照射照明区域时选择性地收集第一信号的图像，或者不存在照明区域的照明的第二信号。第一信号可以具有与照亮照明区域的LED发射的光的部分的波长有效地不同的波长。

67. 发明申请

US20050231723A1 Optical camera alignment 有权
标题翻译：光学相机对准
公开(公告)号：US20050231723A1
公开(公告)日：2005-10-20
申请号：US11086275
申请日：2005-03-22
申请人： Barry Blasenheim , H. Kao , Mark Oldham
发明人： Barry Blasenheim , H. Kao , Mark Oldham
IPC分类号： B01L3/00 , B01L7/00 , B01L9/00 , B01L99/00 , G01N21/25 , G01N21/27 , G01N21/64 , G01N35/00 , G01N35/02 , G01N35/04 , G01N35/10
CPC分类号： G01N21/253 , B01L3/0293 , B01L3/5025 , B01L3/5027 , B01L3/50851 , B01L3/50853 , B01L3/563 , B01L7/52 , B01L9/50 , B01L9/523 , B01L2200/021 , B01L2200/025 , B01L2200/0605 , B01L2200/0642 , B01L2200/0689 , B01L2200/142 , B01L2300/021 , B01L2300/022 , B01L2300/044 , B01L2300/046 , B01L2300/0829 , B01L2300/0851 , B01L2300/0864 , B01L2300/1883 , B01L2400/0406 , B01L2400/0409 , B01L2400/0487 , G01N21/274 , G01N21/6452 , G01N21/6486 , G01N35/0099 , G01N35/028 , G01N35/1002 , G01N35/1074 , G01N2035/00287 , G01N2035/00366 , G01N2035/0405 , G01N2035/0425 , G01N2035/1039
摘要： A camera alignment system that can enable alignment in at least one of three planes and about an axis of at least one of the planes. An alignment mount can mate to a camera and lens. The alignment mount can comprise a mechanism to adjust the camera relative to the lens to that an image plane of the camera aligns with an image plane of the lens in a predetermined orientation. One predetermined orientation can be that the image plane of the camera being parallel to the image plane of the lens.
摘要翻译：一种相机对准系统，其能够实现三个平面中的至少一个和至少一个平面的轴线的对准。对准安装座可与摄像机和镜头配合使用。对准安装座可以包括一个机构，用于相机相对于镜头调整到照相机的图像平面与预定取向的透镜的图像平面对准。一个预定方向可以是相机的图像平面平行于透镜的图像平面。

68. 发明申请

US20050194371A1 Sample tray heater module 失效
公开(公告)号：US20050194371A1
公开(公告)日：2005-09-08
申请号：US11120797
申请日：2005-05-03
申请人： Todd Weinfield , Gary Lim , Donald Sandell , Kevin Bodner , Mark Borodkin , Mark Oldham , Jon Hoshizaki
发明人： Todd Weinfield , Gary Lim , Donald Sandell , Kevin Bodner , Mark Borodkin , Mark Oldham , Jon Hoshizaki
IPC分类号： B01L99/00 , B01D61/18 , B01L3/00 , B01L7/00 , G01N35/00 , G01N35/02 , G01N35/10 , F27D11/00
CPC分类号： B01L3/50255 , B01D61/18 , B01J2219/00288 , B01J2219/00313 , B01J2219/00319 , B01J2219/00335 , B01J2219/00416 , B01J2219/00418 , B01J2219/00423 , B01L7/52 , B01L2200/025 , B01L2200/0631 , B01L2200/0689 , B01L2200/141 , B01L2300/0829 , B01L2300/1805 , B01L2400/049 , G01N1/4077 , G01N35/0099 , G01N35/028 , G01N35/1074 , G01N2035/00485 , G01N2035/102 , Y10T436/25375
摘要： A heater module is described that includes a heat distribution plate including a bottom portion having first and second sides and a plurality of projections extending away from one of the sides. A heat source is provided for heating the heat distribution plate, and, optionally, a heating tray can be used to receive the heat source and heat distribution plate. The heater module is adapted to engage a sample purification tray having a plurality of purification and/or discharge columns which can extend through openings in the heater module and direct a sample into a sample receiving tray. Methods of heating samples using the heater module are also described.

69. 发明申请

US20050190366A1 Fluorescent detector with automatic changing filters 有权
标题翻译：荧光探测器，带自动更换滤光片
公开(公告)号：US20050190366A1
公开(公告)日：2005-09-01
申请号：US10929320
申请日：2004-08-30
申请人： Steven Boege , Mark Oldham , Liana Ilkova
发明人： Steven Boege , Mark Oldham , Liana Ilkova
IPC分类号： G01N21/25 , G01N21/64
CPC分类号： G01N21/6452 , G01N21/253 , G01N2021/6439 , G01N2021/6471 , G01N2021/6476 , G01N2021/6478 , G01N2201/0245
摘要： A fluorometry device and method adapted to determine concentration of spectrally distinguishable species in a biological sample with a plurality of movable optical devices.
摘要翻译：一种荧光测定装置和方法，其适于用多个可移动光学装置确定生物样品中光谱可区分物质的浓度。

70. 发明申请

US20050002026A1 Shaped illumination geometry and intensity using a diffractive optical element 失效
$Shaped illumination geometry and intensity using a diffractive optical element$
标题翻译：使用衍射光学元件形成照明几何形状和强度
公开(公告)号：US20050002026A1
公开(公告)日：2005-01-06
申请号：US10837616
申请日：2004-05-04
申请人： Louis Hoff , Mark Oldham
发明人： Louis Hoff , Mark Oldham
IPC分类号： G01N21/64 , G01J1/20 , G01J3/10 , G01N21/01 , G01N21/76 , G01N21/78 , G01J3/30
CPC分类号： G02B27/0944 , G01J1/20 , G01J3/10 , G02B19/0014 , G02B19/0052 , G02B27/0927
摘要： A method and apparatus to illuminate a target. The apparatus can comprise a first lens configured to receive light from the light source, a diffractive optical element configured to receive the light from the first lens and to regulate the light into regulated light, and second lens configured to receive the regulated light and to direct the regulated light onto a selected area of the target.
摘要翻译：照明目标的方法和装置。该装置可以包括被配置为从光源接收光的第一透镜，被配置为接收来自第一透镜的光并将光调节为调节光的衍射光学元件，以及被配置为接收调节光并引导调节光到目标的选定区域。

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